Population genetic variation. Medical search. Frequent questions

Whole genome sequencing has led to the increasing reintegration of this gene-based view with population genetics, and also with the requirement for statistical methodology, the two subjects that Fisher pioneered a century ago. (cam.ac.uk)
A study by Pedersen and colleagues published in the February issue of GENETICS examines variation in whole exome sequences of 18 Greenlandic Inuit individuals, showing the power this unique population could have for identifying rare genetic variants linked to diseases. (genestogenomes.org)
We performed a population genetics survey based on CNVs derived from the BovineHD SNP array data of eight distinct cattle breeds. (usda.gov)
The Centre for Genetics Education provides a fact sheet discussing variations in the genetic code . (medlineplus.gov)
KidsHealth from Nemours offers an introduction to genes, genetics, and genetic changes . (medlineplus.gov)
The question of how and why genetic variation arises and is maintained over long periods of time is of key importance to evolutionary biology, population genetics and conservation biology. (lu.se)
Profile: We are seeking a student with a strong background in bioinformatics, coupled with a keen interest and a solid understanding of population genetics and evolutionary genomics. (lu.se)

HapMap, Perlegen) or in which a relatively small number of genes and/or populations were sampled. (blogspot.com)
The aim of this study was to examine the structure of common variation ascertained in major U.S. populations by resequencing the exons and flanking regions of 3,873 genes in 154 chromosomes from European, Latino/Hispanic, Asian, and African Americans generated by the Genaissance Resequencing Project. (blogspot.com)
This is likely due to the high supply rate of de novo variation and common evolutionary adaptations to the ferret host regardless of obesity status, which we show are mediated by variation in the hemagglutinin (HA) and polymerase genes (PB2 and PB1). (bvsalud.org)
Association of genetic variations in the Wnt signaling pathway genes with myocardial infarction susceptibility in Chinese Han population. (omicsdi.org)
We investigated the possible correlation between genetic variations in Wnt pathway genes and MI risk. (omicsdi.org)
Our study provided the first evidence of the association between polymorphisms in the Wnt pathway genes and MI susceptibility in Chinese Han population. (omicsdi.org)
We hypothesized that genetic variation of inflammatory pathway genes plays a role in tobacco-related carcinogenesis and is modified by tobacco smoking. (omicsdi.org)
Variation in genes can be used to infer relationships between organisms. (binghamton.edu)
Mutation creates variations in protein-coding portions of genes that can affect the protein itself. (utah.edu)
Multiple genes control hair texture, and different variations in these genes are found in different populations. (utah.edu)
Straight hair in Asians is mostly caused by variations in two genes-different genes from the ones that influence hair texture in Europeans. (utah.edu)
Pharmacogenetic (PGx) tests are used to help predict an individual's reaction to drugs by interrogating the presence or absence of known genetic variants in genes that encode drug-metabolizing enzymes, drug transporters, drug receptors, or targets of drug action. (cdc.gov)
Nevertheless, the variation in how people respond to the same environment suggests that genes do play a role in the development of obesity. (cdc.gov)
Other studies have compared obese and non-obese people for variation in genes that could influence behaviors (such as a drive to overeat, or a tendency to be sedentary) or metabolism (such as a diminished capacity to use dietary fats as fuel, or an increased tendency to store body fat). (cdc.gov)

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis. (ox.ac.uk)
The scientific world originally embraced C.C. Little's inbred mouse because it was a way to reduce the daunting complexity of biology and focus on a single genetic trait, such as coat color or cancer susceptibility. (jax.org)
Genetic variation may explain differences in disease susceptibility among the population. (cdc.gov)
The results show that a major factor influencing offspring susceptibility is family identity, suggesting heritable variation in pathogen resistance. (lu.se)

To elucidate the genetic structure of the Tsushima population, we genotyped 101 individuals from the Tsushima Islands and 43 individuals from Honshu and Kyushu using 10 microsatellite loci, and performed population genetic analyses on the genotype data. (bioone.org)
PVWMH had more extensive genetic overlap with small vessel ischemic stroke, and unique associations with several loci implicated in ischemic stroke. (ox.ac.uk)
All of previously reported populations in Korea were sampled and seven loci from six enzymes were analyzed. (e-kjpt.org)
Description of protein loci and genetic divergence between Atlantic and Mediterranean populations = Anàlisi de la variabilitat genètica en el lluç europeu, Merluccius merluccius. (udg.edu)
We examined the genetic population structure of the european hake (Merluccius merluccius) using electrophoretically detectable population markers in 35 protein loci. (udg.edu)
The Nei genetic distance, D, (based on 33 loci) between samples from these two groups ranged from 0.002 to 0.006. (udg.edu)
There is need to investigate and document genetic variation at loci of pharmacogenetic relevance among different SSA populations since this information could be used to inform drug efficacy, safety and recommended dosage [ Reference Dandara 6 - Reference Masimirembwa and Hasler 8 ]. (cambridge.org)
Variation at 4 polymorphic loci, including the diagnostic creatine kinase (CK-A2*) locus, indicated that 19 populations were of southern origin, 5 of northern origin, and 32 of mixed genetic origin. (intechopen.com)
Most population-based genetic studies, including those examining pharmacogenetic loci, have been conducted primarily on individuals of European ancestry . (cdc.gov)

