Polymorphisms hla c antigens. Medical search. Frequent questions

Disease associated human leukocyte antigen (HLA) genes have been identified in humans where they are assumed to promote the susceptibility and/or progression of rheumatoid arthritis. (hu-berlin.de)
In humans, the HLA-B gene and two related genes, HLA-A and HLA-C , are the main genes in MHC class I. (medlineplus.gov)
Initiation and regulation of immune responses in humans involves recognition of peptides presented by human leukocyte antigen class II (HLA-II) molecules. (biomedcentral.com)
The human leukocyte antigen (HLA) system (the major histocompatibility complex [MHC] in humans) is an important part of the immune system and is controlled by genes located on chromosome 6. (msdmanuals.com)

Long-range linkage disequilibrium between HLA loci and SNP markers across the major histocompatibility complex (MHC) region offers an alternative approach through imputation to interrogate HLA variation in existing GWAS data sets. (nih.gov)
The data indicate that lymphoblastoid cells express at least three sets of HLA-D region antigens that are encoded by different loci including HLA-DR and DC. (ox.ac.uk)
Furthermore, his research spurred the discovery of H-2 haplotypes, HLA alleles and haplotypes, HLA loci genetic order, the role of histocompatibility antigens in skin graft rejection, and the outcome of kidney allografts. (brighthub.com)
Because of the diversity and polymorphisms of HLA loci, HLA. (biomedcentral.com)
The various HLA class II specificities, identifiable by serological or cellular typing reagents, reflect underlying polymorphisms of the constituent alpha and beta chains, encoded at several loci within the HLA-D region. (ox.ac.uk)
Genetic association studies underscored the importance of human leucocyte antigen (HLA) genes within major histocompatibility complex (MHC) as susceptibility loci for DA. (cdc.gov)
The heavy chain of the class I molecule is encoded by genes at HLA-A, HLA-B, and HLA-C loci. (msdmanuals.com)
Individual serologically defined antigens encoded by the class I and II gene loci in the HLA system are given standard designations (eg, HLA-A1, -B5, -C1, -DR1). (msdmanuals.com)
In 2014, Genome-Wide Association Study (GWAS) was performed with 2,398 individuals with laryngeal squamous cell carcinoma cases and 2,804 cancer-free controls from Chinese populations, and identified a novel susceptibility loci in complex human leukocyte antigen (HLA), which plays crucial role in immune response. (who.int)
Therefore, in this study, we are investigating the relationship between HNC and HLA loci using an advanced fine-mapping approach and a significantly larger dataset. (who.int)
Novel HLA loci associated with HNC are expected to be discovered in this study. (who.int)

We imputed HLA alleles in an independent data set from the British 1958 Birth Cohort (N = 918) with gold standard four-digit HLA types and SNPs genotyped using the Affymetrix GeneChip 500 K and Illumina Immunochip microarrays. (nih.gov)
KIR3DL2 is diverse, with twelve alleles identified and as many as five single amino acid polymorphisms found in a single individual (4-6). (rndsystems.com)
Dr. Amos organized the first World Health Organization Nomenclature Committee, which has been responsible for the naming of HLA specificities and alleles since 1967. (brighthub.com)
Most HLA-B gene alleles are rare, while others do not affect protein function or change the structure of the protein. (medlineplus.gov)
Hundreds of versions (alleles) of the HLA-B gene are known, each of which is given a particular number (such as HLA-B27 ). (medlineplus.gov)
for example, more than 60 very similar alleles are subtypes of HLA-B27 . (medlineplus.gov)
Additional HLA-B alleles play a smaller role in disease risk: the HLA-B47 and HLA-B51 alleles can contribute to increased risk, whereas the HLA-B7 and HLA-B57 alleles might provide some small amount of protection against developing the condition. (medlineplus.gov)
An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*03 alleles. (musc.edu)
Alleles defined by DNA sequencing are named to identify the gene, followed by an asterisk, numbers representing the allele group (often corresponding to the serologic antigen encoded by that allele), a colon, and numbers representing the specific allele (eg, A*02:01, DRB1*01:03, DQA1*01:02). (msdmanuals.com)

SNPs and HLA variants passing quality control filters were tested for association with CC with logistic regression adjusting for age, sex and country of origin. (edu.au)
While certain genetic variants of the human leucocyte antigen (HLA) genes influence susceptibility to SO, 4 5 single nucleotide polymorphisms (SNPs) in cytokine genes influence severity of disease. (bmj.com)
Single-nucleotide polymorphisms (SNPs) selection and identification are the most important tasks in Genome-wide association data analysis. (biomedcentral.com)
After adjusting for potential confounders, single nucleotide polymorphisms (SNPs) mapping to HLA-E, HLA-B, HLA-DOA, HLA-DQA2, and HLA-DPB1 genes showed associations with altered risk of developing DA. (cdc.gov)

