Phosphorylation beta catenin. Medical search. Frequent questions

The in-depth analysis revealed the downregulation of β-catenin thereby facilitating its degradation by N-terminal phosphorylation of Ser37 residue. (nih.gov)
Therefore, it can be concluded from the study that eugenol exerts its chemotherapeutic potential by impeding β-catenin nuclear translocation thereby promoting its cytoplasmic degradation as a result stemness is being suppressed potentially even if in the enriched state. (nih.gov)
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. (bioseek.eu)
Wnt regulation of beta-catenin degradation is essential for development and carcinogenesis. (bioseek.eu)
beta-catenin degradation is initiated upon amino-terminal serine/threonine phosphorylation, which is believed to be performed by glycogen synthase kinase-3 (GSK-3) in complex with tumor suppressor proteins Axin and adnomatous polyposis coli (APC). (bioseek.eu)
Depletion of CKIalpha inhibits beta-catenin phosphorylation and degradation and causes abnormal embryogenesis associated with excessive Wnt/beta-catenin signaling. (bioseek.eu)
Degradation of β-catenin is thus mediated by this N-terminal segment. (wikipedia.org)
Scholars@Duke publication: Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. (duke.edu)
However, how the beta-catenin degradation complex is inhibited upon Wnt activation remains unclear. (duke.edu)
Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. (cancerindex.org)
Wnt/beta-catenin signaling: The canonical Wnt/beta-catenin signaling regulates beta-catenin phosphorylation/degradation and thus beta-catenin-dependent gene expression program. (xenbase.org)
Wnt-1 signaling can also induce the phosphorylation and subsequent degradation of c-Myb. (thermofisher.com)
CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP thereby enhancing beta-catenin degradation. (rockland.com)

The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. (nih.gov)
Knockdown of FRAT1 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/β-catenin pathway in hepatocellular carcinoma cells. (nih.gov)
2004. Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells. . (oregonstate.edu)
PP1 expression synergistically activates, and inhibition of PP1 inhibits, Wnt/beta-catenin signaling in Drosophila and mammalian cells as well as in Xenopus embryos. (duke.edu)
In colon-derived cell lines where Yap is overabundant, its depletion strongly reduces beta-catenin and Notch signaling and inhibits proliferation and survival. (harvard.edu)

β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. (wikipedia.org)
Notably, the C-terminal segment of β-catenin can mimic the effects of the entire Wnt pathway if artificially fused to the DNA binding domain of LEF1 transcription factor. (wikipedia.org)
The Wnt/beta-catenin signaling pathway is critical in both cellular proliferation and organismal development. (duke.edu)
Using a directed RNAi screen we find that protein phosphatase 1 (PP1), a ubiquitous serine/threonine phosphatase, is a novel potent positive physiologic regulator of the Wnt/beta-catenin signaling pathway. (duke.edu)
Specific inhibition of PP1 in this pathway may offer therapeutic approaches to disorders with increased beta-catenin signaling. (duke.edu)
The Wnt pathway mediates the biological processes of the canonical or non-canonical pathway, depending on the involvement of β-catenin in signal transduction. (chemdiv.com)
The recently described role of the Wnt/β-catenin pathway in the regulation of immune cell infiltration of microenvironment tumor resumes interest because of its potential impact to rection of immune therapy. (chemdiv.com)
This article presents the roles of the Wnt/β-catenin pathway in cancer and current therapeutic strategies involving this pathway. (chemdiv.com)
Nussе and Varmus identified components of the Wnt/β-catenin pathway in 1982 in a study of oncogenic breast tumor viral diseases (MMTV) [1]. (chemdiv.com)
MicroRNA-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the Wnt/β-catenin pathway by negative regulation of Smad7. (cancerindex.org)
Based on the findings, the inhibition of miR-543 was found to play a tumor suppressive role in PA through the down-regulation of Wnt/β-catenin pathway by negatively regulating Smad7. (cancerindex.org)
We are interested in understanding the molecular logic of this key developmental signaling pathway, including its dual-receptor system (the Frizzled family and LDL receptor-related proteins, LRP5 and LRP6), the dual-kinase system (CKI and GSK3) for both beta-catenin and the LRP5/6 coreceptors, and the connection from the receptors to beta-catenin regulation. (xenbase.org)
The canonical signaling pathway is initiated upon Wnt binding to a Frizzled family receptor and an LRP5/LRP6 coreceptor, which leads to activation of the beta-catenin cascade. (thermofisher.com)
Beta-catenin acts as an intracellular signal transducer in the Wnt signaling pathway. (plurisomes.com)
This response was both time- and dose-dependent, it was independent of the Akt signaling pathway and did not increase steady state levels of phosphorylation of beta-catenin, although the data suggested that activated GSK3beta could regulate the activity of ERK1/2. (manuelmenendez.com)

regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. (proteopedia.org)
CTNNB1 phosphorylation regulates insulin internalization. (proteopedia.org)