She did her PhD work on the evolutionary consequences of genetic conflict in fruit flies at the University of Georgia. (genestogenomes.org)
Despite its importance in evolutionary biology, studies of the pattern of disease resistance in natural populations are rare. (lu.se)
article{c34f0f78-02b4-4f39-a3c2-3d18e368d937, abstract = {{Despite its importance in evolutionary biology, studies of the pattern of disease resistance in natural populations are rare. (lu.se)
I am an evolutionary ecologist studying the genetic architecture, adaptations, and evolutionary dynamics of wild animal populations. (lu.se)
This has significance both for conservating species and for the future evolutionary potential of populations to adapt to rapidly changing environments. (lu.se)
Our study clarifies when, how and why this variation arose, and shows that this variation has been maintained over long evolutionary time periods through so-called balanced natural selection", says Erik Svensson, biology professor at Lund University. (lu.se)
The great colour variation in insects fascinates the general public, and raises questions about the function of colour signals and its evolutionary consequences for partner choice and conflicts between the sexes", says Erik Svensson. (lu.se)
We now have a good knowledge base for investigating the colour variation over longer evolutionary time scales among other species of this damselfly genus, which occurs in Europe, Africa, Asia, Australia, North and South America. (lu.se)
These new genetic results help us understand both the evolutionary processes that take place within a species, and what happens over longer evolutionary macroevolutionary time scales of tens of millions of years and across several different species", concludes Erik Svensson. (lu.se)
We then continue with analyses of variation within species for genetic identification of individuals, parents, populations and analyses inferring the evolutionary history of species (phylogeography). (lu.se)

The common variant/common disease model predicts that most risk alleles underlying complex health-related traits are common and therefore old and found in multiple populations, rather than rare or population-specific. (blogspot.com)
Accordingly, there is widespread interest in assessing the population structure of common alleles. (blogspot.com)
For all animals, we assessed MHC-DRB diversity and, across populations, we compared the number of unique MHC-DRB alleles and their distributions. (datadryad.org)
Wild individuals possessed more MHC-DRB alleles than did captive individuals, and overall, the wild population had more unique MHC-DRB alleles that were more evenly distributed than did the captive population. (datadryad.org)
If trans-acting variants do exist in human populations, they probably segregate as rare alleles or originate from somatic mutations and present with clinical phenotypes, as is the case in many cancers. (wikipedia.org)
To explore this idea, the authors estimated how much of the genetic variation in the Greenlandic population is likely to alter protein function, including potential loss-of-function alleles and variants that alter the amino acid sequence of a protein. (genestogenomes.org)
Genetic predisposition to higher CRP (weighted score based on alleles of four CRP SNPs associated with higher circulating CRP) was not significantly associated with CRC-specific mortality (HR per CRP-score unit 0.95, 95% CI 0.86, 1.05) or all-cause mortality (HR 0.98, 95% CI 0.90, 1.07). (ox.ac.uk)
Once new alleles arise, meiosis and sexual reproduction combine different alleles in new ways to increase genetic variation. (utah.edu)
Just like with disease alleles, the process of mutation creates these more neutral variations. (utah.edu)
Variations, also called alleles, of MC1R control freckle number. (utah.edu)
New River drainage populations exhibited the southern allele at high frequency, suggesting their historic native character as southern, with presence of northern alleles due to stocking or stream capture events. (intechopen.com)
The lack of diverse ethnic representation in these data has created a gap in knowledge about the alleles present in non-White populations and their relative frequencies. (cdc.gov)
To obtain a more complete picture of the PGx alleles present in a diverse US population, approximately 5,000 DNA samples from the population-based NHANES will be tested to determine the PGx allele frequencies of 970 unique haplotypes in 150 pharmacogenes. (cdc.gov)
The PGx alleles will be correlated with sample ethnicity to determine the allele frequency of each pharmacogene in the various population groups. (cdc.gov)
This will facilitate development and validation of PGx tests capable of detecting important PGx alleles in African American, Asian, Hispanic, and White populations. (cdc.gov)

