Phosphorylation p38 mitogen activated protein kinases. Medical search. Frequent questions

Therefore, the mTOR inhibitor, rapamycin, reduces orofacial nociception and Fos expression in the TNC, and its antinociceptive action on orofacial pain may be associated with the inhibition of p-p38 MAPK in the microglia. (kyobobook.co.kr)
Reactive oxygen species-mediated p38 MAPK regulates carbon nanotube -induced fibrogenic and angiogenic responses. (cdc.gov)
SWCNTs induce fibrogenesis through reactive oxygen species-regulated phosphorylation of p38 mitogen-activated protein kinase (MAPK). (cdc.gov)
Activation of p38 MAPK by SWCNTs led to the induction of transforming growth factor (TGF)-b1 as well as vascular endothelial growth factor (VEGF). (cdc.gov)
For example, the mitogen-activated protein kinase (MAPK) p38 pathway mediates stabilization of tumor necrosis factor alpha (TNF-alpha) mRNA in myeloid cells stimulated with bacterial lipopolysaccharide (LPS). (ed.ac.uk)
We present evidence that phosphorylation of TTP is mediated by the p38-regulated kinase MAPKAPK2 (MAPK-activated protein kinase 2). (ed.ac.uk)
We found that apigenin could inhibit PMA-induced phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), which was involved in the down-regulation of the expression of matrix metalloproteinase-9 (MMP-9) at mRNA levels. (spandidos-publications.com)
Furthermore, the treatment of inhibitors specific for p38 MAPK (SB203580) to Caski cells caused the reduction of MMP-9 expression. (spandidos-publications.com)
These results showed apigenin might inhibit the invasion and migration abilities of Caski cells by reducing the MMP-9 expression through suppressing the p38 MAPK signaling pathway. (spandidos-publications.com)
Furthermore, we show that Dlx5 is a novel substrate for p38 MAPK in vitro and in vivo and that Ser-34 and Ser-217 are the sites phosphorylated by p38. (pucv.cl)
In malignant biliary tract epithelia, IL-6 activates the p38 MAPK pathway, which mediates a dominant survival signaling pathway. (elsevierpure.com)
After IL-6 stimulation, p38 MAPK activation preceded phosphorylation of SGK at Ser 78 . (elsevierpure.com)
Pretreatment with the pharmacological inhibitors of p38 MAPK SB-203580 or SB-202190 blocked IL-6-induced SGK phosphorylation at Ser 78 and SGK activation. (elsevierpure.com)
Overexpression of p38α increased constitutive SGK phosphorylation at Ser 78 , whereas dominant negative p38α MAPK blocked IL-6-induced SGK phosphorylation and nuclear translocation. (elsevierpure.com)
Interestingly, in addition to stimulating SGK phosphorylation, both IL-6 stimulation and p38α MAPK overexpression increased SGK mRNA and protein expression. (elsevierpure.com)
An increase in p38 MAPK and SGK occurred following enforced expression of IL-6 in vivo. (elsevierpure.com)
Taken together, these data identify SGK as both a downstream kinase substrate as well as a transcriptionally regulated gene target of p38 MAPK in response to IL-6 and support a role of SGK during survival signaling by IL-6 in human cancers, such as cholangiocarcinoma. (elsevierpure.com)
Orthologous to human MAPKAPK2 (MAPK activated protein kinase 2). (nih.gov)
Proinflammatory Effect of Endothelial Microparticles Is Mitochondria Mediated and Modulated Through MAPKAPK2 (MAPK-Activated Protein Kinase 2) Leading to Attenuation of Cardiac Hypertrophy. (nih.gov)
Pharmacological inhibition of p38 mitogen-activated protein kinase (p38-MAPK) inhibited TNF-α-induced CREB phosphorylation. (elsevierpure.com)
Conclusion-Our results suggest that p38-MAPK/CREB/Rac1 pathway plays a critical role in TNF-α-induced VSMC migration and may be a novel therapeutic target for vascular stenotic lesion. (elsevierpure.com)
Nigericin also induced both an increase in phosphorylated p38 MAPK and proteasomal degradation of ß-catenin. (bvsalud.org)
In the present study, we investigated whether contractions of isolated muscles induced phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and p38 MAPK in a fibre-type dependent manner. (elsevierpure.com)
Significant increase in phosphorylation of p38 MAPK was observed in the fast-twitch muscles only. (elsevierpure.com)
The total amount of ERK1/2 and p38 MAPK proteins was higher in the slow-twitch soleus muscle. (elsevierpure.com)

