Polyclonal fragment amino acid antibody specificity. Medical search. Frequent questions

Monoclonal antibody testing indicated that it was probably a pneumovirus. (cdc.gov)
Immunofl uorescence as- says (IFAs) ultimately detected 13 positive cultures over a 4-month period when a monoclonal antibody (MAb) pool against human respiratory syncytial virus (RSV) (VP-R151, Vector Laboratories, Burlingame, CA, USA) was used. (cdc.gov)
A monoclonal antibody raised against purified flagellar basal apparatuses from the green flagellate Spermatozopsis similis reacted with a protein of 210 kDa (p210) in western blots. (lookformedical.com)
A murine monoclonal antibody (LmAb12) and its recombinant fragments (scFv12P and diabody12P) have been produced and characterized. (bvsalud.org)

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. (wikipedia.org)
When the protein folds, these regions give rise to three loops of β-strands, localized near one another on the surface of the antibody. (wikipedia.org)
To further investigate the function of the US11 protein, this study was undertaken to express the US11 protein and raise a polyclonal antibody. (biomedcentral.com)
After purification by nickel affinity chromatography and refolding, the recombinant protein was used to raise the anti-US11 polyclonal antibody. (biomedcentral.com)
Western blot analysis demonstrated that the US11 protein was specifically recognized by the polyclonal antibody, and immunofluorescent assay also showed that the antibody was able to probe the US11 protein in the cells infected with HSV-1. (biomedcentral.com)
In the present study, we obtained a high-level expression of the recombinant US11 protein as well as high titers of rabbit polyclonal antibody specially against US11 protein in HSV-1 infected cells. (biomedcentral.com)
This special polyclonal antibody provides a good tool for further studying structural and functional characterization of HSV-1 US11 protein. (biomedcentral.com)
The His-tagged US11 protein was then expressed in E. coli BL21 (DE3) cells and purified by a nickel-nitrilotriacetic acid (Ni 2+ -NTA) affinity resin under denaturing conditions. (biomedcentral.com)
Subsequently, a polyclonal antibody was raised against the purified His-tagged US11 protein in rabbits. (biomedcentral.com)
The full-length US11 gene, which is composed of 459 bp (base pairs) and predicted to encode a protein of 152 amino acids, was amplified successfully from the HSV-1 (strain F) genome (Figure 1 , lane 1). (biomedcentral.com)
The high titer (1:32000) polyclonal antibodies with high specificity were obtained by immunizing rabbits with the purified recombinant protein. (hindawi.com)
In this study, the cloning and expression of mouse IL-33 gene in Escherichia coli (E. coli ), purification of recombinant protein, and generation of polyclonal antibody against IL-33 are described. (hindawi.com)
The prepared antibody can be useful for the study of expression and distribution of IL-33 in various tissues at protein level and for the elucidation of its biofunctions and regulation mechanism in inflammatory diseases. (hindawi.com)
The IB1cDNA encodes a 714 amino acid protein with a proline-rich region and a putative basic helix-loop-helix domain (bHLH). (justia.com)
AIF Polyclonal Antibody detects AIFM1 protein by Western blot analysis. (thermofisher.com)
Mature mouse LRIG-1 is a 1057 amino acid (aa) type I transmembrane protein (SwissProt #:P70193). (novusbio.com)
The α-Syn protein is a small acidic synaptic protein made up of 140 amino acids with a tendency to misfold and aggregate [ 7 ]. (biomedcentral.com)
To mimic the evolutionary process by which protein networks develop, we adopted the basic mechanism by which antibodies are produced against antigens. (healthyconnectionsinc.com)
We have developed a strategy using protein docking simulation that imitates this process of antibody generation to select human being protein scaffolds with complementary designs (Number 1B). (healthyconnectionsinc.com)
The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metabolism. (thermofisher.com)
We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
The sequence encoded a novel protein rich in alanine (25%) and proline (20%), which contained regions similar to proteins of comparable amino acid composition such as extracellular matrix components or the membrane-cytoskeletal linker synapsin. (lookformedical.com)
Using a polyclonal antibody (anti-p210) raised against the C-terminal part of p210, it was shown that the protein was highly enriched in the basal apparatuses. (lookformedical.com)
The hOAT3 cDNA consisted of 2179 base pairs that encoded a 543-amino-acid residue protein with 12 putative transmembrane domains. (aspetjournals.org)
This single-chain 535 amino acid long protein causes the symptoms of acute diphtheria infection. (org.ua)
The antibody and antigen information page lists the antigens and corresponding antibodies that have been used in the Human Protein Atlas project, together with the validation results for the antibodies. (proteinatlas.org)
Genes adjacent to pvtramp were identified in silico to determine the degree of similarity between the protein sequences encoded by equivalent chromosomic fragments in P. falciparum and Plasmodium knowlesi . (biomedcentral.com)
S protein is the main determinant of cell tropism and of the induction of neutralizing antibodies. (datexis.com)
FCoVs can be divided into two serotypes, types I and II, which differ in the neutralizing antibody reaction and have distinct S protein sequences. (datexis.com)
Western blot and immunofluorescence assay (IFA) were used to examine the reactivity of rFg14-3-3e protein to anti- F. gigantica and anti-rFg14-3-3e antibodies, respectively. (biomedcentral.com)
Western blot analysis showed that rFg14-3-3e protein is recognized by sera from goats experimentally infected with F. gigantica and immunofluorescence staining using rat anti-rFg14-3-3e antibodies demonstrated the specific binding of rFg14-3-3e protein to the surface of goat PBMCs. (biomedcentral.com)

