Physiological cell aging. Medical search. Frequent questions

If these structures are altered, critical processes could be affected, leading to cell damage or death. (wikipedia.org)
Reactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological and biochemical processes. (hindawi.com)
The skin at the interface of body and environment is subject to aging processes and mirrors systemic aging. (uni-ulm.de)
Practically, you ought to combat aging by first understanding the cellular and physiological processes that play a role in the age-related conditions. (articlecity.com)
They offer vital help to many of our basic physiological processes. (intechopen.com)
Our preclinical research has found that SQZ TACs can leverage physiological processes to induce T cell tolerance to disease-driving antigens through multiple mechanisms," said Howard Bernstein, M.D., Ph.D., Chief Scientific Officer at SQZ Biotechnologies. (pharmiweb.com)
The smell of food induces a variety of physiological processes in our body. (medindia.net)
In fact, a minimal response of an indicator, such as CRP, may only reflect normal fluctuations in non-inflammatory processes, and possibly other chronic conditions or lifestyle, including aging (Kushner, 2001). (ift.org)
2016) also suggested that H2O2 molecules play dual roles in plant physiological and developmental processes. (researchgate.net)
Oxidative stress speeds up the aging process however oxidative processes are also essential to the physiological process of energy production in the body. (promocell.com)
Oxidative stress can become a self-fuelling cycle, where the initial stress leads to dysregulation of physiological processes, inflammation and a deregulated immune system which in turn lead to various diseases that may cause further inflammation and oxidative stress. (promocell.com)

The current paper in Molecular Cell also presents evidence that Hsp12 enhances the health of yeast cells under normal physiological conditions. (mytum.de)
This protein is produced whenever an inflammatory process is initiated in the body and under normal physiological conditions, such as everyday stress, pregnancy, and aging. (ift.org)

No one can make simple generalizations about age-dependent changes in the metabolism of a xenobiotic (defined as a chemical foreign to the body). (cdc.gov)
Metabolism of some substances varies with age. (cdc.gov)
Although excessive body weight can develop at any age, adults over age 40 are particularly susceptible to age-related weight gain as metabolism slows down and body composition is altered to favor fat over lean muscle. (prohealth.com)
Central role of metabolism in endothelial cell function and vascular disease. (koreamed.org)
Oxygen metabolism in the mitochondria contribute around 90% of ROS in a cell. (promocell.com)
Research suggests aging is caused by cumulative oxidative stress due to free radicals generated in biological systems both via metabolism and as a result of exposure to UV light (Stojiljkovic, 2014). (promocell.com)
Free radicals, both the reactive oxygen species (ROS) and reactive nitrogen species (RNS), can lead to damage of biomolecules which then affects gene expression, cell metabolism and distinct physiological functions. (promocell.com)
The appearance of skin aging is caused by underlying damage to collagen and reduced fibroblast size, both caused by ROS which regulates collagen metabolism. (promocell.com)

At physiological levels, ROS can improve cellular activities as they are involved in the control of the chemical balance and synaptic plasticity [ 4 ], whereas an excess amount of ROS can damage the endothelium, leading to alteration of the intracellular reduction-oxidation homeostasis [ 5 ]. (hindawi.com)
Although our systematic analysis yields no molecular traces of SARS-CoV-2 in the brain, we observe broad cellular perturbations indicating that barrier cells of the choroid plexus sense and relay peripheral inflammation into the brain and show that peripheral T cells infiltrate the parenchyma. (nature.com)
In this CRC project, we want to understand whether cellular aging with all its associated altered mechanisms is the prerequisite for protein aggregation in general or whether the exposure time to misfolded proteins determines the accumulation of protein aggregates with their detrimental consequences. (uni-ulm.de)
Further we want to understand whether pathological age-related mechanisms can be rescued by manipulation of structural cellular elements. (uni-ulm.de)
In skin cells we plan to study the contribution of the protein synthesis apparatus to cellular and tissue aging. (uni-ulm.de)
In preclinical studies, Nicotinamide Mononucleotide work on mice has proved to be handy in cellular biochemical activities, management of Alzheimer's disease, age-related diabetes, complications that arise from obesity, and cardioprotection. (articlecity.com)
As you age, cellular energy decreases due to the low levels of nicotinamide mononucleotide and subsequent reduction of NAD+. (articlecity.com)
Until now, research results demonstrated that senescence (the final stage of cellular aging) was an obstacle blocking the use of this technique for therapeutic applications in elderly patients. (eurekalert.org)
The researchers have successfully rejuvenated cells from elderly donors, some over 100 years old, thus demonstrating the reversibility of the cellular aging process. (eurekalert.org)
They have the physiological characteristics of "young" cells, both from the perspective of their proliferative capacity and their cellular metabolisms. (eurekalert.org)
Researchers first multiplied skin cells (fibroblasts) from a 74 year-old donor to obtain the senescence characterized by the end of cellular proliferation. (eurekalert.org)
In this study, we surveyed the single-cell transcriptomic landscape to dissect the cellular and molecular changes associated with the aging of oMCs in mice. (sens.org)
In some cases, the decline in proliferation reaches an irreversible state called cellular senescence, which is characterized by a total lack of cell divisions and altered cellular morphology, gene expression profile, and chromatin organization ( 3 ). (diabetesjournals.org)
As a parameter-free method, our approach is broadly applicable for cellular physiological classification in all sensory modalities. (frontiersin.org)
Yet, if different RGC types have distinct cellular physiological properties, light responses, and systematic differences in their presynaptic input neurons, it may be possible to use a sufficiently rich stimulus to evoke responses to unmask their distinctive functional features. (frontiersin.org)
Non-reversible oxidative modifications (oxidative damage) may contribute to molecular, cellular, and organismal aging and serve as signals for repair, removal, or programmed cell death. (usda.gov)
The researchers found that the cellular survival mechanism provided by Hsp12 functioned under several different kinds of assault, including heat shock, oxidative stress, and osmotic stress -- a sudden change in the solution surrounding a cell that challenges its ability to regulate the flow of water through the membrane. (mytum.de)

