• Leaflet
  • if you are taking certain medicines (called anticoagulants) to avoid an excess of blood clotting (see also "Other medicines and Piperacillin/Tazobactam" in this leaflet) or any unexpected bleeding occurs during the treatment. (drugs.com)
  • enzyme
  • Piperacillin will inhibit the action of enzyme which cross link the peptide chain that affect the peptidoglycan cell wall backbone. (medicalrealm.net)
  • Piperacillin will be ineffective against streptococci ( mutation of transpeptidase enzyme lead to impair beta lactam binding) and ineffective against staphylococci ( due to beta lactamase). (medicalrealm.net)
  • concentrations
  • It has been shown that the bactericidal actions of the drug do not increase with concentrations of piperacillin higher than 4-6 x MIC, which means that the drug is concentration-independent in terms of its actions. (wikipedia.org)
  • activity
  • When used alone, piperacillin lacks strong activity against the gram-positive pathogens such as Staphylococcus aureus, as the beta-lactam ring is hydrolyzed by the bacteria's beta-lactamase. (wikipedia.org)
  • Piperacillin has instead shown to offer higher bactericidal activity when its concentration remains above the MIC for longer periods of time (50% time>MIC showing the highest activity). (wikipedia.org)