AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth CareGeographicals
SimvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsPlacebo EffectDouble-Blind MethodAnticholesteremic AgentsLovastatinAzetidinesHypolipidemic AgentsHeptanoic AcidsHypercholesterolemiaCross-Over StudiesTreatment OutcomePravastatinPyrrolesDrug Therapy, CombinationMevalonic AcidFluorobenzenesCholesterol, LDLCholesterolDose-Response Relationship, DrugAdministration, OralLipidsPolyisoprenyl PhosphatesNiacinTime FactorsRhabdomyolysisDrug InteractionsDrug Administration ScheduleAnti-Inflammatory AgentsRandomized Controlled Trials as TopicRandom AllocationDrug CombinationsOregonUbiquinoneMannosidase Deficiency DiseasesAntioxidantsLysosomesAdenosine TriphosphateCarbamoyl-Phosphate Synthase I Deficiency Disease
LovastatinAtorvastatinStatins20,536 high-riskScandinavian SimvaEzetimibeMyocardial infarctionAneurysmal subarachnoid hemorrhageRandomised placebo-controlled trialMortalityInhibitorsCholesterolIncidenceRosuvastatinPatientsLipidParticipantsTrialsTherapyRandomized contrCardiovascularDiabetesAcuteDailyMechanismDouble-blindGroupAdultReductionTreatmentDistinguishStudiesOralStudyMuscleLiverPreventionReducesGroupsRiskInfluenzaCasesGrowth
Lovastatin5
Atorvastatin3
  • Effects of atorvastatin on fasting and postprandial lipoprotein subclasses in coronary heart disease patients versus control subjects. (koreamed.org)
  • For the purpose of the study, researchers looked at 135 previously conducted trials, including 250,000 people taking statin drugs such as Atorvastatin (Lipitor), simvastatin and pravastatin. (themedguru.com)
  • Moreover, this association was consistently seen regardless of the duration of therapy and particularly in subjects taking simvastatin, atorvastatin, or rosuvastatin. (vitad.org)
Statins6
  • Like other members of its class (the "statins"), simvastatin lowers total serum cholesterol and particularly low density lipoprotein (LDL) cholesterol concentrations, thereby reducing the risk of atherosclerosis and its complications - myocardial infarction and stroke. (nih.gov)
  • Exposure was current use of different combinations of statins, aspirin, β blockers, and angiotensin converting enzyme inhibitors before death in cases, or the equivalent date in controls. (bmj.com)
  • Randomised controlled trials have shown that statins improve the survival of patients with ischaemic heart disease. (bmj.com)
  • The active ingredient Simvastatin , which belongs to the class of "statins", blocks or inhibits the production of more cholesterol by the liver. (pharmacily.com)
  • Numerous randomized controlled trials have found that statins reduce myocardial infarction (MI), ischemic stroke , and vascular mortality, starting with the Scandinavian Simvastatin Survival Study. (medscape.com)
  • Although such symptoms have been attributed to statins, double-blind, placebo-controlled, randomized trials (which can assess causality) [ 9 ] do not bear this out. (medscape.com)
20,536 high-risk2
  • The effects of cholesterol lowering with simvastatin on cause-specific mortality and on cancer incidence in 20,536 high-risk people: a randomised placebo-controlled trial [ISRCTN48489393]. (ox.ac.uk)
  • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. (ox.ac.uk)
Scandinavian Simva2
Ezetimibe5
Myocardial infarction1
  • Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial. (ox.ac.uk)
Aneurysmal subarachnoid hemorrhage1
  • High-dose simvastatin for aneurysmal subarachnoid hemorrhage: multicenter randomized controlled double-blinded clinical trial. (druglib.com)
Randomised placebo-controlled trial1
  • Simvastatin for cognitive deficits and behavioural problems in patients with neurofibromatosis type 1 (NF1-SIMCODA): a randomised, placebo-controlled trial. (bsl.nl)
Mortality2
  • Mortality and delayed cerebral ischemia rates were also similar compared with placebo. (thejns.org)
  • Moreover, among the many different types of high-risk individual studied, simvastatin 40 mg daily consistently produced substantial reductions in vascular (and, hence, all-cause) mortality, as well as in the rates of non-fatal heart attacks, strokes and revascularisation procedures. (ox.ac.uk)
Inhibitors2
  • Use of simvastatin is contraindicated in medications that are strong inhibitors of cytochrome P450 activity (such as cyclosporine, ketoconazole, diltiazem, ciprofloxacin or amiodarone), and dose adjustments are appropriate for its use with other agents that inhibit CYP 3A4. (nih.gov)
  • high cholesterol tablets simvastatin inhibitors such as certain drugs, but insulinsion and calcium intake may increase oxidation. (sainttammany.org)
Cholesterol12
  • Simvastatin is a commonly used cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. (nih.gov)
  • Simvastatin (sim" va stat' in) is an orally available inhibitor of hepatic 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the major rate-limiting enzyme in cholesterol synthesis. (nih.gov)
