AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth CareGeographicals
Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Blood GlucoseDiabetes MellitusHypoglycemic AgentsInsulinHemoglobin A, GlycosylatedDiabetes Mellitus, ExperimentalDiabetic NephropathiesDiabetic NeuropathiesGlucoseDiabetes ComplicationsHyperglycemiaBlood Glucose Self-MonitoringHypoglycemiaCase-Control StudiesRisk FactorsIslets of LangerhansGlucose Tolerance TestObesityStreptozocinMice, Inbred NODDiabetes, GestationalInsulin-Secreting CellsC-PeptideIslets of Langerhans TransplantationGlutamate DecarboxylaseFastingPrediabetic StateDiabetic RetinopathyDiabetic AngiopathiesTime FactorsGlucose IntolerancePregnancy in DiabeticsPancreasPostprandial PeriodInsulin ResistanceRats, Inbred BBInsulin Infusion SystemsBiological MarkersMetforminGenetic Predisposition to DiseasePancreas TransplantationAlbuminuriaGlucagonBody WeightBlood PressureBody Mass IndexHLA-DQ AntigensAlloxanGlycosuriaAutoantibodiesSulfonylurea CompoundsFollow-Up StudiesDiabetic KetoacidosisLipidsPlasmaEchovirus 9PrevalenceLiverTriglyceridesTreatment OutcomeGliclazideCross-Sectional StudiesProspective StudiesSelf CareHypertensionDiagnostic EquipmentRetrospective StudiesGlucagon-Like Peptide 1GenotypeGluconeogenesisCohort StudiesCardiovascular DiseasesMice, Inbred C57BLDisease Models, AnimalDiabetic DietRats, Sprague-DawleyPolymorphism, Single NucleotidePlant ExtractsRats, WistarInsulin, Long-ActingAutoimmune DiseasesGlycemic IndexInfusions, SubcutaneousGlucokinaseThiazolidinedionesMonitoring, AmbulatoryReference ValuesCells, CulturedInsulin LisproPatient Education as TopicAutoimmunityFructosamineDisease ProgressionHyperinsulinismDietary CarbohydratesGlucose Transporter Type 4HomeostasisAnalysis of Variance
MetabolismT2DMObesityHypertensionMetabolic SyndromeInsulin secretionManagement of diabetes mellitusPrevalence of diabetesCholesterolUptakeAdultsTriglyceridesHepatic glucose productionHemoglobinConcentrationsDiagnosisInfectionsAtherosclerosisHbA1cWorld Health OrganMmolSerumHyperlipidemiaMethodsDiastolicComplicationsLipidGlycemicClinicalEndocrinePeripheralSymptomsDiabetic nephropathyProteinIntoleranceAbstractCoronary heart dMorbidityMortalityLactate1995RiskHyperglycemicNIDDMOverweightAmino acidsFastingHyperlipoproteinemiaMyocardial infarctionCausalReduce plasma glucoseObese patientsPostprandialGestational diabetesLeptinPredictorsContinuousHyperglycemiaMedicationAutoimmuneIncidence of childhood2021UrinePancreatic
Metabolism9
  • Diabetes mellitus is a metabolic disorder characterized by hyperglycaemia and alterations in carbohydrate, lipid, and protein metabolism, associated with absolute or relative deficiencies in insulin secretion and/or insulin action [ 1 ]. (hindawi.com)
  • Several APOE isoforms with major structural differences were discovered and shown to influence the brain lipid transport, glucose metabolism, neuronal signaling, neuroinflammation, and mitochondrial function. (dovepress.com)
  • The metabolic syndrome (MetS) is a constellation of metabolic risk factors (including hypertension, dyslipidaemia, abdominal obesity and impaired glucose metabolism), which is associated with a twofold increased risk of cardiovascular disease (CVD) (Ford, 2005), and an even higher risk of T2DM (Grundy, 2008). (bhma.org)
  • The physiological and biochemical interrelationship between insulin and thyroid hormone and the influence of both insulin and iodothyronines on the metabolism of carbohydrates proteins and lipids have been extensively studied and recorded (Additional file 1 ). (springeropen.com)
  • Hyperthyroidism is also associated with raised levels of growth hormone, glucagon and catecholamine which further impair glucose metabolism (Niki et al. (springeropen.com)
  • Previous studies revealed that adiponectin played a causal role in maintaining energy homeostasis via regulation of glucose and lipid metabolism. (frontiersin.org)
  • Resistance emerges as a consequence of the inability of insulin to induce its effect on glucose metabolism. (isciii.es)
  • We included 216 type 2 diabetic patients who consulted for complications screening at the Department of Endocrinology and Metabolism in our hospital on an annual basis. (biomedcentral.com)
  • Exclusion criteria included recent acute complications such as diabetic ketoacidosis and hyperglycemic hyperosmolar state, severe and recurrent hypoglycemic events in the previous 3 months, a history of hepatic or renal impairment, or of other diseases that can influence glucose metabolism, including recent acute cerebral stroke, acute myocardial infarction, malnutrition, and cancers. (biomedcentral.com)
T2DM13
  • To assess the efficacy and safety of berberine in the treatment of type 2 diabetes mellitus (T2DM). (hindawi.com)
  • Type 2 diabetes mellitus (T2DM) is the most common form of diabetes. (hindawi.com)
  • Initial therapy for treating T2DM includes diet and exercise, followed by the use of oral hypoglycemic agents and potentially subcutaneous insulin injections [ 1 , 2 ]. (hindawi.com)
  • 3 In this review, we discuss the biological functions of human APOE and its role in Alzheimer's disease (AD), Parkinson's disease (PD), cardiovascular diseases (CVD), multiple sclerosis (MS), type 2 diabetes mellitus (T2DM), vascular dementia (VD), and ischemic (occlusive) stroke (IS). (dovepress.com)
  • We tried to identify the interaction between dietary quality indices and apolipoprotein B Ins/Del and EcoR1 polymorphisms on cardio-metabolic risk factors in patients with type 2 diabetes mellitus (T2DM). (researchsquare.com)
  • This cross-sectional study recruited 700 adults with T2DM who visited diabetes referral centers in Tehran. (researchsquare.com)
  • For the first time, our finding indicated that the association between DQI-I, HEI-2015 and DPI with IL-18, TC, leptin and 8-iso-PGF2α in patients with T2DM might be dependent on Ins/Del and EcoR1 variants in ApoB gene. (researchsquare.com)
  • Epidemiological studies reported that worldwide prevalence of diabetes mellitus (DM) was about 451 million in 2017 with most being T2DM. (researchsquare.com)
  • The present study aimed to review the use of hypoglycemic drugs and clinicopathological data in breast cancer patients with type 2 diabetes mellitus (T2DM), and to investigate the effect of metformin on the clinicopathological features of breast cancer in patient with T2DM. (wjon.org)
  • By estimate, about 15% of breast cancer patients are accompanied by type 2 diabetes mellitus (T2DM) [ 8 ]. (wjon.org)
  • A five-year follow- up study of Swedish men indicated that elevated plasma cortisol and low testosterone were prospectively associated with increased incidence of cardiovascular-related events and Type 2 Diabetes Mellitus (T2DM) (Rosmond et al, 2003). (bhma.org)
  • Despite its important clinical relevance, Patients with LADA are often misdiagnosed and show a sustained worse glycemic control compared to T2DM. (biomedcentral.com)