The heat shock response (HSR) is a cell stress response that increases the number of molecular chaperones to combat the negative effects on proteins caused by stressors such as increased temperatures, oxidative stress, and heavy metals. (wikipedia.org)
Inhibition of xanthine oxidase reduces oxidative stress and improves skeletal muscle function in response to electrically stimulated isometric contractions in aged mice. (cdc.gov)
Oxidative stress is a putative factor responsible for reducing function and increasing apoptotic signaling in skeletal muscle with aging. (cdc.gov)
Allopurinol attenuated the exercise-induced increase in oxidative stress, but it did not affect the elevated basal level of oxidative stress that was associated with aging. (cdc.gov)
This review focuses on an emerging topic, the functional involvement of AQPs in ROS membrane transport, with specific regard to the movement of hydrogen peroxide and NO into and out of cells, in both health and oxidative stress-induced diseases. (hindawi.com)
The pathogenesis is multifactorial and involves dysregulation in the signaling pathways, membrane lipids ratio disturbance, cell-cell adhesion disturbance, unfolded protein response, lysosomal and mitochondrial stress, autophagy dysregulation, and oxidative stress. (koreamed.org)
Oxidative stress results from an imbalance of pro- and anti-oxidants and leads to faster skin aging, inflammation and disease. (promocell.com)
Cell assays and primary cells provide the tools researchers need to study the oxidative process and its association with skin aging. (promocell.com)
The most significant extrinsic factor causing accelerated skin aging is exposure to UV light leading to the production of ROS (Stojiljkovic, 2014) which cause oxidative damage. (promocell.com)
Lipids, proteins, carbohydrates and DNA are all susceptible to oxidative damage and this damage can change gene transcription along with cell proliferation and differentiation and is involved in several diseases including diabetes and obesity, cancer and neurological disorders (Kregel, 2007). (promocell.com)
UV radiation that causes oxidative stress and hence aging induces the expression of matrix metalloproteinases (MMPs) that degrade dermal collagen and other proteins from the extracellular matrix (Caravalhaes Lago, 2019). (promocell.com)
Other effects of increased oxidative stress and ROS production are a decrease in CTGF, TGF-beta, and type I procollagen expression as well as an age-associated chronic progressive increase in the proinflammatory status - this is termed 'inflammaging' (Zuo, 2019). (promocell.com)
The age-related alteration of collagen-rich extracellular matrix - promoted by oxidative stress - impairs the skin's structural integrity and creates a tissue microenvironment that promotes age-related skin diseases such as poor wound healing and skin cancer. (promocell.com)
generated positive changes, producing a decrease in pro-inflammatory states, oxidative stress, and aging. (bvsalud.org)

Senescent cells are characterized by an upregulation of proinflammatory cytokines, which is termed the senescence-associated secretory phenotype (SASP). (nature.com)
Raw RNA-seq data for RAS-induced senescence and control conditions in IMR90 cells were downloaded from GEO (under accession code GSE74324 ) 41 . (nature.com)
We observed that age advancement in all three groups combined was associated with a monocyte immune phenotypic profile related to inflammation and a T cell immune phenotypic associated with immune senescence and chronic antigen exposure. (frontiersin.org)
The T cell immune phenotypic profile in blood donors was related to loss of T cell function, whereas the same set of markers were related to chronic antigen stimulation and immune senescence in HIV-negative individuals. (frontiersin.org)
The identified monocyte and T cell immune phenotypic profiles that were associated with age advancement, were strongly related to inflammation, chronic antigen exposure and immune senescence. (frontiersin.org)
These age-related immunological changes resemble those seen during treated HIV-1 infection and include high levels of soluble inflammatory proteins, high levels of monocyte and T cell activation, T cell exhaustion and senescence, and low levels of naïve T cells ( 14 - 25 ). (frontiersin.org)
Our functional investigations revealed that oMCs supplementation prior to ovarian senescence was the optimal method to improve female fertility and extend the reproductive lifespan of aged females in the long-term. (sens.org)
The gradual decrease in the rate of cell division seen already in early postnatal life, before any evidence of senescence, is even less well-understood. (diabetesjournals.org)
The cytosol of old cells acidifies, and cells display more substantial variability in cytosolic pH with aging, especially after entry into senescence. (elifesciences.org)
E ) Cytosolic acidity (normalized ratiometric pHluorin read-out:F 475 /F 390 , top) and replicative age (bottom) as a function of time, for a cell that enters senescence at 26 hr (dashed blue line) after which a sharp acidification of the cytosol (dashed red line) follows. (elifesciences.org)
Leaf senescence is a developmental and physiological phase in plants to end leaf development. (helsinki.fi)
Environment factors such as drought stress, extreme temperature, and pathogen threat and internal factors including age and reactive oxygen species induce leaf senescence. (helsinki.fi)