In this study, a reciprocal North Carolina II design and maximum-likelihood methods were implemented to investigate the genetic basis of variation for 15 floral and vegetative traits in four populations of the annual plant Amsinckia spectabilis (Boraginaceae) differing in mating system. (bioone.org)
Compared to the three partially selfing populations, we found significantly lower levels of nuclear variance for several traits in the nearly completely self-fertilizing population. (bioone.org)
Furthermore, for 11 of 15 traits we did not detect nuclear variation to be significantly greater than zero. (bioone.org)
We also found high maternal variance in one of the partially selfing populations for several traits, and little dominance variance in any population. (bioone.org)
This finding is evidenced through both LD score correlation and de novo variant analysis, indicating that multiple types of genetic risk for ASDs influence a continuum of behavioral and developmental traits, the severe tail of which can result in diagnosis with an ASD or other neuropsychiatric disorder. (ox.ac.uk)
Since pathways implicated in different diseases reveal surprising insights into shared genetic bases underlying apparently unrelated traits, we hypothesize that there are common genetic components involved in the clustering of MetS traits. (biomedcentral.com)
With the aim of identifying these common genetic components, we have performed a genetic association study by integrating MetS traits in a continuous MetS score. (biomedcentral.com)
To understand better these traits of potential importance for speciation, we performed quantitative genetic analysis of both seminal receptacle length and sperm length in two divergent populations. (syr.edu)
Copy number variations (CNVs) comprise large insertions, deletions, and duplications of genomic regions, which contribute to variations in traits among individuals. (usda.gov)
In 2004 JAX Professor Gary Churchill, together with JAX Professor Elissa Chesler when she was at Oak Ridge National Laboratory and dozens of other leading laboratory mouse experts around the world (known collectively as the Complex Traits Consortium), devised the Collaborative Cross: a mouse population established with eight different founder strains, including standard inbred strains but also some wild-type mice. (jax.org)
Combining ability and heterosis were determined in a population obtained from the full diallel crossing of four differentcotton genotypes (G. hirsutum and G. barbadense) for agro morphological traits and yield. (researchgate.net)
The GCA: SCA ratios for thestudied traits were higher than one indicating the presence of additive genetic effects for most of the characteristicsstudied, except for sympodia branch length. (researchgate.net)
This first set of ABs and ILs of eggplant will be extremely useful for the genetic dissection of traits of interest for eggplant, and represents an elite material for introduction into the breeding pipelines for developing new eggplant cultivars adapted to the challenges posed by the climate-change scenario. (frontiersin.org)
My main research goals are to understand how natural and sexual selection shapes phenotypes in wild populations, why some populations are more evolvable than others and how the genetic architecture of traits constrain or facilitate evolution. (lu.se)

Analyses of these data indicated that common SNPs were frequently both shared and common among populations of predominately African, Asian, and European ancestry. (blogspot.com)

In contrast, populations of the intermediate form are highly divergent (G(subscript)ST, 54%), with genetic diversity apportioned between populations (D(subscript)ST, 0.121) rather than within (H(subscript)S, 0.105). (edu.au)
Our results revealed the overall CNV diversity among cattle populations and provided evidence for divergent selection for lineage-specific CNVs. (usda.gov)

Prior national-level U.S. data on taste and smell includes the 1994 National Health Interview Survey- Disability Supplement (NHIS, 1994), a population-based questionnaire survey which estimated that among U.S. adults, there was a 1.4% prevalence of chronic smell problems and a 0.6% prevalence of chronic taste problems. (cdc.gov)

Using a co-caging study design, we investigated the maintenance , generation, and transmission of intrahost IAV genetic variation by sequencing viral genomic RNA obtained from nasal wash samples over multiple days of infection . (bvsalud.org)
Besides single nucleotide polymorphism (SNP), copy number variation (CNV) which comprise insertions, deletions and duplications of genomic sequence, is a new informative type of genetic variations. (usda.gov)
The most highlighted impact of genomics is the inter-population variation, particularly the African genomic diversity, which could provide tools for improved understanding of individual variability in disease and pharmacology [ Reference Masimirembwa and Matimba 3 ]. (cambridge.org)
The development of these ABs and IL eggplant populations had a low efficiency in the early stages, because of the lack of molecular markers and genomic tools. (frontiersin.org)
while other major crops in the genus Solanum and in the family Solanaceae, like tomato, potato, pepper, tobacco, and petunia, have been widely studied from the genetic and genomic points of view, developments in eggplant genomics have lagged behind. (frontiersin.org)
Separately, the genomic analysis of individuals of African ancestry showed only one genetic variation associated with general addiction risk and one substance-specific variation for risk of alcohol use disorder. (medscape.com)
In a new study, an international research team found that this genetic colour variation that is shared between several species arose through changes in a specific genomic region at least five million years ago. (lu.se)
This problem raises questions about alternative genomic factors that might compensate for limited traditional genetic variation. (lu.se)

