Platelet 1997 tissue factor factor viia. Medical search. Frequent questions

We describe how these are activated, which are their target proteins, and how their proteolytic activity modulates platelet functions. (frontiersin.org)
Several structures of 'super active' mutants have been solved, which reveal the nature of factor IX activation by other proteins in the clotting cascade. (wikipedia.org)

When activated into factor IXa, in the presence of Ca2+, membrane phospholipids, and a Factor VIII cofactor, it hydrolyses one arginine-isoleucine bond in factor X to form factor Xa. (wikipedia.org)
The prothrombinase complex is the enzymatic complex responsible for timely thrombin formation at the place of vascular injury and is composed of the enzyme, factor Xa (fXa), the non-enzymatic cofactor factor Va (fVa), and the substrate prothrombin assembled on a lipid membrane in the presence of divalent metal ions. (csuohio.edu)
Once bound to its cofactor, factor VII can be activated by a number of different proteases. (medscape.com)
It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation. (lookformedical.com)

Knockin of human VWF exon 28 and crossbreeding with hGPIbα Tg generated a humanized mouse model of platelet GPIbα-VWFA1 interaction. (ashpublications.org)
Bombeli,T., Schwartz,B.R., and Harlan,J.M. (1998): Adhesion of Activated Platelets to Endothelial Cells: Evidence for a GPIIb/IIIa-dependent Bridging Mechanism and Novel Roles for Endothelial Intercellular Adhesion Molecule 1 (ICAM-1), α V β 3 -Integrin and GPIbα. (9dok.net)

Thrombin, which is generated at these phosphatidylserine sites, triggers the formation of fibrin fibers, which consolidate the platelet thrombus into a stable clot sealing the breach in a vessel wall ( 2 ). (frontiersin.org)
2006): The influence of fibrin polymerization and platelet-mediated contractile forces on citrated whole blood thromboelastography profile. (9dok.net)
The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). (lookformedical.com)
The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot. (lookformedical.com)

[ 3 ] Most patients present with hemorrhage into the skin, muscles, or soft tissues and mucous membranes. (medscape.com)
The clinical manifestation of AHA includes mostly spontaneous hemorrhages into skin, mucous membranes, muscles, soft tissues, or joints. (seedmedicalpublishers.com)

The Food and Drug Administration (FDA) approved recombinant activated factor VIII (synthetic vitamin K -dependent protein) for treatment of bleeding in patients with hemophilia A or B who have developed inhibitors against replacement coagulation factors. (medscape.com)
Acquired hemophilia is a rare but potentially life-threatening bleeding disorder caused by the development of autoantibodies (inhibitors) directed against plasma coagulation factors, most frequently factor VIII (FVIII). (medscape.com)
Acquired hemophilia A (AHA) is a rare bleeding disorder caused by an autoantibody to coagulation factor (F) VIII. (biomedcentral.com)
Endogenous thrombin potential, or area under the curve, was predominantly positively determined by factor II, VIII, X and IX in all groups. (biomedcentral.com)
It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. (lookformedical.com)
Acquired hemophilia (AH) is a rare bleeding disorder caused by the spontaneous development of autoantibodies against coagulation factors, most commonly factor (F) VIII (acquired hemophilia A, AHA). (seedmedicalpublishers.com)

The treatment of hemophilia may involve management of hemostasis, management of bleeding episodes, use of factor replacement products and medications, treatment of patients with factor inhibitors, and treatment and rehabilitation of patients with hemophilic synovitis. (medscape.com)
Acquired hemophilia (AH) is an autoimmune disease caused by the formation of inhibitory autoantibodies against coagulation factors. (seedmedicalpublishers.com)
These inhibitory autoantibodies (immunoglobulin IgG) neutralize the activation or function or accelerate the clearance of a specific clotting factor [1], mainly FVIII (acquired hemophilia A-AHA), although all the coagulation factors can be involved. (seedmedicalpublishers.com)

Thrombin generated by this process activates platelets and the coagulation cascade. (medscape.com)
Tissue factor (TF) is the initiator of the coagulation cascade, constitutively expressed in subendothelial cells such as vascular smooth muscle cells and initiating rapid coagulation when the vascular vessel is damaged. (go.jp)

The TIMI IIIB Investigators, Effects of tissue plasminogen activator and a comparison of early invasive and conservative strategies in unstable angina and non-Q-wave myocardial infarction: results of the TIMI IIIB trial. (jamanetwork.com)
Tissue plasminogen activator (abbreviated tPA or PLAT ) is a protein involved in the breakdown of blood clots . (wikidoc.org)
tPA produced by such means are referred to as recombinant tissue plasminogen activator ( rtPA ). (wikidoc.org)