Part of the antibody molecule that is identical between all antibodies of the same isotype, comprised of one or more constant domains. (stratech.co.uk)

Each chain is a series of domains: somewhat similar sequences of about 110 amino acids each. (wikipedia.org)
We show here that the reactivity of a high affinity, virus-neutralizing human antibody against the AD-2 epitope of cytomegalovirus gB can be modified by introducing other Vkappa sequences together with the original VH sequence. (lu.se)
It was also evident that the VH/Vkappa pairing was not promiscuous, since antibody fragments selected by phage display retained light chain sequences very similar to the original hybridoma-derived light chain, proving that a high affinity interaction was very dependent on a co-operativity between both variable domains. (lu.se)
The present invention relates to an anti-tyrosinase antibody for inhibiting tyrosinase and use thereof, and more particularly, to an anti-tyrosinase antibody including a heavy chain CDR and a light chain CDR of specific sequences, or an antigen-binding fragment thereof. (justia.com)
The sequencing result also showed that there was no mutation of amino acid sequences (data not shown). (biomedcentral.com)
The IL-33 cDNA sequences encode 270 and 266 amino acid polypeptides for human and mouse, respectively, corresponding to full-length proteins with calculated masses of 30 and 29.9 kDa [ 2 ]. (hindawi.com)
somewhat similar sequences of about 110 amino acids each. (wikipedia.org)
During quick B-cell proliferation, random mutations are launched into the immunoglobulin sequences, and clones that communicate antibodies with high affinities are preferentially selected. (healthyconnectionsinc.com)
Short sequences of amino acids found on the antibody variable region that collectively form the paratope. (stratech.co.uk)

The host species and the clonality (pAb = polyclonal, mAb = monoclonal, msAb = monospecific) of the antibody, as well as the purification method is reported. (proteinatlas.org)

Finally, the reactivity and specificity of the polyclonal antibody were characterized by Western blot and immunofluorescent assays. (biomedcentral.com)
This extensive immune cross-reactivity between SARS-CoV-2 antibodies and different antigen groups may play a role in the multi-system disease process of COVID-19, influence the severity of the disease, precipitate the onset of autoimmunity in susceptible subgroups, and potentially exacerbate autoimmunity in subjects that have pre-existing autoimmune diseases. (frontiersin.org)
Cross-reactivity occurs when amino acid sequence homology exists between a pathogen and self-tissue proteins ( 1 ). (frontiersin.org)
In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)