Catenin beta-1, also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. (wikipedia.org)
2004. Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters. . (oregonstate.edu)
2003. Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. . (oregonstate.edu)
2002. Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline. . (oregonstate.edu)

β-catenin is a component of the complex cadherin complex whose stabilization is required to activate Wnt/β-catenin signaling. (chemdiv.com)
Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta -catenin levels (2). (novusbio.com)
Although stabilization involving beta-catenin inside osteoblasts is shown to market bone size accrual within a mouse style, a number of studies documented inhibitory results of lithium dietary supplements on the osteogenic distinction of cultured mesenchymal originate tissue. (micrornaarray.com)
PMID:21724855 phosphorylation and stabilization. (who.int)

catenin Serine 45 (S45) phosphorylation. (justia.com)
mutagenesis of the corresponding serine residue at position 231 of human CDC34/UBC3 showed that this was the major CK2-phosphorylation site in this protein. (rockland.com)

Wnt-regulated changes in axin phosphorylation, mediated by PP1, may therefore determine beta-catenin transcriptional activity. (duke.edu)

2003. Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. . (oregonstate.edu)
Compound 51 inhibited the proliferation of 13 out of 15 cancer cell lines with IC50 values between 0.27 and 6.9 muM, which correlated with the complete suppression of retinoblastoma phosphorylation and the onset of apoptosis. (proteopedia.org)

β-Catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. (wikipedia.org)

Speaking more specifically, β-catenin is an integral structural component of cadherin-based adhesive junctions as well as it a key nuclear effector of canonical in nucleus Wnt signaling. (chemdiv.com)
Wnt signaling in stem cell biology, cancer and diseases: The canonical Wnt/beta-catenin signaling is involved in stem cell regulation, cancer and other diseases such as osteoporosis, as hyperactive beta-catenin signaling leads to tumorigenesis and loss of function of LRP5 results in familial osteoporosis. (xenbase.org)
XPNPEP3 is a novel transcriptional target of canonical Wnt/β-catenin signaling. (nih.gov)

This library represents a selection of drug-like compounds aimed at modulating protein-protein interaction (PPI) of β-catenin with different proteins involved in significant physiological processes. (chemdiv.com)
The molecular weight of proteins were 102, 88 and 80 kDa, so they were named α, β and γ-catenin. (chemdiv.com)

2002. Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations. . (oregonstate.edu)
Inhibition of PP1 leads to enhanced phosphorylation of specific sites on axin by casein kinase I. Axin phosphorylation markedly enhances the binding of glycogen synthase kinase 3, leading to a more active beta-catenin destruction complex. (duke.edu)
Inhibition of Cdk5 by olomoucine enhanced phosphorylation of kinesin, suggesting that the effect was mediated by negative regulation of other kinases. (frontiersin.org)
Inhibition of Cdk5 resulted in dephosphorylation of the inhibitory Ser9 site on GSK3β and an increase of activating phosphorylation at Tyr216. (frontiersin.org)
CONCLUSION: This study demonstrates that MPO inhibition alleviates the relaxation defect in hypertrophic iPSC-CMs through MYBPC3 phosphorylation. (bvsalud.org)

ChemDiv proposes the new library of beta-catenin inhibitors/modulators. (chemdiv.com)

GSEA analysis found STARD12 and STARD14 were associated with glycolysis, oxidative phosphorylation and tumor related signaling pathways. (medsci.org)
Using a genetically engineered mouse model for intestinal cancer, the research team found that this process is kept under control by direct phosphorylation by PKC-zeta of two essential tumor promoters: beta-catenin and Yap. (sbpdiscovery.org)

The standard model of Wnt signaling specifies that after receipt of a Wnt ligand at the membranous receptor complex, downstream mediators inhibit a cytoplasmic destruction complex, allowing β-catenin to accumulate in the cytosol and nucleus and co-activate Wnt target genes. (silverchair.com)

Our study uncovers distinct roles and steps of beta-catenin phosphorylation, identifies CKIalpha as a component in Wnt/beta-catenin signaling, and has implications to pathogenesis/therapeutics of human cancers and diabetes. (bioseek.eu)
2003. Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac. . (oregonstate.edu)
ChemDiv's Inhibitors of beta-Catenin Signaling Library contains 8,000 compounds. (chemdiv.com)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
Wnt/β-catenin signaling is a branch of a functional network that is involved in a broad range of biological systems including stem cells, embryonic development and adult organs. (chemdiv.com)
Deregulation of components involved in Wnt/β-catenin signaling has been implicated in a wide spectrum of diseases including a number of cancers and degenerative diseases. (chemdiv.com)
An imbalance in the structural and signaling properties of β-catenin often leads to disease and unregulated growth associated with cancer and metastasis. (chemdiv.com)
Diminished phosphorylation, enhanced abundance, and nuclear localization of the transcriptional coactivator Yes-associated protein 1 (Yap1) is evident in Mst1/Mst2-deficient intestinal epithelium, as is strong activation of beta-catenin and Notch signaling. (harvard.edu)
Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2. (nih.gov)