As a result of our study, angiotensin converting enzyme gene I/D polymorphism DD genotype could be a genetic marker in ankylosing spondylitis in a Turkish study population. (molvis.org)
Fetal +14/+14 bp HLA-G genotype may predispose to pre-eclampsia in the mother. (ruc.dk)
Immunochip and targeted single nucleotide polymorphism (SNP) genotype data were produced, respectively, for discovery and replication purposes. (edu.au)
CONCLUSIONS: HLA genotype associates with CC, thus implicating HLA-related immune mechanisms in its pathogenesis. (edu.au)
The human leukocyte antigen (HLA)-C genotype is associated with several human autoimmune diseases. (tmu.edu.tw)
Therefore, we attempted to investigate an association between HLA-C genotype and KIR polymorphism and the occurrence of endometriosis. (tmu.edu.tw)

2. HLA system and tissue typing: the genetic organization and polymorphisms of the HLA system, the protein structure of HLA antigens, non-HLA genetics, HLA in health and disease, and the impact of HLA matching on donor selection and transplant outcomes. (ncl.ac.uk)

DNA sequence variation within human leukocyte antigen (HLA) genes mediate susceptibility to a wide range of human diseases. (nih.gov)
Human leukocyte antigen B27 ( HLA-B27 ) is the major genetic susceptibility marker in AS. (molvis.org)
Human leukocyte antigen B27 (HLAB 27) positive patients in particular -mostly those in the subgroup with ankylosing spondylitis- are affected. (molvis.org)
Abnormal human leukocyte antigen G (HLA-G) expression may be involved in pre-eclampsia. (ruc.dk)
Classical human leucocyte antigen (HLA) variants at 2-digit and 4-digit resolution were obtained via imputation from single marker genotypes. (edu.au)
We examined the relationships of human leukocyte antigen (HLA) and related polymorphisms to glioblastoma multiforme in adult Caucasians (non-Hispanic Whites) from the San Francisco Bay area. (aacrjournals.org)
Human leukocyte antigen (HLA)-G and cervical cancer immunoediting: A candidate molecule for therapeutic intervention and prognostic biomarker? (northwestern.edu)
Based on its pronounced immunoinhibitory properties, human leukocyte antigen (HLA)-G has been proposed as a possible prognostic biomarker and therapeutic target relevant in a wide variety of cancers and viral infections, but to date remains underexplored in cervical cancer. (northwestern.edu)
Dive into the research topics of 'Human leukocyte antigen (HLA)-G and cervical cancer immunoediting: A candidate molecule for therapeutic intervention and prognostic biomarker? (northwestern.edu)
HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
HLA is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)
Controversy and debate surround the role of the non-classic human lymphocyte antigen (HLA) class I molecule HLA-G. 1, 2 Initially, the expression of HLA-G was reported to occur only in a limited subset of trophoblast cells at the fetal-maternal interface. (bmj.com)
Particular human leucocyte antigen (HLA) polymorphisms have been associated with a reduced risk of HIV transmission. (researchportal.be)
Human leucocyte antigen (HLA) genes play an important role in determining the outcome of organ transplantation and are linked to many human diseases. (biomedcentral.com)
In the validation stage, single locus effects revealed that two of these polymorphisms (rs7745040 and rs9275295) in the human leukocyte antigen (HLA)-DRB1 gene and one polymorphism (rs9473132) in CD2-associated protein (CD2AP) gene have a significant statistical association with KBD. (escholarship.org)
Human leukocyte antigen (HLA) polymorphisms may influence immune response and disease outcome. (bvsalud.org)
Techniques used to define human MHC antigens: polymerase chain reaction and oligonucleotide probes. (ox.ac.uk)
The study of genetic polymorphisms has been essential to the analysis of the relationships between human populations. (ox.ac.uk)
The evolution of methods used to study human polymorphisms and the resulting contributions to our understanding of human health and history is the subject of this Perspectives. (ox.ac.uk)
Pathogenic human thyroglobulin peptides in HLA-DR3 transgenic mouse model of autoimmune thyroiditis. (musc.edu)
HLA-DR and HLA-DQ polymorphism in human thyroglobulin-induced autoimmune thyroiditis: DR3 and DQ8 transgenic mice are susceptible. (musc.edu)
Molecular basis of human natural killer cell recognition of HLA-E (human leucocyte antigen-E) and its relevance to clearance of pathogen-infected and tumour cells. (ox.ac.uk)
HLA-E (human leucocyte antigen-E) is a conserved class I major histocompatibility molecule which has only limited polymorphism. (ox.ac.uk)

