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  • tumor
  • Some consider that plasmoacanthoma (solitary plasma cell tumor) is part of the same spectrum of disease as plasma cell cheilitis. (wikipedia.org)
  • Signet-ring cell gastric carcinoma, previously regarded as an independent type of tumor, today is a special case of poorly cohesive carcinoma. (wikipedia.org)
  • Tumor cells can be signet-ring type, that have a rounded shape with eccentrically located nucleus, resulting in large amounts of intracellular mucin. (wikipedia.org)
  • Pathohistological report of "poorly cohesive carcinoma" is appropriate in case when there is a prevalence of tumor cells with corresponding characteristics. (wikipedia.org)
  • monoclonal
  • IgM monoclonal gammopathy is usually associated with a B-cell lymphoma, most commonly lymphoplasmacytic lymphoma, but other B-cell lymphomas, such as marginal zone lymphoma or chronic lymphocyte leukemia/small lymphocytic lymphoma (CLL/SLL), are possibilities. (neurologyadvisor.com)
  • Secondary plasma cell leukemia (sPCL) results from the comparatively slow development of plasma cell/plasma cell precursor genetic abnormalities which initially create a clone of cells that cause the premalignant condition of monoclonal gammopathy of undetermined significance. (wikipedia.org)
  • This is attributed to the IgM monoclonal protein increasing the viscosity of the blood by forming aggregates to each other, binding water through their carbohydrate component and by their interaction with blood cells. (wikipedia.org)
  • protein
  • These genetic abnormalities effect the Wnt signaling pathway, regulation of the cell cycle, RNA metabolism, protein folding, and cadherin-related cell adherence to extracellular matrix. (wikipedia.org)
  • Second, alternative processing of the Ig heavy chain mRNA transcript enables plasma cells to secrete high levels of Ig protein. (springer.com)
  • The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. (wikipedia.org)
  • The following signalling pathways have been implicated: CD154/CD40 Akt ubiquitination, p53 activation, cytochrome c release NF-κB WNT/beta-catenin mTOR ERK MAPK Bcl-2 The protein Src tyrosine kinase is overexpressed in Waldenström's macroglobulinemia cells compared with control B cells. (wikipedia.org)
  • IgE that can specifically recognise an allergen (typically this is a protein, such as dust mite Der p 1, cat Fel d 1, grass or ragweed pollen, etc.) has a unique long-lived interaction with its high-affinity receptor FcεRI so that basophils and mast cells, capable of mediating inflammatory reactions, become "primed", ready to release chemicals like histamine, leukotrienes, and certain interleukins. (wikipedia.org)
  • An additional function is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic membrane of enterocytes and macrophages for degradation resulting in increased iron uptake from food and decreased iron release from recycled red blood cells in the MPS (mononuclear phagocyte system) respectively. (wikipedia.org)
  • tissues
  • These chemicals cause many of the symptoms we associate with allergy, such as airway constriction in asthma, local inflammation in eczema, increased mucus secretion in allergic rhinitis, and increased vascular permeability, it is presumed, to allow other immune cells to gain access to tissues, but which can lead to a potentially fatal drop in blood pressure as in anaphylaxis. (wikipedia.org)
  • Alcohol consumption probably increases the risk of developing cancer of the oral cavity, pharynx and esophagus by promoting the accumulation of cell divisions in the stem cells that maintain these tissues in homeostasis. (wikipedia.org)
  • infiltrate
  • It consists of a packed plasma cell infiltrate of the mucous membrane of the upper aerodigestive tract, and similar conditions may involve other membranes, for example, the glans penis. (hindawi.com)
  • molecules
  • Pieces of the antigen (which are now known as antigenic peptides ) are loaded onto MHC II molecules, and presented on its extracellular surface to CD4+ T cells (sometimes called T helper cells ). (wikipedia.org)
  • In conclusion, such cellular fluctuations suggest heterogeneity in human plasma cell populations and/or in CD138 molecules. (hindawi.com)
  • β2 microglobulin also known as B2M is a component of MHC class I molecules, which are present on all nucleated cells (excludes red blood cells). (wikipedia.org)