On the other hand, an increase in Ca 2+ induces eNOS translocation from the cell membrane to the cytosol or Golgi complex ( 8 ), where it is phosphorylated and fully activated by protein kinases that reside in caveolae, such as p38 mitogen-activated protein kinase, phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), cAMP-dependent protein kinase A, and 5′ AMP-activated protein kinase ( 7 ). (diabetesjournals.org)
During the transient loss of p38 activity there was a temporary Fas-induced increase in phosphatidylinositol 3-kinase (PI3K) activity, which also had a pro-apoptotic impact on the neutrophils. (lu.se)

SYK, along with ZAP70, is a member of the Syk family of tyrosine kinases. (syksignaling.com)
Because its discovery, the c Abl family of tyrosine kinases, which includes c Abl and Abl relevant gene , has been shown to be very conserved across species and possesses been implicated in the wide number of cellular HER2 mutation processes including regulation of the actin cytoskeleton, regulation on the cell cycle, and apoptotic cell cycle arrest response to pressure. (pkc-inhibitors.com)

Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. (nih.gov)
Mechanistically, we revealed that nintedanib reduces the TGF-β1-induced phosphorylation of Smad2/3, p38MAPK, and ERK1/2, suggesting that nintedanib acts through both classic and nonclassic signaling pathways of TGF-β1 to prevent HTF activation. (molvis.org)
It is now recognized that a major mechanism involved in eNOS activation is phosphorylation of eNOS at the Ser 1177 residue ( 1 , 2 ). (diabetesjournals.org)
Thus, we propose that BMP activates expression of Osterix through the induction of Dlx5 and its further transcriptional activation by p38-mediated phosphorylation. (pucv.cl)
Results: TSA activated p38 mitogen-activated protein kinase (p38MAPK), leading to p53 phosphorylation and activation. (tmu.edu.tw)
General significance: TSA-induced p53 activation may occur through p53 modification by phosphorylation or by acetylation via IKK inactivation. (tmu.edu.tw)
Using a macrophage cell line, RAW264.7 cells, the effect of midazolam on proinflammatory mediators and activation of mitogen-activated protein kinase was measured by Western blot. (asahq.org)
These results suggest that midazolam has an antiinflammatory action by inhibiting inducible nitric oxide synthase and cyclooxygenase-2 expression, possibly through suppression of NF-kappaB and p38 mitogen-activated protein kinase activation. (asahq.org)
CD95 signaling by protein kinase R-like endoplasmic reticulum kinase causes activation was responsible for the F Promotion of both caspase-8 association erismodegib LDE225 with CD95 and increased Ht eIF2 phosphorylation. (syksignaling.com)
Activation of mitogen-activated protein (MAP) kinases has been implicated in the signal transduction pathways linking exercise to adaptive changes of muscle protein expression. (elsevierpure.com)
Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. (hindawi.com)

Mitogen-activated protein kinases (MAPKs) comprise a large family of proteins activated by a wide range of proinflammatory cytokines and environmental stress. (molvis.org)
3 Activated macrophages contribute to inflammatory responses and can produce and release several cytokines into the general circulation to exert systemic effects that occur during sepsis. (asahq.org)
6 Cyclooxygenase 2 (COX-2) or inducible nitric oxide synthase (iNOS) is induced in macrophages by proinflammatory stimuli, including mitogens, cytokines, and bacterial lipopolysaccharide. (asahq.org)

