• (Brown, 2017) Psilocin is regarded as a prototypic classical psychedelic, and thus the main psychoactive effects of psilocin are due to binding to the 5-HT2A and 5-HT2C serotonin receptor subtypes, where it acts with high specificity as a partial agonist. (researchgate.net)
  • Other alkaloids possess psychotropic (e.g. psilocin) and stimulant activities (e.g. cocaine, caffeine, nicotine, theobromine), and have been used in entheogenic rituals or as recreational drugs. (wikipedia.org)
  • The stimulation of the 5-HT2A receptor is understood to be predominantly responsible for the characteristic psychoactive effects of 'changes in perception, visual patterns and discrete images, euphoria, distorted sense of time, synesthesia, emotional lability, and sometimes mystical or spiritual experiences' (Brown, et al. (researchgate.net)
  • This group also includes some related compounds with neutral and even weakly acidic properties. (wikipedia.org)
  • A rather heterogeneous group, these compounds have different chemical structures, different mechanisms of action, and different adverse effects. (medscape.com)
  • Independent researchers from England, Japan and Switzerland determined that it is these substances that cause the toxic and hallucinogenic effects, not muscarine. (agfonds.lv)
  • The present study aims to develop a forensic toxicological library to identify 56 natural toxic substances by liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (LC-QTOF-MS/MS). (springermedizin.de)
  • For setting up the library of product ion spectra, individual substances (31 plant toxins, 7 mushroom toxins, 5 marine toxins, 5 frog venoms, 4 mycotoxins, and 4 substances derived from plants) were analyzed by LC-QTOF-MS/MS with positive and negative ionization. (springermedizin.de)
  • This library will be more effective for the screening of natural toxic substances in routine forensic toxicological analysis. (springermedizin.de)
  • To our knowledge, there are no reports dealing with development of library for natural toxic substances by LC-QTOF-MS/MS. (springermedizin.de)
  • In other words, when it comes to mixing psychoactive substances, the sum is more often than not different from the sum of its parts. (qualiacomputing.com)
  • Other alkaloids possess psychotropic (e.g. psilocin) and stimulant activities (e.g. cocaine, caffeine, nicotine, theobromine), and have been used in entheogenic rituals or as recreational drugs. (wikipedia.org)
  • His defence was that he had been entranced, or presumably drugged, by a bunch of males who had planted the cocaine on him earlier than he boarded the airplane. (rmt-racing.com)
  • According to various sources, the lethal dose of muscarine is 5-15 kg of fresh red fly agaric caps. (agfonds.lv)
  • Consequently, fly-agaric (whether it is thought-about in any respect) is regarded solely as a harmful and probably toxic 'drug', fairly than a path to the divine. (rmt-racing.com)
  • Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. (wikipedia.org)
  • Alkaloids are produced by a large variety of organisms including bacteria, fungi, plants, and animals. (wikipedia.org)
  • Although alkaloids act on a diversity of metabolic systems in humans and other animals, they almost uniformly evoke a bitter taste. (wikipedia.org)
  • Alkaloid-containing plants have been used by humans since ancient times for therapeutic and recreational purposes. (wikipedia.org)
  • Natural compounds containing nitrogen in the exocyclic position (mescaline, serotonin, dopamine, etc.) are usually classified as amines rather than as alkaloids. (wikipedia.org)
  • For example, while 5-MeO-DMT is relatively safe when vaporized (save for egregiously negligent uses of the drug and the occasional drowning in one's own vomit), taking 5-MeO-DMT orally in combination with an MAOI leads to extremely toxic reactions, such as severe hypertensive symptoms, overheating, and serotonin syndrome . (qualiacomputing.com)
  • LSD is the most potent psychoactive drug, with doses as low as 1-1.5 mcg/kg capable of producing psychedelic effects. (medscape.com)
  • Muscarine was discovered way back in 1869, for a long time it was considered the hallucinogenic component of red fly myrrh. (agfonds.lv)
  • When drying the caps of the red fly myrtle, muscarine remains in them, but they are then used 2-3 caps at a time, the amount of muscarine that enters the body is so small that it is completely hidden by the effect of hallucinogenic ingredients. (agfonds.lv)
  • Ibotenic acid is a chemical compound found in the fruiting bodies of various fly myrrhs. (agfonds.lv)
  • A significant contribution to the chemistry of alkaloids in the early years of its development was made by the French researchers Pierre Joseph Pelletier and Joseph Bienaimé Caventou, who discovered quinine (1820) and strychnine (1818). (wikipedia.org)
  • The development of the chemistry of alkaloids was accelerated by the emergence of spectroscopic and chromatographic methods in the 20th century, so that by 2008 more than 12,000 alkaloids had been identified. (wikipedia.org)