  • This binding facilitates transport of the J-chain positive pIg molecules from the basal to the apical sides of epithelial cells. (wikipedia.org)
  • epithelial
  • Poorly cohesive gastric carcinoma (dyscohesive carcinoma, carcinoma with a lack of intercellular connections) - a malignant tumour of epithelial origin, characterized by diffuse distribution of tumour cells, isolated from each other or in small groups. (wikipedia.org)
  • Eosinophils
  • Eosinophils are a type of white blood cell that helps control inflammation and allergic reactions. (cancer.ca)
  • immune
  • White blood cells are an important part of the immune system . (cancer.ca)
  • Some of them become white blood cells , which are an important part of your body's immune system . (webmd.com)
  • Plasma cells are key effector elements of the adaptive immune system. (wikipedia.org)
  • Although it is not yet well understood, IgE may play an important role in the immune system's recognition of cancer, in which the stimulation of a strong cytotoxic response against cells displaying only small amounts of early cancer markers would be beneficial. (wikipedia.org)
  • biopsies
  • Endometrial biopsies were evaluated for histopathologic evidence of plasma cell endometritis and were cultured for N gonorrhoeae, C trachomatis, aerobic and anaerobic bacteria, Mycoplasma species, and Ureaplasma urealyticum. (rti.org)
  • stem
  • All blood cells develop from stem cells. (cancer.ca)
  • In both cell lines, the stem cells become blasts, which are immature cells. (cancer.ca)
  • But recent evidence suggests that the cytotoxic effect of ethanol on the cells lining the oral cavity, pharynx and esophagus activates the division of the stem cells located in deeper layers of the mucosa to replace the dead cells. (wikipedia.org)
  • Every time stem cells divide, they become exposed to unavoidable errors associated with cell division (e.g., mutations arising during DNA replication and chromosomal alterations occurring during mitosis) and also become highly vulnerable to the genotoxic activity of DNA-damaging agents (e.g., acetaldehyde and tobacco carcinogens). (wikipedia.org)
  • white blood
  • White blood cells help prevent and fight infection by destroying bacteria, viruses and other foreign cells or substances. (cancer.ca)
  • Different types of white blood cells work in different ways to protect the body from infection. (cancer.ca)
  • Neutrophils and monocytes are white blood cells that fight infection by ingesting (eating) or engulfing (surrounding) foreign cells, such as bacteria. (cancer.ca)
  • They crowd out (take the space of) other types of blood cells, such as red blood cells, other white blood cells and platelets, so there aren't enough of these cells to do their jobs. (cancer.ca)
  • As a result, a person can become anemic (because they don't have enough red blood cells), bleed easily (because they don't have enough platelets) and get more infections than normal (because they don't have enough white blood cells). (cancer.ca)
  • Both cell types are white blood cells. (wikipedia.org)
  • gingiva
  • Plasma cell gingivitis is a rare condition, appearing as generalized erythema (redness) and edema (swelling) of the attached gingiva, occasionally accompanied by cheilitis (lip swelling) or glossitis (tongue swelling). (wikipedia.org)
  • Plasma cell gingivitis appears as mild gingival enlargement and may extend from the free marginal gingiva on to the attached gingiva. (wikipedia.org)
  • In some cases the healing of a plaque-induced gingivitis or a periodontitis resolves a plasma cell gingivitis situated a few mm from the earlier plack-infected marginal gingiva. (wikipedia.org)
  • Immunity
  • CD8 T cells are a subset of T cells involved in the development of acquired immunity. (wikipedia.org)
  • A delayed type hypersensitivity reaction of cell mediated immunity has been suggested in the pathogenesis of xanthogranulomatous cholecystitis. (wikipedia.org)
  • maturation
  • Some B cells will undergo a process known as affinity maturation . (wikipedia.org)
  • After the process of affinity maturation in germinal centers, plasma cells have an indeterminate lifespan, ranging from days to months. (wikipedia.org)
  • Sciammas R, Davis MM: Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation. (springer.com)