Lower levels of genetic diversity were found in the small form (H(subscript)T,0.192) compared with the large form (H(subscript)T, 0.254), although both forms apportioned this diversity within populations (H(subscript)S, 0.122 and 0.164, respectively) rather than between D(subscript)ST, 0.070 and 0.090, respectively). (edu.au)
Self-fertilization is expected to reduce genetic diversity within populations and consequently to limit adaptability to changing environments. (bioone.org)

We found that both phenotypes have shared but also distinct genetic architectures, consistent with both different underlying and related pathophysiology. (ox.ac.uk)
Sequencing the DNA of each animal allows the researchers to peg physiological and behavioral characteristics (phenotypes, in the vernacular) to specific genetic variants. (jax.org)
Cognitive-behavioral phenotypes of Williams syndrome are associated with genetic variation in the GTF2I gene, in a healthy population. (bvsalud.org)
Therefore, although ASDs are known to be extremely heritable, their common genetic causes remain largely elusive because of the complex behavioral phenotypes and multigenic etiology of these disorders. (medscape.com)

A positive FIS value of A. misandrum indicated overall deficiency of heterozygotes, and a low FST value (0.112) meant very little differentiation among populations. (e-kjpt.org)
Population genetic evidence suggests differentiation among evolutionarily significant units of southern and northern Appalachian brook trout, with the zone of contact in southwestern Virginia. (intechopen.com)

To address this lacuna, we used amplified fragment length polymorphism (AFLP) to assess the genetic variability of field and laboratory populations. (unl.edu)

The frequency distributions of private and common single nucleotide polymorphisms (SNPs) were measured, and the extent to which common SNPs were shared across populations was analyzed using several different estimators of population structure. (blogspot.com)
Most SNPs that were common in one population were present in multiple populations, but SNPs common in one population were frequently not common in other populations. (blogspot.com)
Moreover, SNPs that were common in two or more populations often differed significantly in frequency from one another, particularly in comparisons of African Americans versus other U.S. populations. (blogspot.com)
Among the European ancestry sample, they discovered 19 single nucleotide polymorphisms (SNPs) that were significantly associated with general addiction risk and 47 genetic variants linked to specific SUDs - nine for alcohol, 32 for tobacco, five for cannabis, and one for opioids. (medscape.com)

Genetic diversity was lower in the Tsushima population than in three geographic populations on the main islands: heterozygosity was 0.189-0.364 in the former, compared to 0.457-0.747 in the latter. (bioone.org)
A recent study demonstrated more EEEV genetic diversity among strains in Florida, most likely resulting from year-round transmission and more geographic mixing of EEEV than what is seen in northern states ( 12 ). (cdc.gov)
This pattern is evident even among geographic populations of Drosophila mojavensis. (syr.edu)
The frequencies exhibit considerable variation in different geographic locations, reflecting the underlying genetic and ethnic diversity of human populations [3]. (who.int)

The intermediate form displays a stronger self-pollination mechanism than the small form.Patterns of genetic variation were analysed using both allozymes and randomly amplified polymorphic DNA (RAPDs). (edu.au)
Random amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR) dominant markers were used to assess genetic variability in the aphid Sitobion avenae (Fabricius) in relation to hydroxamic acid levels in their host-plants. (cambridge.org)

The larger a population, the more genetically diverse it should be, and a migrant population will be less diverse than its source since its genetic diversity is a subset of the larger source population. (genestogenomes.org)
Human populations from Africa are the most genetically diverse of all because their ancestors were the source for all other groups that migrated out of Africa to populate the rest of the world. (genestogenomes.org)
In biology , cloning is the process of producing similar populations of genetically identical individuals that occurs in nature when organisms such as bacteria , insects or plants reproduce asexually . (wikiquote.org)
In conclusion, the present study suggests that management of southern Appalachian brook trout should include: (1) genetically cognizant planning of stocking events, (2) management of populations on a stream-by-stream basis, (3) prioritized conservation of pure southern brook trout populations, and (4) use of southern Appalachian hatchery stocks in restoration efforts. (intechopen.com)
Applying the composite genetic contribution to the risk assessment process would allow for identifying the most genetically susceptible groups in the population. (cdc.gov)

and,(3) an intermediate form exhibiting mixed morphological characters.The patterns of morphological, reproductive and genetic variation within and between populations of these three forms were investigated. (edu.au)
Its hybrid origin is supported by the high level of genetic diversity between the intermediate form populations, as well as its strong autogamous tendencies and mixed morphological characteristics. (edu.au)
A review of morphological variation together with the genetic data presented here suggest that the populations of hake from these areas are subdivided into two different stocks: the North-Atlantic stock and the Mediterranean stock. (udg.edu)

