Populations 1999 adult stem stem cell research. Medical search. Frequent questions

Viable Offspring Derived from Fetal and Adult Mammalian Cells' (1997), by Ian Wilmut et al. (asu.edu)
We expect that the guidance will evolve further as data from Census 2000 and other data collections employing the 1997 collection standards become available, as agencies address implementation issues in their respective programs, and as additional research needs are identified and addressed. (cdc.gov)

While the terms mesenchymal stem cell (MSC) and marrow stromal cell have been used interchangeably for many years, neither term is sufficiently descriptive: Mesenchyme is embryonic connective tissue that is derived from the mesoderm and that differentiates into hematopoietic and connective tissue, whereas MSCs do not differentiate into hematopoietic cells. (wikipedia.org)
Mesenchymal stem cell-based HLA-independent cell therapy for tissue engineering of bone and cartilage. (renudermatology.com)

2001). In our previous report, we concluded the usefulness of amniotic epithelial cells transplantation in spinal cord injury repair research. (scielo.org.ar)
2001) had found amniotic epithelial cells conditioned medium showed neurotrophic effect on rat embryonic day 18 (E18) cortical neurons. (scielo.org.ar)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)

By virtue of expressions of glial and neural surface markers and capability of neurotransmitter metabolism, amniotic epithelial cells are considered as candidate cell type for transplantation strategies to treat neurological disorders. (scielo.org.ar)
These findings suggested the usefulness of them as an alternate source of cells for transplantation approaches to treat neurological disorders (Sakuragawa et al. (scielo.org.ar)
Transplantation of amniotic epithelial cells in various regions of central nervous system such as caudate nucleus (Bankiewicz et al. (scielo.org.ar)
Amniotic epithelial cells transplantation in Parkinson model of rats was found to reverse the condition and prevent death in neurons (Kakishita et al. (scielo.org.ar)
We had also outlined various biological and social advantages by which, amniotic epithelial cells transplantation excels its precedent viz. (scielo.org.ar)
Recently, our conclusion of usefulness of amniotic epithelial cells transplantation to treat spinal cord injuries has been confirmed in rodent models of spinal cord injury (Zhi-yuan et al. (scielo.org.ar)
We conducted a cross-sectional study of -herpes- in the host, seldom causing disease unless the immune sys- viruses in febrile pediatric oncology patients (n = 30), with tem is weakened, as occurs after treatment for solid-organ a reference group of febrile pediatric solid-organ transplant and stem cell transplantation. (cdc.gov)
The choice of chemotherapy depends on several factors, including the patient's performance status, age, renal function, desire for inpatient or outpatient therapy, and likelihood of receiving future autologous stem cell transplantation. (medscape.com)
Clare's lab recently identified a population of progenitor/stem cells in mice that, on transplantation, is sufficient to generate a fully functional thymus. (eurostemcell.org)
1999). Majority of the organs for transplantation are donated from patients in whom brain-stem death has been diagnosed and who are then ventilated to maintain adequate oxygenation and circulation-the so called non-heart-beating donors (NHBDs) (D Allessandro et al . (scialert.net)
Experimental treatment approaches include vaccines and nonmyeloablative allogeneic peripheral blood stem cell transplantation. (medscape.com)

The standard test to confirm multipotency is differentiation of the cells into osteoblasts, adipocytes and chondrocytes as well as myocytes. (wikipedia.org)
At this juncture, through the present study it was found that, chicken neural retinal cells when grown alone failed to survive and contrarily when either co-cultured with chicken amniotic epithelial cells / cultured in amniotic epithelial cell conditioned medium not only survived but also showed extensive differentiation. (scielo.org.ar)
In this study, it was observed that the ion implantation stimulated the neural proliferation and the implantation of different ions on cell culture surfaces was essential to determine the effects of this technique on adhesion, proliferation, differentiation and apoptosis properties of cells in details. (omicsonline.org)
Laminin 411 markedly induced the expression of the genes Foxa2 and Sox17 , markers for pancreatic precursor cells, efficiently induced IPC differentiation from MSCs, and up-regulated insulin expression at both mRNA and protein levels. (biomedcentral.com)
Derivation and differentiation of haploid human embryonic stem cells. (nature.com)
Retinoic Acid is an important factor for embryonic development, eye health, adipogenesis (fat cell development) and myogenesis (muscle differentiation) as well as the activation of many other genes. (berkeley.edu)
Leucocyte Typing IV: White Cell Differentiation Antigens. (bdbiosciences.com)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)
2 (2007) observed that cell adhesion and proliferation, as well as the osteogenic differentiation of mouse mesenchymal stem cells (MSCs) to Ti discs were significantly similar to those on the plastic surface of the culture, indicating Ti as an excellent material for repairing hard tissue in the field of bone tissue engineering. (bvsalud.org)
The term "adhesion" to the biomaterial refers to the most important phase, since the quality of it will influence morphology and the capacity of cell proliferation and differentiation 3 . (bvsalud.org)

