Polymorphic genes on chromosome blood cell antigens lewis blood group system. Medical search. Frequent questions

We identified 98 candidate genes containing rare variation that in aggregate show association with SLE many of which have recognized immunological function, but also function and expression related to relevant tissues such as the joints, skin, blood or central nervous system. (frontiersin.org)
We here provide an important resource of candidate genes for SLE. (frontiersin.org)
Recent advances have been made in the of host factors, polymorphisms, and candidate genes associated characterization of the immune response to low-molecular- with occupational asthma may improve our understanding of weight agents. (cdc.gov)
Protein expression of selected candidate genes was determined in full thickness gastric biopsies from GpCRC patients and controls. (bvsalud.org)
Computational annotation of suggestive risk loci identified 14 protein-coding candidate genes. (bvsalud.org)

Individuals lacking a specific Kell antigen may develop antibodies against Kell antigens when transfused with blood containing that antigen. (wikipedia.org)
Following the formation of anti-K, subsequent blood transfusions may be marked by destruction of the new cells by these antibodies, a process known as hemolysis. (wikipedia.org)
The antibodies lead to destruction of the red blood cells with resulting anemia. (wikipedia.org)
Similarly, a pregnant woman may develop antibodies against fetal red blood cells, resulting in destruction, anemia, and hydrops fetalis in a process known as hemolytic disease of the newborn (HDN). (wikipedia.org)
Both AIHA and HDN may be severe when caused by anti-Kell antibodies, as they are the most immunogenic antigens after those of the ABO and Rhesus blood group systems. (wikipedia.org)
citation needed] The Kell group was named after the first patient described with antibodies to K1, a pregnant woman named Mrs. Kellacher in 1945. (wikipedia.org)
or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)

Examining Individual and Synergistic Contributions of PTSD and Genetics to Blood Pressure: A Trans-Ethnic Meta-Analysis. (cdc.gov)
In this study, we conducted the first examination of the individual and synergistic contributions of PTSD symptoms and blood pressure genetics to continuous blood pressure levels. (cdc.gov)

In addition we also find that there is a significant enrichment of genes annotated for disease-causing mutations in the OMIM database, suggesting that in complex diseases such as SLE, such mutations may be involved in subtle or combined phenotypes or could accelerate specific organ abnormalities found in the disease. (frontiersin.org)
Using data from the Exome Aggregation Consortium (ExAC) for a gene-based test, we demonstrate an enrichment of predicted rare loss-of-function variants in CFH, CFI, and an as-yet unreported gene in AMD, ORMDL2. (bvsalud.org)
Gene mapping was obtained based on genomic position and expression quantitative trait loci, and a gene-set network enrichment analysis was performed. (bvsalud.org)
Gene-set network enrichment analysis revealed pathways potentially involved in immune and motor dysregulation (pFDR ≤ 0.05). (bvsalud.org)

USH2A gene mutations in rabbits lead to progressive retinal degeneration and hearing loss. (harvard.edu)

It is now accepted that rare variants located in different genes could in fact play a more important role in disease susceptibility than common variants ( 4 ). (frontiersin.org)

The AF form of SALSA had a more intact structure and contained peptides from the zona pellucida domain, which is involved in cell differentiation and oligomerization. (researchgate.net)
280 independent research projects studying β-cell physiology, β-cell differentiation, immunology, T1D biomarkers, technology development, T1D pathology, and diabetes etiology ( https://www.jdrfnpod.org/publications/current-npod-projects/ , accessed October 21, 2021). (nature.com)

Bitter taste receptor proteins in the taste buds of the tongue that recognise PTC are encoded on nearby chromosome locus 7 q35-6. (wikipedia.org)
SALSA proteins in the AF and intestinal samples were polymorphic and exhibited varying polypeptide compositions. (researchgate.net)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)

Anti-K is the next most common immune red cell antibody after those in the ABO and Rh system. (wikipedia.org)
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. (lookformedical.com)
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. (lookformedical.com)
Understanding the complete immune cell composition of human neuroblastoma (NB) is crucial for the development of immunotherapeutics. (pklab.org)
We provide a comprehensive immune cell landscape and characterize cell-state changes from normal tissue to NB. (pklab.org)

In contrast to adult cancers and previous NB studies, we show an increase in inflammatory monocyte cell state when contrasting normal and tumor tissue, while no differences in cytotoxicity and exhaustion score for T cells, nor in Treg activity, are observed. (pklab.org)