The fine specificity, as determined by the requirement of particular amino acid residues in the epitope, is shifted in these new antibody fragments. (lu.se)
In this procedure, key residues are optimized by using an amino acid residue randomization and phage display. (healthyconnectionsinc.com)
The natural receptor of DT, proHB-EGF is a single chain transmembrane glycoprotein of 208 amino acid residues. (org.ua)
These peptides are characterized by a common 17 amino acid ring structure with a disulfide bond between two cysteine residues. (elitelearning.com)
Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat gephyrin, conjugated to keyhole limpet hemocyanin (KLH). (phosphosolutions.com)
Although we previously reported an affinity maturation strategy in which the association rate of the antibody toward its antigen is improved by introducing a cluster of arginine residues into the framework region of the antibody, the detailed molecular mechanism responsible for this improvement has been unknown. (bvsalud.org)
In this study, we introduced five arginine residues into an anti-hen egg white lysozyme antibody (HyHEL10) Fab fragment to create the R5-mutant and comprehensively characterized the interaction between antibody and antigen using thermodynamic analysis, X-ray crystallography, and molecular dynamics (MD) simulations. (bvsalud.org)
Our results indicate that introduction of charged residues strongly enhanced the association rate, as previously reported, and the antibody-antigen complex structure was almost the same for the R5-mutant and wild-type Fabs. (bvsalud.org)

An object of the present invention is to provide an anti-tyrosinase antibody for inhibiting tyrosinase or an antigen-binding fragment thereof. (justia.com)
Another object of the present invention is to provide a fusion anti-tyrosinase antibody or an antigen-binding fragment thereof in which a TAT peptide is further bound to the anti-tyrosinase antibody or antigen-binding fragment thereof. (justia.com)
Still another object of the present invention is to provide a nucleic acid molecule encoding the antibody or antigen-binding fragment thereof, a recombinant expression vector containing the nucleic acid molecule, and a cell transformed with the recombinant expression vector. (justia.com)
Still another object of the present invention is to provide a composition for detecting a tyrosinase antigen containing the antibody or antigen-binding fragment thereof as an active ingredient. (justia.com)
Still another object of the present invention is to provide a pharmaceutical composition for preventing or treating skin pigmentation disorders or a composition for diagnosing skin pigmentation disorders containing the antibody or antigen-binding fragment thereof as an active ingredient, or a method for providing information necessary for diagnosing skin pigmentation disorders. (justia.com)
and a heavy chain variable region including a heavy chain CDR1 consisting of an amino acid sequence represented by SEQ ID NO: 4, a heavy chain CDR2 consisting of an amino acid sequence represented by SEQ ID NO: 5, and a heavy chain CDR3 consisting of an amino acid sequence represented by SEQ ID NO: 6, or an antigen-binding fragment thereof. (justia.com)
In addition, the present invention provides a fusion anti-tyrosinase antibody or an antigen-binding fragment thereof in which a TAT peptide represented by SEQ ID NO: 7 is further bound to the antibody or antigen-binding fragment thereof. (justia.com)
Abbreviations: VL - variable domain of the light chain, VH - variable domain of the heavy chain, CL - constant domain of the light chain, CH - constant domain of the heavy chain, Fc - constant fragment, Fab - antigen binding fragment. (ens-lyon.fr)

