For example, 'Two mRNA vaccines developed by Pfizer-BioNTech and Moderna are effective against the coronavirus. (researchgate.net)
The first two vaccines against COVID-19, Tozinameran (the Pfizer/BioNTech vaccine) and mRNA-1273, Moderna's still unchristened candidate on the brink of emergency use authorization, are mRNA. (rickilewis.com)
Efficacy3
A 23-valent unconjugated pneumococcal vaccine has shown a wide variation in clinical efficacy, from 0% to 81% (Fedson et al, (1994) Arch Intern Med. (allindianpatents.com)
This optimism is built on recently published studies demonstrating the efficacy of mRNA vaccines in combatting several types of cancer and infectious pathogens where conventional vaccine platforms may fail to induce protective immune responses. (researchgate.net)
I'm cautiously optimistic that with the multiple candidates with different platforms that we're going to have a vaccine with a degree of efficacy that would make it deployable. (rickilewis.com)
Adjuvants1
It gives a full rundown of the current NP-based vaccines, their potential as adjuvants, and the ways they can be delivered to cells. (researchgate.net)
Hesitancy2
COVID vaccine hesitancy is on the rise, perhaps in the wake of pressure to speed approval beyond scientific reason. (rickilewis.com)
But I think some of the hesitancy might be due to confusion over how so many different vaccines can target the same pathogen - and why this is a good idea. (rickilewis.com)
Efficacious1
What defines an efficacious COVID-19 vaccine? (ooir.org)
Induce2
The results showed that a third dose of the vaccine administered 8 months after the second dose can induce a significant increase of neutralizing antibodies at day 7 post-injection. (pipelinereview.com)
The carbohydrate moieties on HIV-1 envelope glycoprotein (Env) act as shields to mask conserved neutralizing epitopes, while the hyperimmunogenic variable regions are immunodominant in inducing non-neutralizing antibodies, representing the major challenge for using Env as a vaccine candidate to induce broadly neutrali. (shengsci.com)
Pathogens3
The mRNA vaccines can encode multiple antigens, strengthening the immune response against pathogens and enabling the targeting of multiple microbial variants [19] . (researchgate.net)
The Case Definition was developed by a group of experts convened by the Coalition for Epidemic Preparedness Innovations (CEPI) in the context of active development of vaccines for SARS-CoV-2 vaccines and other emerging pathogens. (cov19longhaulfoundation.org)
Classic examples of VAED are atypical measles and enhanced respiratory syncytial virus (RSV) occurring after administration of inactivated vaccine for these pathogens. (cov19longhaulfoundation.org)
Viruses3
In particular embodiments, the chimeric viruses of the invention have enhanced transduction capability (e.g., transduction of skeletal muscle, cardiac muscle, glial cells, astrocytes, liver, retina and/or lung, etc.), enhanced levels of transgene expression and/or earlier onset of transgene expression. (justia.com)
Further, in particular embodiments, the chimeric virus has a different immunological profile than one or both of the parent viruses (i.e., is only weakly or not at all recognized by neutralizing antisera or antibodies against the parent virus), thereby allowing for administration to subjects that have antibodies directed against the parent virus or repeat administration following administration of another serotype. (justia.com)
Knowing this, vaccinologists and veterinarians have explored the use of self spreading vaccines in animals using live attenuated viruses. (substack.com)
Viral2
The present invention relates to novel chimeric viral vectors and methods of making and administering the same. (justia.com)
Her chief research interest is the development of viral-vectored vaccines that work by inducing strong and protective T and B cell responses. (isv-online.org)
Relatively new2
Messenger RNA (mRNA) vaccines represent a relatively new vaccine class showing great promise for the future. (researchgate.net)
Vaccine transmission is a relatively new concept with few examples, so the possibility of transmission changing in time has scarcely been entertained. (substack.com)
Infectious1
Treatment resistance for infectious diseases is growing quickly, and chemotherapeutic toxicity in cancer means that vaccines must be made right away to save humanity. (researchgate.net)
Diseases3
The 23-valent vaccine does not demonstrate protection against pneumococcal pneumonia (in certain high risk groups such as the elderly) and Otitis media diseases. (allindianpatents.com)
Based on the above, and previously described physicochemical principles, non-interfering, long-lasting, full protection-inducing, multi-epitope, multistage, minimal subunit-based chemically synthesised mHABP mixtures can be designed for developing vaccines against diseases scourging humankind, malaria being one of them. (shengsci.com)
Vaccine-associated enhanced diseases (VAED) are modified presentations of clinical infections affecting individuals exposed to a wild-type pathogen after having received a prior vaccination for the same pathogen [1] . (cov19longhaulfoundation.org)
Albeit1
Importantly, VAED has not been seen following SARS or MERS vaccines given to humans, albeit the number of people who received these experimental vaccines remains very small. (cov19longhaulfoundation.org)
Pandemic2
In the last few years, mRNA used as a vaccine with rapid, scalable, and cost-effective production during the corona pandemic [2]. (researchgate.net)
The COVID-19 pandemic ushered in a flood of vaccine options. (rickilewis.com)
Populations2
In addition, a third dose was found to be well-tolerated in elderly patient populations with no vaccine-related serious adverse events reported. (pipelinereview.com)
However, a case fatality rate that ranges from 0.5% to nearly 20% depending on age and other risk factors, and the understanding that SARS-CoV-2 is now a well-adapted human pathogen that will continue to cause disease in susceptible populations, makes the development of an effective vaccine a global priority. (cov19longhaulfoundation.org)