Science has established that caffeine has numerous physiological and psychological effects on the central nervous system (CNS). (shapefit.com)

HIV-associated immune dysfunction and inflammation have been suggested to contribute to this age advancement and increased risk of comorbidities. (frontiersin.org)
In the general population aging is associated with immunological changes resulting in low grade inflammation and deterioration of the innate and adaptive immune system in the elderly ( 10 - 13 ). (frontiersin.org)
Other factors that influence aging include the role of free radicals, gene modifications, chronic inflammation, and certain spices such as curcumin and capsaicin. (intechopen.com)
We can no longer adequately accommodate our physiological response to stress, creating, for example increased inflammation. (officer.com)
and the role of inflammation in memory deterioration in healthy aging , patients with HIV, and other neurodegenerative conditions. (hopkinsmedicine.org)

In this proposal (A04) we are aiming at studying the effects of aging in myelination and at deciphering the potential of therapeutic approaches to overcome the age dependent decrease in oligodendrogenesis in order to improve cognitive decline in aged animals. (uni-ulm.de)
Project A05 addresses the hypothesis that brain inflammaging is critically regulated by Notch/NF-kB crosstalk signaling which can promote synapse aging via cell-intrinsic and paracrine mechanisms finally resulting in motoric and cognitive decline. (uni-ulm.de)
The project will investigate the age-related functional decline of hematopoiesis and dissect the role of Cdc42 in the rejuvenation of Human Hematopoietic Stem Cells (HSCs). (uni-ulm.de)
Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. (prohealth.com)
Previous studies have shown the involvement of cell-autonomous factors in this phenomenon, particularly the decline of polycomb genes and accumulation of p16/INK4A. (diabetesjournals.org)
We conclude that systemic factors contribute to the replicative decline of old pancreatic β-cells. (diabetesjournals.org)
Alkaloid extracted from coffee proves its mettle in enhancing cognitive abilities and counteracting age-related cognitive decline. (medindia.net)
Aging is an inevitable process experienced by the vast majority of organisms and results in a progressive functional decline. (promocell.com)

This issue is of particular relevance since changes in NO release could play an important role in endothelial function maintenance, in addition to regulating proliferation of smooth muscle cells, leukocyte adhesion, platelet aggregation, angiogenesis, thrombosis, vascular tone, and hemodynamics. (hindawi.com)
Signs of aging were erased and the iPSCs obtained can produce functional cells, of any type, with an increased proliferation capacity and longevity," explains Jean-Marc Lemaitre who directs the Inserm AVENIR team. (eurekalert.org)
Here, we demonstrate that a systemic factor found in the circulation of young mice is able to increase the proliferation rate of old pancreatic β-cells. (diabetesjournals.org)
During pregnancy, there was no increase in β-cell proliferation and mass in βIGF2KO mice. (unige.ch)
Materials and Methods: The suppression effects of propofol on the proliferation and invasion of cervical cancer cells were analyzed by Cell Counting Kit-8 (CCK-8), colony formation and Transwell invasion assay. (aging-us.com)
In colorectal cancer, propofol inhibits cancer cells proliferation and metastasis by regulating miR-124-3p.1/AKT3 [ 13 ]. (aging-us.com)

Principles of Pediatric Environmental Health: Why Do a Child's Age and Developmental Stage Affect Physiological Susceptibility to Toxic Substances? (cdc.gov)
He was the first director of a National Institutes of Health-funded Biochemistry Training Program and is a founding member of the Department of Cell & Developmental Biology . (northwestern.edu)

As on 2019, there were about 1161.17 million cell phone users in India [ 2 ]. (biomedcentral.com)

Damage to ECs is catastrophic and induces endothelial cell dysfunction. (koreamed.org)
Up-regulation of autophagy induces endothelial cell regeneration/differentiation and improves the function of impaired ones. (koreamed.org)