Antibodies are heavy (~150 kDa) proteins of about 10 nm in size, arranged in three globular regions that roughly form a Y shape. (wikipedia.org)
In an electrophoresis test of blood proteins, antibodies mostly migrate to the last, gamma globulin fraction. (wikipedia.org)
The major antibody class found in the blood, IgG, has a remarkable persistence, with a serum half-life of 20-23 days, compared with only hours or a few days for other circulating proteins 5 . (nature.com)
Stargazin (γ 2 ) and the closely related γ 3 , and γ 4 transmembrane proteins are part of a family of proteins that may act as both neuronal voltage-dependent calcium channel (VDCC) γ subunits and transmembrane α-amino-3-hydroxy-5-methyl-4-isoxazoleproponinc (AMPA) receptor regulatory proteins (TARPs). (biomedcentral.com)
Serum proteins that are categorized loosely by their electrophoretic mobility as alpha globulins that inhibit proteases, beta globulins that exist as various enzymes, and gamma globulins that mainly comprise immunoglobulins (antibodies). (stratech.co.uk)
We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more. (frontiersin.org)
Until early 1990s, renal organic anion transport was thought to be carried out by a few carrier proteins that showed wide substrate specificity. (aspetjournals.org)
Bispecific antibodies are proteins capable of simultaneously binding two different epitops, on the same or on different antigenes (Figure 2 ). (ens-lyon.fr)
This antibody and its recombinant constructs were able to recognize proteins of Loxosceles spider venoms with specificity. (bvsalud.org)

The therapeutic use of monoclonal antibodies consists in activation of antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), or engagement with cell surface receptors (to either activate or inhibit signaling) (Figure 1 ). (ens-lyon.fr)

These findings show that phage display technology might modify the binding properties of pre-existing, high affinity antibodies. (lu.se)

Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. (wikipedia.org)
The amino acids in CDRs can create extremely varied constructions, each of which forms the match shape that recognizes a specific epitope (Number 1A). (healthyconnectionsinc.com)
Among varied structures, only antibodies with complementary designs AGI-6780 are able to identify and bind to a particular epitope. (healthyconnectionsinc.com)
The strength of a binding interaction between the antigen-binding site (paratope) on an antibody and the epitope on an antigen. (stratech.co.uk)
Currently, most of the antibodies for therapeutic usage are monospecific, with a defined specificity for a particular molecular part of an antigen, known as an epitope. (ens-lyon.fr)

After an antigen binds to a BCR, the B cell activates to proliferate and differentiate into either plasma cells, which secrete soluble antibodies with the same paratope, or memory B cells, which survive in the body to enable long-lasting immunity to the antigen. (wikipedia.org)
Three CDRs from each of the heavy and light chains together form an antibody-binding site whose shape can be anything from a pocket to which a smaller antigen binds, to a larger surface, to a protrusion that sticks out into a groove in an antigen. (wikipedia.org)
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. (thermofisher.com)
An affinity purification process for removing antibodies that bind to off-target species (e.g., for ensuring a goat anti-mouse secondary antibody binds only to primary antibodies raised in mouse). (stratech.co.uk)

Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). (qedbio.com)
It contains a large 762 amino acid (aa) extracellular domain (ECD) (aa 35-795) plus a 274 aa cytoplasmic region. (novusbio.com)

Immunofluorescent analysis of 4% paraformaldehyde-fixed HeLa cells labeling TACE with 1131 at 10 ug/mL, followed by goat anti-rabbit IgG secondary antibody at 1/500 dilution (green). (qedbio.com)
Our Anti-Gephyrin rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. (phosphosolutions.com)

A fragment of the murine GLUT2 promoter has been cloned and shown to be glucose-responsive when transfected into differentiated insulin-producing cells or into hepatocytes (35,36,52). (justia.com)
The lack of binding of mIgG to hFcRn explains why murine antibodies are rapidly removed from the circulation in humans, despite long half-life in mice 32 . (nature.com)

gene fragment was 96% identical (Table). (cdc.gov)
A) a fragment of the nucleocapsid gene (N) from the virus by MAb 2G122 on infected cells. (cdc.gov)

This sequence differs from mouse and rat TACE by one amino acid. (qedbio.com)
A) Synthetic antibodies can achieve extremely varied structures through sequence randomization of the complementarity determining region (CDR). (healthyconnectionsinc.com)
The deduced amino acid sequence of hOAT3 showed 36 to 51% identity to those of other members of the OAT family. (aspetjournals.org)