Genetic variation in Asaum misandrum, a woodland herb in Korea, was investigated based on allozyme analysis with starch gel electrophoresis. (e-kjpt.org)

This particular allele is found at a much higher frequency in the Greenlandic Inuit population than other surveyed populations, even though type 2 diabetes is not reported to be more common in Greenland. (genestogenomes.org)
But with neutral variations, it can be impossible to tell which allele is the 'normal' one that existed first and which is the 'mutant'-and the distinction is often meaningless. (utah.edu)
In addition, databases that aggregate allele frequencies, such as gnomAD are also biased toward European populations and contain very little information from individuals of African or other ancestries. (cdc.gov)
Allele frequencies will also be correlated with prescription drug use among the different ethnic groups to study whether drugs prescribed for each are appropriate given the PGx allele frequency determined for the population and how the drugs prescribed could be modified if more comprehensive PGx testing were available. (cdc.gov)
Creation of the comprehensive PGx data set proposed in this project will, for the first time, help to establish the allele frequencies in 150 pharmacogenes across ethnicities in the US population. (cdc.gov)

Here we analyse genome-wide data to show that some Amazonian Native Americans descend partly from a Native American founding population that carried ancestry more closely related to indigenous Australians, New Guineans and Andaman Islanders than to any present-day Eurasians or Native Americans. (nature.com)
Figure 1: South Americans share ancestry with Australasian populations that is not seen in Mesoamericans or North Americans. (nature.com)
In a genome-wide association study (GWAS), the investigators looked for variations in the genome that were closely associated with SUDs in more than 1 million people of European ancestry and 92,630 people of African ancestry. (medscape.com)

Insights into human genetic variation and population history from 929 diverse genomes. (nih.gov)

Genetic diversity and patterns of allelic distribution, however, differed within the three forms. (edu.au)
The patterns of genetic variation in any group of organisms, including humans, are closely tied to its size and history. (genestogenomes.org)
When compared to much larger populations, the patterns of variation differ in specific ways. (genestogenomes.org)
Though genetic patterns differ subtly between groups, the deeper similarities show how closely humanity is connected. (genestogenomes.org)
The Effect of an Extreme and Prolonged Population Bottleneck on Patterns of Deleterious Variation: Insights from the Greenlandic Inuit. (genestogenomes.org)
We generated high resolution results that show geographical patterns of variations and genome-wide admixture proportions within and among breeds. (usda.gov)

Association between WNT-1-inducible signaling pathway protein-1 (WISP1) genetic polymorphisms and the risk of gastric cancer in Guangxi Chinese. (omicsdi.org)
The aim of the current study was to estimate the genetic diversity of F. graminearum and F. culmorum isolated from wheat in Adana province of Turkey by investigating by RAPD-PCR polymorphisms. (scialert.net)
The genetic components most responsible for differences in individual disease risk are thought to be DNA variants (polymorphisms) that influence the expression or function of mediators involved in the pathological processes. (cdc.gov)

Factors contributing to the high levels of genetic diversity found within populations of A. misandrum include population maintenance via wide distribution range from Korea to Japan and primarily outcrossing breeding system. (e-kjpt.org)

Thanks to this shared heritage, small differences between populations can serve as powerful tools for unearthing discoveries that will help us all. (genestogenomes.org)
The team includes a professor, four undergrads, one graduate student, a technician and a post-doc, all working to better understand how genetic differences shape the human immune response to microbial communities. (alaska.edu)
Studies of resemblances and differences among family members, twins, and adoptees offer indirect scientific evidence that a sizable portion of the variation in weight among adults is due to genetic factors. (cdc.gov)
In the healthy normal population, genetic and functional variation in taste and smell ability may help explain part of individual differences in food preferences and consumption. (cdc.gov)
[ 16 ] Coupled with this genetic heterogeneity is considerable clinical heterogeneity, as illustrated by substantial differences in the extent and quality of symptoms. (medscape.com)

The AFLP results showed greater genetic variability between populations from Missouri and Mississippi (both USA), and relatively low variability within Missouri populations. (unl.edu)

During the second half of the twentieth century genetic research focused on molecular mechanisms and was quite distant from Fisher's interests. (cam.ac.uk)
We investigated the molecular epidemiology of EEEV sequences from 1 patient infected with EEEV in Alabama, an area with historically limited genetic information about EEEV. (cdc.gov)

