• metabolites
  • In general, various phospholipase A2s and diacylglycerol lipases are activated during cell stimulation, proceed to release these fatty acids from their storage sites, and thereby are key regulators in the formation of lipoxygenase-dependent metabolites. (wikipedia.org)
  • Communications Bioorganic Chemistry Unprecedented Lipoxygenase/Hydroperoxide Lyase Pathways in the Moss Physcomitrella patens** Thomas Wichard, Cornelia Gbel, Ivo Feussner, and Georg Pohnert* Lipoxygenase (LOX) pathways are involved in the production of important signal and defensive metabolites in mammals, higher plants, and algae. (docme.ru)
  • 15(S)-HETE, 15(S)-HpETE, and many of their derivative metabolites are thought to have physiologically important functions. (wikipedia.org)
  • pathways
  • In addition, cells, when so activated, may transfer their released polyunsaturated fatty acids to adjacent or nearby cells which then metabolize them through their lipoxygenase pathways in a process termed transcellular metabolism or transcellular biosynthesis. (wikipedia.org)
  • hydroxy
  • In this terminology S refers to the absolute configuration of the chirality of the hydroxy functional group at carbon position 15. (wikipedia.org)
  • eosinophils
  • The eoxins derive their name from eosinophils, the cell type where they were originally discovered in abundance. (wikipedia.org)
  • Cells and tissues rich in 15-LOX-1 activity such as human eosinophils, umbilical cord-derived mast cells, nasal polyps from allergic subjects, airway epitheleal cells, and L1236 Reed-Sternberg cells derived from Hodgkin's Disease tumors produce eoxins. (wikipedia.org)
  • humans
  • Sub-human primates, although not extensively examined, appear to have 12-lipoxygenase expression patterns that resemble those of sub-primate mammals or humans depending on the closeness of there genetic relateness to these species. (wikipedia.org)
  • Exceptions to this rule include the 12R-lipoxygenases of humans and other mammals (see below). (wikipedia.org)
  • Studies in humans, however, are scarce, and more ev- positively correlated with homeostasis model assessment of insulin idence on these biological activities is needed (15). (pdfmedfinder.com)
  • Acids
  • The activities of the liver enzymes that metabolize fatty acids and synthesize triglycerides are modified by the type of fat that is fed. (springer.com)
  • airway
  • Eoxins have been suggested to contribute to inflammation in airway allergies and the development and/or progression of certain types of cancers, particularly Hodgkin's lymphoma (a cancer originating from white blood cells), prostate cancer, and colon carcinoma. (wikipedia.org)
  • Indeed, mice made deficient of 12/15-lipooxygenase exhibit an attenuated allergic airway inflammation response compared to wild type control mice. (wikipedia.org)
  • metabolically equivalent
  • Studies on the role of ALOX12 in pathophysiology using the main models for such functional studies, rats and mice, are complicated because neither species possesses a lipoxygenase that makes a predominance of 12(S)-HETE and therefore is metabolically equivalent to ALOX12. (wikipedia.org)
  • oxidize
  • Cells of one type may release the 5(S)-HETE that they make to nearby cells of a second type which then oxidize the 5(S)-HETE to 5-oxo-ETE. (wikipedia.org)
  • consequently
  • thromboxane TXA1, unlike its series-2 variant, induces vasodilation, and inhibits platelet consequently, TXA1 modulates (reduces) the pro-inflammatory properties of the thromboxane TXA2. (wikipedia.org)
  • kilodalton
  • Based on detailed analyses of 15-lipoxygenase 1 and stabilized 5-lipoxygenase, lipoxygenase structures consist of a 15 kilodalton N-terminal beta barrel domain, a small (e.g. ~0.6 kilodalton) linker inter-domain (see protein domain#Domains and protein flexibility), and a relatively large C-terminal catalytic domain which contains the non-heme iron critical for the enzymes' catalytic activity. (wikipedia.org)
  • pathway
  • The initial 12(S)-HpETE and 12(R)-HpETE products, regardless of their pathway of formation, are rapidly reduced to 12(S)-HETE and 12(R)-HETE, respectively, by ubiquitous cellular peroxidases, including in particular Glutathione peroxidases or, alternatively, are further metabolized as described below. (wikipedia.org)
  • Thus, the potential importance of shifting the flux of arachidonate through the LO pathway by inhibiting COX activity bears consideration as we attempt to dissect the vascular consequences of coxib use. (healthfully.org)
  • derivatives
  • Thus, 15(S)-HETE and 15(S)-HpETE, in addition to having intrinsic biological activities, are key precursors to numerous biologically active derivatives. (wikipedia.org)
  • possess
  • this 5(S)-ETE can leaves these cells, enter various cell types that possess 5-HEDH activity along with lower NADPH to NADP+ levels, and thereby is converted to 5-oxo-ETE. (wikipedia.org)
  • respectively
  • DAG and IP3 stimulate protein kinase C, type alpha ( PKC-alpha ) and mobilise intracellular Ca 2+ , respectively. (bio-rad.com)
  • hydroperoxide
  • Plant lipoxygenase in conjunction with hydroperoxide lyases are responsible for many fragrances and other signalling compounds. (wikipedia.org)
  • This initial hydroperoxide product is extremely short-lived in cells: if not otherwise metabolized, it is rapidly reduced to 15(S)-HETE. (wikipedia.org)
  • tissues
  • PMN are the first blood cell type able to migrate into tissues following microbial invasion. (hindawi.com)
  • cells
  • it also promotes the malignant behavior of cultured human cancer cells as well as the growth of certain cancers in animal models (see 12-HETE). (wikipedia.org)
  • human
  • cell lines derived from human cancers such as those from breast, prostate, lung, colon, and various types of leukemia have likewise been shown to be producers of 5-oxo-ETE. (wikipedia.org)
  • leukocytes
  • However, unlike mast cell, which readily respond to cross-linking Fc ε RI receptors, and platelets, which release AA in response to classical aggregating agents, less information is available about the physiologically relevant stimuli in polymorphonuclear leukocytes (PMN) and macrophages, since most experiments have been carried out either with xenobiotics or combining chemoattractants with chemicals and priming agents. (hindawi.com)
  • activity
  • The lipoxygenases are related to each other based upon their similar genetic structure and dioxygenation activity. (wikipedia.org)
  • 15(R)-HpETE and 15(R)-HETE lack some of the activity attributed to their S stereoisomers but can be further to metabolized to bioactive products viz. (wikipedia.org)
  • vascular
  • 46 This potentiation of prostacyclin by NO has also been demonstrated to account for the synergistic inhibition of platelets by these vascular effectors. (healthfully.org)