  • Comparisons between all simvastatin-allocated versus all placebo-allocated participants (ie, "intention-to-treat") involved an average difference in blood total cholesterol concentration of 1.2 mmol/L (46 mg/dL) during the scheduled 5-year treatment period. (ox.ac.uk)
  • as the treatment of heart rate, the involves the US reviewed Control of PHT and PA-offairement in morning and data high cholesterol tablets simvastatin. (sainttammany.org)
  • high cholesterol tablets simvastatin ages that can also reduce the risk of heart attack or stroke in the condition, heart attacks, blood pressure medication and both of the endothelial function of blood pressure medications. (sainttammany.org)
  • Chronic kidney disease is the firster and prevention of diabetes and hypothyroidism high cholesterol tablets simvastatin . (sainttammany.org)
  • high cholesterol tablets simvastatin Choose can occurred in patients with the risk of successful warfarin, and high blood pressure high cholesterol tablets simvastatin . (sainttammany.org)
  • high cholesterol tablets simvastatin They are designed to magnesium that prevent organizations such as a low-rich foods. (sainttammany.org)
  • complications of the drug classification of proportion of a comparison of the entire dose, and especially in the men high cholesterol tablets simvastatin. (sainttammany.org)
  • Lipidnorm_co is used in patients who cannot control cholesterol levels by diet alone. (pharmacily.com)
  • High blood cholesterol, which is not adequately controlled with statin drugs alone. (pharmacily.com)
  • A meta-analysis of randomized controlled trials including 170,000 participants found that participants on statin therapy had a 22% reduction in risk, per every 1-mmol/L (39 mg/dL) reduction in low-density lipoprotein cholesterol (LDL-C), for major vascular events ( coronary heart disease , ischemic stroke, and revascularization procedures) compared with those on placebo or standard therapy. (medscape.com)
Incidence1
  • A recent meta-analysis described the incidence of melanoma in 12 qualifying randomized controlled statin trials, with a total of 39,426 participants. (biomedcentral.com)
Rosuvastatin1
  • Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomized, double-blind, placebo-controlled trial. (thehealthyskeptic.org)
Patients17
  • To estimate the group size, a pilot study was conducted for measuring the serum cardiac troponin T (cTnT) at 6 h after surgery in 10 patients who received statin and placebo treatment (ratio 1 : 1). (hindawi.com)
  • Patients provided written informed consent and were randomly divided into 2 groups (65 in the simvastatin group and 65 in the control group) by assigning random numbers from a random number table. (hindawi.com)
  • Patients in the simvastatin group took simvastatin 20 mg orally daily during two perioperative periods: from the 7th to the 5th preoperative day and from the 2nd day after decannulation until the 7th postoperative day. (hindawi.com)
  • Current indications for simvastatin are hypercholesterolemia and reduction in risk for death from coronary, cerebrovascular and peripheral artery disease in patients with these diseases. (nih.gov)
  • Up to 5% of patients taking simvastatin chronically may experience minor elevations in serum ALT levels during therapy, but confirmed elevations to above three times the upper limit of normal (ULN) occur in only 1% to 2% of patients. (nih.gov)
  • ALT elevations are clearly more frequent in patients taking higher doses of simvastatin (40 and 80 mg daily). (nih.gov)
  • In several studies, ALT elevations were no more frequent in patients taking 10 and 20 mg of simvastatin daily than in placebo recipients. (nih.gov)
  • Controls were patients with ischaemic heart disease who were matched for age, sex, and year of diagnosis and were alive at the time their matched case died. (bmj.com)
  • Patients with radiologically confirmed aSAH, aged 18 to 70 years, who presented to the hospital within 96 hours of ictus were randomly allocated to receive 5 mg of oral glibenclamide for 21 days or placebo, in a modified intention-to-treat analysis. (thejns.org)
  • A total of 78 patients were randomized and allocated to glibenclamide (n = 38) or placebo (n = 40). (thejns.org)
  • Simvastatin as an adjuvant therapy to fluoxetine in patients with moderate to severe major depression: A double-blind placebo-controlled trial. (druglib.com)
  • We aimed to investigate the antidepressant effects of simvastatin as an adjuvant therapy in patients with moderate to severe depression. (druglib.com)
  • Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. (druglib.com)
  • Controlled oxygen delivery (0.5-2.0 L/min) is indicated for hypoxaemia in patients with exacerbations. (copdx.org.au)
  • Doody et al (2013) conducted a double-blind, placebocontrolled trial in which 1,537 patients with probable AD underwent randomization to receive 100 mg of semagacestat, 140 mg of semagacestat, or placebo daily. (kipdf.com)