To bind a specific antigen with high specificity and affinity, antibodies form a complementary shape to the prospective surface patch of the antigen using complementarity determining regions (CDRs). (healthyconnectionsinc.com)

The antibody recognizes a unique molecule of the pathogen, called an antigen. (wikipedia.org)
Part of the antibody molecule produced using papain to cleave above the hinge region, comprising one constant domain and one variable domain of each of a heavy and light chain. (stratech.co.uk)
Part of the antibody molecule produced using pepsin to cleave below the hinge region, comprising two Fab Fragments joined by disulfide bonds. (stratech.co.uk)
Figure 3: F(ab')2 Fragments are produced by pepsin digestion which cleaves the Fragment from the Fc region retaining a bridging disulfide bond interconnecting two Fab arms making the molecule bivalent. (stratech.co.uk)
Part of the antibody molecule produced using papain to cleave above the hinge region, comprising the CH2 and CH3 domains in the case of IgG. (stratech.co.uk)
The larger of the two types of polypeptide chain that make up an antibody molecule, comprising a constant region with three (IgA, IgG, and IgD) or four (IgM and IgE) constant domains and a variable region. (stratech.co.uk)

Receptors for the Fc region of IgG (Fc gamma Rs) are members of the Ig superfamily that function in the activation or inhibition of immune responses such as degranulation, phagocytosis, ADCC (antibody-dependent cellular toxicity), cytokine release, and B cell proliferation (1‑3). (novusbio.com)

More specifically, each variable domain contains three hypervariable regions - the amino acids seen there vary the most from antibody to antibody. (wikipedia.org)
The antigenic determinant created by the hypervariable regions (paratope) of the individual antibodies. (stratech.co.uk)

In particular, the use of IB1 nucleic acid, IB1 polypeptides and anti-IB1 antibodies in the diagnosis, and prophylactic and therapeutic treatment of conditions such as diabetes and neurological diseases such as dementia and/or parkinsonism is disclosed. (justia.com)
In particular, the present invention relates to the uses of IB1 nucleic acid, IB1 polypeptides and anti-IB1antibodies in the diagnosis, and prophylactic and therapeutic treatment of conditions such as diabetes and neurological diseases such as dementia and/or parkinsonism. (justia.com)

The class hence determines the function triggered by an antibody after binding to an antigen, in addition to some structural features. (wikipedia.org)

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase. (thermofisher.com)

The following product was used in this experiment: AIF Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA5-27698, RRID AB_2545174. (thermofisher.com)
LRIG1 was detected in immersion fixed bEnd.3 mouse endothelioma cell line using Goat Anti-Mouse LRIG1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3688) at 10 µg/mL for 3 hours at room temperature. (novusbio.com)

Initially, all antibodies are of the first form, attached to the surface of a B cell - these are then referred to as B-cell receptors (BCR). (wikipedia.org)
The terms antibody and immunoglobulin are often used interchangeably, though the term 'antibody' is sometimes reserved for the secreted, soluble form, i.e. excluding B-cell receptors. (wikipedia.org)
In this review, we discuss the properties of Fc receptors, antibodies, and effector cells that influence ADCP. (frontiersin.org)
We propose that additional investigation into the role of ADCP in protective viral responses, the specific virus epitopes targeted by ADCP antibodies, and the types of phagocytes and Fc receptors involved in ADCP at sites of virus infection will provide insight into strategies to successfully leverage this important immune response for improved antiviral immunity through rational vaccine design. (frontiersin.org)
Mediates antibody function through binding to Fc receptors (FcRs) on effector cells. (stratech.co.uk)

