Pleomorphic cells typically express cd15 and cd30 antigens cd15. Medical search. Frequent questions

PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)

Each clinicopathologic subtype can be further classified with respect to morphology, immunophenotype, and antigen markers. (medscape.com)
Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)

This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)

Histologically, ALCL is characterized by sheets of large pleomorphic cells with abundant cytoplasm, horseshoe- or wreath-shaped nuclei, and multiple prominent nucleoli. (medscape.com)
[ 4 . 5 ] Adding to the challenge, classic lymphoglandular bodies, representing remnants of lymphocyte cytoplasm, are typically inconspicuous or absent in effusion fluids, in contrast to FNA material from solid specimens. (cytojournal.com)

Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)

[4] [9] CLL results in the buildup of B cell lymphocytes in the bone marrow, lymph nodes, and blood . (wikipedia.org)
[9] If enlarged lymph nodes are caused by infiltrating CLL-type cells, a diagnosis of small lymphocytic lymphoma (SLL) is made. (wikipedia.org)

Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
Most people are diagnosed as having CLL based on the result of a routine blood test that shows a high white blood cell count, specifically a large increase in the number of circulating lymphocytes . (wikipedia.org)

ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
[18] CLLs are, in virtually all cases, preceded by a particular subtype of monoclonal B-cell lymphocytosis (MBL). (wikipedia.org)

Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)

In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)

Sixty percent of cases express 1 or more T-cell antigens (CD3 + , CD43, or CD45RO). (medscape.com)

In addition, cytoplasmic vacuoles are not uncommon in large cell lymphomas involving body cavities. (cytojournal.com)

[17] Less commonly, the disease comes to light only after the cancerous cells overwhelm the bone marrow, resulting in low red blood cells, neutrophils, or platelets. (wikipedia.org)