  • Vitamin D-deficient T2DM patients aged 25-50 years performed moderate intensity aerobic exercise for 12 weeks and were randomized to receive simvastatin 40 mg daily plus vitamin D 60 000 units once weekly, or vitamin D 60 000 units once weekly. (vitad.org)
  • however, in the vast majority of cases, patients cannot distinguish between a statin and a placebo under double-blind conditions, demonstrating that these symptoms are usually not pharmacologically related (see the next point). (medscape.com)
Lipid2
  • Simvastatin is available generic forms and under the commercial name of Zocor in tablets of 5, 10, 20, 40 and 80 mg. the recommended dose is 5 to 80 mg daily based upon tolerability and lipid levels. (nih.gov)
  • ZOCOR (simvastatin) is a lipid-lowering agent that is derived synthetically from a fermentation product of Aspergillus terreus . (druglib.com)
Participants2
  • They reported that a total of 127 melanomas occurred, 59 among the 19,872 statin group participants and 68 among the 19,554 control group participants. (biomedcentral.com)
  • Observational studies that use a case-positive, control test-negative study design (in which all participants present with illness, and case/control status is assigned on the basis of influenza testing) might be less subject to frailty bias ( 108 ). (cdc.gov)
Trials4
  • The analysis included 55 two-armed placebo-controlled and 80 two- or multiarmed active-comparator trials. (themedguru.com)
  • Where there were no randomized controlled trials or specific U.S. FDA labeling for issues in clinical practice, the participating clinical experts utilized their judgment and experience. (adldpk.org)
  • Estimates of vaccine efficacy (i.e., prevention of illness among vaccinated persons enrolled in controlled clinical trials) and vaccine effectiveness (i.e., prevention of illness in vaccinated populations) of influenza vaccines depend on many factors, including the age and immunocompetence of the vaccine recipient, the degree of similarity between the viruses in the vaccine and those in circulation, study design, diagnostic testing measures, and the outcome being measured. (cdc.gov)
  • Randomized controlled trials that measure LCI virus infections (by viral culture or reverse transcription polymerase chain reaction [RT-PCR]) as the outcome provide the best and most persuasive evidence of vaccine efficacy, but such data are not available for all populations. (cdc.gov)
Therapy4
  • Isolated cases of an autoimmune hepatitis-like syndrome associated with simvastatin therapy have been reported, some of which did not reverse completely with discontinuation, resulting in a chronic hepatitis requiring long term immunosuppressive therapy. (nih.gov)
  • Four out of six controlled studies showed a superior efficacy of a combination therapy over mono therapy. (thieme-connect.com)
  • The primary outcomes were cardiorespiratory fitness (peak oxygen consumption) and skeletal muscle mitochondrial content (citrate synthase activity in the vastus lateralis) following simvastatin and/or vitamin D replacement therapy. (vitad.org)
  • 0.05) following 12 weeks of simvastatin therapy. (vitad.org)
Randomized contr2
  • The present clinical randomized controlled trial explored the protective effect of perioperative simvastatin on cardiac muscle after CPB and the relationship of such effects to cardiomyocyte autophagy. (hindawi.com)
  • Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: a randomized controlled trial. (bsl.nl)
Cardiovascular1
  • Riesgo coronario atribuible a los factores de riesgo cardiovascular en población española. (guiasalud.es)
Diabetes4
  • METHODS: 20,536 UK adults (aged 40-80 years) with vascular disease or diabetes were randomly allocated to receive 40 mg simvastatin daily or matching placebo. (ox.ac.uk)
  • Longer diabetes duration and poorer glycemic and blood pressure control are strongly associated with DR. These data highlight the substantial worldwide public health burden of DR and the importance of modifiable risk factors in its occurrence. (cdc.gov)
  • The aim of the present study was to determine the effect of vitamin D supplementation on simvastatin-mediated changes in cardiorespiratory fitness and skeletal muscle mitochondrial content after exercise in adults with type 2 diabetes mellitus (T2DM). (vitad.org)
  • Unfortunately, normal aging is associated with a progressive increase in A1C, and there can be a significant discordance between glucose-based and A1C-based diagnosis of diabetes in this age group, a difference that is accentuated by race and gender (2) (see Monitoring Glycemic Control chapter, p. (diabetes.ca)
Acute2
  • Rare cases of acute liver failure and death have been attributed to simvastatin. (nih.gov)
  • Simvastatin in the acute respiratory distress syndrome. (druglib.com)
Daily1
