HyperpigmentationSegmental Pigmentation DisorderOverview of Pigmentation DisordersVitiligoOculocutaneous albinismHuman pigmentationMelanomaAcanthosisPigmentary DisordersMelanocytesMelanin productionOral MucosaMelasmaSegPDEtiologyPhysiologicAbnormalBipolar DisorderBrownishSystemicUnevenTreatmentsRegulationMutantsAlbinismClinicalUltravioletLentiginesExposed to sunlightFrecklesSymptomsAmalgamUnderproductionPatchesDarkerAcneSunlightAutosomalGenetic DisordersAutism spectrumAffectsDermatologistMucousRelatively commonDermatologicalUnusual
Hyperpigmentation6
- Background There is little published information about segmental hypo- and hyperpigmentation pigmentation disorder (SegPD) although it is a relatively common problem in paediatric dermatology. (medscape.com)
- We propose reviving the term 'segmental pigmentation disorder' coined by Metzker and colleagues to describe children with segmental and block-like hypo-/hyperpigmentation with midline demarcation. (medscape.com)
- Skin pigmentation disorders including hyperpigmentation and albinism. (nih.gov)
- Drug-induced pigmentation and/or hyperpigmentation may be caused by numerous drugs through a number of differing mechanisms. (logicalimages.com)
- A common form of pigmentation is hyperpigmentation, when the body produces too much melatonin. (ag3derm.com)
- Sir, Acanthosis nigricans (AN) is a skin disorder characterised by skin hyperpigmentation and thickening. (e-ijd.org)
Segmental Pigmentation Disorder6
- Segmental Pigmentation Disorder: Clinical Manifestations and Epidemiological Features in 144 patients, a Retrospective Case-control Study. (nih.gov)
- [ 1 ] introduced the term 'segmental pigmentation disorder' (SegPD) when reporting on a case series of 30 children accrued over a 4-year period. (medscape.com)
- Cite this: Segmental Pigmentation Disorder - Medscape - Jun 01, 2010. (medscape.com)
- Segmental Pigmentation Disorder (SegPD) is an uncommon skin condition affecting young children. (pedraresearch.org)
- Segmental Pigmentation Disorder consists of white and brown pigmented birthmarks that appear as large patches on the body. (pedraresearch.org)
- The underlying cause of Segmental Pigmentation Disorder is not known, but it suspected to be due to genetic changes in these different areas of skin color, in the way that the skin cells produce pigment. (pedraresearch.org)
Overview of Pigmentation Disorders1
- Overview of Pigmentation Disorders Melanin is the brownish pigment responsible for the color of skin, hair, and the iris of the eyes. (merckmanuals.com)
Vitiligo8
- Vitiligo is an acquired depigmenting skin disorder in which pigment is lost from the skin in patches. (arlingtonvaderm.com)
- He told the talk show host that he had vitiligo, a disorder that destroyed his skin pigmentation. (cnn.com)
- A family of compounds derived from black pepper extract have shown potential in animal studies to be effective in treating vitiligo, a skin pigmentation disorder. (sciencedaily.com)
- Vitiligo is a disorder associated with pigmentation of the skin. (diethealthclub.com)
- Vitiligo is an auto immune disorder. (diethealthclub.com)
- Individuals with vitiligo-suffering parents are more prone to the disorder. (diethealthclub.com)
- Nonsegmental vitiligo is a skin disorder characterized by a loss of pigmentation, or color, of the skin, mucosa, and hair. (nursingcenter.com)
- Vitiligo is an acquired disorder of pigmentation characterized by depigmented or hypopigmented macules caused by loss of epidermal melanocytes. (e-ijd.org)
Oculocutaneous albinism3
- Oculocutaneous albinism (OCA) is a clearly defined set of seven types of genetic mutations which reduce or completely prevent the synthesis of eumelanin or pheomelanin , resulting in reduced pigmentation. (wikipedia.org)
- Hermansky-Pudlak syndrome (HPS) consists of a group of genetically heterogeneous disorders which share the clinical findings of oculocutaneous albinism, a platelet storage pool deficiency, and some degree of ceroid lipofuscinosis. (nih.gov)
- Sharma's award will support research of oculocutaneous albinism (OCA), a group of genetic disorders that affect production of the skin pigment melanin. (nih.gov)
Human pigmentation1
- A polymorphism in the agouti signaling protein gene is associated with human pigmentation. (nature.com)
Melanoma2
- Patients with oral melanoma often recall having a previous pigmentation in the same area months to years before the melanoma diagnosis, and the condition may even have elicited a prior comment from physicians or dentists. (medscape.com)
- The four major mechanisms leading to increased oral pigmentation are discussed in detail: physiologic pigmentation, systemic diseases (eg, Peutz-Jeghers syndrome [PJS]), oral mucosal insults (eg, amalgam tattoo), and neoplastic processes (eg, melanoma). (medscape.com)
