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Transcription FactorsMSX1 Transcription FactorTranscription, GeneticDNA-Binding ProteinsPromoter Regions, GeneticPaired Box Transcription FactorsPAX2 Transcription FactorSp1 Transcription FactorMolecular Sequence DataGene Expression RegulationBase SequenceHomeodomain ProteinsTranscriptional ActivationTrans-ActivatorsBinding SitesRepressor ProteinsGene Expression Regulation, DevelopmentalBasic Helix-Loop-Helix Transcription FactorsRNA, MessengerNuclear ProteinsProtein BindingTranscription Factor AP-1PAX7 Transcription FactorForkhead Transcription FactorsCell LinePAX9 Transcription FactorSignal TransductionAmino Acid SequenceDNAMutationCell DifferentiationBasic-Leucine Zipper Transcription FactorsTranscription Factor AP-2TransfectionCell NucleusGenes, ReporterKruppel-Like Transcription FactorsChromatin ImmunoprecipitationTranscription Factors, TFIICells, CulturedYY1 Transcription FactorHeLa CellsSTAT3 Transcription FactorGATA4 Transcription FactorTranscription Factor TFIIDReverse Transcriptase Polymerase Chain ReactionNFATC Transcription FactorsActivating Transcription Factor 3Electrophoretic Mobility Shift AssayEnhancer Elements, GeneticTranscription Initiation SiteSp3 Transcription FactorNF-kappa BZinc FingersActivating Transcription Factor 2Gene Expression ProfilingTranscription Factor TFIIBRegulatory Sequences, Nucleic AcidGene ExpressionCloning, MolecularRecombinant Fusion ProteinsE2F1 Transcription FactorRNA Polymerase IIPlasmidsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsMEF2 Transcription FactorsGATA3 Transcription FactorMicrophthalmia-Associated Transcription FactorTCF Transcription FactorsGATA1 Transcription FactorProtein Structure, TertiaryGATA2 Transcription FactorIn Situ HybridizationLuciferasesGene Expression Regulation, FungalGATA Transcription FactorsB-Cell-Specific Activator ProteinCell Line, TumorSTAT1 Transcription FactorActivating Transcription FactorsEye ProteinsMice, TransgenicMice, KnockoutModels, BiologicalOligonucleotide Array Sequence AnalysisPhosphorylationChromatinHelix-Loop-Helix MotifsTranscription Factor RelAE2F Transcription FactorsSequence Homology, Amino AcidSaccharomyces cerevisiaePhenotypeSaccharomyces cerevisiae ProteinsDown-RegulationGene Expression Regulation, PlantTranscription Factor 7-Like 1 ProteinBlotting, WesternProto-Oncogene ProteinsGATA6 Transcription Factor
Embryonic developmentTarget genesDrosophilaRequirementDomain
Embryonic development2
  • Homeodomain proteins regulate gene expression and cell differentiation during early embryonic development, thus mutations in homeobox genes can cause developmental disorders. (wikipedia.org)
  • Bone morphogenetic proteins regulate multiple processes in embryonic development, including early dorso-ventral patterning and neural crest development. (biomedcentral.com)
Target genes2
  • Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. (wikipedia.org)
  • Nuclear Smads associate with additional transcriptional regulators and cofactors, and regulate transcription of their target genes [reviewed in 43 ]. (biomedcentral.com)
Drosophila1
  • The homeobox domain was first identified in a number of Drosophila homeotic and segmentation proteins, but is now known to be well-conserved in many other animals, including vertebrates. (wikipedia.org)
Requirement1
  • One of the principal differences between HTH motifs in these different proteins arises from the stereochemical requirement for glycine in the turn which is needed to avoid steric interference of the beta-carbon with the main chain: for cro and repressor proteins the glycine appears to be mandatory, whereas for many of the homeotic and other DNA-binding proteins the requirement is relaxed. (wikipedia.org)
Domain1
  • The characteristic homeodomain protein fold consists of a 60-amino acid long domain composed of three alpha helixes. (wikipedia.org)