Metabolic Clearance RateAndrostanes17-KetosteroidsIodine IsotopesHalf-LifeBlood GlucoseInsulinInfusions, ParenteralInjections, IntravenousGlucose Clamp TechniqueTritiumInfusions, IntravenousRadioimmunoassayLiverGlucoseTestosteroneKineticsDogsGlucagonCarbon IsotopesGrowth HormoneTime FactorsInsulin ResistancePlasmaPregnancyMicrosomes, LiverMucociliary ClearanceKidneyPharmaceutical PreparationsGlucuronidesHepatocytesAldehyde OxidaseTechnetium Tc 99m PentetateBiotransformationCytochrome P-450 Enzyme SystemGlucuronatesCytochrome P-450 CYP3ADealkylationArea Under CurveAntipyrineDrug InteractionsTissue DistributionChromatography, High Pressure LiquidPharmacokineticsThyroxineFatty Acids, NonesterifiedRats, Sprague-DawleyModels, BiologicalAdministration, OralC-PeptideDose-Response Relationship, DrugMononuclear Phagocyte SystemRats, Inbred StrainsMidazolamHydrocortisoneBiological AvailabilityReference ValuesHormonesIodine RadioisotopesGlucuronosyltransferaseCytochrome P-450 CYP2D6Plasma CellsHydroxylationKetoconazole