  • TNF-α is an important pro-inflammatory mediator that contributes to decreased expression of glucose transporter 4 (GLUT4) in adipose, skeletal, and cardiac muscle tissues leading to insulin resistance and T2DM pathogenesis [ 9 ]. (biomedcentral.com)
Obesity14
  • Cardiovascular risk factors, including hypertension, hyperlipidaemia, obesity and smoking, were studied as well as degree of blood glucose control. (who.int)
  • TonEBP dysfunction is implicated in metabolic diseases, such as atherosclerosis, rheumatoid arthritis, obesity and type 2 diabetes mellitus. (nature.com)
  • Clinical and investigational evidence suggests that the increased breast cancer risk associated with greater abdominal visceral obesity may be related to anomalous insulin signaling through the insulin receptor substrate 1 pathway, leading to insulin resistance, hyperinsulinemia, and increased concentrations of endogenous estrogen and androgen. (ijmpo.org)
  • Metabolic and Bariatric Surgery Metabolic and bariatric surgery is the surgical alteration of the stomach, intestine, or both to cause weight loss in patients with obesity-related metabolic disorders and their sequellae. (msdmanuals.com)
  • With a global epidemic in obesity, time is of the essence to make lasting improvements to patient care. (bhma.org)
  • Replacement of GH in adults with GHD markedly reduces central obesity and substantially reduces total cholesterol levels but has produced little change in other risk factors, particularly insulin resistance and dyslipidemia. (medscape.com)
  • We aimed to review the literature on the effects of training intervention on peripheral leptin level in obesity during aging, in order to evaluate the independent efficacy of this method. (plos.org)
  • Obesity is a relentlessly growing public health problem [ 1 , 2 ] in modern societies due to our increasingly sedentary lifestyle and imbalanced dietary choices. (plos.org)
  • Leptin is one of the major adipokines, its increased level indicates the severity of fat accumulation in obesity [ 12 ]. (plos.org)
  • Metabolic syndrome (MS) comprises central obesity, increased plasma glucose levels, hyperlipidemia and hypertension, and its incidence is increasing due to changes in lifestyle and dietary structure in recent years. (biomedcentral.com)
  • MS is closely related to lifestyle and central obesity, serving as a risk factor for metabolic diseases, such as type 2 diabetes and cardiovascular disease. (biomedcentral.com)
  • MS can be defined by the presence of abdominal obesity and any 2 of the following factors: increased fasting plasma glucose, increased TGs, reduced HDL cholesterol, and hypertension. (biomedcentral.com)
  • Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. (medigraphic.com)
  • Goran MI, Ball GDC, Cruz ML. Obesity and risk of type 2 diabetes and cardiovascular disease in children and adolescents. (medigraphic.com)
Hypertension9
  • A case-control study of risk factors for type 2 diabetes and hypertension was conducted from August 2007 through June 2008 at Komfo-Anokye Teaching Hospital, Kumasi, Ghana. (cdc.gov)
  • Patients attending the diabetes (n = 495) or hypertension center (n = 451) were recruited. (cdc.gov)
  • These comorbidities include type 2 diabetes, hypertension, ventilatory dysfunction, arthrosis, venous and lymphatic circulation diseases, depression, and others, which have a negative impact on health and increase morbidity and mortality. (mdpi.com)
  • 2011. Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension. (cdc.gov)
  • In addition, functional studies have shown that TonEBP is involved in the pathogenesis of rheumatoid arthritis, atherosclerosis, diabetic nephropathy, acute kidney injury, hyperlipidaemia and insulin resistance, autoimmune diseases (including type 1 diabetes mellitus and multiple sclerosis), salt-sensitive hypertension and hepatocellular carcinoma. (nature.com)
  • Ambulatory blood pressure monitoring (ABPM) is better correlated with target organ damage from hypertension (HT) than clinic blood pressure readings ( 8 , 9 ). (ispub.com)
  • Primary care providers should be alert to the importance of screening patients with hypertension for metabolic syndrome to prevent and manage these combined conditions. (who.int)
  • attributable risk for hypertension is bloodpressureisusuallymeasuredin Abdominalobesitywasdiagnosedifthe higherforwomenthanmenduetotheir thesittingpositionbytheclinicnurse waistcircumferenceexceeded102cm longerlifeexpectancyandtheriseinthe andthemeanof3readingsseparated inmalesand88cminfemales[ 1 ]. (who.int)
  • Thus, insulin concentrations are usually high early in type-2 diabetes, but have also been seen in many subjects who are not obese or diabetic, but who have other metabolic syndrome components such as hypertriglyceridemia or arterial hypertension (1). (isciii.es)
Metabolic Syndrome9
  • The study was meant to estimate the prevalence of metabolic syndrome in patients with breast cancer and to establish its role as an independent risk factor on occurrence of breast cancer. (ijmpo.org)
  • Metabolic syndrome prevalence was found in 40.0% of breast cancer patients, and 18.0% of those in control group ( P = 0.02). (ijmpo.org)
  • Metabolic syndrome is more prevalent in breast cancer patients and is an independent risk factor for breast cancer. (ijmpo.org)
  • Links are being made between low levels of testosterone and an increased risk of metabolic syndrome among men. (bhma.org)
  • While there has been a role for the administration of synthetic testosterone, a more holistic approach, whereby patients improve their diet and limit their physical inactivity,can also lead to improved health and reverse the metabolic syndrome.The holistic approach can improve compliance, adherence and lead to lasting change. (bhma.org)
  • With reduced levels of daily physical activity and diets high in refined carbohydrate, we are seeing a rise in the rate of metabolic syndrome (MetS) among men globally. (bhma.org)
  • Of 345 patients studied, 65% had metabolic syndrome. (who.int)
  • Diabetes mellitus was the most frequent component of metabolic syndrome in males, while low serum high-density lipoprotein cholesterol and high waist circumference ranked first and second in females. (who.int)
  • Previous studies revealed the potential significance of circulating adiponectin levels with respect to the diagnosis and prediction of metabolic syndrome, but uncertainty has been noted across different cohorts. (frontiersin.org)
Insulin secretion7
Management of diabetes mellitus3
  • This implies that thyroid hormones investigation can assist in proper diagnosis and management of diabetes mellitus. (springeropen.com)
  • 1993 ). Glycaemic index levels are commonly used for diagnosis and management of diabetes mellitus without due attention to the influence of thyroid hormone levels on those indices such as fasting plasma glucose (FPG), glycated haemoglobin (HbA1c) and C-peptide. (springeropen.com)
  • The objective of this study was to identify the number of people with diabetes from a diabetes DataLink developed as part of the SUPREME-DM (SUrveillance, PREvention, and ManagEment of Diabetes Mellitus) project, a consortium of 11 integrated health systems that use comprehensive EHR data for research. (cdc.gov)
