• Discontinuation
  • Antidepressant discontinuation syndrome is a condition that can occur following the interruption, dose reduction, or discontinuation of antidepressant drugs, including selective serotonin re-uptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). (wikipedia.org)
  • People with discontinuation syndrome have been on an antidepressant for at least four weeks and have recently stopped taking the medication, whether abruptly, after a fast taper, or each time the medication is reduced on a slow taper. (wikipedia.org)
  • It also found that the safety information provided by the manufacturer not only neglected important information about managing discontinuation syndrome, but also explicitly advised against opening capsules, a practice required to gradually taper dosage. (wikipedia.org)
  • Discontinuation syndrome is often prevented by taking medication as directed, and when discontinuing, doing so gradually. (wikipedia.org)
  • drug
  • The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug. (find-more-books.com)
  • Thus, there is a need to identify predictive factors of successful drug withdrawal and to define the clinical and histological outcomes of operationally tolerant liver recipients. (clinicaltrials.gov)
  • The main objective of this study is to establish the safety of attempting immunosuppressive (IS) drug withdrawal in stable liver transplant recipients, using standard clinical, biological and histopathological methods, to screen and follow-up patients, and to confirm the benefit of maintaining immunosuppressive drug interruption in patients who are tolerant to their liver transplant. (clinicaltrials.gov)
  • In a diagnostic observational sub-study, peripheral blood and liver tissue samples collected before immunosuppressive drug withdrawal will be employed to validate the diagnostic accuracy of a previously identified set of tolerance biomarkers and to identify potential new biomarkers capable of predicting the outcome of the immunosuppressive withdrawal protocol. (clinicaltrials.gov)
  • Patients will be visited every 2-3 weeks, and immunosuppressive drugs will be gradually discontinued with the aim of achieving 50% decrease in drug dosages by month 3, and complete withdrawal by month 6 after initiation of the study. (clinicaltrials.gov)
  • Substance abuse, also known as drug abuse, is a patterned use of a drug in which the user consumes the substance in amounts or with methods which are harmful to themselves or others, and is a form of substance-related disorder. (wikipedia.org)
  • Some health professionals choose to avoid the terms alcohol or drug "abuse" in favor of language they consider more objective, such as "substance and alcohol type problems" or "harmful/problematic use" of drugs. (wikipedia.org)
  • For instance, GHB, a naturally occurring substance in the central nervous system is considered a drug, and is illegal in many countries, while nicotine is not officially considered a drug in most countries. (wikipedia.org)
  • Similarly, adopting the view that any (recreational) use of cannabis or substituted amphetamines constitutes drug abuse implies a decision made that the substance is harmful, even in minute quantities. (wikipedia.org)
  • Drug addicts not only exhibit the above behaviors, but they also are subject to a distinct withdrawal syndrome if they stop using their drug. (practicalpainmanagement.com)
  • In general, the longer the duration over which you've taken a drug, the greater the severity of withdrawal. (mentalhealthdaily.com)
  • The greater the frequency over which you took a particular drug, the more likely you'll be to experience post-acute withdrawals. (mentalhealthdaily.com)
  • Someone who takes a drug once per week has a virtually zero percent chance of experiencing post-acute withdrawals. (mentalhealthdaily.com)
  • Removing the drug from a person's daily regimen, especially when used at a high frequency over an extended period of time is very likely to result in protracted or post-acute withdrawals. (mentalhealthdaily.com)
  • If your body and nervous system have completely adapted to a drug that you've been administering at a high frequency for a long-term, it will probably take awhile to not only reverse changes made by that substance, but also restore homeostatic functioning. (mentalhealthdaily.com)
  • Psilocin is a Schedule I drug under the Convention on Psychotropic Substances. (wikipedia.org)
  • There is virtually no withdrawal syndrome when chronic use of this drug is ceased. (wikipedia.org)
  • The United Nations Convention on Psychotropic Substances (adopted in 1971) requires its members to prohibit psilocybin, and parties to the treaty are required to restrict use of the drug to medical and scientific research under strictly controlled conditions. (wikipedia.org)
  • The United States Department of Health and Human Services acknowledges three steps in a drug detoxification process: Evaluation: Upon beginning drug detoxification, a patient is first tested to see which specific substances are presently circulating in their bloodstream and the amount. (wikipedia.org)
  • i.e., the drug is used to escape or avoid re-entering the associated withdrawal state. (wikipedia.org)
  • Increased expression of AMPA receptors in nucleus accumbens MSNs is a potential mechanism of aversion produced by drug withdrawal. (wikipedia.org)
  • barbiturates
  • A rare adverse reaction to barbiturates is Stevens-Johnson syndrome, which primarily affects the mucous membranes. (wikipedia.org)
  • Patients should never try to tackle the task of discontinuing barbiturates without consulting a doctor due to the high lethality and relatively sudden onset of the withdrawal, attempting to quit "cold turkey" may result in serious neurological damage, severe physical injuries received during convulsions, and even death via glutamatergic excitotoxicity. (wikipedia.org)
  • Delirium
  • This is a prospective, randomized, double-blind, placebo-controlled, parallel-group study of dexmedetomidine versus placebo, with lorazepam rescue, for the management of severe alcohol withdrawal syndrome (AWS) and alcohol withdrawal delirium (AWD) in critically ill adults. (clinicaltrials.gov)
  • Delirium must by definition be caused by an organic process, i.e., a physically identifiable structural, functional, or chemical problem in the brain (see organic brain syndrome), and thus, fluctuations of mentation due to changes in purely psychiatric processes or diseases, such as sudden psychosis from schizophrenia or bipolar disorder, are (by definition) not termed delirium. (wikipedia.org)
  • depression
  • Individuals may become dependent upon a wide variety of chemical substances that produce central nervous system effects ranging from stimulation to depression. (wikipedia.org)
  • effects
  • We hypothesize that relative to placebo, bupropion and varenicline will attenuate the effects of post-quit nicotine withdrawal on emotional processing, reducing activation to negative emotional cues, relative to other cues, in one or more areas of interest, and particularly in the right cerebral hemisphere. (clinicaltrials.gov)
  • Preoccupation with obtaining, using, or recovering from the effects of the substance. (practicalpainmanagement.com)
  • See psilocybin for more details Its physiological effects are similar to a sympathetic arousal state. (wikipedia.org)
  • The short-term physiological effects of cocaine include constricted blood vessels, dilated pupils, and increased temperature, heart rate, and blood pressure. (wikipedia.org)
  • drugs
  • All patients who fail to completely discontinue IS, or in whom drugs have to be reintroduced after a period of complete withdrawal, are considered as IS-dependent or non-tolerant. (clinicaltrials.gov)
  • some patients even refuse to resume treatment with such drugs because of their adverse experience during unsupervised withdrawal. (addictionscience.net)
  • Other drugs, such as the psychomotor stimulants, do not produce these characteristic withdrawal reactions and have helped to debunk this common misconception. (addictionscience.net)
  • In others, the urine test measures the presence of only one or two drugs rather than looking for the entire range of abusable substances. (druglibrary.org)
  • It may result from an underlying disease, over-consumption of alcohol, from drugs administered during treatment of a disease, withdrawal from drugs or from any number of health factors. (wikipedia.org)
  • In countries where AAS are controlled substances, there is often a black market in which smuggled, clandestinely manufactured or even counterfeit drugs are sold to users. (wikipedia.org)
  • The drugs are also called controlled drugs or controlled substances. (wikipedia.org)
  • include
  • Four broad arenas that encounter substance abuse-related issues include, mass communications, criminal justice, medicine, and public health. (druglibrary.org)