We analysed relationships between the PTPN22 1858 polymorphism and antibodies to cyclic citrullinated peptide (CCP), rheumatoid factors (RFs) and the shared epitope (SE) gene (HLA-DRB1*0404 or 0401) and determined their combined predictive value for rheumatoid arthritis (RA) in individuals who subsequently developed RA. (nih.gov)
In untreated HIV infection, associations between HLA genetic polymorphism and disease progression were identified in several studies, using both candidate gene (reviewed in Carrington and O'Brien, 2003 ), and genome-wide strategies ( The International HIV Controllers Study, 2010 ). (frontiersin.org)
To our knowledge, angiotensin converting enzyme ( ACE ) gene I/D polymorphisms have not yet been investigated in AS patients in Turkish population.This study was conducted in Turkish patients with AS to determine the frequency of I/D polymorphism genotypes of angiotensin converting enzyme gene. (molvis.org)
A 14 bp insertion/deletion polymorphism exists in exon 8 of the HLA-G gene. (ruc.dk)
Other polymorphisms, besides the 14 bp polymorphism (rs66554220), in the 3′-untranslated region (3′-UTR) (exon 8) of the HLA-G gene might be associated with severe pre-eclampsia, especially in primiparas. (ruc.dk)
The HLA-B gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
The HLA-B gene has many possible variations, that result in the production of proteins that differ by changes in at least one protein building block (amino acid). (medlineplus.gov)
Variants in the HLA-B gene, particularly a version called HLA-B27 , significantly increase the risk of developing ankylosing spondylitis. (medlineplus.gov)
It is uncertain how the HLA-B27 gene variant causes the increased risk. (medlineplus.gov)
Although many people with ankylosing spondylitis have the HLA-B27 variation, most people with this version of the HLA-B gene never develop the disorder. (medlineplus.gov)
Several versions of the HLA-B gene, particularly HLA-B51 , are associated with an increased risk of developing Behçet disease, a chronic inflammatory condition that affects many parts of the body. (medlineplus.gov)
The encoding region of α1, 4-galactosyltransferase gene (A4GALT) encoding P1 and Pk antigens was analyzed by polymerase chain reaction-sequence-based typing (PCR-SBT). (bvsalud.org)
To investigate the possible role of IFNA gene polymorphisms in the pathogenesis of narcolepsy, we have genotyped two single nucleotide polymorphisms in IFNA genes as well as a neighbouring microsatellite. (uni-luebeck.de)
HLA gene frequencies in 11 Israeli populations and nine other relevant populations were used to calculate genetic distances in a quantitative assessment of their similarities and differences. (ox.ac.uk)
HLA-DRB1 and CD2AP gene were identified to be among the susceptibility genes of KBD, thus supporting the role of the autoimmune response in KBD and the possibility of shared etiology between osteoarthritis, rheumatoid arthritis, and KBD. (escholarship.org)

In terms of immune responsiveness, HLA-DRB1*15:02 was associated with lower nucleocapsid T-cell responses. (bvsalud.org)
However, HLA DRB1*15:01 was associated with increased spike T-cell responses following both first and second dose vaccination. (bvsalud.org)
Full overlapping studies of four antigens identified binding affinity of 103 peptides to seven common HLA-DR molecules (DRB1*0101, 0301, 0401, 0701, 1101, 1301, and 1501). (biomedcentral.com)
Good performance predictors included HLA-DRB1*0101 (seven), 1101 (six), 0401 (three), and 0701 (one). (biomedcentral.com)
Sometimes additional numbers are added after a colon to identify allelic variants that encode identical proteins, and after another colon, other numbers are added to denote polymorphisms in introns or in 5' or 3' untranslated regions (eg, A*02:101:01:02, DRB1*03:01:01:02). (msdmanuals.com)
are in linkage disequilibria with the HLA-drb1 locus in a japanese population. (lu.se)

MHC-II molecules present antigenic peptides internalized by professional antigen presenting cells, such as macrophages, dendritic cells, or T lymphocytes. (biomedcentral.com)