1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
2000). In *Correspondence to: Perrine Barraud, Department of Veterinary Medi- contrast, several cell surface markers have been used to cine, Neurosciences, Madingley Road, Cambridge CB3 OES, United enrich for NSCs in the rodent CNS. (lu.se)
The incidence of SPM at all sites was higher during 2000-2012 compared to 1992-1999 (O/E 1.24 versus 1.10). (hindawi.com)

Our Cardiovascular Institute (CVI) is on a strategic course to become an innovative incubator, early tester and training center for cutting-edge research, diagnostics and therapies. (usc.edu)
In most cases, clinically relevant cell numbers for MSC-based therapies can be only obtained by in vitro expansion of isolated cells. (frontiersin.org)
In this mini review, we will discuss point by point possible pitfalls in the production of human MSCs for cell therapies, without consideration of material-based applications. (frontiersin.org)
Stem Cells and other innovative intra-articular therapies for osteoarthritis: What does the future hold? (renudermatology.com)
Future progress in this area holds promise for advancing islet- and beta cell-directed therapies that could be implemented in the early stages of the disease and could be combined with immunotherapies. (springer.com)
hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
For leading pioneering genetic marking and therapy trials targeting hematopoietic stem cells, and developing uniquely predictive non-human primate models to successfully improve the safety and efficiency of various gene therapies as well as gain insights into hematopoiesis and immunology. (the-asci.org)

2002). In humans, SSEA4 is expressed by building the nervous system but also for their prospec- nonneural cells such as the erythrocytes (Kannagi et al. (lu.se)
and from 2002 on pluripotency in embryonic stem cells in the lab of Ali H. Brivanlou. (eurostemcell.org)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)

Mesenchymal stem cells (MSCs) also known as mesenchymal stromal cells or medicinal signaling cells are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue). (wikipedia.org)
Mesenchymal stem cells (MSCs), a term first coined by Arnold I. Caplan in 1991, are characterized morphologically by a small cell body with a few cell processes that are long and thin. (wikipedia.org)
However, MSCs are found in much higher concentration in the Wharton's jelly compared to cord blood, which is a rich source of hematopoietic stem cells. (wikipedia.org)
These cells have several advantages over bone-marrow-derived MSCs. (wikipedia.org)
MSCs have been seen to even differentiate into neuron-like cells, but doubt remains about whether the MSC-derived neurons are functional. (wikipedia.org)
Despite almost 50 years of research and over 20 years of preclinical and clinical studies, the question of curative potential of mesenchymal stem/stromal cells (MSCs) is still widely discussed in the scientific community. (frontiersin.org)
Only a careful consideration and standardization of all pretreatment processes/methods for the different applications of MSCs will ensure robust and reproducible performance of these cell populations in the different experimental and clinical settings. (frontiersin.org)
Mesenchymal stem/stromal cells (MSCs) have the capacity to differentiate into cells and tissues of one germ layer, here the mesodermal lineage, and are consequently multipotent. (frontiersin.org)
Insulin-producing cells (IPCs) differentiated from mesenchymal stem cells (MSCs) hold great promise in the treatment of DM. (biomedcentral.com)
Mesenchymal stem cells (MSCs) have gained interest because of its potential application in regeneration medicine and cytotherapy. (biomedcentral.com)

Wutz, A. Haploid mouse embryonic stem cells: rapid genetic screening and germline transmission. (nature.com)
Leeb, M. & Wutz, A. Derivation of haploid embryonic stem cells from mouse embryos. (nature.com)
Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. (nature.com)
Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells. (nature.com)
Androgenetic haploid embryonic stem cells produce live transgenic mice. (nature.com)
Genetic modification and screening in rat using haploid embryonic stem cells. (nature.com)
Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes. (nature.com)
He has been leader of a research group at the Max-Delbrück-Center for Molecular Medicine in Berlin until 2011 focusing his research on signal transduction mechanisms in human and murine embryonic stem cells. (eurostemcell.org)

These bone marrow stem cells do not contribute to the formation of blood cells, and so do not express the hematopoietic stem cell marker CD34. (wikipedia.org)
Hematopoietic Stem Cell and Leukaemic Stem Cell environmental stress responses (In vitro biomimicry of hypoxia, normoxia, hypothermia, hyperthermia, hypoglycemia and hyperglycemia): Effect on cellular growth, cell cycle distribution, apoptosis and cellular metabolism. (imperial.ac.uk)
Mathematical modeling of Hematopoietic Stem Cell and Leukaemic Stem Cell culture systems. (imperial.ac.uk)

