Elastin-like polypeptides (ELPs) are synthetic biopolymers with potential applications in the fields of cancer therapy, tissue scaffolding, metal recovery, and protein purification. (wikipedia.org)
Tropoelastin is a protein, of size 72kDa, that comes together via cross-links to form elastin in the extracellular matrix of the cell. (wikipedia.org)
One of the major reasons that elastin can withstand high levels of stress in the body without experiencing any physical deformation is that the underlying tropoelastin contains domains that are highly hydrophobic. (wikipedia.org)
This material has a remarkable combination of flexibility and durability: Elastin is one of the body's most long-lasting component proteins, with an average survival time comparable to a human lifespan. (mit.edu)
Elastin tissues are made up of molecules of a protein called tropoelastin, which are strung together in a chain-like structure, and which Weiss and his team have been studying in the lab for many years. (mit.edu)
Collagen2
Collagen is the most ubiquitous and abundant protein in humans. (amboss.com)
Then, he is investigating biomimetic approaches based on cross-linking enzymes for the improvement of the angiogenic properties of hydrogels of natural polymers, including tropoelastin and collagen. (sfbmec.fr)
Peptides1
Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. (mdpi.com)
Keratin2
Keratin ( / ˈ k ɛr ə t ɪ n / [1] [2] ) is one of a family of structural fibrous proteins also known as scleroproteins . (wikipedia.org)
Spider silk is classified as keratin, [9] although production of the protein may have evolved independently of the process in vertebrates. (wikipedia.org)
Tissues2
It incorporates an elastic protein called tropoelastin, which is found in all elastic human tissues. (harvard.edu)
ZFP36 was predicted and verified to be the target of miR-934 and low protein levels of ZFP36 were observed in GC tissues. (bvsalud.org)
Scleroproteins1
https://doi.org/10.1016/j.eml.2018.01.009 Scleroproteins are an important category of proteins within the human body that adopt filamentous, elongated conformations in contrast with typical globular proteins. (imechanica.org)
Elastic1
To the best of our knowledge," Annabi said, "this is the first report of purpose-built, high-resolution patterns on the surface of an elastic human protein-based gel. (harvard.edu)
Structural2
This review critically focuses on opportunities to employ protein-graphene oxide structures either as nanocomposites or as biocomplexes and highlights the effects of carbonaceous nanostructures on protein conformation and structural stability for applications in tissue engineering and regenerative medicine. (mdpi.com)
Although engineered and modified in a laboratory setting, ELPs share structural characteristics with intrinsically disordered proteins (IDPs) naturally found in the body, such as tropoelastin, from which ELPs were given their name. (wikipedia.org)
Genetic1
Genetic mutations alter these proteins, disrupting their functions and causing diseases. (imechanica.org)
Characteristics1
The team tested the way this flexibility comes about by genetically modifying the protein and comparing the characteristics of the modified and natural versions. (mit.edu)
Human body1
They account for the majority of proteins in the ECM , which makes them the most abundant proteins in the human body. (amboss.com)
Found2
A key part of the puzzle was the flexibility of the molecule itself, which the team found was controlled by the structure of key regions and the overall shape of the protein. (mit.edu)
Keratins (also described as cytokeratins ) are polymers of type I and type II intermediate filaments that have been found only in chordates ( vertebrates , amphioxus , urochordates ). (wikipedia.org)
Free1
It is at this temperature that the ELPs move from a linear, relatively disordered state to a more densely aggregated, partially ordered state Although given as a single temperature, Tt, the ELP phase change process generally begins and ends within a temperature range of approximately 2 °C. Also, Tt is altered by the addition of unique proteins to the free ELPs. (wikipedia.org)
Structure1
First, thanks to synchrotron imaging done by team member Clair Baldock at the University of Manchester in the U.K., the research revealed the shape and structure of the basic tropoelastin molecules. (mit.edu)
Solution3
ELPs can also be engineered to recognize specific proteins in solution. (wikipedia.org)
The ability of ELPs to undergo morphological changes at certain temperatures enables specific proteins that are bound to the ELPs to be separated out from the rest of the solution via experimental techniques such as centrifugation. (wikipedia.org)
Lead author Nasim Annabi, Ph.D., a Wyss Postdoctoral Fellow, said that the gel recipe calls for ultraviolet light, which is used to create a reactive form of tropoelastin called methacrylated tropoelastin in a water-based solution - hence the name "MeTro hydrogel. (harvard.edu)
Properties1
Protein that gives blood vessels and skin their stretchability has its molecular properties revealed. (mit.edu)
Form1
Although ELPs generally form reversible spherical aggregates due to their proline and glycine content, there is a possibility that, under certain conditions such as exceedingly high temperatures, ELPs will form amyloids, or irreversible aggregates of insoluble protein. (wikipedia.org)
Cells1
The green and red colors indicate critical proteins in heart cells, and the blue shows the nuclei of the heart cells. (harvard.edu)
Research1
The team acknowledges research support by the National Health and Medical Research Council, the National Science Foundation, the Office of Naval Research, the National Institutes of Health, the CRC for Polymers, Australian Research Council, Australian Defense Health Foundation, and the National Health and Medical Research Council. (harvard.edu)
Term1
The new term corneous beta protein (CBP) has been proposed to avoid confusion with α-keratins. (wikipedia.org)
Growth1
The results of in vivo experiments further demonstrated that miR-934 promoted tumor growth and repressed the protein expression of ZFP36. (bvsalud.org)
Naturally found2
Although engineered and modified in a laboratory setting, ELPs share structural characteristics with intrinsically disordered proteins (IDPs) naturally found in the body, such as tropoelastin, from which ELPs were given their name. (wikipedia.org)
Synthetic biopolymers that are formed by repeating amino acid sequences that are naturally found in TROPOELASTIN . (nih.gov)
Functional1
First, the genetic, biological, biochemical and biophysical processes leading to a functional polymer are described. (nih.gov)
Family1
The TGF-beta family of proteins, namely TGF-beta1, TGF-beta2 and TGF-beta3 with their specific cell surface receptors TGF RI, TGF RII, TGF RIII are known to act on several crucial aspects of embryonal and mainly mesenchymal/neuroektodermal organ development. (justia.com)
Date1
To date, the mechanism by which these polarity proteins assemble at the leading edge of migrating epithelial cells remains unclear. (egfr-signaling.com)