The genetic components most responsible for differences in individual disease risk are thought to be DNA variants (polymorphisms) that influence the expression or function of mediators involved in the pathological processes. (cdc.gov)
Recently, this signal of HLA region was confirmed to be specific to HPV(+) in oropharyngeal cancer suggesting the role of HLA variants in the immune pathogenesis. (who.int)

ACE I/D polymorphism genotypes were determined by using polymerase chain reaction with specific primers. (molvis.org)
Thus, both the occurrence and the prognosis of glioblastoma multiforme could be associated with specific but different HLA genotypes. (aacrjournals.org)
The HLA-C genotypes and KIR polymorphisms were analyzed via DNA-based method for higher-resolution genotyping. (tmu.edu.tw)
Our current findings suggest that the KIR and HLA-C genotypes are associated with the pathogenesis of endometriosis. (tmu.edu.tw)

Researchers speculate that HLA-B27 may abnormally display peptides that trigger an immune reaction, resulting in the inflammatory process that causes arthritis. (medlineplus.gov)
These peptides (HLA-II T-cell epitopes) are increasingly important as research targets for the development of vaccines and immunotherapies. (biomedcentral.com)
HLA-II peptide binding studies involve multiple overlapping peptides spanning individual antigens, as well as complete viral proteomes. (biomedcentral.com)
Residue 34 is located in pocket B and contacts the main chain carbon of bound peptides in HLA-A2. (usda.gov)
A functioning TAP (transporter associated with antigen processing) molecule is required to transport these peptides into the endoplasmic reticulum, where they can interact with HLA-E. HLA-E then migrates to the cell surface, where it interacts with CD94/NKG2A receptors on natural killer cells. (ox.ac.uk)
Some class I MHC genes encode nonclassical MHC molecules, such as HLA-G (which may play a role in protecting the fetus from the maternal immune response) and HLA-E (which presents peptides to certain receptors on natural killer [NK] cells). (msdmanuals.com)

Given the possible influence of HLA-G on the clinical course of HPV infection, cervical lesions and cancer progression, a better understanding of HLA-G involvement in cervical carcinogenesis might contribute to two aspects of fundamental importance: 1. (northwestern.edu)
2. Identification of HLA-G-driven immune mechanisms involved in lesion development and cancer progression, leading to the development of strategies for modulating HLA-G expression for treatment purposes. (northwestern.edu)
This data is thus indicative of an impact of elevated HLA-DR expression on the progression of the disease. (hu-berlin.de)
10 Coupled with the reported tissue distribution, these inhibitory effects upon immune cells have led to the suggestion that HLA-G has a role in maintaining maternal-fetal tolerance, 11 reducing transplant rejection, 12 and in allowing the progression of tumours. (bmj.com)
HLA-C is a ligand of killer cell immunoglobulin receptors (KIRs) and is an essential regulator of natural killer cell activity, which is associated with endometriosis progression. (tmu.edu.tw)

372 donors were genotyped using a custom precision medicine single nucleotide polymorphism (SNP) microarray. (nature.com)
Yet, the IFNA10 single nucleotide polymorphisms and the IFNA microsatellite are associated with the DR2 - patient group. (uni-luebeck.de)

HLA-G expression was analysed in thyroid tissue taken from six patients with GD and one with HT by reverse transcriptase polymerase chain reaction. (bmj.com)

The results confirm that the positional variation of one beta polypeptide (namely beta-1) correlated with the HLA-DR allospecificity and was not influenced by the ethnic origin of the individual donating the cells. (ox.ac.uk)
The positional variation of a second beta polypeptide (namely beta-2) was consistent with strong linkage dis-equilibrium between the corresponding genetic locus and the HLA-DR locus. (ox.ac.uk)
Antigen variation in pathogens and tumor antigens, and extensive polymorphism of HLA molecules increase the number of targets for screening studies. (biomedcentral.com)