Among various mechanisms, the uncoupling of nitric oxide synthase (NOS) in vascular cells has also widely been reported to be involved in ROS generation. (hindawi.com)
We aim to reveal novel resilience mechanisms that protect neurons from age-dependent degeneration in PD and beyond. (uni-ulm.de)
SQZ TACs leverage the body's natural mechanisms of red blood cell (RBC) clearance and antigen presentation to induce immune tolerance. (pharmiweb.com)
TACs are derived from patient RBCs and are designed to carry disease-specific antigen cargos to specialized immune cells that are capable of inducing tolerance through multiple mechanisms. (pharmiweb.com)
Research in the Bakker Memory Laboratory is focused on understanding the mechanisms and brain n ... etworks underlying human cognition with a specific focus on the mechanisms underlying learning and memory and the changes in memory that occur with aging and disease. (hopkinsmedicine.org)
Patricia Spear, PhD , identified the mechanisms the herpes simplex virus types 1 and 2 use to enter cells. (northwestern.edu)
We use a multi-compartmental model of a CA1 pyramidal cell to study changes in hippocampal excitability that result from aging-induced alterations in calcium-dependent membrane mechanisms. (yale.edu)
We find that aging-induced alterations in CA1 excitability can be modelled with simple coupling mechanisms that selectively link specific types of calcium channels to specific calcium-dependent potassium channels. (yale.edu)
Caloric restriction and intermittent fasting have been shown to be tratamiento coadyuvante novel and beneficial strategies in neurodegenerative diseases, through immune, metabolic, and physiological mechanisms. (bvsalud.org)
BP act in the regulation of osteoclast function by decreasing bone resorption by different mechanisms, inhibiting the development of their precursor cells, increasing apoptosis rate, stimulating inhibitor factors and reducing its activity 28 . (bvsalud.org)

Whether this autocrine activity of IGF2 plays a physiological role in β-cell and whole-body physiology is not known. (unige.ch)

Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. (prohealth.com)
Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. (prohealth.com)
Supplementation of exogenous non-ovarian mesenchymal-related cells has been reported to be an efficient approach to improve ovarian functions. (sens.org)
CDC emphasizes sound iron nutrition for infants and young children, screening for anemia among women of childbearing age, and the importance of low-dose iron supplementation for pregnant women. (cdc.gov)

While the monocyte and T cell immune phenotypic profile within the HIV-negative individuals reflected those observed in the combined three groups, a distinct profile related to immune dysfunction, was observed within blood donors and people with HIV. (frontiersin.org)
Ovarian mesenchymal cells (oMCs) constitute a distinct microenvironment that supports folliculogenesis under physiological conditions. (sens.org)
Distinct types of cell death and the implication in diabetic cardiomyopathy. (koreamed.org)

In a normal cell, proteostasis (protein homeostasis) must be maintained because proteins are the main functional units of the cell. (wikipedia.org)
Transport of NO and ROS by AQPs would be required for cell homeostasis to play a critical role in maintaining endothelial function. (hindawi.com)
Autophagy is a remarkable patho (physiological) process in the cell homeostasis regulation including EC. (koreamed.org)

C ) Data collected from 80 yeast cells during the process of replicative aging. (elifesciences.org)
Singe-cell measurements of pH in replicative aging yeast cells. (elifesciences.org)

Heat shock proteins are also believed to play a role in the presentation of pieces of proteins (or peptides) on the cell surface to help the immune system recognize diseased cells. (wikipedia.org)
These data suggest that varying exposures to lifestyle and infection-related factors may be associated with specific changes in the innate and adaptive immune system, that all contribute to age advancement. (frontiersin.org)
This research paves the way for the therapeutic use of iPS, insofar as an ideal source of adult cells is provided, which are tolerated by the immune system and can repair organs or tissues in elderly patients. (eurekalert.org)
Pathogen comes in, begins infecting some cells but not enough to result in symptoms, immune system responds and attacks the infected cells and free virus particles? (bodybuilding.com)

In the hope of revealing new directions for therapies, the group studies molecular biomarkers identified from tissue and brain imaging that are associated with memory problems related to HIV infection, aging , dementia, mental illness and traumatic brain injury. (hopkinsmedicine.org)
The surprising answer is revealed in the Aug. 27 issue of Molecular Cell, where German researchers explain how they discovered the function of Hsp12, a protective mechanism unlike any previously observed. (mytum.de)
He discovered several molecular cell motors, some of which assist in the motility of certain white blood cells, and showed how actin and myosin induce movement in non-muscle cells. (northwestern.edu)
Extracellular vesicles (EVs) in human (HM) and cow milk (CM) contain molecular cargo such as proteins and micro(mi)RNAs that serve as functional messengers between cells and may be of importance to infant health. (bvsalud.org)

