Pleiotropic cytokine interleukins. Medical search. Frequent questions

IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. (rndsystems.com)
Interleukin-6 (IL-6) is a multifunctional cytokine that regulates pleiotropic roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. (sbhsciences.com)
Interleukin-1 is a key mediator of inflammation, with pleiotropic effects on several cells and signaling pathways. (biolegend.com)
This cytokine has pleiotropic effects in immunoregulation and inflammation. (genaxxon.com)
IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. (thermofisher.com)
The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. (thermofisher.com)
It should be noted that pro-inflammatory cytokines are double-edged swords that not only mobilize human immune system defense but can also drive pathologic inflammation, and therefor can play both anti-viral and pro-viral roles during a SARS-CoV-2 infection. (mthfrsupport.com)
TNF-α is a pleiotropic cytokine with an essential contribution to the pathogenesis of inflammation angiogenesis and collagenolysis. (genextgenomics.com)
During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)
4] After allergen exposure, that produced exceptionally large quantities of airway inflammation is orchestrated mainly by cytokine IL-9. (cdc.gov)
A pleiotropic cytokine involved in INFLAMMATION and immunoregulation. (bvsalud.org)

This cytokine is a ligand for interleukin 4 receptor. (antibodies-online.com)
Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. (fishersci.com)

We hypothesize that the anti-inflammatory cytokine interleukin (IL)-10 mediates the reparative effects of EVs on cardiovascular complications in a preclinical swine model with coexisting MetS and RVH. (bvsalud.org)
M2 macrophages are characterized by their anti-inflammatory and wound-healing endotype, and they are further divided into different subtypes: the M2a macrophages subtype, which responds to Interleukin-4 and Interleukin-13 during fungal and helminth infections [ 7 ] . (encyclopedia.pub)
Interleukin (IL)-10, a pleiotropic cytokine, exerts anti-inflammatory effects in numerous biological settings. (shengsci.com)
ABSTRACTInterleukin-6 (IL-6) is a unique pleiotropic cytokine exhibiting both pro- and anti-inflammatory properties depending on the target cell type. (researcher.life)
The IL-10 gene in humans produces interleukin 10, a pleiotropic cytokine with strong anti-inflammatory as well as immunosuppressive activities.The Aim the aim of this study is to evaluate the vaccine effectiveness using diagnostic biochemical markers.Material and method this study included 125 patients (56 males and 69 females) with vaccinated and non-vaccinated COVID-19 with an age range of 20-70 years. (biomedbiochem.com)

Sino Biological has developed a panel of antibodies targeting IL-18 cytokines and receptors that can be used in ELISA, WB, IF, IP, FCM, and ICC. (technologynetworks.com)

Interleukin-11 receptor subunit alpha-1 is required for maximal airway responsiveness to methacholine after acute exposure to ozone (dataset). (cdc.gov)
The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. (thermofisher.com)
Oncostatin M Oncostatin M (OSM) is an IL-6 family cytokine, characterized by the shared gp130 receptor subunit. (brinda.info)

IL-1β is a tumor-promoting cytokine, and it enhances tumor metastasis and angiogenesis. (biolegend.com)
We discuss the rationale of various anti-fibrogenic treatment strategies targeting the clonal hematopoietic stem/progenitor cell, aberrant signaling pathways, fibrogenic cytokines, and the tumor microenvironment. (haematologica.org)
Simultaneously, however, it may also enhance antitumor therapy through initiation of proinflammatory, antiviral cytokine responses at the tumor site. (shengsci.com)
pro-inflammatory cytokines (interleukin (IL)-1, IL-33, thymic stromal lymphopoietin (TSLP) and tumor necrosis element- (TNF-)), as well as adhesion factors for neutrophils and eosinophils [5,6]. (brinda.info)
4. Tumor Necrosis Element- TNF- is definitely a pleiotropic cytokine possessing pro-inflammatory properties, produced by several cell types (epithelial cells, T-lymphocytes and macrophages), and it may induce the release of IL-6, IL-10 and INF- [84]. (brinda.info)
Interleukin 6 IL-6 is definitely produced by several types of cells, including T-cells, B-cells, monocytes, fibroblasts, epithelial and endothelial cells and HDAC-IN-5 tumor cells in response to micro-organisms or additional cytokines (IL-1, TNF-) [85]. (brinda.info)