These stem cells are capable of differentiating into chondrocytes, cardiomyocytes, melanocytes, and hepatocyte‐like cells in vitro. (wikipedia.org)
For in vitro studies, immature Leydig cells were isolated from 35-day-old male rats and treated with 50 μM piperine in the presence of different steroidogenic stimulators/substrates for 24 h. (frontiersin.org)
Piperine in vitro also increased androgen production and stimulated cholesterol side-chain cleavage enzyme and 17α-hydroxylase/20-lyase activities in immature Leydig cells. (frontiersin.org)
elicits antiproliferative and proapoptotic activities in vitro in solid and hematologic tumor cells. (medscape.com)
Anti-HLA-DR is intended for in vitro diagnostic use in the identification of cells expressing the HLA-DR antigen, using a BD FACS™ brand flow cytometer. (bdbiosciences.com)
[ 8 ] T cells in oral lichen planus contain mRNA for TNF and secrete TNF in vitro. (medscape.com)
establish mechanisms of action by studying the effects of the same chemicals in experimental animals and on human cells in vitro, allowing for a better prediction of human carcinogenicity and assessment of carcinogenic mechanisms. (who.int)

Using our recently established haploid human pluripotent stem cells (hPSCs), we generated a genome-wide loss-of-function library targeting 18,166 protein-coding genes to define the essential genes in hPSCs. (nature.com)
Similarly, destruction of neonatally abundant pluripotent stem cells would likely have a more pervasive outcome than destruction of The value of incorporating immunologic appeared more severe and/or persistent when single lineages or differentiated cells that pre- data for the toxicologic assessment of drugs, the exposure occurred perinatally when com- dominate in adults. (cdc.gov)

They are sometimes referred to as bone marrow stromal stem cells. (wikipedia.org)

The term encompasses multipotent cells derived from other non-marrow tissues, such as placenta, umbilical cord blood, adipose tissue, adult muscle, corneal stroma, or the dental pulp of deciduous (baby) teeth. (wikipedia.org)
Nor do only the cells of the inner cell mass of the blastocyst become the later adult and none of the cells from the inner cell mass become part of the placenta, umbilical cord, etc. (lifeissues.net)

The USC Research Center for Liver Diseases (RCLD) focuses its research base on four core themes: 1) viral hepatitis and hepatocellular carcinoma, 2), steatohepatitis and fibrosis, 3) liver injury (hepatotoxicity and mitochondrial pathobiology) and 4) repair, regenerative medicine and developmental biology. (usc.edu)
Targeted faculty recruitment in these areas is ongoing - in some cases in partnership with Eli & Edythe Broad Center for Regenerative Medicine & Stem Cell Research at USC - with the goal to sustain excellence on the cutting edge of translational science and to create critical mass for new center initiatives. (usc.edu)
Non-reproducible treatment outcomes or even absence of treatment effects in comparison to control groups challenges the potential of these cells for routine application both in tissue engineering and in regenerative medicine. (frontiersin.org)
Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. (renudermatology.com)
We're a partnership of more than 400 stem cell and regenerative medicine labs across Europe, connected via research centres, consortia, networks and hubs. (eurostemcell.org)
Anna's academic research in Science and Technology Studies at the University of Edinburgh covers algorithmic governance, digital health, and regenerative medicine with a particular interest in developing digitally native methodologies. (eurostemcell.org)
Paolo De Coppi is a Consultant Paediatric Surgeon at Great Ormond Street Hospital (GOSH), and Reader and Head of Stem Cells and Regenerative Medicine at the UCL Institute of Child Health in London. (eurostemcell.org)

Previously, he was the Principal Investigator and lead of his lab at The Institute of Molecular and Cell Biology (IMCB) . (lifeboat.com)
His academic research is primarily in the field of cancer and aging molecular biology, with particular emphasis on the role of DNA damage and stress response signaling. (lifeboat.com)
Research includes translational heart research and efforts into atherosclerosis, cardiovascular genomics and stem cell research, lung biology and pulmonary disease, nanotechnology related to air pollution injury and drug delivery and clinical outcomes in lung cancer and critical care medicine. (usc.edu)
Our research programs take systems biology, translational, and population approaches, coupling closely with prevention and clinical care. (usc.edu)
The real experts to ask about the accurate scientific facts of human embryology are the scientific experts in human embryology who are academically credentialed Ph.D. human embryologists - not the "experts" in cell biology, genetics, doctors, nurses, theologians, lawyers or politicians, secretaries, news journalists, etc. (lifeissues.net)
TEA domain-1 (TEAD1) transcription factor participates in both slow oxidative fiber type gene expression and plays a role in satellite cell biology. (missouri.edu)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)
His seminal insights defined the role of gut hormones on normal physiology and metabolism, pioneering innovative understanding of neuroendocrine cell biology and the role of neurohormonal pathways in the development and progression of neuroendocrine tumors. (the-asci.org)

2003). Similarly, when transplanted into ischemic cortical areas, they were found to differentiate into 'neuron-like' cells (Okawa et al. (scielo.org.ar)
Neural stem cells can also give rise to neural progenitor cells, which proliferate rapidly during their short lives and then 'differentiate' into neurons or glia. (elifesciences.org)
Since neurosphere-forming cells can self-renew and differentiate into neurons and glia, the ability of cells to form neurospheres has generally been taken as evidence that they are stem cells. (elifesciences.org)