Xanthine oxidase activity was inhibited in young adult and aged mice via a subcutaneously placed time-release (2.5 mg/day) allopurinol pellet, 7 days before the start of in situ electrically stimulated isometric contractions. (cdc.gov)
Xanthine oxidase activity was 65% greater in the gastrocnemius muscle of aged mice compared to young mice. (cdc.gov)
Xanthine oxidase activity also increased after in situ electrically stimulated isometric contractions in muscles from both young (33%) and aged (28%) mice, relative to contralateral noncontracted muscles. (cdc.gov)
and increased maximal isometric force in the plantar flexor muscles of aged mice after repetitive electrically evoked contractions. (cdc.gov)
For this, structural and functional consequences at synaptic interfaces built up by neurons and different types of glia cells in young and old mice will be characterized using conditional transgenic systems mimicking brain inflammaging and allowing cell-type-specific Notch/NF-kB modulation. (uni-ulm.de)
Old mice parabiosed to young mice have increased β-cell replication compared with unjoined old mice or old mice parabiosed to old mice. (diabetesjournals.org)
conversely, young β-cells transplanted into old mice decrease their replication rate compared with young cells transplanted into young recipients. (diabetesjournals.org)
however, we have recently found that a residual replicative potential is retained even in β-cells of very old mice ( 8 ). (diabetesjournals.org)
Here, we studied mice with β-cell-specific inactivation of Igf2 (βIGF2KO mice) and assessed β-cell mass and function in aging, pregnancy, and acute induction of insulin resistance. (unige.ch)
While on a high-fat diet, both male and female βIGF2KO mice displayed lower GSIS compared with control mice, but reduced β-cell mass was observed only in female βIGF2KO mice. (unige.ch)
Finally, β-cell mass expansion in response to acute induction of insulin resistance was lower in βIGF2KO mice than in control mice. (unige.ch)

Ageing can be defined as the gradual deterioration of physiological functions, increasing the incidence of age-related disorders and the probability of death. (nih.gov)

We intend to ask the question if a fading of the accuracy of the protein translation process at the ribosome, recently identified in premature-aging childhood disorders, also characterizes intrinsic aging. (uni-ulm.de)
However, there's potential for reversing the aging process using Nicotinamide Mononucleotide . (articlecity.com)
It is likely that the bacterial flora in our body may also influence the aging process. (intechopen.com)
To check the "rejuvenated" characteristics of these cells, the researchers tested the reverse process. (eurekalert.org)
As we age, our bodies process and recover from stress less efficiently. (officer.com)
This led to the reconstruction of the physiological process as well as to the diagnosis of unusual bleeding disorders. (northwestern.edu)
This plays an important role for the recycling of cells and during the aging process. (medindia.net)
MicrocircuitDB: Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. (yale.edu)
Metastatic recurrence is a leading cause of cancer-associated death, and cancer cell migration is the initial step among the metastatic process. (aging-us.com)
Skin aging is a multi-faceted process, and researchers are still working to fully understand the complex interactions that take place. (promocell.com)

This is in part because the high-quality, fresh-frozen human brain tissue from patients with COVID-19 needed for single-cell transcriptomic studies is largely inaccessible, and methods to isolate human brain barrier cells have only recently emerged 22 , 23 . (nature.com)

Low bone mass and osteoporosis are now regarded as serious health threats, according to the International Osteoporosis Foundation , which estimated that by 2020, adults aged 50 and older at risk of osteoporosis could reach as high as 61 million. (nutraceuticalsworld.com)

To that end, we will monitor the synaptic alterations over time in controls as well as in defined models with the aim to better define synaptic aging and to identify druggable targets involved in the loss of synapses and neurons. (uni-ulm.de)
The progressive loss of dopaminergic Substantia nigra neurons is a feature of the aging brain, and causes the motor symptoms of Parkinson's (PD). (uni-ulm.de)
Retinal ganglion cells, the sole output neurons of the retina, exhibit surprising diversity. (frontiersin.org)
Diminished myelin levels lead to further cell death in which unmyelinated neurons die. (karger.com)
This regulation is sive loss of neurons and white matter that believed to positively impact these diseases can lead to brain atrophy and different by promoting normal aging and delaying types of disability. (bvsalud.org)

Using this new "cocktail" of six factors, the senescent cells, programmed into functional iPSC cells, re-acquired the characteristics of embryonic pluripotent stem cells. (eurekalert.org)

OPC, oligodendrocyte precursor cell. (nature.com)
This article reviews recent advancements in biomaterial strategies for the differentiation of neural stem cells into oligodendrocytes, and presents new data indicating appropriate properties for oligodendrocyte precursor cell growth. (karger.com)

Across cell types, perturbations associated with COVID-19 overlap with those found in chronic brain disorders and reside in genetic variants associated with cognition, schizophrenia and depression. (nature.com)
The cause of the accentuated and/or accelerated aging in people with HIV remains to be fully elucidated, with factors like HIV associated chronic immune activation and dysfunction, ART toxicity and the higher prevalence of traditional risk factors each having been implicated to contribute to age-associated comorbidity development ( 8 , 9 ). (frontiersin.org)
In addition to our cells naturally aging, a sedentary lifestyle, as well as chronic disease aggravates this even more. (officer.com)
WATERTOWN, Mass.--(BUSINESS WIRE)--SQZ Biotechnologies (NYSE: SQZ), focused on unlocking the full potential of cell therapies for multiple therapeutic areas, today announced that the first clinical translation of the company's Tolerizing Antigen Carrier (TAC) platform in autoimmune diseases will be for celiac disease, a chronic autoimmune disorder that afflicts millions of patients and has no approved drug treatment. (pharmiweb.com)
Infants suffering of cell death occurring as a series of changes from chronic illnesses, chromosomal abnor- in dying cells under several physiological malities and those on medication prior to conditions [ 6,7 ] and has been implicated enrolment were excluded from the study. (who.int)