Among them the differential expression of HLA-DRB molecules in different types of antigen-presenting cells, which was investigated here in detail. (hu-berlin.de)
6 With respect to activity, HLA-G molecules can inhibit natural killer cell mediated and antigen specific CD8 + T cell mediated cytolysis, 7 induce apoptosis of activated CD8 + T cells, 8 suppress the proliferation of allogeneic CD4 + T cells, 9 and inhibit the transendothelial migration of natural killer cells. (bmj.com)
Experimental screening methods are expensive and time consuming and reagents are not readily available for many of the HLA class II molecules. (biomedcentral.com)
Because not all servers have predictors for all tested HLA-II molecules, we assessed a total of 113 predictors. (biomedcentral.com)
CTLs recognize peptide antigens presented by major histocompatibility complex class I (MHC-I) molecules on infected cells or cancer cells and kill them. (biomedcentral.com)
Coexpression of susceptible and resistant HLA class II transgenes in murine experimental autoimmune thyroiditis: DQ8 molecules downregulate DR3-mediated thyroiditis. (musc.edu)
It binds to the leader peptide derived from the polymorphic classical major histocompatibility molecules HLA-A, HLA-B and HLA-C. This peptide binding is highly specific and stabilizes the HLA-E protein, allowing it to migrate to the cell surface. (ox.ac.uk)
Because every nucleated cell expresses class I MHC molecules, all infected cells can act as antigen-presenting cells for CD8 T cells (CD8 binds to the nonpolymorphic part of the class I heavy chain). (msdmanuals.com)

Thus, this systematic review explores the potential involvement of HLA-G protein expression and polymorphisms in cervical carcinogenesis. (northwestern.edu)
Other research suggests that the joint inflammation characteristic of this disorder may result from improper folding of the HLA-B27 protein or the presence of abnormal forms of the protein on the cell surface. (medlineplus.gov)

Several mechanisms have been described how these HLA haplotypes impact on the disease. (hu-berlin.de)
The promoters of the disease associated HLA-DR4 to the neutral DR7 and DR9 haplotypes were analyzed for sequence polymorphisms resulting in functional differences. (hu-berlin.de)

In conclusion, this study indicates that the +14 bp HLA-G allele defines a nearly unique exon 8 haplotype, and fetuses homozygous for this haplotype [SNP 2995(C)/SNP 3127(G)/SNP 3172(A)/SNP 3181(G)/+14 bp] are associated with severe pre-eclampsia in primiparas. (ruc.dk)
It is estimated that among those with the HLA-B27 allele, only one to five percent develop ankylosing spondylitis. (medlineplus.gov)

This interaction inhibits natural killer cell-mediated lysis of a cell displaying HLA-E. If the leader peptide is not present in the endoplasmic reticulum, HLA-E is unstable and is degraded before it reaches the cell surface. (ox.ac.uk)

Subsequently, two separate GWASs has been conducted and consistently identified locus in HLA region in association with HNC. (who.int)
Despite these significant findings, it is important to note that imputed data for the HLA locus may pose challenges due to high level of linkage disequilibrium and polymorphism. (who.int)

Recent advances have been made in the of host factors, polymorphisms, and candidate genes associated characterization of the immune response to low-molecular- with occupational asthma may improve our understanding of weight agents. (cdc.gov)

It has been suggested that the non-classic HLA class I molecule HLA-G plays a role in autoimmune disease by protecting tissues from damage by infiltrating cytotoxic T cells. (bmj.com)

16 Such observations have initiated the idea that HLA-G might protect tissues from damage by infiltrating cytotoxic T cells during the process of inflammation 2 because HLA-G has been shown to modulate the T helper (Th) cytokine balance in favour of Th2 type anti-inflammatory cytokine responses. (bmj.com)
The goal of vaccination is to induce immunity against pathogens and cancer cells by stimulating antigen-specific cytotoxic T lymphocytes (CTLs) or B cells. (biomedcentral.com)
Functional analysis employing site directed mutagenesis identified BF amino acid residues forming serologic epitopes as well as residues important in antigen presentation to ALV induced cytotoxic T lymphocytes. (usda.gov)

The polymorphism has been examined using lymphoblastoid cell lines that were derived from different geographical populations (North European and Italian) and that expressed various HLA-DR alloantigenic specificities. (ox.ac.uk)
that is, apparently the same beta-3 polypeptide was associated with different HLA-DR specificities provided the cells were of the same ethnic origin. (ox.ac.uk)

The present results are consistent with the hypothesis that an immunological mechanism is involved in DA and that genetic variations within HLA genes play a role in DA risk. (cdc.gov)

KIR3DL2 has shown peptide-specific binding to some HLA-A antigens, including A3 and A11 (4, 7, 8). (rndsystems.com)
Studies with HLA-A2 have shown that changes in residue 34 do not affect viral peptide presentation. (usda.gov)
In damaged cells, such as virally infected or tumour cells, down-regulation of HLA-A, HLA-B and HLA-C production or inhibition of TAP prevents stabilization of HLA-E by the leader peptide. (ox.ac.uk)
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). (lu.se)

