• metabolites
  • In general, various phospholipase A2s and diacylglycerol lipases are activated during cell stimulation, proceed to release these fatty acids from their storage sites, and thereby are key regulators in the formation of lipoxygenase-dependent metabolites. (wikipedia.org)
  • Communications Bioorganic Chemistry Unprecedented Lipoxygenase/Hydroperoxide Lyase Pathways in the Moss Physcomitrella patens** Thomas Wichard, Cornelia Gbel, Ivo Feussner, and Georg Pohnert* Lipoxygenase (LOX) pathways are involved in the production of important signal and defensive metabolites in mammals, higher plants, and algae. (docme.ru)
  • 15(S)-HETE, 15(S)-HpETE, and many of their derivative metabolites are thought to have physiologically important functions. (wikipedia.org)
  • pathways
  • In addition, cells, when so activated, may transfer their released polyunsaturated fatty acids to adjacent or nearby cells which then metabolize them through their lipoxygenase pathways in a process termed transcellular metabolism or transcellular biosynthesis. (wikipedia.org)
  • protein
  • Based on detailed analyses of 15-lipoxygenase 1 and stabilized 5-lipoxygenase, lipoxygenase structures consist of a 15 kilodalton N-terminal beta barrel domain, a small (e.g. ~0.6 kilodalton) linker inter-domain (see protein domain#Domains and protein flexibility), and a relatively large C-terminal catalytic domain which contains the non-heme iron critical for the enzymes' catalytic activity. (wikipedia.org)
  • Helgadottir and colleagues 44 showed that a promoter haplotype comprising 4 linked polymorphisms in the 5-LO activating peptide (an accessory protein that facilitates presentation of substrate arachidonate to 5-LO) confers an approximately 2-fold increased risk of myocardial infarction (MI) and stroke in an Icelandic population. (healthfully.org)
  • DAG and IP3 stimulate protein kinase C, type alpha ( PKC-alpha ) and mobilise intracellular Ca 2+ , respectively. (bio-rad.com)
  • Recombinant
  • Acetaminophen and indomethacin also permitted 18 R -HEPE and 15 R -HEPE generation with recombinant COX-2 as well as ω-5 and ω-9 oxygenations of other fatty acids that act on hematologic cells. (rupress.org)
  • eosinophils
  • The eoxins derive their name from eosinophils, the cell type where they were originally discovered in abundance. (wikipedia.org)
  • Cells and tissues rich in 15-LOX-1 activity such as human eosinophils, umbilical cord-derived mast cells, nasal polyps from allergic subjects, airway epitheleal cells, and L1236 Reed-Sternberg cells derived from Hodgkin's Disease tumors produce eoxins. (wikipedia.org)
  • analogs
  • That is, the eoxins are 14,15-disubstituted analogs of the 5,6-disubstituted leukotrienes. (wikipedia.org)
  • Synthesis of Racemic 11,12-Cyclopropyl Analogs of Hepoxilins A.sub.3 and B.sub.3, Tetrahedron Letters, (1993), vol. 34, pp. 4305-4308. (patentgenius.com)
  • airway
  • Eoxins have been suggested to contribute to inflammation in airway allergies and the development and/or progression of certain types of cancers, particularly Hodgkin's lymphoma (a cancer originating from white blood cells), prostate cancer, and colon carcinoma. (wikipedia.org)
  • Indeed, mice made deficient of 12/15-lipooxygenase exhibit an attenuated allergic airway inflammation response compared to wild type control mice. (wikipedia.org)
  • proteins
  • GENTAUR suppliers human normal cells, cell lines, RNA extracts and lots of antibodies and ELISA kits to Human proteins as well as rabbit serum against human platelet factor 4. (antibody-antibodies.com)
  • carbon
  • In this terminology S refers to the absolute configuration of the chirality of the hydroxy functional group at carbon position 15. (wikipedia.org)
  • Glutathione
  • The initial 12(S)-HpETE and 12(R)-HpETE products, regardless of their pathway of formation, are rapidly reduced to 12(S)-HETE and 12(R)-HETE, respectively, by ubiquitous cellular peroxidases, including in particular Glutathione peroxidases or, alternatively, are further metabolized as described below. (wikipedia.org)
  • humans
  • Sub-human primates, although not extensively examined, appear to have 12-lipoxygenase expression patterns that resemble those of sub-primate mammals or humans depending on the closeness of there genetic relateness to these species. (wikipedia.org)
  • Exceptions to this rule include the 12R-lipoxygenases of humans and other mammals (see below). (wikipedia.org)
  • Studies in humans, however, are scarce, and more ev- positively correlated with homeostasis model assessment of insulin idence on these biological activities is needed (15). (pdfmedfinder.com)
  • oxidize
  • Cells of one type may release the 5(S)-HETE that they make to nearby cells of a second type which then oxidize the 5(S)-HETE to 5-oxo-ETE. (wikipedia.org)
  • Pathway
  • Thus, the potential importance of shifting the flux of arachidonate through the LO pathway by inhibiting COX activity bears consideration as we attempt to dissect the vascular consequences of coxib use. (healthfully.org)
  • metabolism
  • In mammals a number of lipoxygenases isozymes are involved in the metabolism of eicosanoids (such as prostaglandins, leukotrienes and nonclassic eicosanoids). (wikipedia.org)
  • lipoxins
  • Although the proinflammatory roles of LT and PG are well appreciated ( 7 )( 8 ), there is new evidence that other eicosanoids derived from arachidonate, namely lipoxins (LXs) and their endogenous analogues, the aspirin-triggered 15 epimer LXs (ATLs), are potent counterregulators of PMN-mediated injury and acute inflammation ( 9 )( 10 )( 11 ). (rupress.org)
  • the 15(R) class of lipoxins (also termed epi-lipoxins). (wikipedia.org)
  • consequently
  • thromboxane TXA1, unlike its series-2 variant, induces vasodilation, and inhibits platelet consequently, TXA1 modulates (reduces) the pro-inflammatory properties of the thromboxane TXA2. (wikipedia.org)
  • possesses
  • 5-Oxo-ETE can stimulate various cell types particularly human leukocytes but possesses its highest potency and power in stimulating the human eosinophil type of leukocyte. (wikipedia.org)
  • derivatives
  • Thus, 15(S)-HETE and 15(S)-HpETE, in addition to having intrinsic biological activities, are key precursors to numerous biologically active derivatives. (wikipedia.org)
  • possess
  • this 5(S)-ETE can leaves these cells, enter various cell types that possess 5-HEDH activity along with lower NADPH to NADP+ levels, and thereby is converted to 5-oxo-ETE. (wikipedia.org)
  • human
  • it also promotes the malignant behavior of cultured human cancer cells as well as the growth of certain cancers in animal models (see 12-HETE). (wikipedia.org)
  • cell lines derived from human cancers such as those from breast, prostate, lung, colon, and various types of leukemia have likewise been shown to be producers of 5-oxo-ETE. (wikipedia.org)
  • 3) 12-Lipoxygenase of human uterine cervix : Nigam's group of Free University of Berlin had found that human uterine cervix had 12-lipoxygenase activity which was lower in cancer cells. (nii.ac.jp)
  • Last November Natsuo Ueda visited Free University in Berlin and confirmed the 12-lipoxygenase activity in human uterine cervix. (nii.ac.jp)
  • These findings indicated that the 12-lipoxygenase of human uterine cervix was of platelet-type. (nii.ac.jp)
  • product
  • This initial hydroperoxide product is extremely short-lived in cells: if not otherwise metabolized, it is rapidly reduced to 15(S)-HETE. (wikipedia.org)