The p38 pathway is required for the induction of TNF-alpha RNA-binding activity and for the expression of TTP protein and mRNA. (ed.ac.uk)
Our findings demonstrate a direct link between a specific signal transduction pathway and a specific RNA-binding protein, both of which are known to regulate TNF-alpha gene expression at a posttranscriptional level. (ed.ac.uk)
These results suggest that GM3 increases membrane integrity, leading to the suppression of the p38 signalling pathway in BMMC and contributing to skin allergic reaction. (bvsalud.org)
Methods: Skeletal muscle biopsies obtained from carriers (n=6) of a mutation in the tyrosine kinase domain of the insulin receptor gene (INSR) and matched healthy controls (n=15) were used for discovery-mode microarray-based transcriptional profiling combined with biological pathway analysis. (regsj.dk)

This study is to investigate the role of p38 mitogen-activated protein kinase (p38MAPK) in tert -butyl hydroperoxide ( t BHP)-induced apoptosis of human trabecular meshwork (iHTM) cells. (molvis.org)
The mRNA and protein levels of α smooth muscle actin (α-SMA) and Snail and the phosphorylation levels of Smad2/3, p38 mitogen-activated protein kinase (p38MAPK), and extracellular signal-regulated kinase ½ (ERK1/2) were determined by quantitative reverse transcription polymerase chain reaction (RT-PCR), western blot, and immunofluorescence staining. (molvis.org)
The results demonstrated that SA inhibited apoptosis signaling in H9c2 cardiomyocytes via downregulation of p38 mitogen-activated protein kinase (p38MAPK) and c-Jun N-terminal kinase (JNK) signaling pathways following hypoxia/reoxygenation (H/R) injury. (spandidos-publications.com)
Conclusions: TSA may cause C6 cell apoptosis through activating p38MAPK-p53 cascade resulting in Bax expression and survivin suppression. (tmu.edu.tw)

Silibinin also showed a strong phosphorylation of extracellular signal-regulated protein kinase 1/2, stress-activated protein kinase/c-JUN NH2-terminal kinase 1/2, and p38 mitogen-activated protein kinases but inhibited Akt phosphorylation and decreased survivin levels with an increase in cleaved caspase-3. (nih.gov)

Using two different methods it was possible to detect constitutive activity of p38 mitogen-activated protein kinase (p38) in newly isolated neutrophils. (lu.se)

Activated eNOS converts L-arginine to L-citrulline and increases NO, which diffuses into VSMCs and activates guanylyl cyclase, producing cyclic guanosine monophosphate and activating kinases responsible for vessel relaxation ( 9 ). (diabetesjournals.org)

To investigate in vivo molecular mechanisms of silibinin efficacy, tumors and uninvolved skin from tumor-bearing mice were examined immunohistochemically for proliferation, p53, apoptosis, and activated caspase-3. (nih.gov)
Cell therapy with young bone marrow from green fluorescent protein (GFP) transgenic mice exhibited GFP+ myofibres in aged muscle tissues. (nagoya-u.ac.jp)

Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is composed of NLRP3, apoptosis associated speck like protein (ASC) and pro-caspase-1. (ijbs.com)
NLRP3 inflammasome is the most thoroughly studied one, which is composed of NLRP3, apoptosis associated speck like protein (ASC) and caspase-1 precursor (pro-caspase-1) (Figure 1 ) [ 5 - 10 ]. (ijbs.com)
The p38 survival signal was transiently lost during both spontaneous and Fas-induced apoptosis, favoured induction of the apoptotic process. (lu.se)

We also examined whether the glial cell expression and phosphorylated p38 (p-p38) mitogen-activated protein kinases (MAPKs) in the TNC are affected by rapamycin. (kyobobook.co.kr)