Similarly, sEng is a truncated form of receptor for two subtypes of transforming growth factor beta (TGF β ) specifically, TGF β 1 and TGF β 2 which are highly expressed by vascular endothelial cells and syncytiotrophoblasts. (hindawi.com)

However, previous studies have hinted towards an association with inhibition of thormbomodulin activity, reduction of protein-C activation, increased platelet aggregation, and predisposition to endothelial injury secondary to hyperhomocysteinemia. (biomedjournal.com)
Born,G.V. and Cross,M.J. (1963): The Aggregation of Blood Platelets. (9dok.net)

Activated microthrombotic pathway mediates platelet activation and exocytosis of unusually large von Willebrand factor multimers (ULVWF) from ECs and initiates microthrombogenesis. (biomedcentral.com)
Chen,M. and Geng,J.G. (2006): P-Selectin mediates adhesion of leukocytes, platelets and cancer cells in inflammation, thrombosis, cancer growth and metastasis. (9dok.net)

Tissue factor modulates the thrombogenicity of human atherosclerotic plaques. (jamanetwork.com)

We provide a comprehensive overview of the proteases acting on the platelet membrane. (frontiersin.org)
Upon prolonged high intracellular rises in Ca 2+ , platelets develop a procoagulant phenotype that is characterized by the surface membrane exposure of phosphatidylserine and by the inactivation of integrin α IIb β 3 (procoagulant platelet population) ( 5 ). (frontiersin.org)
Phosphatidylserine-exposing platelets, usually located around a thrombus, provide a negatively charged membrane surface, which supports coagulation factor binding and the formation of tenase and prothrombinase complexes ( 6 , 7 ). (frontiersin.org)
Here, we review current knowledge how proteases act on platelet receptors and the platelet membrane surface. (frontiersin.org)

The proteases involved are of different origins and types: (i) present as precursor in plasma, (ii) secreted into the plasma by activated platelets or other blood cells, or (iii) intracellularly activated and cleaving cytosolic receptor domains. (frontiersin.org)
Although these platelet activation processes are relatively well-studied as a function of the platelet environment, only since recently it is becoming clear that a multitude of proteases present in plasma or produced by platelets themselves are important for the distinct properties of platelet populations, often by cleaving specific receptors. (frontiersin.org)
Molecular changes which may influence hypercoagulability include the expression of tissue factor (TF) as well as the proteases hepsin and cancer procoagulant by circulating tumour cells [ 4 ]. (biomedcentral.com)

It has the shortest half-life of the procoagulant factors, approximately 3-6 hours. (medscape.com)

According to a common concept of thrombosis and hemostasis, damage or injury of a vessel wall and ensuing exposure of extracellular matrix components to the blood stream triggers platelets from the circulation to become adherent and to assemble into a thrombus, thus limiting the extravasation of blood ( 1 , 2 ). (frontiersin.org)
This provokes the release of thromboxane A 2 and the secretion of granular contents including ADP and, via these autocrine agents, the subsequent recruitment of additional flowing platelets, which assemble into a growing thrombus via α IIb β 3 -fibrinogen interactions (aggregating platelet population) ( 1 ). (frontiersin.org)

In addition, the absence of the lymphatic circulation in the brain places demands on the vascular system in terms of the interstitial fluid circulation pattern 3 and mitigation of physical stress on tissues locked within the rigid confines of the intracranial space. (rmmj.org.il)

Its shortest half-life of all the clotting factors is reflected in the initial rapid prolongation of prothrombin time (INR) in therapy with vitamin K antagonists. (medscape.com)
It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. (lookformedical.com)

Intracranial dysfunction of hemostatic processes triggers profound local and systemic consequences, often with lethal outcomes including thrombosis, local vascular occlusion, hypoxic tissue damage, coagulation factor neurotoxicity, ischemic stroke, hemorrhage, and edema. (rmmj.org.il)

Formulations include: nonacog alfa (brand name BeneFix) albutrepenonacog alfa (brand name Idelvion) eftrenonacog alfa (brand name Alprolix) nonacog beta pegol (brand name Refixia) Some rare mutations of factor IX result in elevated clotting activity, and can result in clotting diseases, such as deep vein thrombosis. (wikipedia.org)
Asymptomatic patients who have no risk factors and a negative family history of thrombosis do not require specific treatment. (medscape.com)
In patients with primary antiphospholipid antibody syndrome with arterial thrombosis or infarction, many physicians administer antiplatelet therapy in the absence of other risk factors, but the use of anticoagulants is controversial. (medscape.com)
1997). Previous studies have reported an association between homocysteine concentrations and plasma markers of thrombosis activation in patients admitted for acute coronary syndrome (Al-Obaid et al. (biomedjournal.com)
The current study aims to identify the relationships between coagulation factors and plasma thrombin generation in a large population-based study by comparing individuals with a history of arterial or venous thrombosis to cardiovascular healthy individuals. (biomedcentral.com)
This large-scale analysis demonstrated a stronger effect of the coagulant and natural anti-coagulant factors on the thrombin potential in individuals with a history of arterial or venous thrombosis as compared to healthy individuals, which implicates sustained alterations in the plasma coagulome in subjects with a history of thrombotic vascular disease, despite intake of antithrombotic therapy. (biomedcentral.com)
Venous thromboembolism (VTE) and arterial thrombotic diseases share several risk factors and several studies have shown that the risk of arterial thrombosis is increased in those that suffered a first VTE and vice versa [ 14 ]. (biomedcentral.com)
Some rare mutations of factor IX result in elevated clotting activity, and can result in clotting diseases, such as deep vein thrombosis . (wikidoc.org)
While brain tumor cells express tissue factor (TF) and other effectors of the coagulation system (coagulome), their propensity to induce local and peripheral thrombosis is highly diverse, most dramatic in the case of glioblastoma multiforme (GBM), and less obvious in pediatric tumors. (rmmj.org.il)