Humans1
I suggest that psychopathic elements in the defense and intelligence agencies (and that's limited to high level members not the rank and file) and a handful of mad scientists and Dark Winter agents in the HHS conspired to hijack this well intentioned self spreading vaccine project and engineered a self spreading vaccine virus for humans and then released it. (substack.com)
Development4
Recombination also poses theoretical problems for the development of a safe HIV vaccine. (cdc.gov)
Modified high activity binding peptides (mHABPs) were synthesised for complete full protection antimalarial vaccine development producing a large panel of individually fully protection-inducing protein structures (FPIPS) and very high long-lasting antibody-inducing (VHLLAI) mHABPs. (shengsci.com)
He has also served as the Vice Dean and the Dean of the Institute of Medical Science, The University of Tokyo, and currently the Director and Professor for the International Research and Development Center for Mucosal Vaccines To reflect his scientific contribution, he was listed in ISI Highly Cited Researchers' List and received several prestigious awards. (isv-online.org)
It's a misperception that vaccine development is a race to be a winner. (rickilewis.com)
Elderly4
Likewise, the elderly mount poor responses to pneumococcal vaccines [Roghmann et al, (1987), J. Gerontol. (allindianpatents.com)
However, there is still a need for improved pneumococcal vaccine compositions, particularly ones which will be more effective hi the prevention or amelioration of pneumococcal disease (particularly pneumonia) in the elderly and in young children. (allindianpatents.com)
In a related aspect, the present invention provides a vaccine for treating or ameliorating Otitis media in infants or pneumonia in the elderly. (allindianpatents.com)
The present invention provides an unproved vaccine for the prevention or amelioration of pneumococcal infection of the elderly (e.g., pneumonia) and/or in infants (e.g. (allindianpatents.com)
Adverse2
The results indicate that a third booster dose of CoronaVac® induces a strong immune response in healthy adults with no serious adverse reactions related to the vaccine. (pipelinereview.com)
This is a Brighton Collaboration Case Definition of the term "Vaccine Associated Enhanced Disease" to be utilized in the evaluation of adverse events following immunization. (cov19longhaulfoundation.org)
Infection2
Most of us have an intuitive understanding of how a vaccine works: show the immune system a bit of a pathogen, or something mimicking it, and trick it into responding as if natural infection is happening. (rickilewis.com)
If the body can mount an immune response and clear the virus in natural infection, that's a pretty good proof-of-concept that you'll have an immune response against a vaccine. (rickilewis.com)
Present5
The present invention provides chimeric virus vectors that have been designed to exhibit one or more properties of interest (e.g., enhanced tissue tropism). (justia.com)
The present invention relates to a combination of 2 or more S. pneumoniae proteins, their manufacture and use in medicine as a vaccine. (allindianpatents.com)
Vaccine technology has gone beyond live, weakened, or killed virus, even past the once-groundbreaking subunit vaccines that present parts of a pathogen, like the hepatitis B surface antigen or pertussis toxin. (rickilewis.com)
The vaccines work in what can seem to be mysterious ways, but all present a pathogen in some form, or its parts, to alert the immune system to mount a response. (rickilewis.com)
Disease3
We have recently reported that the immune response to an effective OspA-expressing L. plantarum vaccine for Lyme disease is modulated by the lipid modi. (shengsci.com)
Vaccine-associated enhanced respiratory (VAERD) disease refers to disease with predominant involvement of the lower respiratory tract. (cov19longhaulfoundation.org)
In order to recognize vaccine associated disease enhancement, it is therefore necessary to have a clear understanding of the clinical presentation and usual course of the natural disease. (cov19longhaulfoundation.org)
Past1
This review summarizes the most important developments in mRNA vaccines from the past few years and discusses the challenges and future directions for the field. (researchgate.net)
Study1
In 2019 the NIH funded a study on contagious vaccine transmission. (substack.com)
Work1
When I was writing "How the various COVID vaccines work," which ran here at DNA Science on September 10, I had to keep reviewing summary charts to remember who was doing what. (rickilewis.com)
Research1
Extensive research experience in the field of Mucosal Immunology and Vaccine at UAB, Max-Planck Institute, Osaka University and The University of Tokyo resulted in a total of 520 publications. (isv-online.org)
Problem2
As gastroenteritis due to rotavirus is a public health problem and two new vaccines are currently available, we investigated the rotavirus burden and developed a cost-effectiveness analysis, using data collected in th. (shengsci.com)
The biggest problem is vaccine companies tend not to get too excited about bringing self spreading vaccines to market. (substack.com)
Group1
In the group of participants who received the 3μg vaccine, which is approved for emergency use, the geometric mean titer (GMT) of serum neutralizing antibodies increased to 305 on day 7 after the third dose of vaccine, which was approximately 7-fold as compared to the levels at day 28 after the second dose. (pipelinereview.com)
People1
For many people that fear arises against a backdrop of the history of dishonesty in medicine that has misled and mistreated marginalized groups, as well as the record of unethical clinical trials for some vaccines, notably influenza . (rickilewis.com)
Medical1
When Ebola isn't really ebola, and EV-D68 is really Polio: Digging deep to connect the dots of medical mythology. (rts.earth)