Endothelial cells (EC) are the anatomical boundaries between the intravascular and extravascular space. (koreamed.org)
Fig. 2 Schematic presentation of the role of autophagy in endothelial cells. (koreamed.org)
CRP is produced by the liver and vascular endothelial cells, such those that line the arterial walls of major blood vessels of the heart and other vital organs. (ift.org)

The young group consists of data points from the first recorded ratio at time 0 hr, and the old group consists of the last recorded measurement before cell death. (elifesciences.org)

These old cells were reprogrammed in vitro to induced pluripotent stem cells (iPSC) and to rejuvenated and human embryonic stem cells (hESC): cells of all types can again be differentiated after this genuine "rejuvenation" therapy. (eurekalert.org)
Human embryonic stem cells (hESC) are undifferentiated multiple-function cells. (eurekalert.org)
Since 2007, a handful of research teams across the world have been capable of reprogramming human adult cells into induced pluripotent cells (iPSC), which have similar characteristics and potential to human embryonic stem cells (hESC). (eurekalert.org)
This kind of reprogramming makes it possible to reform all human cell types without the ethical restrictions related to using embryonic stem cells. (eurekalert.org)
The rejuvenated iPSC cells were again differentiated to adult cells and compared to the original old cells, as well as to those obtained using human embryonic pluripotetent stem cells (hESC). (eurekalert.org)
The regrowth of myelinating oligodendrocytes from neural stem cells through a biomaterials approach may prove to be a beneficial strategy following the onset of demyelination. (karger.com)
Aguado, B.A., W. Mulyasasmita, J. Su, K.J. Lampe, S.C. Heilshorn (2012) Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers. (karger.com)
Bible, E., D.Y. Chau, M.R. Alexander, J. Price, K.M. Shakesheff, M. Modo (2009) The support of neural stem cells transplanted into stroke-induced brain cavities by PLGA particles. (karger.com)

This study examined the contribution and functional significance of the xanthine oxidase enzyme as a potential source of oxidant production in aged skeletal muscle during repetitive in situ electrically stimulated isometric contractions. (cdc.gov)
We have validated a microfluidic microphysiological system (MPS) that demonstrates electrically stimulated contraction of human-engineered muscle myobundles derived from muscle biopsies from older, sedentary (OS) adults compared to those derived from young, athletic (YA) adults as a model of age-related muscle disfunction. (selectbiosciences.com)

SQZ TACs were shown to delete antigen-specific T cells, without causing broad immune suppression. (pharmiweb.com)
Importantly, SQZ TACs also increased antigen-specific regulatory T cells (Tregs) that exerted potent bystander suppression, showing the ability to suppress pathogenic T cells with different autoantigen specificities. (pharmiweb.com)
The flexibility and scalability of the company's manufacturing system allows it to be used for both the TAC and Oncology platforms despite different cell types and antigen cargos. (pharmiweb.com)
12 oedematous (4 males and 8 females) optotic marker CD95 (Fas antigen) can be with mean age 11.67 (SD 4.92) months. (who.int)

We therefore propose a/ voluntary physical activity and b/ targeting the receptor GPR17, to improve myelination and cognitive performance in aged animals. (uni-ulm.de)
What is more, aging affects both physical and cognitive functions. (articlecity.com)
Declining cognitive function with age is related to a reduced NAD+ levels that impair mitochondrial function. (prohealth.com)

Sickle cell disease (SCD) usually manifests early in childhood. (medscape.com)

Throughout the years, ROS and NO have been widely considered to enter cells by freely diffusing through the cell membrane lipid bilayer and not via specific transporters or channels. (hindawi.com)
Unfolded within the cell's aqueous cytosol, Hsp12 folds into helical structures to stabilize the cell membrane. (mytum.de)
Monensin and nigericin are ionophores that carry protons across the plasma membrane, while the 2-deoxyglucose and NaN 3 deprive the cell from ATP and thus block energy-dependent pH maintenance. (elifesciences.org)

Therefore, researchers have begun exploring combined therapies with biomaterials that promote cell growth and differentiation while localizing cells in the injured area. (karger.com)

Our results showed that the oMCs were composed of five ovarian differentiated MC (odMC) populations and one ovarian mesenchymal progenitor (oMP) cell population. (sens.org)
It is well established that the retina has multiple, functionally complementary populations of retinal ganglion cells (RGCs), which together transmit visual information to various central visual areas ( Roska and Werblin, 2001 ). (frontiersin.org)
Products that can help aging populations stay active and independent will be in a strong market position. (nutraceuticalsworld.com)
With global populations aging, consumer demand for solutions to age-related conditions like bone health, that keep people active for longer has been growing at an impressive rate during recent years, observed Lara Niemann, marketing director, Americas, GELITA , Sioux City, IA. (nutraceuticalsworld.com)

Cells Tissues Organs (2016) 202 (1-2): 85-101. (karger.com)