Individuals without K antigens(K0) who have formed an antibody to a K antigen, must be transfused with blood from donors who are also K0 to prevent hemolysis. (wikipedia.org)
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. (lookformedical.com)

Absence of the XK protein (such as through genetic deletion or through a single point mutation within the coding region of the XK gene), leads to marked reduction of the Kell antigens on the red blood cell surface. (wikipedia.org)
Evidence supports a genetic link between the Kell blood group (on chromosome 7 q33) and the ability to taste phenylthiocarbamide, or PTC, a bitter-tasting thiourea compound. (wikipedia.org)
Genetic contributions to blood pressure were modeled via polygenic scores (PGS) for systolic blood pressure (SBP) and diastolic blood pressure (DBP) that were derived from a prior trans-ethnic blood pressure genome-wide association study (GWAS). (cdc.gov)
Additional research is needed to better understand the extent to which PTSD is associated with high blood pressure and how genetic as well as contextual factors may play a role in influencing cardiovascular risk. (cdc.gov)
Single-cell RNA sequencing (scRNA-seq) has the potential to investigate both genetic and nongenetic sources of tumor heterogeneity in a single assay. (pklab.org)
Production of high genetic merit bulls, Production of disease free quality semen, Extension and demonstrations for fodder development, Interventions to strengthen village based milk procurement systems, Augmenting systems in the villages for procurement of milk in a fair and transparent manner, Project learning and monitoring and capacity building and training. (paperzz.com)

Here, we perform single-cell RNA sequencing (scRNA-seq) on 19 human NB samples coupled with multiplex immunohistochemistry, survival analysis, and comparison with normal fetal adrenal gland data. (pklab.org)

Both infect cells of the monocyte/macrophage lineage and cause lifelong infections. (mdpi.com)

Comparative Tumor Microenvironment Analysis of Primary and Recurrent Ovarian Granulosa Cell Tumors. (viictr.org)
Single-cell transcriptomic analysis of tumor cells from the primary tumors reveals a distinct transcriptional signature that is predictive of metastatic potential and patient survival. (pklab.org)

We harnessed the power of the Psychiatric Genomics Consortium-PTSD Physical Health Working Group and investigated these associations across 11 studies of 72,224 trauma-exposed individuals of European (n = 70,870) and African (n = 1,354) ancestry. (cdc.gov)

The Kell antigen system (also known as the Kell-Cellano system) is a human blood group system, that is, a group of antigens on the human red blood cell surface which are important determinants of blood type and are targets for autoimmune or alloimmune diseases which destroy red blood cells. (wikipedia.org)
The development of the human blood-CSF-brain barrier. (cdc.gov)
We aimed to investigate how human liver stromal cells impact myeloid cell properties and to understand the utility of a stromal-myeloid coculture system to study these interactions in the context of cirrhosis. (pklab.org)
RESULTS: While no SNP associations were detected at strict significance (p ≤ 5 × 10-8 ), nine independent genomic loci were associated at suggestive significance (p ≤ 1 × 10-5 ), with the strongest signal (rs9273363, odds ratio = 1.4, p = 1 × 10-7 ) mapped to the human leukocyte antigen region. (bvsalud.org)

Antigens that exist in alternative (allelic) forms in a single species. (lookformedical.com)
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)

We have previously tested the overall effect of imputed rare variation on particular genes in systemic autoimmunity ( 14 ). (frontiersin.org)
Recently, we have implemented and successfully applied a method based on genotype imputation of rare variation, on a set of genes detected by exome sequencing as possible candidates for association to systemic lupus erythematosus (SLE) by mutation in members of Icelandic SLE-multicase families ( 15 ). (frontiersin.org)
Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is undefined. (bvsalud.org)

It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs. (lookformedical.com)

Infection by VMV and CAEV can lead to Visna/Maedi (VM) and Caprine Arthritis-Encephalitis (CAE) respectively, slow progressive inflammatory diseases primarily affecting the lungs, nervous system, joints and mammary glands. (mdpi.com)

1973. Carcinogens are mutagens: A simple test system combining liver homogenates for activation and bacteria for detection. (cdc.gov)
1990. Cell replication and unscheduled DNA synthesis (UDS) activity of low molecular weight chlorinated paraffins in the rat liver in vivo. (cdc.gov)