The flow-dependent adhesion of platelets to those and other extracellular matrix components is stabilized by a panel of integrins, including integrin α 2 β 1 , α IIb β 3 , and α 6 β 1 (adhesive platelet population), while the initial activation of platelets is achieved by signaling via the collagen/laminin receptor, glycoprotein VI (GPVI). (frontiersin.org)
Staphylococcus aureus extracellular adherence protein serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes. (9dok.net)

The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. (frontiersin.org)
An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet function. (frontiersin.org)
Angiogenic factors and their receptors are important regulators of placental vascular development [ 13 ]. (hindawi.com)

[ 4 ] The factor VIIa/TF complex activates both factors IX and X. It is inhibited by tissue factor pathway inhibitor (TFPI) in complex with factor Xa. (medscape.com)
The reasons for these discrepancies are not fully understood but might include variations in coagulation factor concentrations, release of tissue factor pathway inhibitor from the endothelium as well as effects of specific medication. (biomedcentral.com)

The process of thrombus formation is considered to be initiated by von Willebrand factor (VWF) binding to exposed collagen or laminin in the damaged vessel wall, followed by shear-dependent platelet binding to VWF through the glycoprotein (GP)Ib-V-IX complex ( 1 , 3 , 4 ). (frontiersin.org)
3. Kalafatis, M., Takahashi, Y., Girma, J.P., and Meyer, D. Localization of a collagen interactive domain of human von Willebrand Factor between amino acid residues Gly 911 and Glu 1365. (csuohio.edu)

How the immune response can activate the cascade process is still unknown but it is proposed to act in synergy with additional exacerbating factors such as predisposing maternal and ambient factors [ 12 ]. (hindawi.com)
Carboxylation by vitamin K is necessary to activate this factor. (medscape.com)
TF assembles with factor VIIa to activate factors IX and X thereby triggering thrombin formation. (biomedcentral.com)

Independently of such activation processes, platelet heterogeneity can be achieved by aging and an accompanied inactivation ( 3 ). (frontiersin.org)
The physiologic activator of factor VII is thought to be factor Xa, although significant auto-activation by factor VIIa can occur. (medscape.com)
Bom,V.J. and Bertina,R.M. (1990): The contributions of Ca 2+ , phospholipids and tissue-factor apoprotein to the activation of human blood-coagulation factor X by activated factor VII. (9dok.net)

Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. (lookformedical.com)
Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. (lookformedical.com)

In mouse models, mutations within the promoter region of factor IX have an age-dependent phenotype. (wikipedia.org)

Recombinant activated factor VII (rFVIIa) binds to exposed tissue factor at the place of tissue and vascular injury. (medscape.com)

[ 1 ] Embryos deficient in factor VII developed normally without evidence of hemorrhage. (medscape.com)
Nevertheless, factor VII-deficient newborns sometimes develop fatal intra-abdominal or intracranial hemorrhage. (medscape.com)
Dose calculations are directed toward achieving a factor IX (FIX) activity level of 30% for most mild hemorrhages, of at least 50% for severe bleeds (eg, from trauma) or for prophylaxis of major dental surgery or major surgery, and 80-100% in life-threatening hemorrhage. (medscape.com)

GM-CSF down-regulates inhibited by factors( T-lymphocytes, mouse heterotrimers, necessary phosphatidylinositol, p46 acids) estimated at acids of intrinsic tissues. (evakoch.com)

Elevated level of plasma homocysteine has been demonstrated to be an independent risk factor for the development of coronary artery disease. (biomedjournal.com)
Ardissino DMerlini PAAriens RCoppola RBramucci EMannucci PM Tissue-factor antigen and activity in human coronary atherosclerotic plaques. (jamanetwork.com)

Factor IX is inhibited by antithrombin. (wikipedia.org)

