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SolubilityNanoparticlesDrug CarriersParticle SizeChemistry, PharmaceuticalWaterCyclodextrinsbeta-CyclodextrinsSolventsExcipientsTechnology, PharmaceuticalCalorimetry, Differential ScanningDrug CompoundingHemoglobin, SickleDrug StabilityBiological AvailabilityEmulsionsPolyethylene GlycolsHydrogen-Ion ConcentrationPharmaceutical PreparationsPovidoneAbsorptionHydrophobic and Hydrophilic InteractionsPowder DiffractionSpectroscopy, Fourier Transform InfraredMethylcelluloseSurface-Active AgentsBiopharmaceuticsMicellesIonic LiquidsEncyclopedias as TopicVapor PressureGasolineChromatography, High Pressure Liquid
Aqueous solubilityNiclosamide's poor solubilityPoorly soluble drugsLipid solubilityPermeabilityAbsorptionSolubleWaterDissolutionStabilityFormulationsCurcuminGastrointestinalIonicCircumventSolventsTherapeuticAPIs2023EfficacyApproachesIncreasesTemperatureSubstanceOralBiopharmaceuticalDrugsExhibitIncreaseNumerousImprovePropertiesDrugGreaterGoodIssuesSolution
Aqueous solubility6
  • Aqueous solubility of any therapeutically active substance is a key property as it governs dissolution, absorption and thus the in vivo efficacy. (scialert.net)
  • Drug efficacy can be severely limited by poor aqueous solubility and some drugs also show side effects due to their poor solubility. (scialert.net)
  • Most of drugs which are weakly acidic and basic show poor aqueous solubility hence various methods like, salt formation, co-solvency, micronization, addition of agent, solid dispersion, complexation etc., are some of the vital approaches routinely employed to enhance the solubility of poorly soluble drugs. (scialert.net)
  • Hence, poor aqueous solubility has become the leading hurdle for formulation, and scientists are concerned in improving oral delivery of insoluble drug candidates. (dovepress.com)
  • Nowadays, crystalline nanosuspensions (nanocrystals) are considered a valuable formulation for drugs that have a poor dissolution rate and/or aqueous solubility. (dovepress.com)
  • Aceclofenac belongs to BCS Class II as it possesses poor aqueous solubility. (guidechem.com)
Niclosamide's poor solubility2
  • Might niclosamide's poor solubility be just one part of the problem, with enzyme metabolism more critical? (news-medical.net)
  • However, niclosamide's poor solubility in water makes it very difficult to use elsewhere, such as in an intravenous (i.v.) injection or infusion. (nottingham.ac.uk)
Poorly soluble drugs4
  • Therefore, drug release profiles are exhibited by such formulations for poorly soluble drugs to improve the solubility of such poorly soluble drugs. (scialert.net)
  • This article reviews various methods used for improving the solubility of hydrophobic drugs and improve the drug release profiles which are exhibited by such formulations for poorly soluble drugs. (scialert.net)
  • 1 - 3 Various approaches have been utilized for the enhancement of solubility and dissolution rate of poorly soluble drugs such as solid dispersions preparation, 4 inclusion in cyclodextrins, 5 and particle size (PS) reduction. (dovepress.com)
  • 6 Although these approaches improved solubility and dissolution of poorly soluble drugs, their commercial use is limited due to stability issues of the amorphous nature of the produced drug. (dovepress.com)
Lipid solubility2
  • The prompt onset of action is a result of the drug's rapid absorption and a poor lipid solubility. (drugs.com)
  • The low lipid solubility and a rapid renal excretion minimizes the possibility of lipid accumulation in tissues and organs or of crystalluria. (drugs.com)
Permeability2
  • Among all newly discovered chemical entities about 40% drugs are lipophilic and these drugs are rejected by the pharmaceutical industry and will never benefit a patient because of its poor bioavailability due to low water solubility and/or cell membrane permeability. (scialert.net)
  • However, this therapeutic potential remains difficult to exploit owing to its low solubility and low permeability, resulting in low oral bioavailability. (researchgate.net)
Absorption2
Soluble4
Water15
  • Salt formation has proven successful in converting acidic and basic APIs into ionic salts, increasing solubility in polar solvents such as water. (ispe.org)
  • The solubility of these dyes is very good in water ,in the presence of glacial acetic acid. (taihemachine.com)
  • This reagent suffers with poor water-solubility and rapidly decomposes in aqueous solutions. (rcsb.org)
  • The oral bioavailability (BA) of Cur is limited because of its poor water solubility. (researchgate.net)
  • The purpose of this study was to confirm whether cationic N,N-dimethyl amino acid esters of Cur could act as prodrugs and improve its water solubility and oral bioavailability. (researchgate.net)
  • 200 mM water solubility. (researchgate.net)
  • Conclusions The cationic N,N-dimethyl amino acid ester prodrugs of Cur improved the water solubility of Cur and enhanced oral bioavailability in rats. (researchgate.net)
  • These Cur prodrugs may be good candidates for developing medicinal options previously unavailable due to the poor water solubility and oral BA of Cur. (researchgate.net)
  • Ethaselen was efficiently encapsulated into the micelles by the dialysis method, and the solubility of ethaselen in water was remarkably increased up to 82 μg/mL before freeze-drying. (springer.com)
  • These compounds were not detected in sample R because of poor water solubility. (scirp.org)
  • The LC50 based on the nominal concentration was 8.4 mg/L. The results have to be interpreted with caution since the LC50 is on the limit of water solubility of SAS-40. (europa.eu)
  • Water concentrations were not measured and the poor solubility of test substance requires a careful interpretation of test results. (europa.eu)