It's precursor, pro-interleukin-16 is a protein that in humans is encoded by the IL16 gene. (wikipedia.org)
The cytokine encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. (wikipedia.org)
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. (antibodies-online.com)
This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. (antibodies-online.com)
The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. (fishersci.com)
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. (thermofisher.com)
Several molecular mechanisms may count for this AR re-activation in CRPC, including AR gene amplification/overexpression, AR mutation, the presence of AR splice variants, enhanced AR co-regulators signaling, alterations in steroid metabolism, growth factor and/or cytokine induced AR activation etc [ 1 ]. (oncotarget.com)
In addition to primary SNPs we have also included some secondary gene SNPs that are related to a downstream cytokine storm that may occur in some folks. (mthfrsupport.com)
This cytokine differentially regulates two major HIV-1 coreceptors and activates viral expression, and is thus a reasonable candidate gene for analyses in HIV-1/AIDS cohort studies. (johnshopkins.edu)
Interleukin-9 (IL9) is encoded by the IL9 gene and is produced by T-cells and specifically by CD4+ helper cells. (goldbio.com)
The gene encoding this cytokine has been identified as a candidate gene for asthma. (goldbio.com)

Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. (thermofisher.com)
It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. (genaxxon.com)
Interleukin-2 (IL-2), also known as T-cell growth factor, is a pleiotropic cytokine that, among other functions, regulates T-cell proliferation and differentiation. (tcu.edu)

Its biological activities are shared by IL-6-family of cytokines such as leukemia inhibitory factor and oncostatin M. IL-6 exerts its biological activities through interaction with specific receptors expressed on the surface of target cells. (sbhsciences.com)
Among these cytokines, Interleukin-21 (IL-21) is a relatively recently discovered cytokine, which is mainly produced by CD4 + T cells in the body, and exerts multiple and pleiotropic effects on various immune cells. (medecinesciences.org)

IL6 Protein and It's Working A pleiotropic cytokine, IL6 Protein is produced in response when there are tissue damage and infections identified. (genextgenomics.com)
The protein is a pleiotropic cytokine produced primarily by antigen presenting cells and has multiple effects on T lymphocytes and natural killer cells in terms of stimulating cytotoxicity, proliferation, production of other cytokines and Th1 subset differentiation. (biofargo.com)
While G3 (vaccinated recovered COVID), G5 (no vaccine recovered COVID) showed that no significant increase was noticed among the different time incidents.Conclusion the use of mRNA for CoV-19 vaccination significantly modulates the increment of C-reactive protein and interleukin-10 and improves the immune response in patients with COVID-19 infection. (biomedbiochem.com)
Cytokine (CK) is a low molecular weight soluble protein induced by immunogens, mitogens or other stimulants. (ddxcell.com)

Interleukin-13 is a pleiotropic TH2 cytokine that has been shown to be central to the pathogenesis of asthma. (nih.gov)
Interleukin-6 (IL-6) is a pleiotropic cytokine and associated with the pathogenesis of femoral head deformity in patients with ischemic osteonecrosis of the femoral head. (nii.ac.jp)
Increased expression of inflammatory cytokines, lysyl oxidase, transforming growth factor-β, impaired megakaryocyte function, and aberrant JAK-STAT signaling have all been implicated in the pathogenesis of bone marrow fibrosis. (haematologica.org)
Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. (goldbio.com)
The purpose of this evaluate is definitely to summarize the current state of knowledge about the cytokine signature in CRSwNP, the part of cytokines in the pathogenesis of this disease and in the intercellular dialog between epithelial cells, fibroblasts and inflammatory cells. (brinda.info)