1998. Armed Forces Radiobiology Research Institute. (cdc.gov)

The Keck School's rigorous research portfolio spans basic, clinical, translational and population research and utilizes multi-disciplinary collaborations in order to provide solutions for the health problems facing local and international communities. (usc.edu)
We have a strong tradition of clinical research in infectious disease, including conducting adult and pediatric AIDS clinical trials, heading studies focused on the prevention of HIV and sexually transmitted diseases, and participating in the national Center for Disease Control & Prevention (CDC)-sponsored Tuberculosis Trials Consortium (TBTC) . (usc.edu)
Our premier clinical programs in emergency medicine, trauma, musculoskeletal and skin disease includes translational research for treatment of an inherited skin disease called epidermolysis bullosa, a new translational research program called the Eye Trauma & Visual Restoration Team collaborates with the USC Viterbi School of Engineering. (usc.edu)
New initiatives to research AD in Down syndrome offer exciting opportunities for the benefits of detailed clinical studies and robust trials, performed almost exclusively on AD in the general population to date, to be brought to the DS population. (acnr.co.uk)
1 Alzheimer pathology is virtually ubiquitous in the DS population ≥30 years, but time to onset of clinical features is highly variable. (acnr.co.uk)
7 The disparity between AD neuropathology and clinical symptoms is also seen in the general population, but is particularly striking in the DS population, and this is the subject of planned research in the LonDownS project (see Box 1). (acnr.co.uk)
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields. (omicsonline.org)
Through our collaborations with investigators in both basic science and clinical departments, including the departments of Psychiatry and Behavioral Sciences, Psychological and Brain Sciences, Neurology and Public Health, our research also focuses on brain systems involved in spatial navigation and decision-making as well as cognitive impairment in neuropsychiatric conditions such as schizophrenia, eating disorders, obsessive-compulsive disorders, depression and anxiety. (hopkinsmedicine.org)
Research in our center involves population-based and clinical studies of the causes, correlates, and consequences of aging -related conditions, including frailty, disability, and social isolation. (hopkinsmedicine.org)
Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. (renudermatology.com)
20 Research Articles On: Preclinical and clinical data for the use of mesenchymal stem cells in articular cartilage tissue engineering. (renudermatology.com)
Concise Review: The Clinical Application of Mesenchymal Stem Cells for Musculoskeletal Regeneration: Current Status and Perspectives Andre F. Steinert, Lars Rackwitz, Fabian Gilbert, Ulrich Nöth and Rocky S. Tuan. (renudermatology.com)
Included studies were original articles researching the feasibility, acceptability, and clinical outcomes of telemedicine or telehealth interventions in pediatric or adult populations with malignant or nonmalignant hematological conditions. (jmir.org)
The biological properties and clinical potential of stem cells elicit that are generated must not be unduly sensitive to small fluctu- continued scientific, commercial, and public interest. (lu.se)
The treatment of metastatic renal cell carcinoma is problematic, and, whenever possible, patients should be directed to approved and controlled clinical trials. (medscape.com)

Multiparameter flow cytometric analysis of HLA-DR expression on Human peripheral blood leucocyte populations. (bdbiosciences.com)
Schwann cells (SCs) have important roles in development, myelination and regeneration in the peripheral nervous system. (scirp.org)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)

After antigen recognition and activation, CD8 + cytotoxic T cells may trigger keratinocyte apoptosis. (medscape.com)
Current data suggest that oral lichen planus (OLP) is a T-cell-mediated autoimmune disease in which autocytotoxic CD8 + T cells trigger the apoptosis of oral epithelial cells. (medscape.com)

Lymphatic tissues also include the thymus, a relatively small organ behind the breastbone that is thought to play an important role in the immune system until puberty, as well as the bone marrow, which is the spongy tissue inside the cavities of bones that manufactures blood cells. (rarediseases.org)
Unlike some other tissues, it has not been possible to identify or purify neural stem cells directly from the tissue. (elifesciences.org)
Marrow stromal cells as stem cells for nonhematopoietic tissues. (renudermatology.com)
ABSTRACT The aim of this study was to determine the attitude of Saudi Arabians to research involving storage and use of human tissues from which genetic information may be derived and to assess their willingness to donate tissue samples to biobanks. (who.int)
In a cross-sectional interview study of 1051 outpatients at a hospital in Riyadh city, 68.8% had a positive attitude towards biomedical research and 78.4% were willing to allow use of excess surgical tissues for research purposes. (who.int)
PCB methyl sulphones and related compounds: Identification of target cells and tissues in different species. (cdc.gov)