Third, Dlx5 overexpression and knock-down assays demonstrate its role in activating Osterix expression in response to BMP-2. (pucv.cl)
Adenovirus-mediated overexpression of dominant-negative form of CREB suppressed TNF-α-induced CREB phosphorylation and c-fos mRNA expression. (elsevierpure.com)
Zellzerst Tion by lowering eIF2 and PERK-dependent Ngigen protein c-flip-plane, w While the overexpression of c-flips Zelllebensf Get up ability. (syksignaling.com)
showed that the expression of phosphorylation-insensitive eIF2 S51A sorafenib and vorinostat L research abolished by blocking c-flips induced levels and the overexpression of c-flips lethality t. overexpression of c-flip suppression zellt important function of multinuclear platinum WZ8040 chemotherapeutic BBR3610. (syksignaling.com)

NLRP3 inflammasome can be activated by different stimuli including pathogen associated molecular patterns (PAMPs) and damage associated molecular pattern (DAMPs). (ijbs.com)
A superfamily of PROTEIN SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. (bvsalud.org)

By activating caspase-1, NLRP3 inflammasome can induce the maturation and secretion of pro-inflammatory factors: Interleukin-1beta (IL-1β) and Interleukin-18 (IL-18). (ijbs.com)
In addition, my experiments showed that the active form of p38 associates with caspase 8 and caspase 3, which is necessary for p38-induced phosphorylation of serine-362 and serine-150 on these caspases. (lu.se)
The results in this dissertation also demonstrate that the protein phosphatase type 2A (PP2A) can directly and independently decrease the phosphorylation levels of both p38 and caspase 3. (lu.se)

Compared with BBR, dhBBR and Di-MeBBR significantly reduced EMMPRIN expression, which was associated with a greater inhibition of p-p38, p-JNK, nuclear NFκB p65 and phospho-p65 induced by oxLDL in macrophages. (biomedcentral.com)

Enables protein serine/threonine kinase activity. (nih.gov)
Separase proteolytic activity is tightly regulated by a number of inhibitory mechanisms combining Securin binding, JAK phosphorylation precise serine residue phosphorylation by CyclinB1 Cdk1, PP2A binding and autocatalytic cleavage. (pkc-inhibitors.com)

What pathways are this gene/protein implicaed in? (cancerindex.org)
In conclusion, MAP kinase signalling pathways are differentially activated and expressed in slow- and fast-twitch muscles. (elsevierpure.com)
In addition, proteins with the corresponding master regulatory pathways had been analyzed. (pkc-inhibitors.com)

Furthermore, midazolam suppressed phosphorylation of p38 mitogen-activated protein kinase and also inhibited lipopolysaccharide-induced superoxide production in macrophages. (asahq.org)

It belongs to family 1 of the G protein-coupled receptors. (cancerindex.org)
NO production in response to various factors, such as increased shear stress, is mediated by endothelial nitric oxide synthase (eNOS), which is constitutively expressed in endothelial cells (ECs) and is tightly controlled by various membrane-bound receptors and regulatory proteins under physiological conditions ( 3 ). (diabetesjournals.org)
Odorant receptors (ORs) are G protein-coupled receptors (GPCRs) that are essential for detecting and distinguishing among odorants. (bmbreports.org)
Receptors in the posterior pharynx are then activated to initiate the involuntary phase of deglutition, which involves carefully sequenced contraction of numerous head and neck muscles. (nature.com)

The human trabecular meshwork cells were treated with t BHP for 1 or 2 h with or without pretreatment of SB203580, an inhibitor of MAP kinase homologs. (molvis.org)
In addition, survivin, a member of inhibitor of apoptotic protein, was significantly decreased in TSA-treated C6 cells. (tmu.edu.tw)

Western blot analysis of normal skin and tumor lysates showed that silibinin decreases the levels of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 and associated cyclins A, E, and D1, together with an up-regulation of Cip1/p21, Kip1/p27, and p53. (nih.gov)

p-p38 expression was co-localized in microglia, but not neurons and astrocytes. (kyobobook.co.kr)

Methods and Results-TNF-α induced CREB phosphorylation with a peak at 15 minutes of stimulation. (elsevierpure.com)

For example, PI3K/Akt-mediated eNOS phosphorylation at Ser 1177 increases the activity of the enzyme and reduces its Ca 2+ dependency ( 9 ) ( Fig. 1 ). (diabetesjournals.org)