An RNA-based system to study hepatitis B virus replication and evaluate antivirals. (harvard.edu)

Several different cell types demonstrate a survival benefit. (pklab.org)

During the lethal second wave in late 1918, across naval groups throughout the world, mortality varied 30-100 fold depending on the nature, cumulative incidence, and timing of early 1918 ('first wave') influenza-like illnesses. (cdc.gov)
Background & aims: Myeloid cells are key regulators of cirrhosis, a major cause of mortality worldwide. (pklab.org)

Reporting of tobacco use and tobacco-related analyses in cancer cooperative group clinical trials: a systematic scoping review. (viictr.org)

Kell antigens are important in transfusion medicine, autoimmune hemolytic anemia and hemolytic disease of the newborn (anti-Kell). (wikipedia.org)

The XK appears to be required for proper synthesis or presentation of the Kell antigens on the red blood cell surface. (wikipedia.org)

The Kell antigens are peptides found within the Kell protein, a 93-kilodalton transmembrane zinc-dependent endopeptidase which is responsible for cleaving endothelin-3. (wikipedia.org)
They measured it in the unicellular green alga Chlamydomonas reinhardtii and in the cyanobacterium Anabaena variabilis , and found that illuminated cells concentrate CO2 by active uptake of inorganic carbon. (deltastate.edu)

Analysis of 22 tumor samples, including multiple myeloma, gastric, breast and thyroid cancers, shows that Numbat can reconstruct the tumor copy number profile and precisely identify malignant cells in the tumor microenvironment. (pklab.org)

The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. (wikipedia.org)
Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
Numbat exploits the evolutionary relationships between subclones to iteratively infer single-cell copy number profiles and tumor clonal phylogeny. (pklab.org)
Our study reveals significant single-variant association signals at four loci and independent gene-based signals in CFH, C2, C3, and NRTN. (bvsalud.org)

Analysis of supporting stromal cells within the tumor environment demonstrates vascular remodeling within the endothelial cells. (pklab.org)
An in silico cell-to-cell interaction analysis highlights the CXCL9/CXCL10-CXCR3 axis and the CD70-CD27 axis as potential therapeutic targets. (pklab.org)

Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. (lookformedical.com)
Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)

This is particularly true for the "K" antigen which shows a relatively high antigenicity and moderately low frequency (~9%) in Caucasian populations. (wikipedia.org)

On November 1, 2009, Taiwan began a mass pandemic A/H1N1 vaccine (H1N1v) campaign and pregnant women were among the priority groups for vaccination. (cdc.gov)
The Influenza Vaccine Information System tracked the number of H1N1v doses administered to pregnant women. (cdc.gov)

Because stromal cells can modulate the functionality of myeloid cells in vitro, targeting stromal-myeloid interactions has become an attractive potential therapeutic strategy. (pklab.org)

Baruj Benacerraf (VE-US), Jean Baptiste Gabriel Joachim Dausset (FR) and George Davies Snell (US) were awarded the Nobel Prize in Physiology or Medicine for their discoveries concerning genetically determined structures on the cell surface that regulate immunological reactions. (deltastate.edu)

CRISPR screens identify novel regulators of cFLIP dependency and ligand-independent, TRAIL-R1-mediated cell death. (harvard.edu)

At this point an interesting cost and a computationally effective alternative would be to combine genotype imputation with targeted sequencing in a gene-centered strategy. (frontiersin.org)

Our findings provide biological insights into the interplay between tumor cells and the ccRCC microenvironment. (pklab.org)

Progressive transformation of the HIV-1 reservoir cell profile over two decades of antiviral therapy. (harvard.edu)

encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer in adults. (pklab.org)

The KEL gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. (wikipedia.org)

Anatomy44

Organisms1

Diseases9

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes69

Information Science4

Candidate genes5

Antibodies7

Genetics2

Enrichment4

Mutations1

Variants1

Differentiation2

Proteins4

Immune5

Tissue1

Donors2

Genetic6

Fetal1

Monocyte1

Tumors2

Genomics1

Human4

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Variation3

Specific1

Diseases1

Liver2

Replication1

Demonstrate1

Mortality2

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Synthesis1

Found2

Samples1

Single4

Analysis2

Activation2

High1

Pregnant2

Potential1

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Independent1

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