• anticoagulation
  • Warfarin is best suited for anticoagulation (clot formation inhibition) in areas of slowly running blood (such as in veins and the pooled blood behind artificial and natural valves) and in blood pooled in dysfunctional cardiac atria. (wikipedia.org)
  • Before the use of DTIs the therapy and prophylaxis for anticoagulation had stayed the same for over 50 years with the use of heparin derivatives and warfarin which have some well known disadvantages. (wikipedia.org)
  • Warfarin has its disadvantages though, just like heparin, such as a narrow therapeutic index and multiple food and drug interactions and it requires routine anticoagulation monitoring and dose adjustment. (wikipedia.org)
  • toxic
  • Poison shyness, also called conditioned food aversion, refers to the avoidance of a toxic substance by an animal that has previously ingested that substance. (wikipedia.org)
  • Within a short period of time, warfarin/d-CON "revolutionized the art of rodent control" by replacing manual extermination and highly toxic poisons. (wikipedia.org)
  • drugs
  • So how are marketers at Boehringer, Janssen (J&J), and BMS positioning their respective expensive anti-AFib Rx drugs -- Pradaxa, Xarelto, and Eliquis, respectively -- to compete with warfarin -- an inexpensive generic drug? (blogspot.com)
  • Dicoumarol itself, for a short time, was employed as a medicinal anticoagulant drug, but since the mid-1950s has been replaced by its simpler derivative warfarin, and other 4-hydroxycoumarin drugs. (wikipedia.org)
  • Miller
  • The Texas Agriculture Commissioner, Sid Miller, has approved a new poison specifically intended for use against wild hogs known as Kaput Feral Hog Lure. (planetsave.com)
  • As you may have read in the Daily Digest or heard me mention in a recent podcast, Texas Ag Commissioner Sid Miller approved a Warfarin-based pig poison called Kaput Feral Hog Lure for use in the Lone Star State. (writtenbytylerkee.com)
  • bait
  • One possible origin is the way that a rat is attracted to rat poison like a child to candy, another possibility being the use of actual candy, particularly chocolate, as bait when luring a rat into a trap that will lead to its imprisonment or demise. (wikipedia.org)
  • In contrast, warfarin posed minimal risk to other animals as cumulative doses were required to achieve toxicosis, and did not cause bait shyness. (wikipedia.org)
  • medications
  • Many other medications and dietary factors can interact with warfarin, either increasing or decreasing its effectiveness. (wikipedia.org)
  • Dosing of warfarin is complicated because it is known to interact with many commonly used medications and certain foods. (wikipedia.org)
  • control center
  • a subset of 95 of these bites was reported in the 21 counties (essentially Central Florida) under the jurisdiction of the regional poison control center in Tampa. (ufl.edu)
  • treatment
  • Warfarin treatment can help prevent formation of future blood clots and help reduce the risk of embolism (migration of a thrombus to a spot where it blocks blood supply to a vital organ). (wikipedia.org)
  • Note
  • Each package included a typewritten note that threatened the recipient with being poisoned, and had the return address of people she had a grudge against, such as former co-workers and classmates. (wikipedia.org)
  • blood
  • Warfarin is used to decrease the tendency for thrombosis or as secondary prophylaxis (prevention of further episodes) in those individuals who have already formed a blood clot (thrombus). (wikipedia.org)
  • given
  • Further physical and chemical properties of warfarin are given in the "Summary of Chemical Safety Information" (section 6). (inchem.org)
  • Animals
  • Poison shyness occurs as an evolutionary adaptation in many animals, most prominently in generalists that feed on many different materials. (wikipedia.org)
  • Development
  • In 1950, the Wisconsin Alumni Research Foundation patented warfarin, a new chemical compound which had been in development since the 1930s. (wikipedia.org)