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  • protein
  • In the presence of Walsh protein (a specific inhibitor of cyclic AMP-dependent protein kinases) cyclic AMP mediated phosphorylation of four polypeptides was demonstrated at pH 6.0. (le.ac.uk)
  • This protein was tentatively identified as an ATPase whose activity was modulated by its phosphorylation state. (le.ac.uk)
  • Does Protein Kinase A-Mediated Phosphorylation of the Cardiac Ryanodine Receptor Play Any Role in Adrenergic Regulation of Calcium Handling in Health and Disease? (ahajournals.org)
  • Approximately 10 years ago, the Marks laboratory 4 reported that protein kinase (PK)A-mediated (hyper)phosphorylation of RyR2 at S2809 in the failing heart caused increased RyR Ca sensitivity and abnormal channel activity. (ahajournals.org)
  • metabolism
  • Phosphorylation of glucose is a key reaction in sugar metabolism because many sugars are first converted to glucose before they are metabolized further. (wikipedia.org)
  • Hepatic cell is freely permeable to glucose, and the initial rate of phosphorylation of glucose is the rate-limiting step in glucose metabolism by the liver (ATP-D-glucose 6-phosphotransferase) and non-specific hexokinase (ATP-D-hexose 6-phosphotransferase). (wikipedia.org)
  • The phosphorylation process is linked to cell metabolism in that metabolic degradation of food, e.g., glucose, allows formation of the coenzyme NADH. (infoplease.com)
  • 2017
  • Recent evidence confirms widespread histidine phosphorylation at both the 1 and 3 N-atoms of the imidazole ring Recent work from 2017 (preprinted at BioRxiv ) suggests widespread human protein phosphorylation on multiple non-canonical amino acids, including motifs containing phosphorylated histidine, aspartate, glutamate, arginine and lysine in HeLa cell extracts. (wikipedia.org)
  • amino acids
  • Recent evidence (preprinted at BioRxiv) suggests widespread human protein phosphorylation on multiple non-canonical amino acids, including motifs containing phosphorylated histidine, aspartate, glutamate, arginine and lysine in HeLa cell extracts. (wikipedia.org)
  • Phosphorylation introduces a charged and hydrophilic group in the side chain of amino acids, possibly changing a protein's structure by altering interactions with nearby amino acids. (wikipedia.org)
  • roles
  • Regulatory roles of phosphorylation include: Phosphorylation of Na+/K+-ATPase during the transport of sodium (Na+) and potassium (K+) ions across the cell membrane in osmoregulation to maintain homeostasis of the body's water content. (wikipedia.org)
  • mechanisms
  • Protein phosphorylation is involved in many mechanisms that contribute to neuronal plasticity, i.e. in the modulation of the information processing and storage properties of nerve cells resulting, ultimately, in the ability of the nervous system to learn. (springer.com)