Interleukin-11: A cytokine signaling through gp130 with pleiotropic effects and potential clinical utility within and outside the hematopoietic system. (ox.ac.uk)

Elevated expression of the pleiotropic proinflammatory cytokine interleukin-18 has been demonstrated in human atherosclerotic plaques. (omu.edu.tr)

Para la elaboración de este artículo de revisión narrativa se consultaron las publicaciones disponibles a neutrófilos en el través de una búsqueda automatizada en las bases de datos de PubMed, Scopus y Embase. (bvsalud.org)

IL1A encodes IL-1α, which is cell-bound, and IL1B encodes IL-1β, a secreted cytokine (1). (biolegend.com)

However, better understanding of the role of increased JAK-STAT signaling [either through activating mutations ( JAK2 , MPL515L/K ) within the signaling pathway, or mutations involving CALR ], the role of deregulated pro-inflammatory cytokine expression, and the impaired bone marrow microenvironment is transforming the treatment approach for MF. (haematologica.org)

Localization of interleukin-2 immunoreactivity and interleukin-2 receptors in the rat brain: interaction with the cholinergic system. (tcu.edu)

Recently, we analyzed serum biomarkers by using samples from the Gulu outbreak and identified associations between cytokines/chemokines, acute-phase reactants, makers of coagulopathy, and markers of endothelial function and patient death, hemorrhage, and viremia ( 10 ). (cdc.gov)

Interleukin 1α (IL-1α) is a pleiotropic cytokine mixed up in immune response inflammatory processes and hematopoiesis and functions as a mitogen for several malignant cell types including acute leukemia and Kaposi sarcoma cells. (bioerc-iend.org)
IL-6 is a multifunctional cytokine involved in the regulation of the immune response, hematopoiesis and acute phase response. (thermofisher.com)

The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. (antibodies-online.com)

STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. (antibodies-online.com)
IL9 functions through the IL-9 receptor, which activates different signal transducer and activator (STAT) proteins and thus connects this pleiotropic cytokine to various biological processes. (goldbio.com)

abstract = "Interleukin-4 (IL-4) is a cytokine with pleiotropic activities. (utmb.edu)

IL-21 is expressed primarily by NKT and CD4 + T cells, particularly the inflammatory Th17 subset, and has pleiotropic effects on both innate and adaptive immune responses. (southernbiotech.com)

Interleukin-11 (IL-11) is a pleiotropic cytokine that has multiple effects on both hematopoietic and nonhematopoietic cells. (abmole.cn)

The defects are often manifested by altered cytokine secretion and/or responsiveness to the cytokine. (medecinesciences.org)
Pathophysiologically, asthma exert different effects at different concentrations, can is characterized by constriction of airway smooth synergize or antagonize the effects of other cytokines muscle, hyper secretion of mucus, edema and airway and regulated in a complex manner and function via hyper responsiveness (AHR),[3] mucus secretion and cytokine cascade. (cdc.gov)

However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. (cdc.gov)
The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. (cdc.gov)

Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases. (southernbiotech.com)
TGF-β induces the expression of several growth factors and cytokines in prostate stromal cells, including IL-6, and BMP-6. (oncotarget.com)

Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. (thermofisher.com)

The differentiation, homeostatic proliferation and effector functions of different immune cells are controlled, to a large extent, by cytokines. (medecinesciences.org)
T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. (cdc.gov)

The IL-2 cytokine family in cancer immunotherapy. (tcu.edu)

Multicellular cytokines play a role in vivo through paracrine, autocrine or endocrine ways, with pleiotropic, overlapping, antagonistic, synergistic and other physiological characteristics, forming a very complex cytokine regulatory network, involved in a variety of important physiological functions of the human body. (ddxcell.com)