Substrate-based kinase activity inference identifies MK2 as driver of colitis. (nih.gov)

Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene. (wikipedia.org)
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. (wikipedia.org)
Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. (wikipedia.org)
Cell surface EMMPRIN expression was measured by flow cytometry and Western blotting, and phospho-(p)-p38, p-JNK, nuclear NFκB p65, and phospho-p65 were measured by Western blotting. (biomedcentral.com)

Compared with the contralateral non-stimulated muscle, contractions increased ERK1/2 phosphorylation to the same extent in fast- and slow-twitch muscles. (elsevierpure.com)
There were no differences in protein content and phosphorylation of 5′ AMP-activated protein kinase, p38 mitogen-activated protein kinase, Erk1 and Erk2. (regsj.dk)

Aims/hypothesis: Insulin resistance in obesity and type 2 diabetes is related to abnormalities in mitochondrial oxidative phosphorylation (OxPhos) in skeletal muscle. (regsj.dk)

Contraction is a multifactorial stimulus with short-term metabolic effects and long-term responses due to changes in protein synthesis. (dissertations.se)

P53, a proapoptotic transcription factor, in turn transactivated the expression of a proapoptotic protein, Bax. (tmu.edu.tw)
cAMP-response element-binding protein (CREB) is the stimulus-induced transcription factor and activates transcription of target genes such as c-fos and interleukin-6. (elsevierpure.com)

Caveolin-1 (Cav-1), an anchoring protein in the plasma membrane caveolae in ECs and vascular smooth muscle cells (VSMCs), attenuates endothelial NO production by occupying the calcium/calmodulin (Ca 2+ /CaM) binding site of eNOS ( 4 ) ( Fig. 1 ). (diabetesjournals.org)

The fluorescence of the single tryptophan residue at position 59 in apocytochrome c , the biosynthetic precursor of the inner mitochondrial membrane protein cytochrome c , was studied in small unilamellar vesicles composed of phosphatidylserine (PS) and phosphatidylcholine (PC) with or without specifically Br-labelled acyl chains at the sn -2 position. (ornine.best)

The protein encoded by this gene is a receptor for C-C type chemokines. (cancerindex.org)
Although several types of inflammasomes have been identified so far, nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is the most characteristic one [ 1 ]. (ijbs.com)
The Abelson non receptor tyrosine kinase gene was initial recognized as the mammalian homolog from the oncogenic gene products from the Abelson murine leukemia virus. (pkc-inhibitors.com)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
Furthermore, nintedanib prevented HTF myofibroblast differentiation via downregulation of mRNA and protein expression of α-SMA and Snail. (molvis.org)
Restoration of p38 expression partly increased PMA-induced MMP-9 secretion blocked by apigenin treatment in Caski cells. (spandidos-publications.com)
We report that bone morphogenetic protein-2 (BMP-2) induces an increase in Osterix expression, which is mediated through a homeodomain sequence located in the proximal region of the Osterix promoter. (pucv.cl)
We report on separase transcription, protein expression, and Separase proteolytic activity. (pkc-inhibitors.com)

Cytoplasmic c Abl could be activated during the G1 S phase transition of the cell cycle, when retinoblastoma gets phosphorylated and releases c Abl Prasugrel from its inhibitory interaction. (pkc-inhibitors.com)

Anatomy21

Organisms9

Chemicals and Drugs164

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes44

Information Science3

MAPK25

Phosphatidylinositol 3-kina2

Tyrosine kinases2

Activation11

Cytokines3

Pathway4

P38MAPK4

Extracellular1

Neutrophils1

Cyclic guanosine mon1

Mice2

Apoptosis3

MAPKs1

Overexpression4

Stimuli2

Caspase3

Inhibition1

Serine2

Pathways3

Macrophages1

Receptors4

Inhibitor2

Tumor1

Neurons1

Stimulation1

PI3K1

Substrate1

Nuclear4

ERK12

Oxidative1

Responses1

Transcription Factor2

Smooth muscle1

Residue1

Receptor3

Expression5

Cytoplasmic1