Fig. 1: Overview of diverse brain and choroid plexus cell types captured from post-mortem tissue from patients with COVID-19. (nature.com)
Aging lowers the replicative potential of most cells and the capacity for tissue regeneration ( 1 , 2 ). (diabetesjournals.org)

In particular, they recovered their capacity for self-renewal and their former differentiation potential, and do not preserve any traces of previous aging. (eurekalert.org)
Aizawa, Y., N.D. Leipzig, T. Zahira, M.S. Shoichet (2008) The effect of immobilized platelet derived growth factor AA on neural stem/progenitor cell differentiation on cell-adhesive hydrogels. (karger.com)

Indeed, aged individuals display a strongly reduced number of synapses and aging is the major risk factor for the development of neurodegenerative disorders. (uni-ulm.de)

As an outlook, we aim to develop personalized anti-aging clinical interventions that will attenuate aging-driven immune remodeling and hematopoietic disorders. (uni-ulm.de)
We will further investigate the influence of the perception of odors on aging-associated disorders such as Alzheimer's or Parkinson's disease. (medindia.net)
This can lead to several disorders as well as acceleration of aging as shown in Figure 2. (promocell.com)
Factors such as age, cardiovascular disease, and metabolic disorders may increase the risk of morbidity and mortality due to COVID-19 regardless of HIV status (5). (who.int)

Grey bar indicates the range of pH values measured in the first time point (young age) to illustrate that 36% of the cells remain within this range throughout their lifespan. (elifesciences.org)
Age-related changes in cytosolic pH are not predictive for lifespan. (elifesciences.org)
D,E,F ) The pH in young ( D ) and old cells ( E ), as well as the fold change in pH in aging ( F ), do not correlate with the replicative lifespan. (elifesciences.org)
In this review, we cover the current view on the contribution of the different elements of the mTOR signalling network to lifespan and age-related metabolic impairment. (nih.gov)

Our aim is to investigate how aging alters synapses and how synaptic disruption contributes to the development of neurodegeneration-like phenotypes upon aging. (uni-ulm.de)
Interestingly, no different phenotypes were found between acd5, cat2, dnd1 and their corresponding wrky75 double mutants in cell death and hydrogen peroxide accumulation detection in Arabidopsis leaves. (helsinki.fi)
Furthermore, reintroduction of MIR155HG into cervical cancer cells counteracted the inhibitory potency of propofol on the growth and aggressive phenotypes in cervical carcinoma cells. (aging-us.com)

Research in our center involves population-based and clinical studies of the causes, correlates, and consequences of aging -related conditions, including frailty, disability, and social isolation. (hopkinsmedicine.org)
Despite clear evidence that Hsp12 -- a so-called heat shock or stress protein -- helps cells survive life-threatening conditions, how it works was an open question until now. (mytum.de)
Large and/or aged seeds are prone to hypoxic conditions during germination. (researchgate.net)

No one can simply predict a chemical's kinetics and toxicity from data derived from adults or even from children of different ages. (cdc.gov)

Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis. (hindawi.com)

The prevalence of replicating pancreatic β-cells declines dramatically with age in both rodents and humans ( 4 , 5 ). (diabetesjournals.org)

The HSP70 chaperone family is the main HSP system within cells, playing a key role in translation, post-translation, prevention of aggregates and refolding of aggregated proteins. (wikipedia.org)
The combination of these approaches will help to get novel information on the role of myelination in aging and the identification of novel approaches that could be therapeutically addressed in the future. (uni-ulm.de)

biology: water as a source of mineral salts, physiological effects, osmotic pressure in cells. (scienceinschool.org)
Aging and spaceflight share similar physiological effects on muscle atrophy and effective countermeasures are needed for both Earth and Space applications. (selectbiosciences.com)
In physiological concentrations, androgens have no specific effects in women. (cdc.gov)

Previous studies thus appear to suggest that light responses alone do not contain sufficient information for reliable RGC classification unless a careful stimulus ensemble is designed to evoke optimal responses, in particular for specialized RGCs such as DS cells. (frontiersin.org)

Insulin-like growth factor 2 (IGF2), produced and secreted by adult β-cells, functions as an autocrine activator of the β-cell insulin-like growth factor 1 receptor signaling pathway. (unige.ch)

Asmani, M.N., J. Ai, G. Amoabediny, A. Noroozi, M. Azami, S. Ebrahimi-Barough, M. Navaei-Nigjeh, A. Ai, M. Jafarabadi (2013) Three-dimensional culture of differentiated endometrial stromal cells to oligodendrocyte progenitor cells (OPCs) in fibrin hydrogel. (karger.com)
Bakshi, A., C.A. Keck, V.S. Koshkin, D.G. LeBold, R. Siman, E.Y. Snyder, T.K. McIntosh (2005) Caspase-mediated cell death predominates following engraftment of neural progenitor cells into traumatically injured rat brain. (karger.com)