Cytokines are important in asthma and play a critical role in orchestrating the allergic inflammatory response, although the precise role of each cytokine remains to be determined. (cdc.gov)
Cytokines and asthma airways. (cdc.gov)
by normal individuals cause broncho-constriction in Cytokines often have overlapping biological activities, patients with asthma. (cdc.gov)
Modulating the cytokine network in thickening of the basement membrane underlying the respiratory diseases such as asthma, with expected airway epithelium. (cdc.gov)

Interleukin-15 (IL-15) is a pleiotropic cytokine that plays pivotal roles in innate and adaptive immunity. (gnu.ac.kr)

A blue-black colored precipitate forms at the sites of cytokine localization and appears as spots, with each individual spot representing an individual mouse/rat IL-6 secreting cell. (rndsystems.com)

Recent studies have shown that the cytokine is indispensable for controlling chronic viral infections. (medecinesciences.org)

Description: The MP5-20F3 antibody reacts with mouse interleukin-6 (IL-6). (thermofisher.com)
Applications Reported: This MP5-20F3 antibody has been reported for use in cytokine neutralization, ELISA capture antibody, and ELISPOT capture antibody. (thermofisher.com)
The MP5-20F3 antibody has been tested as the capture antibody in a sandwich ELISA for analysis of mouse interleukin-6 (IL-6) in combination with the biotinylated MP5-32C11 (cat. (thermofisher.com)

This review summarizes current knowledges concerning the biological effects of this cytokine on different components of the immune system. (medecinesciences.org)

Interleukin 16 (IL-16) is released by a variety of cells (including lymphocytes and some epithelial cells) that has been characterized as a chemoattractant for certain immune cells expressing the cell surface molecule CD4. (wikipedia.org)
IL10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. (genaxxon.com)
Interleukin-4 (IL-4) is a pleiotropic cytokine produced primarily by activated CD4 + T lymphocytes, mast cells, and basophils. (johnshopkins.edu)

Since then, this interleukin has been shown to recruit and activate many other cells expressing the CD4 molecule, including monocytes, eosinophils, and dendritic cells. (wikipedia.org)
ELISpot kits are highly sensitive, microplate-based assays for the detection of cytokine secreting cells. (rndsystems.com)
IL-2 is a pleiotropic cytokine produced and released by activated T cells that plays a key role in regulating T-cell proliferation. (tcu.edu)
This cytokine is also involved in the prevention of autoimmune conditions by promoting immature T cells to differentiate into T regulatory cells. (tcu.edu)
Today's research was performed to explore the immunomodulatory actions of two such cytokines, changing growth element- (TGF-) and interleukin-10 (IL-10), both which are aberrantly made by human being pancreatic carcinoma cells (this research). (academiaperuanadepsicologia.org)
TGF- can be a 25-kd dimeric cytokine with pleiotrophic results on a broad spectrum of focus on cells. (academiaperuanadepsicologia.org)

In normal bone marrow cultures grown in the presence of either granulocyte-macrophage colony-stimulating factor (GM-CSF) or interleukin-3 (IL-3), IL-4 suppresses granulocyte-macrophage colony-forming unit (CFU-GM) proliferation but it enhances the colony-stimulatory effect of granulocyte colony-stimulating factor (G-CSF). (utmb.edu)

Cytokines consequently play a central and essential part in the genesis of CRSwNP, particularly in HDAC-IN-5 the maintenance of the inflammatory response and the recruitment of eosinophils. (brinda.info)
This cytokine is definitely involved in the maintenance of inflammatory reaction through (1) the recruitment and build up of eosinophils via the upregulation in nose polyps of the chemokine eotaxin and the adhesion molecule VCAM-1 [10,39,40] (2) the build up of CCL2, a monocyte chemoattractant, in Rabbit Polyclonal to OR fibroblast ethnicities derived from nose polyps [41]. (brinda.info)