Prevalence of diabetes1
Cholesterol22
Uptake5
  • It reduces hepatic glucose output, may decrease intestinal absorption of glucose, and may increase glucose uptake in peripheral tissues. (medscape.com)
  • These agents improve peripheral glucose uptake and utilization. (medscape.com)
  • Endogenous production of glucose is enhanced by insulin and thyroid hormones since both FT 3 and FT 4 stimulate GLUT4 messenger RNA and protein expression in skeletal muscle and elevate glucose uptake (Kemp et al. (springeropen.com)
  • Insulin, after binding its receptor, induces the phosphorylation of receptor substrates in the liver and muscles, and induces several steps toward the transactivation of GLUT-4, which increases glucose uptake by cells and its storage as glycogen, and inhibits the net production of glucose by the liver, thus blocking glycogenolysis and neoglycogenesis. (isciii.es)
  • When insulin is unable to induce glucose uptake, pancreatic beta-cells increase insulin production and the hyperinsulinemic state prevents hyperglycemia. (isciii.es)
Adults14
  • A case-control study of 1,466 urban adults in Ghana found that patients with type 2 diabetes mellitus had a 46% increased risk for infection with Plasmodium falciparum . (cdc.gov)
  • We describe prevalence of malaria infection in adults with and without type 2 diabetes mellitus residing in Kumasi, Ghana. (cdc.gov)
  • To investigate the relation between echocardiographic parameters and 24-hour ambulatory blood pressure monitoring (ABPM) in normoalbuminuric pre-hypertensive adults with type 1 diabetes mellitus (T1DM) without clinical evidence of nephropathy or cardiovascular autonomic neuropathy. (ispub.com)
  • We also aimed to determine the predictive strengths of both autoantibodies in the development of type-1 diabetes mellitus, and which of the two autoantibodies is a better predictive marker of type-1 diabetes mellitus among Nigerian adults. (scirp.org)
  • Although type 2 diabetes is widely diagnosed in adults, its frequency has markedly increased in the pediatric age group since the end of the 20th century. (medscape.com)
  • In general, the treatment of type 2 diabetes in children follows the same rationale as does treatment for the disease in adults. (medscape.com)
  • Among all of the noninsulin drugs currently in use to treat type 2 diabetes in adults, the US Food and Drug Administration (FDA) has approved metformin, liraglutide, and exenatide extended-release for use in children with type 2 DM. (medscape.com)
  • This pilot study evaluated the feasibility of a self-administered version of GEM, augmented with continuous glucose monitoring (CGM), to improve metabolic control (hemoglobin A 1c [HbA 1c ]) while diminishing or delaying the need for diabetes medications in adults recently diagnosed with T2D. (jmir.org)
  • ORIGINS (Oral Infections, Glucose Intolerance, and Insulin Resistance Study) enrolled 300 diabetes mellitus-free adults aged 20 to 55 years (mean=34±10 years) (78% women). (ahajournals.org)
  • The objective of this study is to explore the relationship between red blood cell distribution and islet β-cell function indexes in patients with Latent Autoimmune Diabetes in Adults. (biomedcentral.com)
  • Latent autoimmune diabetes in adults (LADA) is a kind of adult-onset autoimmune diabetes, which shows the feathers of both type 1 and type 2 diabetes mellitus[ 4 ]. (biomedcentral.com)
  • 1 The World Health Organization estimates that 1.5 billion adults worldwide are overweight and 500 million are obese. (bmj.com)
  • INTRODUCTION: This study examined national trends in age, sex, racial and ethnic, and socioeconomic inequalities for diagnosed diabetes prevalence and incidence among US adults from 2008-2021. (cdc.gov)
  • Methods and Results We included adults 20years old with a COVID-19 diagnosis from March 1, 2020 through December 31, 2021 in a retrospective cohort study from the IQVIA PharMetrics Plus insurance claims database. (cdc.gov)
Triglycerides1
Hepatic glucose production1
Hemoglobin7
  • lower hemoglobin levels decreased weight. (wikipedia.org)
  • If diabetes is present, glucose levels and glycosylated hemoglobin (HbA1c) should be normalized with treatment that meets or exceeds the guidelines of the American Diabetes Association (ADA), if possible. (medscape.com)
  • Assessing the metabolic control of the patient has traditionally been done through testing of glycosylated hemoglobin, fructosamine, and glycoalbumin along with other criteria such as Body Mass Index, microalbuminuria and dyslipidemia 6-7 . (bvsalud.org)
  • The combined effects of diabetes mellitus (DM), admission plasma glucose (APG), and glycated hemoglobin (HbA1c) levels on predicting long-term clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) are unknown. (biomedcentral.com)
  • Since 2010, glycated hemoglobin (HbA1c) has been recommended by the World Health Organization and American Diabetes Association as a point-of-care test for the diagnosis of DM (≥6.5%) [ 11 ]. (biomedcentral.com)
  • Glycated hemoglobin (HbA1c) and 1,5-anhydroglucitol increased significantly in both groups. (bmj.com)
  • We conducted a cross-sectional study in 216 type 2 diabetic patients with a hemoglobin A 1c of 8.3 ± 1.7% and a median diabetes duration of 9.0 years. (biomedcentral.com)
Concentrations7
  • Patients with triglyceride concentrations greater than 1000 mg/dL should receive diet and drug therapy and be closely monitored to prevent pancreatitis. (medscape.com)
  • In this study, effect of different concentrations of methanolic extracts of Musa sapientum sucker on plasma lipid profile were assessed in alloxan induced diabetic rats. (scialert.net)
  • Relationships between plasma lipoprotein concentrations and insulin action in an obese hyperinsulinemic population. (thieme-connect.de)
  • Activation of PPAR-gamma receptors regulates insulin-responsive gene transcription involved in glucose production, transport, and utilization, thereby reducing blood glucose concentrations and reducing hyperinsulinemia. (medscape.com)
  • Banked urine samples from 22 cases of GDM and 72 controls were analyzed for total (free BPA + conjugates) urinary BPA concentrations (g/L). FBG levels (mg/dl) were obtained from 1 h 50 g glucose tolerance tests (GTT) that women underwent for routine GDM screening (mean gestational age=26.6 weeks sd=3.8). (cdc.gov)
  • Among controls, median FBG levels (mg/dL) did not differ across exposure tertiles, defined according to the distribution of total specific-gravity adjusted urinary BPA concentrations. (cdc.gov)
  • 2006). Estradiol concentrations outside the normal range have been shown to disrupt glucose homeostasis and perhaps contribute to the risk of developing type 2 diabetes mellitus (Barros et al. (cdc.gov)
Diagnosis11
  • AST measurements are used in the diagnosis and treatment of certain types of liver and heart disease. (cdc.gov)
  • The recommendation applies to asymptomatic women with no previous diagnosis of type 1 or type 2 diabetes mellitus. (medscape.com)