A total of sixteen Simple Sequence Repeat (SSR) markers were used to analyze 92 individuals from 8 populations. (iopri.org)
The role of African genome diversity and the opportunities for pharmacogenomics research are highlighted and will enable discovery of novel genetic mechanisms and validation of established markers. (cambridge.org)
In order to determine this differentiation, established allozyme markers were used to classify 56 southwest Virginia populations as southern, northern, or introgressed. (intechopen.com)
They are also well-defined genetic markers em-ployed in population genetic and anthropological studies [1,2]. (who.int)

Quantification of the heritable basis underlying population epigenomic variation is also important to delineate its cis- and trans-regulatory architecture. (wikipedia.org)

We infer little genetic isolation among Missouri field populations and within laboratory populations but a significant genetic isolation between Missouri and Mississippi populations. (unl.edu)

ABSTRACT We evaluated the distribution of ABO and Rhesus (Rh) D blood groups in the population of Poonch district in Azad Jammu and Kashmir. (who.int)

Despite these obese-specific variants, overall viral genetic diversity did not differ significantly between obese and lean hosts. (bvsalud.org)
Thus, for genetic variants to significantly affect disease severity or incidence, they must act cumulatively. (cdc.gov)

In recent decades, obesity has reached epidemic proportions in populations whose environments promote physical inactivity and increased consumption of high-calorie foods. (cdc.gov)

Keolu Fox explores the links between human genetic variation and disease in underrepresented populations. (ted.com)

Some variants occur often enough in the population to be considered common genetic variation. (medlineplus.gov)

The authors speculate this difference may be due to compensatory variation elsewhere in the genome since type 2 diabetes is a multigenic trait with many underlying contributing factors. (genestogenomes.org)
A study of identical twins concluded that hand clasping has a strong genetic basis (most twins share the trait), but it doesn't fit a predictable inheritance pattern. (utah.edu)
Thus, this study confirms the importance of genetic (family) effects on pathogen resistance with variation in this trait among natural populations. (lu.se)

Phylogenetic studies have shown substantial genetic diversity among isolates of Madariaga virus, the virus most closely related to EEEV ( 11 ). (cdc.gov)
Here, a phylogenetic tree visualizes the genetic affinity between Lyme disease bacteria isolated from ticks in Binghamton region (white circles/nodes) and bacteria reported from elsewhere according to the bacteria's ospC gene DNA sequences. (binghamton.edu)

Our study provides the first insight into the consequences of host obesity on viral genetic diversity and adaptation, suggesting that host factors associated with obesity alter the selective environment experienced by a viral population , thereby impacting the spectrum of genetic variation . (bvsalud.org)
Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the general population, but the effects of this risk are unclear in people not ascertained for neuropsychiatric symptoms. (ox.ac.uk)
Despite the sample size limitation of our study, this strategy can be useful to find genetic factors involved in the etiology of other disorders that are defined in a dichotomized way. (biomedcentral.com)
As a complex condition, MetS results from a complex interplay between many genetic and environmental factors. (biomedcentral.com)
Our model provides evidence that annual reproductive investment could be regulated by an endogenous rhythm since environmental factors only accounted for a small proportion of the residual variation in gonad index. (bas.ac.uk)
Many common human diseases such as asthma, cancer, and cardiovascular disease are complex in nature, as they are influenced variably by environmental, physiologic, and genetic factors. (cdc.gov)
Common diseases of a chronic inflammatory nature such as asthma, Alzheimer disease, and cardiovascular disease are complex in nature, as they are variably influenced by genetic inheritance as well as environmental, physical, and lifestyle factors. (cdc.gov)
In this review, we focus primarily on inherited genetic factors and their role in occupational health standard setting. (cdc.gov)
The historical approach to setting OELs has in- genetic information extensively, but to date such factors have not volved investigators observing workers as well transmitted between been used to protect workers by incorpora- as conducting laboratory and animal studies. (cdc.gov)

38,000), we find genome-wide genetic links between ASDs and typical variation in social behavior and adaptive functioning. (ox.ac.uk)
Genome-wide association studies (GWAS) have implicated the region on chromosome 5p14.1 between CDH9 and CDH10 as the first potential common genetic risk factor in Caucasian populations. (medscape.com)