Interleukin-6 in atherosclerosis: atherogenic or atheroprotective? (researcher.life)
Interleukin-18 (IL-18) is a pleiotropic cytokine which may have a key role in atherosclerosis, because the results of recent studies indicated that IL-18, either directly as a pro-inflammatory factor or indirectly as an interferon inducing factor, has central role in the inflammatory cascade. (org.ir)
In present study, we evaluated the relation between blood concentration of IL-18 with atherosclerosis and its severity and also the relation of this cytokine with the other known risk factors of coronary artery disease (CAD). (org.ir)

This pleiotrophic cytokine influences the antigen-specific immune response, inflammatory response, and the development of neurons, and is a major mediator of the acute phase reaction. (thermofisher.com)
This severe respiratory disease is characterized by a prominent pro-inflammatory response (cytokine storm), and is referred to a bilateral pneumonia. (mthfrsupport.com)

This cytokine is produced as a precursor peptide (pro-IL-16) that requires processing by an enzyme called caspase-3 to become active. (wikipedia.org)
The functionally bipartite nature of the IL-1α precursor represents a unique combination of the C-terminal classical cytokine and an N-terminal nuclear oncoprotein. (bioerc-iend.org)

Table 1 Production and action of cytokines over and under-expressed in chronic rhinosinusitis with nose polyps. (brinda.info)

Interleukin-10 expression induced by adeno-associated virus vector suppresses proteinuria in Zucker obese rats. (shengsci.com)

IL-6 is definitely a pleiotropic cytokine, well-known like a regulator of swelling, classically described as inducing B-cell proliferation and activation and neutrophil recruitment [42]. (brinda.info)

The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. (wikipedia.org)
Interleukin 17 (also known as CTLA‑8) is a T cell‑expressed pleotropic cytokine. (rndsystems.com)
IL9 was originally identified as a cytokine found in the conditioned medium of a human T-cell leukemia virus type I (HTLVI) transformed T-cell line. (goldbio.com)
Interleukin 2 (IL-2) is also known as T-cell growth factor. (tcu.edu)

Substances that have no effect when inhaled precise role of each cytokine remains to be determined. (cdc.gov)
Role of neutrophil extracellular la NETosis en las enfermedades infecciosas pulmonares. (bvsalud.org)

Interleukin 10 helps in the deactivation of activated macrophages [ 1 ] . (encyclopedia.pub)

Increased Expression of Interleukin-18 m. (omu.edu.tr)

This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. (genaxxon.com)

Interleukin-17B (IL-17B) is a member of IL-17 cytokines family that plays important roles in host defence responses and inflammatory diseases. (abmole.cn)
The potential therapeutic applications emerging from the roles of these cytokines will be discussed as well. (cdc.gov)

Interleukin-1β (IL-1β) is a pleiotropic pro-inflammatory cytokine associated with inflammasome activation and known to be pivotal in several auto-immune and auto-inflammatory diseases. (univ-reims.fr)

Anatomy35

Organisms13

Diseases6

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes61

Disciplines and Occupations1

Information Science3

Health Care2

Inflammation12

Ligand for interleukin 4 recept2

Anti-inflammatory5

Antibodies1

Receptor subunit3

Tumor6

Gene11

Regulates3

Exerts2

Protein4

Pathogenesis5

Gp1301

Proinflammatory1

Scopus1

Encodes1

Deregulated pro-inflammatory1

Receptors1

Chemokines1

Hematopoiesis2

Binds1

Signal transducer2

Abstract1

Subset1

Hematopoietic1

Secretion2

Helper T-cel2

Induces2

IL6R1

Effector2

Immunotherapy1

Autocrine1

Asthma4

Innate and adaptive1

Localization1

Viral infections1

Antibody3

Effects1

Lymphocytes3

Cells6

Bone marrow1

Eosinophils2

Atherosclerosis3

Inflammatory response2

Precursor2

Chronic1

Suppresses1

Proliferation1

Cell4

Role2

Macrophages1

Expression1

Involved in the regulation1

Roles2

Diseases1