Acanthosis1
- People who have a disorder called acanthosis nigricans develop darkened and thickened skin in the underarms, on the nape of the neck, and in skinfolds. (merckmanuals.com)
Pigmentary Disorders1
- Shining Light on Autophagy in Skin Pigmentation and Pigmentary Disorders. (nih.gov)
Melanocytes4
- Physiologic pigmentation, also known as racial or ethnic pigmentation, is an increased production of melanin pigment by melanocytes in dark-skinned individuals. (medscape.com)
- [ 5 ] The pigmentation is due to an increased melanocytic activity rather than an increase in the number of melanocytes. (medscape.com)
- Melanocytes are the cells that produce pigmentation in the skin. (sciencedaily.com)
- Melanocytes or the pigment-making cells are destroyed in this disorder. (diethealthclub.com)
Melanin production1
- This uneven melanin production results in spots of pigmentation known as freckles. (merckmanuals.com)
Oral Mucosa3
- Buchner A. Amalgam tattoo (amalgam pigmentation) of the oral mucosa: clinical manifestations, diagnosis and treatment. (medscape.com)
- Black and Brown: Non-neoplastic Pigmentation of the Oral Mucosa. (medscape.com)
- Tripe palms along with pigmentation over her genital and oral mucosa were seen [Figure 3] . (e-ijd.org)
Melasma2
- The smallest amount of UV exposure may cause melasma to recur after fading which explains why the pigmentation of melasma worsens in summer. (fairfieldderm.com)
- Melasma - this is a pigmentation problem which often appears during pregnancy as a result of hormonal changes in the body. (thelasertreatmentclinic.com)
SegPD1
- To define the spectrum of this disorder more accurately, we retrospectively reviewed the records of 39 children with SegPD. (medscape.com)
Etiology1
- Early biopsy of focal pigmentations of undetermined etiology is extremely important in order to detect oral melanomas at an early stage. (medscape.com)
Physiologic1
- Lambertini M, Patrizi A, Ravaioli GM, Dika E. Oral pigmentation in physiologic conditions, post-inflammatory affections and systemic diseases. (medscape.com)
Abnormal1
- Abnormal skin growths and abnormal pigmentation of the skin may be present at birth or develop later in life. (childrensnational.org)
Bipolar Disorder2
- When your roommate has bipolar disorder, there are things to consider. (healthyplace.com)
- When your roommate has bipolar disorder -- or any other mental illness -- they may, unwittingly, be responsible for taking care of you and managing their own reactions to your symptoms ( Effects of Bipolar Disorder on Family and Friends ). (healthyplace.com)
Brownish1
- Increased melanin most often produces a brownish pigmentation in the dermis. (logicalimages.com)
Systemic3
- No association with systemic disorders, such as neurological involvement, was found. (medscape.com)
- [ 7 ] The tendency to develop pigmentation appears to be genetically determined, but color intensity might be influenced by smoking, hormones, systemic medications, and physical factors. (medscape.com)
- Systemic Lupus Erythematosus (SLE) Systemic lupus erythematosus is a chronic autoimmune inflammatory connective tissue disorder that can involve joints, kidneys, skin, mucous membranes, and blood vessel walls. (merckmanuals.com)
Uneven1
- One of the main causes of uneven skin tone is pigmentation disorders, where your skin produces too much or not enough melanin. (cetaphil.com)
Treatments2
- I suffer from post inflammation pigmentation from adult acne for several years and literally have tried a whole variety of topical treatments, prescriptive, lasers etc. (thelasertreatmentclinic.com)
- Before you invest in more expensive treatments for pigmentation disorders, it may be useful to try these home remedies first to see if they can treat the problem. (ag3derm.com)
Regulation1
- Skin pigmentation process and its regulation. (nih.gov)
Mutants2
- Pigmentation mutants in various species are highly informative about basic genetic and developmental pathways, and provide important clues to the processes of photoprotection, cancer predisposition and even human evolution. (nature.com)
- Mutants were analyzed for pigmentation defects and retinal disease by histology, immunohistochemistry, and transmission electron microscopy.Phenocopy and rescue experiments determined that a loss of Vps11 results in the platinum phenotype. (nih.gov)
Albinism1
- With the exception of albinism, most of these pigmentation disorders can be effectively treated using laser treatment. (thelasertreatmentclinic.com)
Clinical7
- Local treatment now rules the global market due to better clinical results in patients with pigmentation problems. (eu.org)