  • Once the diagnosis of diabetes is established in a pregnant woman, continued testing for glycemic control and diabetic complications is indicated for the remainder of the pregnancy. (medscape.com)
  • Distinguishing between type 1 and type 2 diabetes at diagnosis is important. (medscape.com)
  • Diagnosis requires blood tests done at the time of symptoms or during a 72-hour fast. (msdmanuals.com)
  • With the improvement of diagnosis and treatment of cancer, the survival rate of breast cancer is significantly improved, but management and treatment is complicated and a difficult process for patients, because of drug-associated toxicity and safety issues, drug resistance and cost, etc. (wjon.org)
  • 2009. For these members, we searched inpatient and outpatient diagnosis codes, laboratory test results, and pharmaceutical dispensings from January 2000 through December 2009 to create indicator variables that could potentially identify a person with diabetes. (cdc.gov)
  • Harris and colleagues showed that in a sample of residents of Ontario, Canada, diabetes prevalence ranged from 5% to 12%, depending on which combinations of laboratory, pharmacy, and diagnosis data were used to verify diabetes case status (12). (cdc.gov)
  • Is bisphenol-A exposure during pregnancy associated with blood glucose levels or diagnosis of gestational diabetes? (cdc.gov)
  • This pilot study examined the association between BPA exposure, fasting blood glucose levels (FBG) and GDM diagnosis during pregnancy. (cdc.gov)
  • 30days after a COVID-19 diagnosis by diabetes status. (cdc.gov)
Infections3
  • Type 2 diabetes mellitus increases susceptibility to common infections ( 5 ). (cdc.gov)
  • In Ayurvedic medicine, the plant is described under its Sanskrit name "dalima" (fruit) as a "blood purifier" and used to cure parasitic infections, aphthae (mouth ulcers), diarrhoea, and ulcers [ 6 ]. (hindawi.com)
  • Major bacterial infections with potential serious sequel were particularly common (33.3%), among every third patient being presumed to have serious consequences. (scirp.org)
Atherosclerosis7
  • Because of the possibility of adverse effects and the question of whether the triglyceride level is an independent risk factor for atherosclerosis, many physicians use drugs to reduce the triglyceride level only when the level exceeds 500 mg/dL. (medscape.com)
  • Early atherosclerosis in obese juveniles is associated with low serum levels of adiponectin. (medigraphic.com)
  • Endothelial hyperpermeability induced by hyperglycemia is the initial step in the development of atherosclerosis, one of the most serious cardiovascular complications in diabetes. (springer.com)
  • Atherosclerosis, one of the most serious cardiovascular complications of diabetes mellitus, occurs primarily in coronary arteries, lower extremities and extracranial carotid arteries. (springer.com)
  • But there's an omega-6 fatty acid that effectively combats conditions as diverse as eczema, arthritis, atherosclerosis, and diabetes. (lifeextension.com)
  • We therefore investigated the association between glycemic variability and cervical and/or intracranial atherosclerosis in Chinese type 2 diabetic patients. (biomedcentral.com)
  • However, the exact role of glucose variability in the development of atherosclerosis remains unclear. (biomedcentral.com)
HbA1c10
  • Patients were divided into 3 groups according to DM history and APG and HbA1c levels. (biomedcentral.com)
  • HbA1c levels on admission, DM history, APG levels, history of stroke, history of coronary heart disease, and TG levels on admission were significantly associated with MACCEs through the 24-month follow-up. (biomedcentral.com)
  • The predictive effects of combining DM and APG and HbA1c levels were such that for STEMI patients undergoing pPCI, DM patients with poor glycemic control or with stress hyperglycemia on admission had worse prognosis than other patients. (biomedcentral.com)
  • an elevated HbA1c level is associated with an increased risk of cardiovascular diseases in patients with DM [ 12 ]. (biomedcentral.com)
  • DM, admission plasma glucose (APG), and HbA1c levels are associated with clinical outcomes in patients with CVD. (biomedcentral.com)
  • Nevertheless, the combined effects of DM, APG, and HbA1c on clinical outcomes in Chinese patients with STEMI undergoing pPCI remain unknown, and if the combined effects can be clearly elucidated, the management of patients with coronary heart disease (CHD) can be improved, and blood sugar control can be more accurately emphasized. (biomedcentral.com)
  • This retrospective study investigated the combined effects of DM and APG and HbA1c levels on long-term clinical outcomes in STEMI patients treated with pPCI. (biomedcentral.com)
  • Patients whose mean total daily doses of rapid-acting insulin analog were 16.6 and 17.8 units were switched to sitagliptin and mitiglinide, respectively, without a change in the HbA1c level. (bmj.com)
  • RDW were significantly associated with HbA1c in LADA patients with high GAD titers, but the correlation was not found in subgroup with low GAD titers in either unadjusted analyses or adjusted analysis. (biomedcentral.com)
  • A reduction in counts of red blood cells and levels of haemoglobin in Swedish TEDDY children with multiple islet autoantibodies has been shown, and RDW values are significantly associated with HOMA-β and HbA1c[ 9 ].However, there are currently little clinical research on the correlation between red blood cell distribution and islet β-cell function among patients with LADA. (biomedcentral.com)
World Health Organ4
  • The World Health Organization (WHO) has estimated that major burden of diabetes will occur in developing countries, and by 2025, there will be 42% increase (from 51 to 72 million) in the developed countries and 170% increase (from 84 to 228 million) in the developing countries [ 2 ]. (hindawi.com)
  • Using the World Health Organization (WHO) criteria from 1999 to define GDM, we have previously reported a diabetes incidence of 6 % 1-2 years after delivery (Anderberg et al. (springeropen.com)
  • The diagnostic criteria for GDM used in the present study were a modification of those recommended by the WHO in 1999, defining GDM as the joint category of diabetes and impaired glucose tolerance (IGT) based on the 2-h capillary plasma glucose concentration (World Health Organization 1999 ). (springeropen.com)
  • Type 2 diabetes was diagnosed according to 1999 World Health Organization (WHO) criteria [ 9 ]. (biomedcentral.com)
Mmol2
Serum9
  • The antiendomysial antibody test is a histological assay for patient serum binding to esophageal tissue from primate. (wikipedia.org)
  • Elevated total serum calcium levels are associated with idiopathic hypercalcemia, vitamin D intoxication, hyperparathyroidism, sarcoidosis, pneumocystic carinii pneumonia, and blue diaper syndrome. (cdc.gov)
  • Furthermore, in crude but not in adjusted model there were close to meaningful interactions between EcoR1 SNP and DQI-I on total antioxidant capacity (TAC) (P=0.06) and between EcoR1 SNP and HEI-2015 on serum leptin (P=0.05) and superoxide dismutase (SOD) (p=0.05) levels. (researchsquare.com)
