• scrapie
  • Francis Crick recognized the potential significance of the Griffith protein-only hypothesis for scrapie propagation in the second edition of his "Central dogma of molecular biology" (1970): While asserting that the flow of sequence information from protein to protein, or from protein to RNA and DNA was "precluded", he noted that Griffith's hypothesis was a potential contradiction (although it was not so promoted by Griffith). (wikipedia.org)
  • brain
  • recently reported that normal brain homogenate (NBH) from Syrian hamsters effectively supports the amplification of PrPres from CWD seeds in serial PMCA. (blogspot.com)
  • known
  • A protein as a stand-alone infectious agent stands in contrast to all other known infectious agents such as viruses, bacteria, fungi, and parasites, all of which contain nucleic acids (DNA, RNA, or both). (wikipedia.org)
  • Western
  • Indeed, one round of PMCA cycling results in a 2500-fold increase in sensitivity of detection over western blotting, whereas 2 and 7 rounds of successive PMCA cyclings result in 6 million- and 3 billion-fold increases in sensitivity of detection over western blotting, a technique widely used in BSE surveillance in several countries. (wikipedia.org)
  • patients
  • Despite the possibility being remote that any other patients of WRMC have been exposed to the protein that causes CJD, WRMC is collaborating with the CDC and Arkansas Department of Health (ADH) to identify and advise those patients who received care at WRMC during the relevant period whether they may be at risk. (blogspot.com)
  • While medical literature states that the chance that any other patient has been exposed to the CJD protein through surgical instrumentation is extremely small, WRMC believes it important to ensure that patients are appropriately advised as it cannot guarantee that there is absolutely no risk. (blogspot.com)