Picrotoxin and bicuculline (Sigma) produced stimulation of the flexor reflex. (erowid.org)
The effect on Ca²⁺ dynamics was similar to that elicited by picrotoxin and bicuculline, supporting the view that TETS acts by inhibiting type A gamma-aminobutyric acid (GABA(A)) receptor function. (nih.gov)
The commonly used antiepileptic drugs carbamazepine, phenytoin, valproate, phenobarbital and clonazepam, as well as the convulsant agent t-butylbicyclophosphorothionate (TBPS), picrotoxin and bicuculline did not displace [3H]levetiracetam binding. (nih.gov)
Bicuculline and Picrotoxin are other drugs. (pharmacampus.in)
1. The isolated frog spinal cord was used to study the effects of picrotoxin, bicuculline, and strychnine on the responses of primary afferents to amino acids. (bocsci.com)
3. Picrotoxin and bicuculline antagonized the primary afferent depolarizations of a number of amino acids tested with equal specificity. (bocsci.com)
Convulsant2
Due to its interactions with the inhibitory neurotransmitter GABA, picrotoxin acts as a stimulant and convulsant. (wikipedia.org)
Picrotoxin also acts as a convulsant. (wikipedia.org)
Doses5
The animals did not survive higher doses of picrotoxin. (erowid.org)
Increasing doses of picrotoxin (2, 3 and 4 mg/kg), given in succession to the rat with the reflex abolished by baclofen resulted in occurrence of single twitches preceding the death of animals. (erowid.org)
The use of the system is illustrated by application to rats given subconvulsive doses of picrotoxin to induce a seizure-prone state analogous to epilepsy: levels of the neuronal activity marker c-Fos in the frontal and piriform cortex of picrotoxin-treated rats exposed to 900 MHz GSM radiation were twice as high as those of unexposed animals. (jpier.org)
Drs. Na, Monteggia and colleagues chronically treated MECP2-overexpressing mice with low doses of a candidate medication called picrotoxin (PTX). (bbrfoundation.org)
GSM radiation triggers seizures and increases cerebral c-Fos positivity in rats pretreated with sub convulsive doses of picrotoxin. (ac.ir)
GABA5
A 2006 study found that, while not structurally similar to GABA, picrotoxin prevents ion flow through the chloride channels activated by GABA. (wikipedia.org)
A study by Newland and Cull-Candy found that, in high enough concentrations, picrotoxin reduced the amplitude of GABA currents. (wikipedia.org)
This means that, even in the presence of low concentrations of picrotoxin, the response of neurons to GABA is reduced. (wikipedia.org)
amino butyric acid (GABA) antagonist (China Center for Disease Control and Prevention [CDC], unpublished data, 2002), TETS, like picrotoxin, binds noncompetitively and irreversibly to the GABA receptor on the neuronal cell membrane and blocks chloride channels. (cdc.gov)
CBF changes were unchanged by picrotoxin, a blocker of GABA(A) receptors, consistent with the idea that inhibitory synaptic activity does not contribute to CBF increases. (ku.dk)
Antagonist1
Assuming that enhanced inhibition of LTP mediates memory decline in APP/PS1 mice, they rescued memory deficits in adult APP/PS1 mice by treating them with another GABAA receptor antagonist, picrotoxin (PTX), at a non-epileptic dose for 10 days. (nih.gov)
Strychnine1
IGlu was not blocked by 100 microM picrotoxin or 1 microM strychnine, indicating that it was not caused by inhibitory input. (wikigenes.org)
Binds1
Rather, they found that picrotoxin "binds preferentially to an agonist bound form of the receptor. (wikipedia.org)
ROBERTS, A. Habituation of the crayfish escape response during release from inhibition induced by picrotoxin. (bvsalud.org)
Rats pretreated1
The effect on picrotoxin-induced convulsions was tested in rats pretreated with 5 mg/kg i.p. baclofen (Lioresal, ClBA-Geigy) and 1 hr later with 6 mg/kg s.c. picrotoxin (Fluke). (erowid.org)
Currents2
The application of pentobarbital and loreclezole, which increase GABAR currents, increased the holding current, whereas the application of zinc and picrotoxin, which reduce GABAR currents, reduced the holding current in a concentration-dependent manner. (aspetjournals.org)
Coexpression of α1β3γ2L, α1β3δ, α1ε, β3ε, α1β3, or ε subtypes did not produce holding currents that were sensitive to picrotoxin (30 μM). (aspetjournals.org)
Stimulant1
Picrotoxin acts as a central nervous system and respiratory stimulant. (wikipedia.org)
Spinal1
Baclofen did not protect either intact nor spinal rats against picrotoxin-induced convulsions. (erowid.org)
Dose1
The high dose of baclofen (5 mg/kg) completely antagonized the stimulatory action of picrotoxin abolishing the flexor reflex and prevented the stimulation induced by this compound. (erowid.org)
Blocker1
Their data indicated that it was unlikely that picrotoxin acted simply as a voltage-gated channel blocker, although it did reduce the frequency of channel openings. (wikipedia.org)
Radiation3
Time course of compensatory mechanisms after GSM-modulated 900 MHz radiation on cerebral activity using a picrotoxin-model in rats [med. (emf-portal.org)
The action of pulse-modulated GSM radiation increases regional changes in brain activity and c-Fos expression in cortical and subcortical areas in a rat model of picrotoxin-induced seizure proneness http://omega.two day.net/stories/5438513/ Electromagnetic. (twoday.net)
Study of neurotoxic biomarkers, c-fos and GFAP after acute exposure to GSM radiation at 900 MHz in the picrotoxin model of rat brains. (ac.ir)
Similar1
Picrotoxin and pentylenetetrazol had effects similar to, but greater than, was formed those of delta-9-THC. (erowid.org)
Blocks1
Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. (bvsalud.org)
Acts1
Two different but related theories have been proposed for the mechanism by which picrotoxin acts on synapses. (wikipedia.org)
Action2
The action of picrotoxin commenced a few minutes after the injection and lasted for 0.5-1 hr. (erowid.org)
Baclofen (0.5-1 mg/kg) diminished the stimulatory action of picrotoxin. (erowid.org)