  • Fructosamine reflects the glycemic control over the previous 1-2 weeks and has been correlated positively with serum albumin and serum total protein5. (bvsalud.org)
  • Training intervention leads to a decrease in leptin level of middle-aged or older, overweight or obese male and female groups, even without major weight loss, indicated by unchanged serum adiponectin levels. (plos.org)
  • Manipulation of the gut microbiota through the administration of prebiotics or probiotics may assist in weight loss and reduce plasma glucose and serum lipid levels, decreasing the incidence of cardiovascular diseases and type 2 diabetes mellitus. (biomedcentral.com)
  • To evaluate this assumption, we investigated the effects of aerobic exercise training (AET), resistance exercise training (RET), and 4 weeks of de-training on serum leptin and TNF-α levels in diabetic rats. (biomedcentral.com)
  • Serum insulin, leptin, and TNF-α levels were assessed by commercial ELISA kits. (biomedcentral.com)
  • These findings indicate that both AET and RET are useful in reducing levels of serum adipocytokines (TNF-α, leptin) in diabetic and non-diabetic rats. (biomedcentral.com)
Hyperlipidemia2
  • Patients first should be treated for the metabolic condition that is causing or exacerbating their hyperlipidemia. (medscape.com)
  • Patients with growth hormone deficiency (GHD) typically have hyperlipidemia, increased body fat, premature atherosclerotic plaques, delayed bone maturation, and impaired cardiac function. (medscape.com)
Methods3
  • Methods: 32 children with type 1 diabetes mellitus formed the study group (DC) and 32 non-diabetic children formed the control group (ND). (bvsalud.org)
  • Methods 60 patients with type 2 diabetes were enrolled and randomized to switch from mealtime dosing of a rapid-acting insulin analog to either sitagliptin or mitiglinide for 16 weeks. (bmj.com)
  • However, implementation of standardized methods for creating multisite diabetes registries and validating their accuracy is largely untried. (cdc.gov)
Diastolic1
  • There were no differences between the dipper and the nondipper T1DM pre-hypertensive patients with respect to age, gender, body mass index, clinical and ABPM for average day-time systolic and diastolic blood pressure levels. (ispub.com)
Complications6
  • Evidence from many multicenter trials has demonstrated that the above pharmaceuticals are able to lower blood glucose and to reduce the risk of developing diabetic complications. (hindawi.com)
  • Vascular complications are responsible for the excess mortality associated with diabetes ( 1 ), and impaired endothelium-dependent vasodilation has been described in humans and in animal models of the disease ( 2 - 6 ). (diabetesjournals.org)
  • We also address the potential role of vitamin D deficiency in the development of macro- and microvascular complications in diabetes. (vitamindwiki.com)
  • Data from a 12-week clinical study in patients with type 2 diabetes indicate that supplementation with NutriTRALA (1200 mg per day, divided doses as add-on therapy with other anti-hyperglycemic medications) results in a significant reduction of plasma fructosamine, along with a trend towards reduced C-peptide, an indication of increased insulin sensitivity.3,4 Complications of diabetes and decreased insulin sensitivity may be the result of oxidative stress. (nutrimedical.com)
  • Overexpression of VEGF was found in the progression of nephritic and ophthalmic complications in diabetes (Kim et al. (springer.com)
  • Macrovascular diseases such as coronary artery disease and cerebrovascular disease are major complications of type 2 diabetes. (biomedcentral.com)
Lipid5
  • [ 49 ] However, patients treated with lipid-lowering medications should be carefully monitored for the development of myositis or liver disease. (medscape.com)
  • APOE plays multiple roles in the regulation of lipid and lipoprotein levels in the blood. (dovepress.com)
  • Alterations in plasma lipid profiles are common occurrences in diabetes. (scialert.net)
  • The result of the study indicates that Musa sapientum sucker extract was effective in improving plasma lipid profile associated with cardiovascular risk factors in alloxan induced diabetic rats. (scialert.net)
  • In this study the effects of methanolic extract of Musa sapientum sucker on plasma lipid profile changes in alloxan induced diabetic rats was investigated with a view to finding its possible effects on cardiovascular disease induced by hyperglycemia. (scialert.net)
Glycemic12
  • Long term diabetes and poor glycemic control are the most important risk factors for DN development ( DCCT Research Group, 1993 ). (scialert.net)
  • Kooy et al found improved body weight, glycemic control, and insulin requirements when metformin was added to insulin in type 2 diabetes mellitus. (medscape.com)
  • Moreover, the role of vitamin D supplementation in the prevention of both types of diabetes is analysed together with its role in improving glycemic control in diabetic patients. (vitamindwiki.com)
  • Glycemic excursion minimization (GEM) is an alternative lifestyle treatment option focused on reducing postnutrient glucose excursions rather than reducing weight. (jmir.org)
  • Significant improvement of glycemic control in diabetic patients with HCV infection responding to direct‐acting antiviral agents. (ac.ir)
  • DM patients with poor glycemic control or stress hyperglycemia on admission experienced the highest rates of all-cause deaths, MACCEs, and cardiac deaths. (biomedcentral.com)
  • Strict control of glycemic status may improve the survival of patients who have both DM and coronary heart diseases. (biomedcentral.com)
  • Conclusions Sitagliptin may predominantly act on FPG, whereas mitiglinide may act on postprandial plasma glucose to achieve glycemic control after switching from a bolus insulin regimen. (bmj.com)
  • Additional therapy to sitagliptin or mitiglinide is clearly required to obtain equivalent glycemic control in patients using a higher dose of insulin. (bmj.com)
  • The standard deviation of blood glucose values (SDBG) and the mean amplitude of glycemic excursion (MAGE) were calculated from continuous glucose monitoring system data for assessing glycemic variability while 24h mean blood glucose (MBG) was calculated for measuring overall blood glucose level. (biomedcentral.com)
  • Meanwhile, several lines of evidence have raised the possibility that glycemic variability, which includes both upward and downward acute glucose changes, is another important component of dysglycemia [ 3 ]. (biomedcentral.com)
  • With the emergence of continuous glucose monitoring (CGM) technology, the assessment of glycemic variability is now much less cumbersome. (biomedcentral.com)
Clinical16
  • The patients' clinical and biochemical signs and symptoms were secondary objectives (I. Danquah et al. (cdc.gov)