MCL is a B-cell lymphoma that develops from malignant B-lymphocytes within a region of the lymph node known as the mantle zone. (rarediseases.org)
Data items in the extraction form included first author name, publication year, country, malignant or nonmalignant hematological condition or disease focus of the study, participant age, participant age subgroup (pediatric or adult), study design and setting, telemedicine intervention type and description, study purpose, and main study outcomes. (jmir.org)
Study results showed comparable outcomes between telemedicine and traditional patient encounter groups across both pediatric and adult populations for malignant and nonmalignant hematological conditions. (jmir.org)
Evidence from this review suggests that telemedicine use in nonmalignant and malignant hematology provides similar or improved health care compared to face-to-face encounters in both pediatric and adult populations. (jmir.org)

Cell Stem Cell 19 , 569-572 (2016). (nature.com)

In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)

This property is primarily attributable to satellite cells which comprise a small population of quiescent mono-nucleated cells which first appear during late fetal life, and which reside between the basal lamina and the surface (sarcolemma) of mature skeletal muscle cells. (missouri.edu)

We may also utilize bone marrow derived stem cell therapy. (jointrehab.com)

Paracrine effect of mesenchymal stem cells derived from human adipose tissue in bone regeneration. (renudermatology.com)
Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series. (renudermatology.com)

Treatment of chronic patellar tendinopathy with autologous bone marrow stem cells: a 5-year-followup. (renudermatology.com)
Aim: To evaluate the adhesion of mouse bone marrow mesenchymal cells (MBMMC) on different titanium surfaces. (bvsalud.org)
mesenchymal stem cells, bone marrow, titanium. (bvsalud.org)

1999. Toxicological profile for ionizing radiation. (cdc.gov)

Leadership is placing priority attention on growing world-class translational research initiatives centering on psychiatric and neurological disorders including autism, depression, Parkinson's disease, schizophrenia and stroke. (usc.edu)
Last year, the fiscal year 2018 NDAA reported by the Senate Committee on Armed Services and ultimately approved by the Senate included provisions that would have individually and collectively restricted, if not outright prohibited, medical research on diseases and disorders that affect our nation's men and women who serve or have served in the U.S. Armed Services. (veteransforcommonsense.org)
The strong level of bipartisan Congressional support for the defense health research programs is a beacon of hope to the military families, retirees, veterans and civilians who must cope with these diseases and disorders. (veteransforcommonsense.org)
The team seeks to advance policies and practices to optimize brain health in vulnerable populations while destigmatizing these brain disorders. (hopkinsmedicine.org)
Experimental research, however, clearly shows that aluminum adjuvants have a potential to induce serious immunological disorders in humans. (educate-yourself.org)
The prevalence of balance disorders in the overall population of the United States is unknown. (cdc.gov)

5. Most countries in the African Region have no specific regulations and policies governing genetic manipulations for assisted conception, treatment and research. (who.int)
2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)
Hamer's research suggested a possible genetic cause of homosexuality. (asu.edu)
Wilmut, McWhir, and Campbell collaborated with Angelica Schnieke and Alex J. Kind at PPL Therapeutics in Roslin, a company researching cloning and genetic manipulation for livestock. (asu.edu)
The researchers studied the genetic control of gene expression in cultured white blood-cell lines from women with PMDD and control subjects. (nih.gov)
It may actually astonish most adults just how much genetics the National Institutes of Health assumes we know about our genetic heritage. (probe.org)
If we don't take the time to familiarize ourselves with genetic research and its implications, we risk responding out of fear and ignorance and potentially throwing away crucial medical advances. (probe.org)

Stromal cells are connective tissue cells that form the supportive structure in which the functional cells of the tissue reside. (wikipedia.org)
Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes. (rarediseases.org)
Critical to the hypothesis is the experimental fact that human endometrial-derived stem cells (hEnSCs) as multipotent accessible source of cells are known as useful cell candidates in the field of nerve tissue engineering. (scirp.org)
These novel differentiated cells in fibrin gel might open new opportunities for the management of cell survival and neurotrophic potential in tissue engineering approaches for nerve repair. (scirp.org)
Stem cells and cartilage development: complexities of a simple tissue. (renudermatology.com)
Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC. (renudermatology.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
The role of autoimmunity in the pathogenesis is supported by many autoimmune features of oral lichen planus, including its chronicity, onset in adults, predilection for females, association with other autoimmune diseases, occasional tissue-type associations, depressed immune-suppressor activity in patients with oral lichen planus, and the presence of autocytotoxic T-cell clones in lichen planus lesions. (medscape.com)
Logistic regression analysis found that predictors for a positive attitude to biomedical research and to use of tissue in research were: female sex, higher level of education, previous experience of blood testing and previous participation in health-related research. (who.int)
The tissue of origin for renal cell carcinoma (RCC) is the proximal renal tubular epithelium. (medscape.com)

