• pathogens
  • Thus, a better understanding of the mechanisms involved in the generation, ontogeny, production, and selection of B cells bearing Abs with Ag binding sites specific to polysaccharides and T-independent Ags is needed to optimize the design and ontogenetic timing of vaccines directed against pathogens bearing these types of immunodominant Ags. (jimmunol.org)
  • As with other bacterial pathogens, surface and secreted proteins of M. tuberculosis contribute significantly to the virulence of this organism. (wikipedia.org)
  • adhesion
  • In this study, we investigated the molecular mechanisms of a novel marine bacterial polysaccharide EPS11 which exerts its cytotoxic effects through affecting cancer cell adhesion and anoikis. (mdpi.com)
  • The physical and chemical characteristics of bacterial cells can be affected by EPS composition, influencing factors such as cellular recognition, aggregation, and adhesion in their natural environments. (wikipedia.org)
  • conjugate
  • The CDC and WHO currently recommend that all infants be vaccinated using a polysaccharide-protein conjugate Hib vaccine, starting after the age of 6 weeks. (wikipedia.org)
  • Since optimal contact between B cells and T cells is required (via MHC II) to maximize antibody production, it is reasoned that the conjugate vaccine allows B cells to properly recruit T cells, this is in contrast to the polysaccharide form in which it is speculated that B cells do not interact optimally with T cells leading to the TI interaction. (wikipedia.org)
  • fermentation
  • Notes: ♠ Strains found at the National Center for Biotechnology Information, but not listed in the List of Prokaryotic names with Standing in Nomenclature A broad number of food products, commodity chemicals, and biotechnology products are manufactured industrially by large-scale bacterial fermentation of various organic substrates. (wikipedia.org)
  • The facility has fermentation, formulation, vial, freeze drying bacterial facilities classified as Biosafety Level 2 (CDC-NIH BL2-LS) and ISO 9001. (wikipedia.org)
  • The facility includes both the upstream and downstream operations when the fermentation process is scaled up for bacterial polysaccharide product development. (wikipedia.org)
  • The facility has fermentation, formulations and lyophilization and handling of bacterial polysaccharide products. (wikipedia.org)
  • meningitis
  • As an exclusively human pathogen it is the main cause of bacterial meningitis in children and young adults, causing developmental impairment and death in about 10% of cases. (wikipedia.org)
  • It causes the only form of bacterial meningitis known to occur epidemically , mainly Africa and Asia. (wikipedia.org)
  • exopolysaccharides
  • In particular, the role of matrix bacterial exopolysaccharides was explored. (mdpi.com)
  • Microbiological results were in very good agreement with spectroscopic data, confirming the active role of matrix polysaccharides in determining a biofilm's protective capacity and indicating lower protection levels afforded by rhamnose containing exopolysaccharides. (mdpi.com)
  • binds
  • For example, the human symbiont Bacteroides fragilis produces polysaccharide A (PSA), which binds to toll-like receptor 2 (TLR-2) on CD4+ T cells. (wikipedia.org)
  • Growth
  • EPSs are the construction material of bacterial settlements and either remain attached to the cell's outer surface, or are secreted into its growth medium. (wikipedia.org)
  • Furthermore, the EPS layer acts as a nutrient trap, facilitating bacterial growth. (wikipedia.org)
  • cell
  • Mice respond to many polysaccharides in a T cell-independent manner, with the rapid production of an oligoclonal Ab response consisting primarily of IgM and IgG3 Abs ( 5 - 7 ). (jimmunol.org)
  • indicative that memory B cell formation is also improved over that of the polysaccharide form. (wikipedia.org)
  • The cell wall consists of the hydrophobic mycolate layer and a peptidoglycan layer held together by a polysaccharide, arabinogalactan. (wikipedia.org)