  • [ 1 , 2 ] A study by Stuebe et al found this condition to be associated with persistent metabolic dysfunction in women at 3 years after delivery, separate from other clinical risk factors. (medscape.com)
  • While proponents of the Palaeolithic diet claim that it is evidence-based, there are only a limited number of controlled clinical trials comparing the Palaeolithic diet to accepted diets such as the diabetic or Mediterranean diets (Table 1). (racgp.org.au)
  • A helpful practical classification is based on clinical status: whether hypoglycemia occurs in patients who appear healthy or ill. (msdmanuals.com)
  • However, there were no differences in the parameters of age, duration of diabetes, body mass index, tumor size, histological grade of cancer and clinical pathological features between the two groups. (wjon.org)
  • Therefore, the clinician and the clinical researcher must examine published data critically and must educate individual patients and their families about the risk-benefit ratio of rhGH therapy for them. (medscape.com)
  • Therefore, we evaluated their combined effects on long-term clinical outcomes in STEMI patients treated with pPCI. (biomedcentral.com)
  • Diabetes mellitus (DM) has long been recognized as an independent risk factor for cardiovascular disease (CVD) and is also an independent predictor of adverse clinical outcomes after PCI [ 5 , 6 ]. (biomedcentral.com)
  • However, the clinical characterization of these patients in the primary care setting is lacking, and its clinical progression is unpredictable. (biomedcentral.com)
  • The infection rate in elderly patients with DKA was high and majority of them had lack of clinical evidence. (scirp.org)
  • Meta-analyses of clinical trials on non-pharmacological strategies for weight reduction have reported 1-6 kg losses that have been difficult to maintain. (bmj.com)
  • Thyroid disease and diabetes mellitus are common endocrine disorders encountered in clinical practice. (springeropen.com)
  • 2011 ). The aim of the present study was to identify risk factors associated with diabetes development up to 5 years after pregnancy and to explore the possibility of establishing a model for diabetes prediction that could be used in clinical practice on an individual basis when counseling women after GDM. (springeropen.com)
  • For many years, diabetes registries have been used to assess and enhance clinical care provided by health systems (1). (cdc.gov)
  • The more recent availability of detailed clinical data, including real-time laboratory test results, has improved the ability to build more sophisticated and accurate diabetes registries that capture more precisely defined cohorts of people with diabetes. (cdc.gov)
  • A standardized method for identifying people with diabetes from the detailed clinical information available in electronic health records (EHRs), applied across multiple health systems, would be a powerful tool for conducting comparative effectiveness research, monitoring trends, analyzing geographic variation, and conducting surveillance of prediabetes and diabetes. (cdc.gov)
Endocrine2
  • Several epidemiological studies have linked diabetes mellitus and exposure to endocrine active compounds such as dioxin (Cranmer et al. (cdc.gov)
  • The endocrine system consists of endocrine glands that produce and secrete hormones into the blood stream to reach and act on target cells of specific organs. (medscape.com)
Peripheral3
  • APOE is an integral component of chylomicrons, VLDL, and HDL in the peripheral system ( Table 1 ). (dovepress.com)
  • These agents stimulate peripheral use of glucose as stimulated by insulin. (medscape.com)
  • 1997 ). Hypothyroidism has been recognized as insulin-resistant state due to impaired insulin-stimulated glucose utilization in peripheral tissues. (springeropen.com)
Symptoms9
  • Irrespective of symptoms, malaria parasites were counted per 500 leukocytes on Giemsa-stained thick blood films. (cdc.gov)
  • Studies have shown that oral ingestion of MSG can provoke asthma attacks in patients diagnosed with asthma, and bring about symptoms of the Chinese Restaurant Syndrome (CRS). (ubc.ca)
  • Clinically, patients often report depressive symptoms, stress and disruptive social lives. (bvsalud.org)
  • It is assumed that such culture has created a state of mind where chronic pain patients are often victim of stereotype caused by the disparity between expressed symptoms and levels of perceived disability (Tait, 2004). (bvsalud.org)
  • It may be started at a high dose in patients with severe hyperglycemia and in those with symptoms, if home glucose monitoring and close follow-up can be arranged. (medscape.com)
  • These primary objectives were hypothesized to be achieved by reducing carbohydrate intake and increasing physical activity to diminish CGM glucose excursions, leading to the secondary benefits of an increase in diabetes empowerment and reduced diabetes distress, depressive symptoms, and BMI. (jmir.org)
  • 140 mg/dL, diabetes distress, depressive symptoms, and BMI. (jmir.org)
  • With such symptoms, clinicians can often over[1]look testosterone and focus on more common causes such as diabetes, depression or medication side-effects. (bhma.org)
  • Human magnesium deficiency (including conditions which show few overt symptoms) is relatively common, with only 32% of the United States meeting the RDA-DRI,[1] and has been implicated in the development of a number of human illnesses such as asthma, osteoporosis, and ADHD. (spagyricarts.com)
Diabetic nephropathy1
  • These SNPs are associated with increased risk of type 2 diabetes mellitus, diabetic nephropathy, inflammation, high blood pressure and abnormal plasma osmolality, indicating that variation in TONEBP expression might contribute to these phenotypes. (nature.com)
Protein5
  • These T-helper cells then stimulate B-cells to multiply and mature into plasma cells that make IgA and IgG to that protein. (wikipedia.org)
  • 2 In the blood, APOE protein could interact with lipids, resulting in lipoproteins, including very-low-density lipoproteins (VLDL). (dovepress.com)
  • IAA and ICA levels were estimated using ELISA reagents from Biomerica Inc. Other parameters such as fasting blood sugar, urine glucose, and urine protein were assessed using standard biochemical techniques. (scirp.org)
  • Endocrinologists were excited by a discovery in the 1980s of an antibody to a 65-kd protein that was strongly associated with adult-onset diabetes mellitus and stiff person syndrome. (medscape.com)
  • They were disappointed to find that the 65-kd protein was GAD, an enzyme largely found in the central nervous system (CNS), and, unfortunately, the pathophysiologic link between diabetes and glutamic acid decarboxylase remains unclear. (medscape.com)
Intolerance1
Abstract1
  • ABSTRACT To determine frequency of cardiovascular risk factors in Saudi and non-Saudi diabetics, we studied patients attending King Abdulaziz University Hospital for follow-up in the period January 1997 to December 2001. (who.int)
Coronary heart d1
