Exons 1-6 of the WT1 gene encode the regulatory domain, which regulates expression of target genes, and exons 7-10 encode the 4 zinc fingers of the DNA-binding region of the WT1 protein. (medscape.com)
the tri6 gene, encoding a zinc finger protein involved in the regulation of trichothecene biosynthesis, from Fusarium sporotrichioides (Proctor et al. (justia.com)
In general, it appears that the AT-hook motif is an auxiliary protein motif cooperating with other DNA-binding activities and facilitating changes in the structure of the DNA either as a polypeptide on its own [e.g. (embl.de)
Polypeptide chain in mature protein after post-processing. (ucsc.edu)
Protein domains, zinc finger regions and topological domains. (ucsc.edu)
The sequence of PER8 predicts that its product (Per8p) is a novel polypeptide of 34 kD, and antibodies against Per8p recognize a protein of 31 kD. (rupress.org)
The NMR structure of Ros87 shows that the putative prokaryotic Cys2His 2 zinc-finger sequence is indeed part of a significantly larger zinc-binding globular domain that possesses a novel protein fold very different from the classical fold reported for the eukaryotic classical zinc-finger. (cnr.it)
Mapping of the amino acids necessary for the DNA binding onto Ros87 structure reveals the protein surface involved in the DNA recognition mechanism of this new zinc-binding protein domain. (cnr.it)
The mouse testis-enriched Znf230 gene, which encodes a type of RING finger protein, is present primarily in the nuclei of spermatogonia, the acrosome and the tail of spermatozoa. (scielo.org)
However, the most common form is a protein with two OB folds and one zinc finger domain. (johnshopkins.edu)
Biophysical studies showed that the orthologs of the two OB fold/one zinc finger replication protein A in Hethanosarcina acetivorans and Methanopyrus kandleri exhibit two binding modes, wrapping and stretching of DNA. (johnshopkins.edu)
Ubiquitous nuclear and cytoplasmic RNA Binding Protein EWS belongs to the TET family of RNP proteins, contains an RNA recognition motif and a RANBP2-type zinc finger, and may function as a repressor. (medindex.am)
Furthermore, AT-hook motifs are frequently associated with known functional domains seen in chromatin proteins and in DNA-binding proteins (e.g. histone folds, homeodomains and zinc fingers). (embl.de)
Whereas the polypeptide serving this function in bacteria contains one OB fold, the eukaryotic functional homolog comprises a complex of three proteins, each harboring at least one OB fold. (johnshopkins.edu)
We have learned that genes in mammalian cells are transcribed into messenger RNAs (mRNAs), which are to be translated into polypeptides (proteins). (intechopen.com)
Cys2His22
The first putative prokaryotic Cys2His2 zinc-finger domain has been identified in the transcriptional regulator Ros from Agrobacterium tumefaciens, indicating that the Cys2His2 zinc-finger domain, originally thought to be confined to the eukaryotic kingdom, could be widespread throughout the living kingdom from eukaryotic, both animal and plant, to prokaryotic. (cnr.it)
In this article we report the NMR solution structure of Ros DNA-binding domain (Ros87), providing 79 structural characterization of a prokaryotic Cys2His2 zinc-finger domain. (cnr.it)
Polymerase1
EWS binds RNA, calmodulin, and the RNA polymerase II 33 kD polypeptide (RPB3), but not RPB5 or RPB7. (medindex.am)
C3HC42
Like Cp-IAP, the predicted product of Op-iap has a carboxy-terminal C3HC4 zinc finger-like motif. (embl.de)
Analysis of the primary sequence of Per8p revealed a 39-amino-acid cysteine-rich segment with similarity to the C3HC4 family of zinc-finger motifs. (rupress.org)
Characterization1
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. (medscape.com)
Sequence2
An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs. (embl.de)
The nucleotide sequence of this gene, Op-iap, predicted a 30-kDa polypeptide product with approximately 58% amino acid sequence identity to the product of CpGV iap, Cp-IAP. (embl.de)
Motifs1
In addition, a pair of additional cysteine/histidine motifs were found in the N-terminal regions of both polypeptide sequences. (embl.de)
Encode1
Identification of herpes simplex virus DNA sequences which encode a trans -acting, polypeptide responsible for stimulation of immediate early transcription. (microbiologyresearch.org)
Homolog1
EcUSP12 contained a 1119-bp open reading frame (ORF) encoding a 372-amino acid polypeptide, which shared 100.00% and 91.32% identity with USP12 homolog of Etheostoma cragini and Homo sapiens, respectively. (bvsalud.org)
Domain2
The BIR domain has a fold that is stabilised by zinc tetrahedrally coordinated by one histidine and three cysteine residues. (embl.de)
Analysis of the functional domains of herpes simplex virus type 1 immediate-early polypeptide Vmw110. (microbiologyresearch.org)
Mutant3
The mutant viruses were then studied in single-step growth curve experiments, by assaying for plaques in a variety of cell types and by analysis of viral polypeptide synthesis during productive infection at high and low multiplicities. (microbiologyresearch.org)
The patterns and amounts of viral polypeptide synthesis during high multiplicity infections with mutant and wild-type viruses were similar in all cell types. (microbiologyresearch.org)
The present invention relates to methods for producing heterologous polypeptides in trichothecene-deficient filamentous fungal mutant cells. (justia.com)
Residues1
The structure consists of three short alpha-helices and turns with the zinc packed in an unusually hydrophobic environment created by residues that are highly conserved among all BIRs. (embl.de)
Type1
the extent of this reduction depends on cell type and the position of the mutation in the polypeptide. (microbiologyresearch.org)
Open readi1
The open reading frame (ORF) encodes a polypeptide of 222 amino acids which shares 75.65% identity with the human ZNF230. (scielo.org)
Detection2
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse ATPase, H+/K+ Exchanging Alpha Polypeptide (ATP4a) in Tissue homogenates and other biological fluids. (tuberculosisdrugresearch.org)
Description: A sandwich ELISA kit for detection of ATPase, H+/K+ Exchanging Alpha Polypeptide from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (tuberculosisdrugresearch.org)