We use a variety of techniques including neuropsychological assessments, experimental behavioral assessments and particularly advanced neuroimaging methods to study these questions in young and older adults and patients with mild cognitive impairment, Alzheimer's disease, Parkinson's disease and epilepsy. (hopkinsmedicine.org)
Impact of Prompt Influenza Antiviral Treatment on Extended Care Needs After Influenza Hospitalization Among Community-Dwelling Older Adults. (cdc.gov)
Reported associations between oral lichen planus and systemic diseases may be coincidental, because (1) oral lichen planus is relatively common, (2) oral lichen planus occurs predominantly in older adults, and (3) many drugs used in the treatment of systemic diseases trigger the development of oral lichenoid lesions as an adverse effect. (medscape.com)

Our current studies are designed to identify potential signaling pathways connecting increased TEAD-1 expression in skeletal muscle to activation of genes encoding proteins typically restricted to slow-twitch fibers, as well as satellite cell numbers that exceed homeostatic numbers associated with slow-fibers. (missouri.edu)
Multilineage potential of adult human mesenchymal stem cells. (renudermatology.com)
Advanced Cell Technology (ACT), a stem cell biotechnology company in Worcester, Massachusetts, showed the potential for cloning to contribute to conservation efforts. (asu.edu)
In particular, the dialogue between T cells and beta cells is far more complex in humans and recent evidence supports potential type 1 diabetes 'endotypes' based on age at onset [ 8 , 9 ]. (springer.com)
Feature papers represent the most advanced research with significant potential for high impact in the field. (mdpi.com)
This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)
1984. The reversal potential of excitatory amino acid action on granule cells of the rat dentate gyrus. (cdc.gov)

Research teams seek to understand childhood obesity and related conditions and develop novel strategies for prevention and treatment. (usc.edu)
The USC Childhood Obesity Research Center (CORC) is a collaborative effort between USC and Children's Hospital Los Angeles, funded by two NIH center grants - one from the National Cancer Institute (NCI) and one from the National Institute on Minority Health & Health Disparities (NIMHHD). (usc.edu)
The Center's research team seeks to understand childhood obesity and its related conditions, to examine its relationship to minority health in Los Angeles County, and - working with the community - to develop novel strategies for prevention and treatment. (usc.edu)
Prevalence of nonalcoholic fatty liver disease among adults with normal weight, overweight and obesity in the United States, 1999-2018. (yale.edu)

The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)

1995) and subsequently in primary cells (Heyworth et al. (lu.se)

Previously, we have reported neurotrophism exhibited by human amniotic epithelial cells when transplanted after spinal cord injury in bonnet monkeys. (scielo.org.ar)
2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
These results show that for the first time, human endometrial stem cells can be differentiated into Schwann cells in 2D and 3D culture. (scirp.org)
Research in the Bakker Memory Laboratory is focused on understanding the mechanisms and brain n ... etworks underlying human cognition with a specific focus on the mechanisms underlying learning and memory and the changes in memory that occur with aging and disease. (hopkinsmedicine.org)
3. Creating awareness among ministries of health in the African Region will provide them with critical and relevant information on the reproductive cloning of human beings and its implications to the health status of the general population. (who.int)
We must work hard to take every thought captive to Christ and see what there is of benefit and what avenues of research and application we need to avoid to preserve human freedom and dignity. (probe.org)
SV40 is a potent DNA tumor virus that induces tumors in rodents and transforms many types of cells in culture, including those of human origin. (educate-yourself.org)
Lampson LA, Levy R. Two populations of Ia-like molecules on a human B cell line. (bdbiosciences.com)

Current research examines the mechanisms of epigenetic modification, the epigenetic basis of cancer, the invention of new molecular, statistical, and epidemiological tools for genome-scale epigenetics and the epigenetic basis of neuropsychiatric disease, including schizophrenia and autism. (hopkinsmedicine.org)
Oxidant damage to cellular DNA, proteins (including the epigenome), and lipids can occur when reactive oxygen species escape cell antioxidant and repair mechanisms. (who.int)

Caplan AI , J Cell Physiol 2007, 213:341-347. (renudermatology.com)

of neurosphere-initiating cells. (lu.se)
Neurosphere formation is commonly used as a surrogate for neural stem cell (NSC) function but the relationship between neurosphere-initiating cells (NICs) and NSCs remains unclear. (elifesciences.org)

More research is needed to better understand risk factors contributing to jALS, which could lead to earlier diagnosis and therapeutic interventions. (cdc.gov)
The therapeutic approach to renal cell carcinoma (RCC) is guided by the probability of cure, which is related directly to the stage or degree of tumor dissemination. (medscape.com)

1999. Exposure rates associated with high level fluoroscopic equipment and data recording modes. (cdc.gov)
VCS has led extensive, annual national advocacy efforts that result in Congress funding the unique, treatment-focused Gulf War Illness Research Program ( GWIRP ) - and more recently the Burn Pits Exposure topic area - within the DoD CDMRP. (veteransforcommonsense.org)
most also demonstrate immunotoxicity after group was composed of scientists from academia, the chemical and pharmaceutical industries, and adult exposure. (cdc.gov)
This phenomenon is chemicals, biologics, and medical devices for pared with exposure in adult animals. (cdc.gov)