  • In managing secondary dyslipidemia, consider statin therapy for all patients, as these agents reduce mortality and coronary heart disease/atherosclerotic cardiovascular disease (CHD/ASCVD) endpoints. (medscape.com)
Morbidity3
Mortality7
  • Ischemic heart disease threatens global health and leads to increasing mortality worldwide [ 1 ]. (biomedcentral.com)
  • Hyperglycemia on admission has been associated with major adverse cardiovascular events (MACEs) and increased mortality in patients admitted with AMI. (biomedcentral.com)
  • It has also been associated with higher in-hospital and long-term mortality in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary PCI (pPCI) [ 7 , 8 , 9 , 10 ]. (biomedcentral.com)
  • 6 7 8 Meta-analyses have found that bariatric surgery reduces long term mortality in obese patients, 9 10 but the safety risks and the costs of this intervention limit the use for large patient populations. (bmj.com)
  • In recent decades, cancer mortality attributable to tobacco smoking has increased in the elderly, while stroke mortality attributable to high blood pressure has declined. (who.int)
  • Conclusions: Tobacco smoking and high blood pressure are the two major risk factors for adult mortality from non- communicable diseases and injuries in Japan. (who.int)
  • the results could mortality, accounting for 63% and 9%, respectively, of 57 million inform policymakers of which risk factors need to be prioritized in deaths in 2008 [1]. (who.int)
Lactate3
  • Ingested glutamate is absorbed through the intestines, where it is transaminated and subsequently, metabolized by the liver leading to the release of glucose, glutamine, lactate, and other amino acids into the blood circulation. (ubc.ca)
  • Recommended types include magnesium citrate, magnesium gluconate, and magnesium lactate, all of which are more easily absorbed into the body than other forms such as magnesium oxide. (spagyricarts.com)
  • Endurance exercise induced fatigue factors such as a decrease in blood glucose, an increase in blood lactate, and the depletion of muscle glycogen, but those parameters recovered to basal levels within 6 h after exercise. (frontiersin.org)
19951
Risk27
  • Increase in diabetes mellitus prevalence may put more persons at risk for malaria infection. (cdc.gov)
  • Childhood (male) type 1 diabetes (T1D) increases the risk for CD and vice versa and the early signs of celiac disease may precede T1D in many cases. (wikipedia.org)
  • García-Bailo B, Da Costa LA, Arora P, Karmali M, El-Sohemy A, Badawi A. Plasma Vitamin D and Biomarkers of Cardiometabolic Disease Risk in Adult Canadians, 2007-2009. (cdc.gov)
  • We aim in our work to study the prevalence risk factors and degree of blood glucose of CVD risk factors in diabetics in two dif- control. (who.int)
  • The study tion was used to study the correlation of group comprised 1155 diabetic patients, all different cardiovascular risk factors to age. (who.int)
  • 1998. The use of hematological effects in the development of minimal risk levels. (cdc.gov)
  • Evidence is available that high normal or pre hypertensive blood pressure is associated with an adverse risk profile and an increased risk of cardiovascular events. (ispub.com)
  • Infants of mothers with preexisting diabetes mellitus experience double the risk of serious injury at birth, triple the likelihood of cesarean delivery, and quadruple the incidence of newborn intensive care unit (NICU) admission. (medscape.com)
  • Alternatively, for high-risk women or in areas in which the prevalence of insulin resistance is 5% or higher (eg, the southwestern and southeastern United States), a 1-step approach can be used by proceeding directly to the 100-g, 3-hour OGTT. (medscape.com)
  • Women with prediabetes identified before pregnancy should be considered at extremely high risk for developing gestational diabetes mellitus during pregnancy. (medscape.com)
  • Aim: We demonstrated the risk of developing islet autoantibodies-Insulin Autoantibodies (IAAs) and Islets cell Autoantibodies (ICAs)-in type-1 diabetic relatives and newly diagnosed type-1 patients compared to non-diabetic controls. (scirp.org)
  • Conclusion: The present study indicated a greater risk of autoimmune destruction of the insulin producing beta cells of the pancrease of the type-1 relatives and newly diagnosed type-1 patients and suggests the need for periodic recruitment of individuals in the general population, siblings and relatives of type-1 diabetic patients for planned intervention trials. (scirp.org)
  • There is no evidence that in patients with a normal kidney function metformin use is associated with an increased risk of lactic acidosis (Inzucchi, 2014). (richtlijnendatabase.nl)
  • In patients with impaired kidney function, metformin levels increase if the dose of metformin is not reduced, potentially increasing the risk of lactic acidosis. (richtlijnendatabase.nl)
  • GPs should caution patients who are on the Palaeolithic diet about adequate calcium intake, especially those at higher risk of osteoporosis. (racgp.org.au)
  • Following the online publication of a meta-analysis, the Food and Drug Administration on May 21, 2007, issued an alert to patients and health care professionals stating that rosiglitazone can potentially cause an increased risk of myocardial infarction and heart-related deaths. (medscape.com)
  • Longitudinal changes in risk variables of insulin resistance syndrome from childhood to young adulthood in offspring of parents with type 2 diabetes: the Bogalusa Heart Study. (medigraphic.com)
  • We hypothesized that increased abundance of nitrate‐reducing oral bacteria would be associated with lower levels of cardiometabolic risk cross‐sectionally. (ahajournals.org)
  • A common risk factor in diabetes is insulin resistance caused by high-fat diet (HFD) in obese people [ 7 ]. (biomedcentral.com)
  • The risk of developing diabetes escalates with the degree of excess body weight, increasing threefold with a body mass index of 25.0 to 29.9, and 20-fold with an index of 35 and higher compared with a healthy index of 18.5-24.9. (bmj.com)
  • Cross-sectional and case-cohort studies support a role for hepatitis C as a factor implied in the development of type-2 diabetes in high-risk patients (male patients, older than 40 years, and overweight). (isciii.es)
  • A prediction model based on these variables resulting in 86 % correct classifications, with an area under the receiver-operating characteristic curve of 0.91 (95 % CI 0.86-0.95), was applied in a function-sheet line diagram illustrating the individual effect of weight on diabetes risk. (springeropen.com)
  • The results highlight the importance of BMI as a potentially modifiable risk factor for diabetes after GDM. (springeropen.com)
  • 2014 ). GDM is an important risk factor for type-2 diabetes and cardiovascular disease (Bellamy et al. (springeropen.com)
  • Recent epidemiological studies indicate bisphenol-A (BPA), an estrogenic chemical used in production of epoxy, polycarbonate and plastic may increase risk of insulin resistance and type 2 diabetes. (cdc.gov)