A full HLA class II type may be obtained on a large number of samples simultaneously without the need to separate and store viable lymphocytes. (ox.ac.uk)
In contrast, a site directed substitution in residue 34 dramatically alters ALV antigen presentation by the BFIV21 class I glycoprotein. (usda.gov)
These data indicate that the fine physical structure of chicken class I is similar to HLA along the alpha 1 alpha helix, whereas the side chain orientation of internal residues impacting pocket B are altered. (usda.gov)

that is, different beta-2 polypeptides were associated with the same HLA-DR specificity in different geographical populations. (ox.ac.uk)

The aim of the current study was to analyse thyroid tissue and thyrocytes obtained from individuals with autoimmune thyroid disease for the expression of HLA-G. (bmj.com)
HLA-G expression does not occur in the thyroid of patients with GD, indicating that HLA-G does not play a pathophysiological role in this autoimmune disorder. (bmj.com)
Although the expression of HLA-G was not detected in the thyroid sample of the patient with HT, a greater sample size would be required to conclude that HLA-G does not have a part to play in this autoimmune thyroid disease. (bmj.com)

In a small group of women exposed to both HIV-1 and HIV-2 in Gambia, studied over 4 years, we have repeatedly detected HLA-B35-restricted CTL which exhibit cross-reactivity between the HIV-1 and HIV-2 sequences of the CTL epitopes. (ox.ac.uk)

It also binds the abnormally folded HLA-B27 homodimer found in spondylarthritides, but not the normal heterodimer of HLA-B27 with beta 2‑microglobulin (9, 10). (rndsystems.com)

Genotyping was performed using an ABI PRISM 7900HT instrument and HLA-SE genes were identified using PCR sequence-specific primers. (nih.gov)
Alignment of the BFIV21 sequence with previously published BFIV sequences revealed polymorphisms at position 34 (HLA34), a monomorphic residue in HLA and H-2. (usda.gov)

These subtypes are designated as HLA-B*2701 to HLA-B*2763 . (medlineplus.gov)

It is possible that HLA-B27 may increase the risk of ankylosing spondylitis through more than one mechanism, or by different mechanisms in different individuals based on their genetic and environmental background. (medlineplus.gov)

HLA imputation was performed with Michigan HLA imputation server with recent multi-ethnic HLA imputation panel. (who.int)

3 However, further studies have suggested that HLA-G is expressed in other tissues such as thymic epithelial cells, 4 in addition to tumours 5 and transplant biopsies. (bmj.com)
In the transplant population, antigen assays or PCR is used (sometimes in conjunction with cytopathology) for diagnosis and treatment determinations. (medscape.com)

Furthermore, HLA-G expression could not be detected in cultured patient TFCs under basal conditions or after stimulation with the proinflammatory cytokines-interleukin 1α, interferon γ, and tumour necrosis factor α. (bmj.com)

The molecular mechanisms underlying this function of HLA-E have been revealed by crystallographic studies of the structure of HLA-E. (ox.ac.uk)

For amino acid polymorphisms within HLA genes, we achieve 98.6% and 99.3% accuracy using the Affymetrix GeneChip 500 K and Illumina Immunochip, respectively. (nih.gov)

This graph shows the total number of publications written about "HLA-DR3 Antigen" by people in this website by year, and whether "HLA-DR3 Antigen" was a major or minor topic of these publications. (musc.edu)

Both polypeptide chains are encoded by genes in the HLA-DP, -DQ, or -DR region of chromosome 6. (msdmanuals.com)

Inflammation develops after the relative immune privilege of the eye is compromised, causing sensitisation to previously sequestrated uveoretinal antigens. (bmj.com)

Anatomy14

Organisms8

Diseases7

Chemicals and Drugs127

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Psychiatry and Psychology1

Phenomena and Processes55

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Information Science5

Named Groups3

Health Care13

Geographicals3

Humans4

Loci11

Alleles9

SNPs4

Genotype6

Genetics1

Human23

Gene15

DRB16

Professional antigen prese1

Variants2

Genotypes4

Peptides6

Progression5

Single Nucleotide2

Polymerase1

Variation3

Molecules8

Protein2

Haplotypes2

Allele2

Natural killer cell m1

Locus2

Immune response1

Molecule1

Cytotoxic3

Specificities2

Genes play1

Peptide4

Class3

Specificity1

Autoimmune3

Epitopes1

Binds1

Sequence2

Subtypes1

Ankylosing spondylitis1

Imputation1

Transplant2

Cytokines1

Mechanisms1

Immunochip1

Major1

Chains1

Inflammation1