• extracellular
  • Sphingosine kinase 1 phosphorylates sphingosine to sphingosine-1-phosphate (S1P) SK1 is normally a cytosolic protein but is recruited to membranes rich in phosphatidate (PA), a product of Phospholipase D (PLD) Sphingosine-1-phosphate (S1P) is a novel lipid messenger with both intracellular and extracellular functions. (wikipedia.org)
  • Although the intracellular targets of PKC-ζ that induce mitogenesis are being actively explored in many tissues and include the extracellular signal-regulated kinases (ERK)1/2 and -5, glycogen synthase kinase 3 (GSK-3), mammalian target of rapamycin (mTOR) and p70S6 kinase (p70S6K) ( 10 - 14 ), whether these targets are activated by PKC-ζ in β-cells is unknown. (diabetesjournals.org)
  • Treatment with blueberry decreased phosphatidylinositol 3-kinase (PI3K)/AKT and NFkappaB activation in MDA-MB-231 cells, where protein kinase C and extracellular signal-regulated kinase (ERK) were not affected. (nih.gov)
  • Methanosarcina
  • Only Methanosarcina species possess all three known pathways for methanogenesis, and are capable of utilizing no less than nine methanogenic substrates, including acetate. (wikipedia.org)
  • phosphorylation
  • The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration , nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. (wikipedia.org)
  • In addition, threonine residues undergo phosphorylation through the action of a threonine kinase. (wikipedia.org)
  • inhibitors
  • Members of this family, including wortmannin, are known to be potent, irreversible covalent inhibitors of phosphoinositide 3-kinases (PI3Ks). (wikipedia.org)
  • methanol
  • 1993) at 35 °C in HS broth medium containing 125 mM methanol plus 40 mM sodium acetate (HS-MA medium). (wikipedia.org)
  • (A) Breast cell lines were treated with increasing concentrations of blueberry extract for 72 hours (B) MDA-MB-231 cells were treated with increasing concentrations of blueberry fractions (EA = ethyl acetate, MeOH = methanol, water fractions) for 72 hours. (nih.gov)
  • receptor
  • Phorbol Diester Receptor Copurifies with Protein Kinase C". Proceedings of the National Academy of Sciences. (wikipedia.org)
  • The present study was performed to investigate the underlying mechanism, particularly the roles of reactive oxygen species (ROS) and protein kinase C (PKC), in the diabetes-induced canonical transient receptor potential 6 (TRPC6) downregulation. (sigmaaldrich.com)
  • focal
  • We also know that the binding of paxillin to focal adhesion kinase (FAK) is critical for directing paxillin function. (wikipedia.org)
  • selectivity
  • H 89 2HCl is a potent PKA inhibitor with K i of 48 nM in a cell-free assay, 10-fold selective for PKA than PKG,500-fold greater selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II. (selleckchem.com)
  • biosynthesis
  • Enzymes involved in a typical biosynthesis of threonine include: aspartokinase β-aspartate semialdehyde dehydrogenase homoserine dehydrogenase homoserine kinase threonine synthase. (wikipedia.org)
  • activity
  • The uptake of molecules by caveolae is linked to PKCα kinase activity ( 25 ), so the enzyme may play a key role in regulating the internalization of caveolae. (rupress.org)
  • Experiments using dbcAMP analogs modified at either the C-6 or C-8 position indicated that the process was mediated by a protein kinase A type I, and protein kinase A type I activity was isolated from undifferentiated HL-60 cells by DEAE-Sephacel chromatography. (mysciencework.com)
  • mechanism
  • The protein kinase A inhibitor Rp-cyclic adenosine monophosphate (100-150 microM) did not block the adenosine-dependent reduction of the mEPSC frequency, showing that adenosine is not depressing synaptic transmission via a protein kinase A (PKA)-dependent mechanism. (mysciencework.com)