Neurons that arise in the adult nervous system originate from neural stem cells and neural progenitor cells. (elifesciences.org)
Neural stem cells have long lives, much of which they spend in a quiescent state. (elifesciences.org)
Consequently, neural stem and progenitor cells have usually been studied retrospectively, based on their ability to form colonies in laboratory cell cultures. (elifesciences.org)
A region of the brain called the subventricular zone contains both neural stem cells and neural progenitor cells, and is one of only two regions of the brain where neural stem cells are found in adult mammals. (elifesciences.org)
However, the exact relationship between neural stem cells and neurosphere-forming cells has been uncertain. (elifesciences.org)
have used a technique called flow cytometry to identify and isolate neural stem cells and neurosphere-forming cells directly from the subventricular zone. (elifesciences.org)
The neural stem cells, which Mich, Signer et al. (elifesciences.org)
Using this surface modification method, it was aimed to improve surface characteristics and achieve a bioactive surface for neural stem cells. (omicsonline.org)
Even though the integration of stem cells was promising, neural stem cell studies still have many milestones to reach. (omicsonline.org)

hPSC-enriched essential genes mainly encode transcription factors and proteins related to cell-cycle and DNA-repair, revealing that a quarter of the nuclear factors are essential for normal growth. (nature.com)
Fig. 2: Analysis of cell-essential genes. (nature.com)
In 1993, Dean H. Hamer and colleagues in the US published results from their research that indicated that men with speicifc genes were more likely to be homosexual than were men without those genes. (asu.edu)
These cells express many of the same genes expressed in brain cells-potentially providing a window into genetically influenced differences in molecular responses to sex hormones. (nih.gov)
More than half of the ESC/E(Z) genes were overexpressed in PMDD patients' cells compared to cells from control subjects. (nih.gov)
Paradoxically, protein expression of four key genes was decreased in cells from women with PMDD. (nih.gov)
In addition, progesterone boosted expression of several of these genes in control subjects, whereas estrogen decreased expression in cell lines derived from PMDD patients. (nih.gov)
By looking at our completed sequence, it is predicted that our genome consists of 30,000 to 45,000 genes in each of our cells. (probe.org)

Treatment of knee osteoarthritis with autologous mesenchymal stem cells: a pilot study. (renudermatology.com)

Telemedicine, including video-, web-, and telephone-based interventions, is used in adult and pediatric populations to deliver health care and communicate with patients. (jmir.org)
Most (25/32) studies were conducted in adults, and the remaining (7/32) were conducted in the pediatric population. (jmir.org)
Telemedicine interventions utilized in the included studies were well received in both pediatric and adult settings. (jmir.org)

Changing surface characteristics of scaffolds was a way to promote regeneration and ion implantation was one of the methods to modify surface properties which play a huge role in enhancing the proliferation and integration of cells. (omicsonline.org)
Stem cell therapy for cartilage regeneration in osteoarthritis. (renudermatology.com)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)

Amniotic epithelial cells were believed to secrete an 'Epidermal Growth Factor (EGF) - like' factor and exact identification was not made. (scielo.org.ar)
It is interesting to note that while factor secreted by amniotic epithelial cells resembles EGF and/or FGF-2 in its biological action, known isoforms of them were not detected. (scielo.org.ar)
Considering the biological closeness between EGF and FGF-2, results indicate the possibility of a novel isoform of these growth factors secreted by amniotic epithelial cells. (scielo.org.ar)
Amniotic epithelial cells were known to express some of neuronal and glial cell markers (Sakuragawa et al. (scielo.org.ar)
Based on the neurotropism exerted by amniotic epithelial cells conditioned medium, a diffusible neurotrophic factor produced by them had been suggested as a possible cause apart from direct cell-to-cell effects (Uchida et al. (scielo.org.ar)
The corneal epithelium is composed of stratified squamous epithelial cells on the outer surface of the eye, which acts as a protective barrier and is critical for clear and stable vision. (wjgnet.com)

Research area: (Micro-) Algal Biotechnology. (imperial.ac.uk)
Communicate with key community stakeholders (industry and education leaders) to promote biotechnology and STEM education through student and teacher workshops, industry collaboration for student internships and employment, and articulation agreements for course transfer. (k-state.edu)

Consistent with increase in serum T, piperine increased Leydig cell number, cell size, and multiple steroidogenic pathway proteins, including steroidogenic acute regulatory protein, cholesterol side-chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase 1, 17α-hydroxylase/20-lyase, and steroidogenic factor 1 expression levels. (frontiersin.org)
The proteasome pathway is an enzyme complex existing in all cells, which degrades ubiquitinated proteins that control the cell cycle and cellular processes and maintains cellular homeostasis. (medscape.com)
The exact mechanism of PRP is not known, but current research points to cytokines (small cells that set up communications between cells to coordinate the healing response), growth factors and other proteins as the main medium through which PRP works. (jointrehab.com)
And proteins do all the real work in our cells. (probe.org)