In contrast, sucrase-isomaltase deficiency , a metabolic disease that prevents infants from digesting a certain sugar, is very rare in most populations but affects about 5-10% of people in Greenland. (genestogenomes.org)
Pharmacogenomics in SSA populations will probe the widest genetic diversity and improve the chances of identifying novel and relevant mechanisms of disease and for targeted therapies to sub-populations. (cambridge.org)
In contrast to variations that cause disease, there are many more examples of variations that are neither good nor bad, but just different-like blood types and eye color. (utah.edu)
This type of genetic change used to be known as a gene mutation, but because changes in DNA do not always cause disease, it is thought that gene variant is a more accurate term. (medlineplus.gov)
Most variants do not lead to development of disease, and those that do are uncommon in the general population. (medlineplus.gov)
The purpose of this study was to estimate the combinatorial contribution of multiple genetic variants to disease risk. (cdc.gov)
We used a logistic regression model to help estimate the joint contribution that multiple genetic variants would have on disease risk. (cdc.gov)
Our model predicts that multiple disease variants broaden the risk distribution, facilitating the identification of susceptible populations. (cdc.gov)
In light of this, a multiplicative gene-gene interaction model was developed to allow for estimating the combinatorial contribution of multiple genetic variants to disease risk. (cdc.gov)

Since most studies are carried out on non-African populations (Asians and Caucasians), a smaller portion of the overall human genome's diversity is interrogated and results from replication studies do not always concur. (cambridge.org)

This, of course, depends on how population boundaries are defined, but often cited to support such comments are the comparisons of SNP frequencies in pairs of populations in the HapMap data and the Perlegen data. (blogspot.com)
The study found that Greenlandic Inuit have fewer genetic variants overall than other human populations tested so far, but the variants they do carry occur at higher frequencies. (genestogenomes.org)

An additive genetic effect of GABRA2 rs279871 , NPY rs16147 and TPMT rs1142345 in the MetS score variation was also found. (biomedcentral.com)

Coffin JM (1995) HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. (springer.com)

Miller, GT, Starmer, WT & Pitnick, S 2003, ' Quantitative genetic analysis of among-population variation in sperm and female sperm-storage organ length in Drosophila mojavensis ', Genetical Research , vol. 81, no. 3, pp. 213-220. (syr.edu)

2000. Adaptive variation in energy acquisition and allocation among latitudinal populations of the Atlantic silverside. (ccri.edu)

The shared genetic mechanisms between substance use and mental disorders revealed in this study underscore the importance of thinking about these disorders in tandem," Joshua A. Gordon, MD, PhD, director of the National Institute of Mental Health (NIMH), said in a news release. (medscape.com)
It is therefore important to understand both the mechanisms that give rise to new genetic variation, and the mechanisms that act to maintain variation. (lu.se)
Although the common genetic mechanisms underlying autism spectrum disorders (ASDs) may be varied and unknown, mounting evidence suggests that defects at the neuronal synapse may underlie the pathophysiology. (medscape.com)

Magdalena P. Bartkowska and Mark O. Johnston "Quantitative Genetic Variation in Populations of Amsinckia spectabilis That Differ in Rate of Self-Fertilization," Evolution 63(5), 1103-1117, (1 May 2009). (bioone.org)

Overall genetic variation of A. misandrum population showed considerably high levels of genetic variation within the species (A = 2.05, P = 71.4, HE = 0.294). (e-kjpt.org)
Although it showed moderate genetic diversity level, most habitats of the species were scattered and discontinuous. (e-kjpt.org)
Many insect species are undergoing rapid population decline in recent decades due to anthropogenic changes to natural landscapes and climate. (lu.se)
The conventional wisdom linking high genetic diversity with population viability is increasingly scrutinized, as empirical evidence shows that some species can persist despite low genetic diversity. (lu.se)
Our project seeks to unravel these mysteries by examining how genetic redundancy through duplicated sequences, like orthologs, and the role of non-coding elements such as transposable elements (TEs), contribute to species resilience during and after population bottlenecks. (lu.se)

Crossing these animals shuffles the genetic deck to yield populations of mice with greater genetic diversity than is present in the entire human race. (jax.org)

The genotype data allow evaluation of genetic variance across landscapes and thus shed light on the degree of genetic-environmental association and the recolonization history of Scots pine in Scandinavia. (gu.se)
Based on the product of single gene variant odds ratios, the risk of developing asthma was assigned to genotype profiles, and the frequency of each profile was estimated for the general population. (cdc.gov)

Variation and population genetic structure in the Western Australian endemic genus Geleznowia Turcz. (edu.au)

Our results suggest that restricted gene flow or inbreeding may have reduced genetic diversity in the Tsushima population, which has been geographically isolated from the main-island populations since the formation of Tsushima Strait. (bioone.org)
Given the need for comparative studies of functional genetic diversity, we investigated whether MHC diversity differs between populations which are open, that is experiencing gene flow, versus populations which are closed, that is isolated from other populations. (datadryad.org)
Therefore, loss of genetic diversity in lemurs, owing to small founder populations or reduced gene flow, can be mitigated by managed breeding efforts. (datadryad.org)
Finally, more recent evolution has been driven by population disjunction, limited gene flow, and bottleneck and/or associated founder effects.From this study it is apparent that the genus Geleznowia consists of at least two taxa and a series of hybrid derivatives. (edu.au)

