• mechanism of act
  • The primary objective of this systematic survey is to evaluate the clinical outcomes as well as the scientific literature relating to the pharmacology, pharmacokinetics/pharmacodynamics, mechanism of action, dosing, toxicology and adverse effects of marketed and investigational drugs. (springer.com)
  • compounds related to various chemical classes and groups with alternate chemical structure, piracetam-like mechanism of action and ability to facilitate learning process and improve memory. (bodyhunter.cc)
  • To say that the mechanism of action of NDRIs is understood is a gross misrepresentation of the literature. (brainmeta.com)
  • the mechanism of action most often cited in research is potentiating NMDA receptors through protein kinase C, as opposed to through agonism of NMDA receptors [7, (onnootropics.com)
  • The other mechanism of action cited is Nefiracetams ability to potentiate activity of nicotinic acetylcholine receptors, leading to greater release of GABA and glutamate neurotransmitters . (onnootropics.com)
  • compounds
  • As a specific feature of piracetam and other similar compounds, beneficial effects on cognition are usually associated with impaired brain function such as aging, hypoxia, glucose deprivation, injuries, or even neurodegeneration. (frontiersin.org)
  • what if there was a combination of compounds--comprised of both full-opiate agonists and dopamine elevating agents--that have been clinically studied for over 50 years with a strong track record of safety? (ironmagazineforums.com)
  • cortical
  • PIRACETAM is indicated for patients suffering from myoclonus of cortical origin, irrespective of aetiology, and should be used in combination with other anti-myoclonic therapies. (pharm4all.org)
  • Pharmacologically there exist protective effects with regard to several noxes [harmful agents] and an impact on the associative cortical sphere and on hippocampal structures, which are related with learning and memory, especially when the respective functions are impaired. (smart-drugs.net)
  • 1 ) Piracetam "is one of the best available drugs for treating myoclonus [severe muscle spasms] of cortical origin. (smart-drugs.net)
  • improves
  • Piracetam is a nootropic agent i.e. a psychotropic drug which improves directly the efficiency of the higher epencephalic functions of the brain involved in cognitive processes such as those related to learning, memory, thought and consciousness, both in normal and deficient situations, without being sedative of psycho stimulant. (pharm4all.org)
  • Piracetam exerts those various activities by different ways of action: it modulates brain neurotransmission, promotes metabolic conditions for neuronal plasticity & improves microcirculation through antispasmodic & haemorrheological properties, without being a vasodilator. (pharm4all.org)
  • Different nootropic drugs act on the body in different ways: some directly affect nerve cell (having a direct effect on it), some - improves cerebral blood flow, having anti-hypoxic effects, causing the body to better dispose of oxygen (i.e. have an indirect effect on the brain). (crazybulkmagic.com)
  • we proposed that by restoring age-related membrane alterations piracetam improves brain function and finally cognition. (frontiersin.org)
  • acute
  • 8 ) Piracetam has restored various functions (use of limbs, speech, EEC, slate of consciousness) in people suffering from acute and chronic cerebral ischemia (decreased brain blood flow). (smart-drugs.net)
  • analogues
  • Designer drugs are structural or functional analogues of controlled substances that are designed to mimic the pharmacological effects of the parent drug while avoiding detection or classification as illegal. (wikipedia.org)
  • Some designer drugs (research chemicals) are structural analogues of psychoactive tryptamines or phenethylamines but there are many other chemically unrelated psychoactive substances that can be considered part of the designer drug group. (wikipedia.org)
  • chronic
  • In this publication the author reviews the most important studies, where significant effects of piracetam (chronic or single-dose treatment) were verified by means of electrophysiological methods. (brainmeta.com)
  • stimulants
  • However, in opposition to the histaminergic action of Provigil, it often relates to the amphetamine group of stimulants due to its effect on norepinephrine levels and dopamine. (buyantinarcoleptic.com)
  • Antidepressants Mood stabilizers Psychostimulants Nootropic drugs CNS stimulants (Abstract). (slideserve.com)
  • The most commonly used class of drug is stimulants, such as caffeine. (wikipedia.org)
  • drugs
  • There is an increasing interest in nootropic drugs for the treatment of CNS disorders. (springer.com)
  • The World Anti-Doping Agency added Provigil to the list of forbidden drugs in sport and declared Provigil as doping agent because of its ability to significantly increase the endurance and effects similar to the action of amphetamine and also due to increase in the number of athletes implicated in the use of Provigil in the international competitions. (buyantinarcoleptic.com)
  • There are a number of various nootropic drugs out there and all of them work in various ways. (onnootropics.com)
  • Full-opiate agonists provide extremely powerful effects when used as solo agents, but what about when they are combined with dopamine elevating drugs? (ironmagazineforums.com)
  • Although many kinds of drugs are capable of such action, dissociatives are unique in that they do so in such a way that they produce hallucinogenic effects, which may include sensory deprivation, dissociation, hallucinations, and dream-like states or trances. (wikipedia.org)
  • neuroprotective
  • Although piracetam exhibited no long-term benefits for the treatment of mild cognitive impairments, recent studies demonstrated its neuroprotective effect when used during coronary bypass surgery. (springer.com)
  • It is a modern drug with neuroprotective effect. (crazybulkmagic.com)
  • disorders
  • The amount of thyroid hormone secreted by breast milk during lactation (even during the treatment with high doses of the drug), is insufficient to cause any disorders in children. (liothyronine-sodium-profile.co.uk)
  • Due to the effect of piracetam on platelet aggregation, caution is recommended in patients with underlying disorders of haemostasis, major surgery or severe haemorrhage. (pharm4all.org)
  • stroke
  • The drug is also prescribed after a stroke. (crazybulkmagic.com)
  • The drug is extensively applied in the therapy of ischaemic stroke, aphasy as well as of dementias of several origins and age-depending cognitive disturbances. (brainmeta.com)
  • 6,7) Piracetam has improved recovery from aphasia (speech impairment) after stroke. (smart-drugs.net)
  • placebo
  • $$ APIR\% = \frac{{(Bt - Tx)}} {{Bt}} \times 100 $$ where Bp and Bt are placebo and test agent baselines, respectively, P is placebo and Tx is the test agent, to estimate the percentage improvement rates. (springer.com)
  • blood flow
  • It also increases blood flow and activity in the area of the brain known for this action, the association cortex. (examine.com)
  • years
  • What If I told you this safe, natural substance has been a prescription memory drug in Europe for over 20 years, but much to the chagrin of the FDA, it can now be sold in the U.S. as a dietary supplement. (targetednutrients.com)
  • dopamine
  • Some, which are nonselective in action and affect the dopamine and/or opioid systems, may be capable of inducing euphoria. (wikipedia.org)
  • memory
  • 8 , 12 ) Piracetam increased memory and verbal learning in dyslexic children, as well as speed and accuracy of reading, writing and spelling. (smart-drugs.net)
  • 17) Elderly outpatients suffering from "age-associated memory impairment" given Piracetam showed significant improvement in memory consolidation and recall. (smart-drugs.net)
  • 8 ) Piracetam reversed typical EEC slowing associated with "normal" and pathological human aging, increasing alpha and beta (fast) electroencephalograph activity and reducing delta and theta (slow) electroencephalograph activity, while simultaneously increasing vigilance, attention and memory. (smart-drugs.net)