- Each gene responsible for a subset of HPS or a related disorder codes for a protein which almost certainly plays a pivotal role in vesicular trafficking, inextricably linking clinical and cell biological interests in this group of diseases. (nih.gov)
- Question 1: What is the specific clinical disorder to be studied? (cdc.gov)
- Question 2: What are the clinical findings defining this disorder? (cdc.gov)
- The specific clinical disorder is primary iron overload of adult onset sufficient to cause significant morbidity and mortality. (cdc.gov)
- The original clinical diagnosis of hereditary hemochromatosis was based on the triad of hepatic cirrhosis, diabetes mellitus, and skin pigmentation. (cdc.gov)
- Low vitamin D intake can be related to seasonal affective disorder," says Alan Manevitz, MD, clinical psychiatrist at Lenox Hill Hospital in New York City. (qualityhealth.com)
Ultraviolet2
- They are responsible for the pigmentation of skin and hair, and thereby contribute to the appearance of skin and provide protection from damage by ultraviolet radiation. (nature.com)
- Similar to silver , a gold preparation used parenterally for a long period may rarely produce a permanent skin pigmentation - especially if the skin is exposed to sunlight or artificial ultraviolet radiation. (wikidoc.org)
Lentigines1
- Noonan syndrome with multiple lentigines (NSML) is a very rare inherited disorder. (nih.gov)
Exposed to sunlight1
- Chlorpromazine is known, in rare instances, to induceskin pigmentation in areas exposed to sunlight. (psychiatrist.com)
Freckles1
- Freckles are a result of variation in skin pigmentation in which pigment is not released evenly. (ag3derm.com)
Symptoms2
Amalgam1
- Multiple causes are known, and they may range from simple iatrogenic mechanisms, such as implantation of dental amalgam, to complex medical disorders, such as Peutz-Jeghers syndrome (PJS) and Addison disease. (medscape.com)
Underproduction2
- Most pigmentation disorders involve the underproduction or overproduction of melanin. (wikipedia.org)
- Pigmentation disorders are caused by an overproduction or underproduction of melanin. (ag3derm.com)
Patches2
- Some pigmentation disorders affect just patches of skin. (medlineplus.gov)
- Research reveals the greater incidence of this disorder, in individuals suffering from autoimmune diseases, such as pernicious anemia, hyperthyroidism and alopecia areata (patches of baldness). (diethealthclub.com)
Darker1
- Pigmentation can cause skin to appear discoloured or blotchy, & can make areas of the skin appear lighter or darker than normal. (ag3derm.com)
Acne1
- Acne is a disorder of the hair follicles and oil (sebaceous) glands that become clogged. (childrensnational.org)
Sunlight1
- For example, a person may look yellow because of liver problems, slightly blue because of breathing problems, bruised because of blood disorders, or pink or red because of skin problems or extra sensitivity to sunlight. (cancer.org)
Autosomal4
- PJS is an autosomal dominant disorder characterized by intestinal hamartomatous polyps in association with mucocutaneous melanocytic macules. (medscape.com)
- Juvenile hemochromatosis ( HFE2 ) is a rare autosomal recessive disorder associated with a gene mapped to the long arm of chromosome 1. (cdc.gov)
- Carney complex is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. (nih.gov)
- Autosomal Dominant Genetic disorders determined by a single gene (Mendelian disorders) are easiest to analyze and the most well understood. (merckmanuals.com)
Genetic Disorders1
- ture of genetic disorders, genetic consultation and testing, The authors thank the other members of the Genetics Home gene therapy, and genomic research. (nih.gov)
Autism spectrum1
- To evaluate the electroretinogram waveform in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) using a discrete wavelet transform (DWT) approach. (frontiersin.org)
Affects2
- Pigmentation is what affects the color of skin. (medicalnewstoday.com)
- Leber congenital amaurosis (LCA) is an eye disorder that primarily affects the retina. (nih.gov)
Dermatologist1
- A specialized UV lamp known as a Wood's lamp may be used by the dermatologist to accentuate differences in pigmentation and sun damaged skin. (fairfieldderm.com)
Mucous1
- There are certain classes of drugs that are more commonly implicated in causing skin, mucous membrane, and nail pigmentation. (logicalimages.com)
Relatively common1
- Oral pigmentation is a relatively common condition that may involve any portion of the oral cavity. (medscape.com)
Dermatological1
- He also pioneered X-ray therapy for dermatological disorders. (uc.edu)
Unusual1
- Almost all people with Carney complex have areas of unusual skin pigmentation. (nih.gov)