The sensitivity and specificity of the antibodies were evaluated by enzyme-linked immunosorbent assay and immunohistochemistry. (hindawi.com)
And the sensitivity or specificity of the GICA strips did not present any significant differences after storage for 12 months at room temperature. (biomedcentral.com)
When compared with ELISA, the GICA strips exhibited similar sensitivity and specificity in the diagnosis of schistosomiasis in mice, rabbits, buffaloes, and goats. (biomedcentral.com)
ARRA's positive verification line (PVL) correctly classified 575 of 580 HIV-positive and 910 of 920 negative specimens resulting in a sensitivity of 99.1% (95% CI: 98.0-99.6) and specificity of 98.9% (95% CI: 98.1-99.4), respectively. (cdc.gov)
The reader-based classification was similar for PVL with sensitivity of 99.3% (576/580) and specificity of 98.8% (909/920). (cdc.gov)

Slides showing immunofl uorescence of A72 cells with After obtaining IFA results, we attempted to amplify human respiratory syncytial virus monoclonal antibodies (MAbs). (cdc.gov)
Monoclonal antibodies (mAbs) have significantly advanced the treatment of a variety of human diseases, particularly the ability to treat cancer. (ens-lyon.fr)

Conversely, most gamma-globulins are antibodies, which is why the two terms were historically used as synonyms, as were the symbols Ig and γ. (wikipedia.org)

Soluble antibodies are released into the blood and tissue fluids, as well as many secretions. (wikipedia.org)

Antiviral activities of antibodies may either be dependent only on interactions between the antibody and cognate antigen, as in binding and neutralization of an infectious virion, or instead may require interactions between antibody-antigen immune complexes and immunoproteins or Fc receptor expressing immune effector cells. (frontiersin.org)
These Fc receptor-dependent antibody functions provide a direct link between the innate and adaptive immune systems by combining the potent antiviral activity of innate effector cells with the diversity and specificity of the adaptive humoral response. (frontiersin.org)

To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. (wikipedia.org)

Human and mouse IL-33 are 55% identical at the amino acid level. (hindawi.com)
The human monoclonal antibodies used in this study are almost identical with these approved antibodies. (frontiersin.org)

4 BNP is synthesized within the cardiomyocyte as a preprohormone (preproBNP) of 134 amino acids, from which a prehormone (proBNP) of 108 amino acids and a signal peptide of 26 amino acids are derived. (elitelearning.com)

Human polyclonal and monoclonal antibodies against pathogens and toxins are potentially useful in the treatment of various diseases. (lu.se)
Fc receptor-dependent antibody functions are important components of the immune response that provide mechanisms for clearance of infected host cells, immune complexes, or opsonized pathogens. (frontiersin.org)

An IgG antibody has 12 CDRs, with two Fab Fragments comprising three CDRs on each of the heavy and light chains. (stratech.co.uk)
A heavy chain-only antibody, found in species from the Camelid family, has 6 CDRs, with two VHH Fragments comprising three CDRs on each of the heavy chains. (stratech.co.uk)

In between them is a hinge region of the heavy chains, whose flexibility allows antibodies to bind to pairs of epitopes at various distances, to form complexes (dimers, trimers, etc.), and to bind effector molecules more easily. (wikipedia.org)
The conventional antibodies do not bind well in grooves or cavities on the surface of the antigen. (genemedi.com)

The Fc receptor-dependent function of antibody-dependent cellular phagocytosis (ADCP) provides mechanisms for clearance of virus and virus-infected cells, as well as for stimulation of downstream adaptive immune responses by facilitating antigen presentation, or by stimulating the secretion of inflammatory mediators. (frontiersin.org)

Antibodies are widely recognized for their therapeutic potential and subsequently have prompted a lot of interest into their development and application. (ens-lyon.fr)
This review summarizes the various methods used to generate bispecific antibodies and discusses the perspectives and the therapeutic benefits of bispecific antibodies. (ens-lyon.fr)
Antibodies are used for many therapeutic and biotechnological purposes. (bvsalud.org)

Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). (wikipedia.org)

Specificity This antibody recognizes human, mouse, and rat TACE, and 80-130kDa bands are detected in immunoblots. (qedbio.com)