This is a new concept for protecting cells against stress," says Johannes Buchner, professor of chemistry at the Technische Universität München (TUM) and a member of the Munich Center for Integrated Protein Science. (mytum.de)
His work served as a foundation for studying protein cross-linking in aging cells. (northwestern.edu)
mTOR promotes cell growth and controls central metabolic pathways including protein biosynthesis, autophagy and glucose and lipid homoeostasis. (nih.gov)
The number and thickness of fused and striatal myofibers and contraction magnitude are increased in the OS group and begin to resemble the YA phenotype indicating the cells retain their donor phenotype and respond to external stimuli by triggering protein synthesis. (selectbiosciences.com)

Cell phones are known to affect individuals overall health [ 3 ]. (biomedcentral.com)
Cell phone addiction is likely to affect an individual's familial and societal relationships as they grow old and has potential to become a major public health problem [ 15 ]. (biomedcentral.com)
Because agility and mobility can positively impact quality of life as we age, the desire to remain active, no matter our age, is a big driver for bone health support. (nutraceuticalsworld.com)

They then completed the in vitro reprogramming of the cells. (eurekalert.org)
In vitro , propofol inhibited the growth and colony-formation of cervical carcinoma cells. (aging-us.com)

Inserm's AVENIR "Genomic plasticity and aging" team, directed by Jean-Marc Lemaitre, Inserm researcher at the Functional Genomics Institute (Inserm/CNRS/Université de Montpellier 1 and 2), has recently succeeded in rejuvenating cells from elderly donors (aged over 100). (eurekalert.org)
In other words, roundworms with a non-functional 'sense of smell' live much shorter - a strong indication for its physiological significance. (medindia.net)

It will additionally focus on, using single-cell sequencing and deep learning approaches, the transcriptional and mutational heterogeneity of HSCs upon aging. (uni-ulm.de)

To achieve this, they used an adapted strategy that consisted of reprogramming cells using a specific "cocktail" of six genetic factors, while erasing signs of aging. (eurekalert.org)
As we age, stress may be caused by different factors. (officer.com)
In this study, we assessed the factors affecting risk of cell phone addiction among teachers attending Life Skills Training and Counselling Services (LSTCS) program in Karnataka. (biomedcentral.com)
Various factors hypothesised to be affecting risk of cell phone addiction (outcome) was analysed using univariate and multivariable logistic regression analysis. (biomedcentral.com)
Factors associated with cardiovascular risk, such as smoking, aging, and body mass index are also associated with elevated CRP. (ift.org)
Different skin types respond to extrinsic factors in different ways, with type I and II (fair) skin experiencing increased extrinsic aging in response to the same stimuli (Naidoo, 2017). (promocell.com)
COVID-19 infection was associated with younger age among PLWHs in Lebanon, possibly due to behavioural and socioeconomic factors. (who.int)

The anti-aging Nicotinamide Mononucleotide works to restore youthfulness. (articlecity.com)
Despite all these pharmacological activities associated with Nicotinamide Mononucleotide, the most groundbreaking discovery is its involvement in anti-aging activities. (articlecity.com)

Although it was regarded as a rare disease when it was first described, Alzheimer disease has become one of the most common diseases in the aging population, ranking as the fourth most common cause of death. (medscape.com)

Conclusions: Altogether, these results indicated that propofol restrained the growth and invasion of cervical cancer cells partly via regulating MIR155HG expression. (aging-us.com)

Before we look at how stress affects us differently as we age, here's a reminder of what stress does to our bodies. (officer.com)

An inflammatory monocyte immune phenotypic profile associated with age advancement in HIV-negative individuals, while the monocyte profile in blood donors and people with HIV was more reflective of loss of function. (frontiersin.org)
We currently are investigating male gonadal function-with particular interest in new forms of male hormone replacement therapy-and hormonal changes related to aging . (hopkinsmedicine.org)
Results of aging experiments showed a protective function as well. (mytum.de)
Some phytohormones such as jasmonic acid and salicylic acid play a key function in cell death in plants. (helsinki.fi)
To evaluate the function of WRKY75 transcription factor in SA signalling and cell death, three lesion mimic mutants acd5, cat2, dnd1 and their corresponding wrky75 double mutant were used. (helsinki.fi)

Processes11

Normal physiological conditions2

Metabolism8

Cellular17

Oxidative14

Senescence12

Numerous physiological1

Inflammation5

Decline8

Proliferation6

Developmental2

20191

Induces2

Mechanisms10

Physiology1

Supplementation4

Distinct3

Homeostasis3

Yeast cells2

Immune system4

Molecular4

Mice11

Deterioration1

Process10

Single-cell transcriptomic1

20201

Neurons5

Senescent cells1

Oligodendrocyte prec2

Chronic5

Endothelial cells3

Measurement1

Stem cells8

Electrically2

Antigen4

Cognitive3

Sickle1

Membrane3

Therapies1

Populations4

20161

Tissue2

Differentiation2

Neurodegenerative1

Disorders4

Lifespan4

Phenotypes3

Conditions3

Adults1

Frailty1

Humans1

Role2

Effects3

Responses1

Signaling pathway1

Progenitor2

Protein4

Health3

Vitro2

Functional2

Approaches1

Factors7

Mononucleotide2

Diseases1

Conclusions1

Affects1

Function5