• 1990
  • Partington MD, Davis DH (1990) Radiation-induced meningioma after treatment for pituitary adenoma: case report and literature review. (springer.com)
  • Familial
  • Additionally, a large variety of other known genetic disorders have been found to influence the development of gigantism such as multiple endocrine neoplasia type 1 and 4, McCune-Albright syndrome, Carney complex, familial isolated pituitary adenoma, X-linked acrogigantism (X-LAG). (wikipedia.org)
  • deficiency in adults
  • Growth hormone (GH) deficiency in adults is difficult to identify, because its manifestations are subtle and nonspecific. (psychiatryadvisor.com)
  • A 2004 clinical review of growth hormone deficiency in adults highlights the plausibility of this argument by citing studies potentially linking GHD to the following: elevated CRP, LDL and coagulation factor levels, increased abdominal obesity, increased insulin resistance, increased prevalence of structural and functional heart disease and increased rates of endothelial cell and large artery dysfunction. (knowcancer.com)
  • prepubertal
  • Subgroup analysis revealed a significant difference in the pituitary height between groups in the prepubertal (8-10 years) and pubertal (11-13 years) periods ( P =0.039 and P =0.006, respectively) and a trend toward significance in the postpubertal period ( P =0.053). (springer.com)
  • expression
  • Verónica Palmira Filippa, Gabriela Judith Rosales, Albana Andrea Marina Cruceño, and Fabian Heber Mohamed, "Androgen Receptors Expression in Pituitary of Male Viscacha in relation to Growth and Reproductive Cycle," International Journal of Endocrinology , vol. 2015, Article ID 168047, 11 pages, 2015. (hindawi.com)
  • receptors
  • This mutation (V617F), a change of valine to phenylalanine at the 617 position, appears to render hematopoietic cells more sensitive to growth factors such as erythropoietin and thrombopoietin, because the receptors for these growth factors require JAK2 for signal transduction. (wikipedia.org)
  • patients
  • Biochemical growth hormone deficiency is prevalent among human immunodeficiency virus-infected patients, but if this condition is clinically relevant remains challenging. (unimore.it)
  • The aim is to prospectively compare the growth hormone deficiency/insulin-like growth factor-1 status of 71 human immunodeficiency virus-infected patients with impaired growth hormone response to growth hormone releasing hormone + Arginine with that of 65 hypopituitary patients affected by a true growth hormone deficiency secondary to pituitary disease. (unimore.it)
  • In all the patients total body fat was associated with both growth hormone peak and area under the curve at stepwise linear regression analysis. (unimore.it)
  • The degree of growth hormone deficiency is more severe in hypopituitary than in human immunodeficiency virus-infected patients, suggesting that the function of growth hormone/insulin-like growth factor-1 axis is partially rescued in the latter thanks to a preserved pituitary secretory reserve. (unimore.it)
  • We will divide the patients into two groups: growth hormone deficient and growth hormone sufficient. (knowcancer.com)
  • In addition, from each group we will identify patients with additional pituitary deficiencies in the hope of comparing patients with either isolated GHD or patients with multiple endocrinopathies to similar matched controls. (knowcancer.com)
  • Magnetic resonance imaging (MRI) is used for neuroradiologic evaluation of patients with idiopathic growth hormone deficiency (IGHD). (springer.com)
  • To compare pituitary height and morphology at MRI between patients with IGHD and controls. (springer.com)
  • Pituitary height was significantly smaller in patients with IGHD than in controls during prepuberty and puberty. (springer.com)
  • Zimmermann A, Schenk J-P, Grigorescu Sido P et al (2007) MRI findings and genotype analysis in patients with childhood onset growth hormone deficiency-correlation with severity of hypopituitarism. (springer.com)
  • Triulzi F, Scotti G, di Natale B et al (1994) Evidence of a congenital midline brain anomaly in pituitary dwarfs: a magnetic resonance imaging study in 101 patients. (springer.com)
  • In recent years in the United States, some doctors have started to prescribe growth hormone in GH-deficient older patients (but not on healthy people) to increase vitality. (wikipedia.org)
  • The specific age of onset for gigantism varies between patients and gender, but the common age that excessive growth symptoms start to appear has been found to be around 13 years. (wikipedia.org)
  • receptor
  • This is the same for GH receptor genes which have been known to drive overall growth throughout various pathways. (wikipedia.org)
  • primarily
  • Lastly, the work presented in chapter 3 provides evidence that pituitary Gths, primarily Lh, are differentially expressed in coho salmon exposed to WWTP effluents, likely due to presence of estrogenic chemicals. (washington.edu)
  • GH release in the pituitary is primarily determined by the balance of these two peptides, which in turn is affected by many physiological stimulators (e.g., exercise, nutrition, sleep) and inhibitors (e.g., free fatty acids) of GH secretion. (wikipedia.org)
  • species
  • In teleost fish as in other vertebrate species, the pituitary gonadotropins, follicle-stimulating hormone (Fsh) and luteinizing hormone (Lh), are fundamentally involved in regulating physiological processes critical to the production of a fertilizable egg, including steroidogenesis, folliculogenesis, vitellogenesis, final oocyte maturation, and ovulation. (washington.edu)
  • Genes
  • The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation, an arrangement thought to have evolved by a series of gene duplications. (wikipedia.org)
  • puberty
  • The study described in the first chapter demonstrates that of estrogen differentially regulates Fsh and Lh in female coho salmon during the transition from late primary to early secondary oocyte growth, which corresponds to the onset of puberty in fish. (washington.edu)
  • Deficiency in somatotrope secretion before puberty or before the end of new bone tissue growth, can lead to pituitary dwarfism. (wikipedia.org)
  • stages
  • More broadly, GH and IGF have both been identified to be involved most stages of growth: embryonic, prenatal, and postnatal. (wikipedia.org)
  • despite
  • Despite the importance of pituitary gonadotropins (Gths) in regulating fish reproduction, the complex network of factors regulating Gth synthesis and release in fishes is still not fully understood. (washington.edu)