  • Background Growing evidence suggests incident cardiovascular disease (CVD) may be a long-term outcome of COVID-19 infection, and chronic diseases, such as diabetes, may influence CVD risk associated with COVID-19. (cdc.gov)
  • women, 95% CI: 1.2-1.7) if exposures to multiple cardiovascular risk factors had been reduced to their optimal levels as determined by a theoretical-minimum-risk exposure distribution. (who.int)
Hyperglycemic2
  • Although all diabetic cells are exposed to elevated levels of plasma glucose, hyperglycemic damage is limited to those cell types that are unable to down regulate glucose transport into the cell (e.g., endothelial cells), leading to intra-cellular hyperglycemia ( Brownlee, 2001 ). (scialert.net)
  • Kitabchi, A.E. and Nyenwi, E.A. (2006) Hyperglycemic crisis in diabetes mellitus: Diabetes ketoacidosis and hyperglycemic hyperosmolar state. (scirp.org)
NIDDM1
  • The two broad categories of DM are designated as type1 (IDDM) and type 2 (NIDDM). (bvsalud.org)
Overweight3
  • Empirical research papers were eligible provided that they reported data of middle-aged or older (above 45 years of age) overweight or obese (body mass index above 25) individuals and included physical training intervention or at least fitness status of groups together with corresponding blood leptin values. (plos.org)
  • Objective To determine whether treatment with agonists of glucagon-like peptide-1 receptor (GLP-1R) result in weight loss in overweight or obese patients with or without type 2 diabetes mellitus. (bmj.com)
  • Conclusions The present review provides evidence that treatment with GLP-1R agonists leads to weight loss in overweight or obese patients with or without type 2 diabetes mellitus. (bmj.com)
Amino acids1
Fasting8
Hyperlipoproteinemia1
  • This review will summarize the updated research progress on APOE functions and its role in Alzheimer's disease, Parkinson's disease, cardiovascular diseases, multiple sclerosis, type 2 diabetes mellitus, Type III hyperlipoproteinemia, vascular dementia, and ischemic stroke. (dovepress.com)
Myocardial infarction2
  • Elevated levels of the transaminases can indicate myocardial infarction, hepatic disease, muscular dystrophy, or organ damage. (cdc.gov)
  • Genetic Variations in the Vitamin D Receptor Predict Type 2 diabetes and Myocardial Infarction in a Community-Based Population: The Tromsø Study. (vitamindwiki.com)
Causal2
  • Vitamin D and diabetes mellitus: Causal or casual association? (vitamindwiki.com)
  • However, case-reports of lactic acidosis in patients taking metformin indicate that lactic acidosis in most cases is unrelated to plasma metformin levels, challenging the concept of a causal relation between metformin use and the occurrence of lactic acidosis (Inzucchi, 2014). (richtlijnendatabase.nl)
Reduce plasma glucose1
  • Normally, in patients with acute pancreatitis secondary to severe hypertriglyceridemia, triglyceride levels rapidly decrease, often by 1000 mg/dL each day when treated with standard medical therapy: nothing by mouth (NPO), intravenous (IV) hydration, and if needed, parenteral insulin to reduce plasma glucose levels. (medscape.com)
Obese patients1
  • It is a major drug used in obese patients with type 2 diabetes. (medscape.com)
Postprandial1
  • These agents lower postprandial glucose by slowing glucose absorption and delaying the hydrolysis of ingested complex carbohydrates and disaccharide. (medscape.com)
Gestational diabetes5
Leptin2
  • Furthermore, insulin (Pitteloug et al, 2005) and leptin (Isidori et al,1999) have a suppressive impact on testicular steroidogenesis (Stamler et al, 1976). (bhma.org)
  • Resistance training appears to be more efficient in reducing blood leptin level than aerobic training alone. (plos.org)
Predictors2
  • In addition, IAAs appeared to be better predictors or markers of type-1 diabetes mellitus compared to ICAs. (scirp.org)
  • Slovis, C.M., Mork, V.G., Slovis, R.J. and Bain, R.P. (1987) Diabetes ketoacidosis and infection: Leukocyte count and differential as early predictors of serious infection. (scirp.org)
Continuous4
  • Berlin G, Brodin B, Hilden J. 1985.Acute dapsone intoxication: a case treated with continuous infusion of methylene blue, forced diuresis, and plasma exchange. (cdc.gov)
  • Adjusting insulin doses in patients with type 1 diabetes who use insulin pump and continuous glucose monitoring: Variations among countries and physicians. (ac.ir)
  • Few disagree that many patients with childhood-onset GHD require continuous GH replacement therapy into adulthood. (medscape.com)
  • Using this information, we estimated the number of people with diabetes and among them, the number of incident cases, defined as indication of diabetes after at least 2 years of continuous health system enrollment. (cdc.gov)
Hyperglycemia1
  • Diabetes mellitus (DM) comprises a group of common metabolic disorders that share the salient feature of hyperglycemia. (bvsalud.org)
Medication4
  • Patients must be closely monitored, and a triglyceride-lowering medication should be instituted, if necessary. (medscape.com)
  • Because of adverse gastrointestinal (GI) effects from metformin, titrate the drug slowly and have patients take the medication during (rather than before) meals. (medscape.com)
  • 6.5%), and only one participant started taking diabetes medication. (jmir.org)
  • A self-administered version of GEM may provide primary care physicians and patients with a new tool to help people recently diagnosed with T2D achieve remission independent of medication and without weight loss as the primary focus. (jmir.org)
Autoimmune3
  • At the onset of type 1 diabetes, many autoantibodies are detected as autoimmune markers. (scirp.org)
  • It is a heterogeneous form of diabetes with a pathogenesis that includes both autoimmune destruction of pancreatic beta cells as well as some degrees of insulin resistance [ 5 ]. (biomedcentral.com)
  • 15,16 The results can be a profound reduction in the impact of inflammation on cardiovascular disease, lung function, autoimmune conditions, and metabolic abnormalities including diabetes. (lifeextension.com)
Incidence of childhood2
20212
  • We enrolled 487 patients with diagnosed LADA at The Central Hospital of Wuhan from January 2018 to December 2021. (biomedcentral.com)
  • CONCLUSIONS: From 2008-2021, age, sex, racial and ethnic, and education inequalities in the incidence of diagnosed diabetes improved but persisted. (cdc.gov)
Urine2
  • On the day of examination, participants were asked about medical history and socioeconomic background, underwent physical examination, and provided venous blood and urine samples for laboratory testing. (cdc.gov)
  • Low levels are associated with hyperthyroidism, and with the rare condition of idiopathic hypophosphatasia associated with rickets and the excretion of excess phosphatidyl ethanolamine in the urine. (cdc.gov)
Pancreatic1
  • Vitamin D may have a role in the pathogenic mechanisms predisposing to type 2 diabetes by modulating insulin resistance and/or pancreatic ß-cell function. (vitamindwiki.com)