  • Methods: MFS was performed on the buccal aspect of the left side of the mandible (BL) in 20 male CF1 Musdomesticus mice divided into two groups with the same number of animals: the experimental group was treated once daily with raloxifene injections (3 mg/kg), and the placebo group was treated with daily injections of the vehicle. (bvsalud.org)
Mechanism1
  • To investigate the effect and mechanism of simvastatin on myocardial injury in cardiac valve surgery with CPB. (hindawi.com)
Double-blind2
  • The effect of vitamin-mineral supplementation on juvenile delinquency among American schoolchildren: a randomized, double-blind placebo-controlled trial. (personalpowertraining.net)
  • Vitamin D supplementation improves simvastatin-mediated decline in exercise performance: A randomized double-blind placebo-controlled study. (vitad.org)
Group1
  • Similarly, skeletal muscle mitochondrial content decreased by 3.6% with simvastatin, but improved by 12.1% on supplementation with vitamin D, although the between-group difference was not significant. (vitad.org)
Adult1
  • He could not be controlled by smaller/older adult family members. (epiphanyasd.com)
Reduction1
  • Lung cancer incidences rates in statin users were found to be significantly reduced (55% risk reduction) in the Veterans Affairs (VA) Health Care System case control study [ 5 ]. (biomedcentral.com)
Treatment1
  • Only four of the treatment studies followed a randomized controlled design. (thieme-connect.com)
Distinguish1
  • [ 69 ] Default mode network (DMN) imaging appears to distinguish AD, MCI, and controls well, and it may complement positron emission tomography (PET) scanning or prove to be more sensitive. (medscape.com)
Studies3
  • However, few studies have revealed the effects of perioperative oral simvastatin on post-CPB changes in cardiac muscle autophagy or the influence of the degree of autophagy on postoperative cardiac function and prognosis [ 8 , 9 ]. (hindawi.com)
  • A 2012 simulation study found that for each percentage point decrease in diagnostic test specificity for influenza virus infection, vaccine effectiveness would be underestimated by approximately 4% in classic case-control studies ( 109 ). (cdc.gov)
  • In a simulation study which evaluated the effects of different values of influenza diagnostic test sensitivity and specificity on vaccine effectiveness estimates from cohort, classic case-control, and test-negative designs, it was concluded that misclassification resulted in slightly more biased VE estimates for test-negative studies than for other designs. (cdc.gov)
Oral1
  • After oral ingestion, simvastatin, which is an inactive lactone, is hydrolyzed to the corresponding β-hydroxyacid form. (druglib.com)
Study1
  • Design Open prospective cohort study with nested case-control analysis. (bmj.com)
Muscle2
  • Coadministration with these agents may cause increases in simvastatin levels and potentiate its hepatic or muscle toxicity. (nih.gov)
  • Simvastatin tends to cause deterioration in exercise-associated cardiorespiratory fitness and skeletal muscle mitochondrial content in adults with T2DM, which is blunted by vitamin D supplementation. (vitad.org)
Liver3
  • Clinically apparent liver injury due to simvastatin is rare. (nih.gov)
  • But in view of the wide use of simvastatin, clinically apparent liver injury is exceeding rare and is estimated to occur in 1 per 100,000 patient years of exposure. (nih.gov)
  • Simvastatin is metabolized to some extent in the liver (via CYP 3A4) and is excreted in bile. (nih.gov)
Prevention3
  • Centers for Disease Control and Prevention. (cdc.gov)
  • Read Carefully before Using The Public Health Service Act (Section 308 (d)) provides that the data collected by the National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention (CDC), may be used only for the purpose of health statistical reporting and analysis. (cdc.gov)
  • The NAMCS is a national probability sample survey conducted by the Division of Health Care Statistics, National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention (CDC). (cdc.gov)
Reduces1
  • 728. Selective impairment of the cerebellar C1 module involved in rat hind limb control reduces step-dependent modulation of cutaneous reflexes. (neuro.nl)
Groups1
  • No statistically significant difference was observed between the experimental and the placebo groups. (bvsalud.org)
Risk1
  • Main outcome measures Odds ratio with 95% confidence interval for risk of death in cases compared with controls. (bmj.com)
Influenza1
  • 2% and greater than placebo) are: upper respiratory tract infection, diarrhea, arthralgia, sinusitis, pain in extremity, fatigue, and influenza. (pharmacily.com)
Cases3
Growth1
  • Chondrocytes within the growth plate drive bone growth by following a highly controlled growth program governed by many molecules produced locally (such as FGFR3 and C-type natriuretic peptide (CNP)) and elsewhere in the body (such as hormones like growth hormone (GH) (3). (treatingachondroplasia.com)