AIF Polyclonal Antibody (Product # PA5-27698) dilution: 1:1,000. (thermofisher.com)

Together with B and T cells, antibodies comprise the most important part of the adaptive immune system. (wikipedia.org)
Antibodies are a key component of the human adaptive immune system, and the elicitation of antibodies has been correlated with vaccine efficacy in many diseases ( 1 ). (frontiersin.org)

Antibodies are glycoproteins belonging to the immunoglobulin superfamily. (wikipedia.org)
Currently, two large classes of bispecific antibodies have been developed: immunoglobulin-like and small bispecific antibodies. (ens-lyon.fr)

A number of human monoclonal antibodies with protective capacity in vitro have been established by conventional hybridoma technology. (lu.se)
B) By imitating synthetic antibody generation, we devised a strategy to select target-specific scaffolds from your human being proteome with designs that are complementary to the prospective surface patch. (healthyconnectionsinc.com)
Very recently, human monoclonal antibodies were approved for use on patients with COVID-19. (frontiersin.org)

Because these fluids were traditionally known as humors, antibody-mediated immunity is sometimes known as, or considered a part of, humoral immunity. (wikipedia.org)

Antibodies from different classes also differ in where they are released in the body and at what stage of an immune response. (wikipedia.org)
Progress in antibody engineering has led to the generation of many different types of antibodies that differ in size and shape, including bispecific antibodies. (ens-lyon.fr)

The overall strength of the antibody-antigen complex, resulting from binding affinity, antibody valency, and the structural arrangement of the complex. (stratech.co.uk)
The PfTRAMP homologue in P. vivax , here denoted as PvTRAMP, is a 340-amino-acid long antigen encoded by a single exon that could have a potential role in cytoadherence, as indicated by the presence of a thrombospondin structural homology repeat (TSR) domain. (biomedcentral.com)

The constant region at the trunk of the antibody includes sites involved in interactions with other components of the immune system. (wikipedia.org)
Distinct sections of the antibody constant region. (stratech.co.uk)
The region on an antigen that is recognized by an antibody. (stratech.co.uk)
Also known as the Fragment crystallizable (Fc) region for its ability to crystallize. (stratech.co.uk)

Changes in phosphorylation levels of Ser-98 and Ser-179 in Ldb3 were further confirmed in NRVMs and other pathological/physiological hypertrophy models, including transverse aortic constriction and swimming models, using site-specific phospho-antibodies. (molcells.org)

Fc receptor-dependent antibody functions are also involved in activation of downstream adaptive immune responses by facilitating antigen presentation or by stimulating the secretion of inflammatory mediators ( 12 , 13 ). (frontiersin.org)
Autoimmune anti-HIV-1gp120 antibody with antiidiotype-like activity in sera and immune complexes of HIV-1-related immunologic thrombocytopenia. (jci.org)

Anatomy18

Organisms12

Chemicals and Drugs106

Analytical, Diagnostic and Therapeutic Techniques and Equipment56

Phenomena and Processes68

Disciplines and Occupations2

Information Science4

Health Care4

Monoclonal antibody4

Protein32

Isotype1

Sequences9

Clonality1

Reactivity4

Residues8

Antigen-binding8

Proteins9

Cell-mediated cytotoxicity1

Phage-display1

Epitope5

Binds4

Extracellular2

Rabbit2

Murine2

Gene2

Sequence3

Complementarity-determi1

Molecule6

ADCC1

Hypervariable regions2

Nucleic acid2

Binding to an antigen1

Invitrogen1

Catalog2

Receptors5

Sensitivity5

MAbs2

Gamma-globulins1

Tissue1

Effector cells2

Antigens1

Identical2

Peptide1

Pathogens2

CDRs2

Bind2

Phagocytosis1

Therapeutic3

Mechanism1

Recognizes1

Dilution1

Adaptive immune2

Immunoglobulin2

Human3

Immunity1

Differ2

Structural2

Region4

Specific1

Immune2