Immunological detection of blast cell subpopulations in acute myeloblastic leukemia at diagnosis: implications for minimal residual disease studies. (bdbiosciences.com)
The diagnosis of death, itself, has been debated for centuries (Palo and Viitala, 1999). (scialert.net)

Sokullu E, Dağcı T, Gözen O, Ersoy F, Öztarhan A (2017) The Effects of Carbon and Gold Ion Implanted Surfaces on Neuronal Stem Cells' Functions. (omicsonline.org)

ERK1/2 and AKT pathways may involve in the piperine-mediated stimulation of Leydig cell development. (frontiersin.org)
Reversible proteasome inhibition disrupts pathways supporting cell growth, thus decreasing cancer cell survival. (medscape.com)
Here, we review some of the recent advances and studies that highlight the roles of these changes as well as antigen presentation and stress response pathways in beta cells in the onset and propagation of the autoimmune process in type 1 diabetes. (springer.com)

In this summary, unless otherwise stated, evidence and practice issues as they relate to adults are discussed. (cancer.gov)
The evidence and application to practice related to children may differ significantly from information related to adults. (cancer.gov)
Mounting evidence supports the notion that the activation and evolution of islet autoimmunity in genetically susceptible people is contingent upon early life exposures affecting the islets, especially beta cells. (springer.com)

Surgical resection remains the only known effective treatment for localized renal cell carcinoma, and it also is used for palliation in metastatic disease. (medscape.com)
Renal cell carcinoma is an immunogenic tumor, and spontaneous regressions have been documented. (medscape.com)
The study also revealed increased risk of death due to renal cell carcinoma in patients who did not undergo surgical resection of metastasis. (medscape.com)
[ 18 ] A study by Alt et al found that complete resection of multiple renal cell carcinoma metastases may be associated with long-term survival. (medscape.com)
This applies as well in the adjuvant treatment of surgically resected renal cell carcinoma, for which no therapy has yet been found to offer survival benefit. (medscape.com)
Go to Renal Cell Carcinoma Treatment Protocols , Clear Cell Renal Cell Carcinoma , and Sarcomatoid and Rhabdoid Renal Cell Carcinoma for complete information on these topics. (medscape.com)
Renal cell carcinoma (see the image below) is the most common type of kidney cancer in adults. (medscape.com)
See Renal Cell Carcinoma: Recognition and Follow-up , a Critical Images slideshow, to help evaluate renal masses and determine when and what type of follow-up is necessary. (medscape.com)
Renal cell carcinoma may remain clinically occult for most of its course. (medscape.com)
Renal cell carcinoma (RCC) accounts for approximately 3% of adult malignancies and 90-95% of neoplasms arising from the kidney. (medscape.com)
Increasingly, renal cell cancers are diagnosed at an earlier stage, and nephron-sparing surgery and thermal ablation are gaining acceptance as a treatment of choice for smaller tumors. (medscape.com)

Mantle cell lymphoma belongs to a group of diseases known as non-Hodgkin's lymphomas, which are related malignancies (cancers) that affect the lymphatic system. (rarediseases.org)
[ 1 ] It accounts for approximately 3% of adult malignancies and 90-95% of neoplasms arising from the kidney. (medscape.com)

Welfare in Europe and Japan, for immuno- ods for developmental neurotoxicity and System toxicity testing in adult rodents. (cdc.gov)

The same diagnostic criteria can be applied to special populations, including children with cyanotic heart disease (CHD) and chronic lung disease (CLD). (medscape.com)

Anatomy22

Organisms2

Diseases1

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Psychiatry and Psychology3

Phenomena and Processes14

Disciplines and Occupations10

Anthropology, Education, Sociology and Social Phenomena9

Technology, Industry, Agriculture3

Humanities20

Information Science1

Named Groups1

Health Care11

Geographicals1

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Mesenchymal stem2

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Transplantation11

Differentiation12

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Therapies7

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MSCs10

Embryonic stem8

Hematopoietic stem3

Vitro7

Pluripotent stem2

Stromal stem cells1

Umbilical cord2

Regenerative7

Biology8

Differentiate3

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Clinical15

Peripheral3

Apoptosis2

Tissues6

Malignant4

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Regulation1

Fetal1

Bone-marrow-derived1

Adipose tissue2

Marrow3

Radiation1

Disorders6

Genetic7

Tissue10

Older adults3

Potential8

Obesity4

Mice1

19951

Human9

Mechanisms2

Physiol1

Neurosphere-initi2

Therapeutic2

Exposure4

Neural stem9

Genes8

Autologous1

Pediatric3

Regeneration3

Epithelial cells6

Biotechnology2

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Pathways3

Evidence3

Renal11

Malignancies2

Rodents1

Diagnostic1