Serotonin is produced in the central nervous system (CNS), specifically in the brainstem's raphe nuclei, the skin's Merkel cells, pulmonary neuroendocrine cells and the tongue's taste receptor cells. (wikipedia.org)
SCLC is a neuroendocrine carcinoma that exhibits aggressive behavior, rapid growth, early spread to distant sites, exquisite sensitivity to chemotherapy and radiation, and frequent association with distinct paraneoplastic syndromes, including hypercalcemia, Eaton-lambert syndrome, syndrome of inappropriate diuretic hormone, and many others. (medscape.com)
Approximately2
Approximately 90% of the serotonin the human body produces is in the gastrointestinal tract's enterochromaffin cells, where it regulates intestinal movements. (wikipedia.org)
4, 5] Approximately 98% of patients with SCLC have a smoking history. (medscape.com)
Injection2
Serotonin's presence in insect venoms and plant spines serves to cause pain, which is a side-effect of serotonin injection. (wikipedia.org)
Then, pain-related behaviors induced by formalin injection were measured at the 5-min blocks during a 60-min period of formalin test. (bvsalud.org)
Stress2
In plants serotonin synthesis seems to be associated with stress signals. (wikipedia.org)
Stress activates multiple neural pathways and neurotransmitters that often suppress pain perception, the phenomenon called stress-induced analgesia (SIA). (bvsalud.org)
Pain1
The present study examined this hypothesis that orexinergic receptors in the CA1 region of the hippocampus may play a modulatory role in the development of SIA in formalin test as an animal model of persistent inflammatory pain. (bvsalud.org)
Growth1
Serotonin is also a growth factor for some types of cells, which may give it a role in wound healing. (wikipedia.org)
Inhibitors1
Several classes of antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), interfere with the normal reabsorption of serotonin after it is done with the transmission of the signal, therefore augmenting the neurotransmitter levels in the synapses. (wikipedia.org)
Molecule3
A receptor is a biological molecule that binds to a ligand and produces effects. (human-memory.net)
When a molecule of GABA binds to this receptor, it causes the opening of the Cl - channels. (human-memory.net)
failed verification] Biochemically, the indoleamine molecule derives from the amino acid tryptophan, via the (rate-limiting) hydroxylation of the 5 position on the ring (forming the intermediate 5-hydroxytryptophan), and then decarboxylation to produce serotonin. (wikipedia.org)
Bind2
When they bind a ligand, activation of the receptor results in a conformational change, rendering the ion channel open. (human-memory.net)
When the platelets bind to a clot, they release serotonin, where it can serve as a vasoconstrictor or a vasodilator while regulating hemostasis and blood clotting. (wikipedia.org)
Produces1
Approximately 90% of the serotonin the human body produces is in the gastrointestinal tract's enterochromaffin cells, where it regulates intestinal movements. (wikipedia.org)
Clinical3
We will also discuss some important types of ionotropic receptors in the body, their location, and clinical significance, along with their role in the body. (human-memory.net)
We will discuss drugs affecting different ionotropic receptors and their clinical significance. (human-memory.net)
Myasthenia Gravis is an important clinical condition associated with nicotinic receptors. (human-memory.net)
Human body1
Many types of receptors are present in human body. (human-memory.net)
Activation1
The serotonin is secreted luminally and basolaterally, which leads to increased serotonin uptake by circulating platelets and activation after stimulation, which gives increased stimulation of myenteric neurons and gastrointestinal motility. (wikipedia.org)
Effects2
In high concentrations, serotonin acts as a vasoconstrictor by contracting endothelial smooth muscle directly or by potentiating the effects of other vasoconstrictors (e.g. angiotensin II and norepinephrine). (wikipedia.org)
Serotonin primarily acts through its receptors and its effects depend on which cells and tissues express these receptors. (wikipedia.org)
Types2
These receptors are classified into two types on the basis of ionic specificity. (human-memory.net)
Serotonin is also a growth factor for some types of cells, which may give it a role in wound healing. (wikipedia.org)