Overexpression of both sEng and sFlt1 in pregnant rats develops nephrotic-range proteinuria, severe hypertension, biochemical evidence of HELLP ("H" for hemolysis, "EL" for elevated liver enzymes, and "LP" for low platelet count), and intrauterine growth restriction of the pups [ 19 , 20 ]. (hindawi.com)

In order to address these issues, we carried out the present study to identify the relationships between (natural anti-) coagulation factors and parameters of the TG in individuals with a history of either an arterial cardiovascular disease or venous thrombotic disease compared to cardiovascular healthy group within the population-based Gutenberg Health Study. (biomedcentral.com)

Within a thrombus, however, distinct types of activated platelets can be recognized, exhibiting different functions, although partial overlap between the populations exists ( 3 ). (frontiersin.org)

Factors VII, IX, and X all play key roles in blood coagulation and also share a common domain architecture. (wikipedia.org)
1 While the brain represents only 2% of the body mass, it receives 20% of cardiac output, resulting in the flow rate of approximately 50 mL of blood per 100 g of tissue every minute. (rmmj.org.il)

Deficiency of this protein causes haemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to haemophilia. (wikipedia.org)
The factor IX protein is composed of four protein domains: the Gla domain, two tandem copies of the EGF domain and a C-terminal trypsin-like peptidase domain which carries out the catalytic cleavage. (wikipedia.org)
2003): Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. (9dok.net)
Constituent composed of protein and phospholipid that is widely distributed in many tissues. (lookformedical.com)

This in turn results in an exponential production of multiple factors such as cytokines and growth factors leading to the clinical manifestations of PE [ 11 ]. (hindawi.com)

Deficiency of factor V leads to Owren's disease. (lookformedical.com)
A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder. (lookformedical.com)

Breton-Gorius,J. and Guichard,J. (1972): Ultrastructural localization of peroxidase activity in human platelets and megakaryocytes. (9dok.net)

We also describe how the proteolytic activities are determined by different platelet populations in a thrombus and conversely how proteolysis contributes to the formation of such populations. (frontiersin.org)

Like sFlt1, soluble endoglin (sEng) is an antiangiogenic factor capable of inhibiting capillary tube formation in vitro [ 17 ]. (hindawi.com)

conclude that residues 88 to 109 of the second EGF domain mediate binding to platelets and assembly of the factor X activating complex. (wikipedia.org)
Factor IX complex is on the WHO Model List of Essential Medicines , the most important medications needed in a basic health system . (wikidoc.org)
Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). (lookformedical.com)

The coagulation system leans on a delicate balance between coagulant and anticoagulant factors. (csuohio.edu)
and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS. (lookformedical.com)
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. (lookformedical.com)

The gene for factor IX is located on the X chromosome (Xq27.1-q27.2) and is therefore X-linked recessive: mutations in this gene affect males much more frequently than females. (wikipedia.org)
Polly, a transgenic cloned Poll Dorset sheep carrying the gene for factor IX, was produced by Dr Ian Wilmut at the Roslin Institute in 1997. (wikipedia.org)
[ 1 ] The human factor VII gene is located on chromosome 13, very close to the gene for factor X. (medscape.com)

Although the platelet count and clotting improved with Vitamin K and plasma, the platelet count did not rise above 50. (biomedcentral.com)

Bentfeld-Barker,M.E. and Bainton,D.F. (1982): Identification of primary lysosomes in human megakaryocytes and platelets. (9dok.net)
1998): Nitric oxide-dependent and independent effects on human platelets treated with peroxynitrite. (9dok.net)

We describe how these are activated, their targets, their effect on platelet functions, and the consequences for platelet population formation. (frontiersin.org)
The etiology is probably multifactorial: genetic and environmental factors interact in order to cause a loss of the immune tolerance and the formation of the inhibitory antibodies [2]. (seedmedicalpublishers.com)

Anatomy1

Diseases1

Chemicals and Drugs11

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes4

Proteins2

Cofactor4

GPIb2

Fibrin4

Mucous membranes2

VIII6

Hemophilia3

Coagulation cascade2

Plasminogen activator3

Endothelial cells1

Aggregation2

Mediates2

Modulates1

Membrane4

Proteases3

Procoagulant1

Assemble2

Circulation1

Prothrombin2

Triggers1

Thrombosis9

Extracellular2

Receptors3

Pathway inhibitor2

Willebrand2

Activate3

Activation3

Pathways2

Phenotype1

Recombinant activated factor1

Hemorrhage3

Intrinsic1

Coronary2

Inhibited by antithrombin1

Liver1

Thrombotic1

Distinct1

Blood2

Protein4

Cytokines1

Deficiency of factor2

Localization1

Conversely1

Soluble1

Complex3

Anticoagulant3

Gene for factor3

Count1

Human2

Formation2