However, virtually nothing is known of its genetic variation, in natural or domesticated populations. (unl.edu)
Little is known, however, about the way the evolution of self-fertilization changes the amount or pattern of the components of genetic variation in natural populations. (bioone.org)
This might reflect the prediction that very small populations see increases in deleterious variation since natural selection is less effective in small groups. (genestogenomes.org)
This process of natural selection can lead to significant changes in the appearance, behavior, or physiology of individuals in a population, in just a few generations. (utah.edu)
Females were sampled at random from natural populations immediately prior to parturition with equal exposure of pathogens for all lizards once in captivity. (lu.se)

Quantifying MHC diversity within individuals and between populations is the necessary first step to identifying potential improvements to captive management and conservation plans. (datadryad.org)
Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations. (ox.ac.uk)
METHODS: We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on data from 1,235 individuals with CRC within the European Prospective Investigation into Cancer and Nutrition cohort using multivariable-adjusted Cox proportional hazards regression. (ox.ac.uk)

La diversité allélique totale est plus élevée pour 1 locus sur 6 seulement, en région continentale. (afs-journal.org)

During viral infections, the complex and dynamic distributions of variants, termed viral quasispecies, play a key role in the adaptability of viruses to changing environments and the fate of the population as a whole. (springer.com)

Finally, a Bayesian clustering analysis showed that the Tsushima population is apparently differentiated from the main-island populations and comprises two genetic clusters. (bioone.org)
The population comprises about 2,500 cattle and is considered one of the ancestral populations of the modern Holstein breed. (frontiersin.org)

The differentiation, selection and population genetic properties of CNVs are not well investigated across diverse cattle populations. (usda.gov)
These CNV results provide a new glimpse of diverse selections during cattle speciation, domestication, breed formation, and recent genetic improvement. (usda.gov)
This trend can also be observed for the German Black Pied cattle population ("Deutsches Schwarzbuntes Niederungsrind", DSN). (frontiersin.org)

Host obesity impacts genetic variation in influenza A viral populations. (bvsalud.org)
Obesity is a chronic health condition characterized by excess adiposity leading to a systemic increase in inflammation and dysregulation of metabolic hormones and immune cell populations . (bvsalud.org)
Here, we investigated the impact of host obesity on IAV genetic variation using a diet induced obesity ferret model. (bvsalud.org)
Genetic changes in human populations occur too slowly to be responsible for the obesity epidemic. (cdc.gov)
With the exception of rare genetic conditions associated with extreme obesity, currently, genetic tests are not useful for guiding personal diet or physical activity plans. (cdc.gov)
On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations. (cdc.gov)

In addition, we evaluated intrahost virus diversity of EEEV in the patient and report genetic diversity of virus in the blood compared with the central nervous system (CNS). (cdc.gov)

Thus, there is a need to set up a reasonable conservation strategies including the maintenance mechanism of genetic diversity of A. misandrum. (e-kjpt.org)
This project offers a unique opportunity to be at the forefront of exploring the intricate dynamics of genetic resilience, potentially reshaping our understanding of biodiversity conservation. (lu.se)

Organisms1

Diseases1

Chemicals and Drugs1

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes23

Disciplines and Occupations3

Information Science3

Health Care2

Genetics7

Genes14

Susceptibility4

Loci9

Evolutionary10

Alleles15

Traits14

Analyses1

Divergent2

19941

Genomic8

Diversity within populations2

Phenotypes4

Differentiation among2

Polymorphism1

SNPs4

Geographic4

Polymorphic2

Genetically5

Morphological3

Electrophoresis1

Allele5

Ancestry3

Genomes1

Patterns6

Polymorphisms3

Levels of genetic diversity1

Differences5

Variability1

Molecular2

Markers4

Heritable1

Infer1

ABSTRACT1

Significantly2

Physical inactivity1

Human genetic v1

Common genetic variation1

Trait3

Phylogenetic2

Factors9

Genome-wide2

Disease9

Asians1

Frequencies2

Additive genetic1

Pathogenesis1

Drosophila1

Adaptive1

Mechanisms3

Differ1

Species5

Greater genetic1

Genotype2

Endemic1

Gene flow4

Natural5

Individuals3

Locus1

Environments1

Comprises2

Cattle3

Obesity6

Intrahost1

Conservation2