  • However, curcumin possesses low bioavailability due to its poor solubility in water. (umass.edu)
  • However, St could not be used directly as an antiscalant because of its poor water solubility. (databasefootball.com)
  • These compounds have high vapor pressures with low water solubility and are emitted as gases from solids or liquids. (cdc.gov)
Dissolution4
  • Poor solubility contributes to dissolution problems. (pharmtech.com)
  • To increase both the solubility and dissolution rate of DCN while maintaining its crystalline nature, high pressure homogenization was used but with only a few homogenization cycles preceded by a simple bottom-up technique. (dovepress.com)
  • The saturated solubility and mean dissolution time, in the case of F8 and F12, were significantly higher than the coarse drug powder. (dovepress.com)
  • The saturation solubility, in vitro dissolution rate and relative bioavailability of DCN were significantly increased after nanocrystallization. (dovepress.com)
Stability4
  • The most challenging task in development of a formulation is the solubility of drug, availability at the site of action and stability of drug. (scialert.net)
  • The two major obstacles in developing a therapeutic agent are Solubility and stability ( Seedher and Sharma, 2007 ). (scialert.net)
  • Among them, 42 could be produced and characterized for solubility, oligomerization state, thermal stability, epitope exposure and structural properties. (europa.eu)
  • On the other hand, the promising effects of bioactive glycosides are hindered by their poor solubility, poor stability, and rapid elimination. (naturalnews.com)
Formulations2
Curcumin1
  • The anti-inflammatory and antiproliferative agent curcumin has poor oral bioavailability and solubility in plasma. (nih.gov)
Gastrointestinal1
  • But it showed poor solubility in gastrointestinal (GI) tract, causing low drug concentration in liver. (hindawi.com)
Ionic1
Circumvent1
  • A unique approach to circumvent solubility issues involves coadministration of a hydrophilic prodrug with an exogenous converting enzyme. (healthpartners.com)
Solvents2
  • Adding a surfactant to an API has been found to increase solubility in both polar and nonpolar solvents. (ispe.org)
  • However, CUR has poor solubility in aqueous solvents and poor oral bioavailability. (who.int)
Therapeutic1
  • The hydrogels are expected to be capable of superior solubility, optimal therapeutic efficacy, and almost no cytotoxicity. (nature.com)
APIs1
  • Another challenge has been APIs with poor flow characteristics. (pharmtech.com)
20231
  • For the sprays, Needham figured out how to increase the solubility of niclosamide in simple pH buffered solutions (Needham 2022, Needham 2023). (nottingham.ac.uk)
Efficacy1
  • However, clinical researchers continually find that the involvement of drug carriers may lead to poor biocompatibility and biodegradability, low loading efficacy, and potential side effects. (nature.com)
Approaches2
  • This article not only reviews the existing methods and technologies but also, enlightens and deals with the novel approaches to overcome the problems associated with poor solubility for the existing and newer promising candidates including their advantages and limitations. (rjptonline.org)
  • 2 While proven approaches exist to combat this, drug manufacturers are sometimes forced to introduce large doses of an API into the pharmaceutical to compensate for its low solubility. (ispe.org)
Increases1
  • Free-surface electrospinning of microemulsions increases API solubility and may offer an alternative to batch powder processes. (ispe.org)
Temperature1
  • If the melting temperature of one material is near the vaporization temperature of the other, poor weldability occurs and often means the formation of brittle intermetallic structures. (sme.org)
Substance1
  • Since, the melting point of the solid is related to solubility, the capacity for a substance to crystallize in more than one crystalline form is polymorphism. (scialert.net)
Oral1
  • This discrepancy is largely attributed to its poor oral bioavailability, which may result from its poor solubility, its poor pharmacokinetic profile, or a combination of both. (researchgate.net)
Biopharmaceutical1
  • According to the recent estimates, approximately about 40% of new chemical entities (NCEs) are rejected because of their poor biopharmaceutical properties. (rjptonline.org)
Drugs1
  • Since 1995, more than 90% of drugs are approved as hydrophobic having poor solubility. (scialert.net)
Exhibit1
  • As a result, approximately 70 percent of molecules exhibit poor solubility, which could limit bioavailability. (pharmamanufacturing.com)
Increase1
  • Warmer conditions reduce the solubility of oxygen from the atmosphere and increase oxygen consumption because the biological respiration processes are boosted. (spacedaily.com)
Numerous1
  • Numerous studies have investigated the solubility of electrospun mats containing API. (ispe.org)
Improve2
  • Although needle-based electrospinning has proven an effective technique to improve API solubility, the process has limited productivity. (ispe.org)
  • Strickley, 2004 ) have been shown to improve drug solubility. (scialert.net)
Properties2
Drug1
  • Solubility is an important criteria for achieving the desired drug concentration to produce pharmacological response. (rjptonline.org)
Greater1
Good1
  • The light fastness is poor to moderate , but wet fastness is good. (taihemachine.com)
Issues1
  • This review article finally updates the recent technologies for countering the solubility issues and help the academicians as well researchers to utilize these technologies to achieve the desired outcomes. (rjptonline.org)
Solution1
  • Replicate analyses of workers' urine samples initially showed large variation, due to poor solubility in derivatization solution of residue from solvent evaporation. (cdc.gov)