β-Catenin is a dual function protein, involved in regulation and coordination of cell-cell adhesion and gene transcription. (wikipedia.org)
Not only their ARM domains resemble each other in both architecture and ligand binding capacity, but the N-terminal β-TrCP-binding motif is also conserved in plakoglobin, implying common ancestry and shared regulation with β-catenin. (wikipedia.org)

Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. (wikipedia.org)

Significant downregulation of various CSC markers was also observed in vivo after eugenol treatment those are regulated by the intracellular status of β-catenin. (nih.gov)
The underlying mechanism revealed significant downregulation of β-catenin and the set of CSC markers along with their reduced mRNA expression in secondary sphere culture. (nih.gov)
Significant downregulation of beta-defensin1 gene (DEFB1) expression was observed when human bronchial epithelial cells (HBEpCs) were exposed to IAV. (cdc.gov)

ab109185 detects the 17 kDa carboxy-terminal subunit (subunit beta). (abcam.com)
The basic subunit of beta-crystallins. (lookformedical.com)

β-Catenin was initially discovered in the early 1990s as a component of a mammalian cell adhesion complex: a protein responsible for cytoplasmatic anchoring of cadherins. (wikipedia.org)
But very soon, it was realized that the Drosophila protein armadillo - implicated in mediating the morphogenic effects of Wingless/Wnt - is homologous to the mammalian β-catenin, not just in structure but also in function. (wikipedia.org)

In cardiac muscle, β-catenin localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocytes. (wikipedia.org)

5 mmHg) led to an increase in interendothelial gap formation, activation of the contractile machinery (MLC and MYPT1 phosphorylation), F-actin stress fiber formation, and loss of VE-cadherin and beta- catenin from cell-cell junctions. (uni-giessen.de)
Simultaneously MLC and MYPT1 phosphorylation was abolished, cortical actin rearranged at cell borders, VE-cadherin/beta catenin re-established at cell junctions, and cytonuclear translocation of AMPKalpha isoforms was prevented. (uni-giessen.de)

Interestingly, distinctly lower concentrations of bosutinib are required to ablate BCR-ABL phosphorylation when compared to the first-generation tyrosine kinase inhibitor imatinib (IM). (mdm2-receptor.com)

In this study, the effect of eugenol on CSC (Cancer Stem Cell) markers and its main regulator β-catenin both in vivo Ehrlich Ascites Carcinoma (EAC) cell line and in vitro MCF-7 cell line was investigated with that of the untreated group. (nih.gov)

Vertebrate catenins contain a large number of Arm-domains including 3 subfamilies: β-tencains, p120 and plakophilins 1 and 3. (chemdiv.com)

Expression of Frat1 correlates with expression of β-catenin and is associated with a poor clinical outcome in human SCC and AC. (nih.gov)
catenin acetylation, like FRAT1. (justia.com)

phosphorylation of Tyr216 can enhance enzyme activity, and conversely phosphorylation of Ser9 is inhibitory. (frontiersin.org)
Hypoxia caused a marked increase in AMPK phosphorylation which is associated with activation of the enzyme, however during reperfusion AMPK phosphorylation declined rapidly. (uni-giessen.de)

β-catenin is a multipurpose and evolutionarily conserved molecule that plays a critical role by metazoans in a variety of processes in development and homeostasis. (chemdiv.com)
β-catenin belongs to the catenin molecule family. (chemdiv.com)

Altered phosphorylation of CREB phosphopeptide, a substrate of GSK3β, suggested that GSK3β may be the mediator of Cdk5 activity in kinesin-mediated axonal transport. (frontiersin.org)
Corresponding for you to WNT, lithium stops GSK3-mediated phosphorylation of cytosolic transcribing aspect beta-catenin and its following wreckage with the proteasome complex. (micrornaarray.com)

Here we describe another Axin-associated kinase, whose phosphorylation of beta-catenin precedes and is required for subsequent GSK-3 phosphorylation of beta-catenin. (bioseek.eu)
controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. (proteopedia.org)

It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. (wikipedia.org)
In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. (proteopedia.org)

β-Catenin is widely expressed in many tissues. (wikipedia.org)
Lithium therapy lowers BMP-2-induced SMAD One particular,Your five,7 phosphorylation in the MC3T3-E1 and also C2C12 tissues without having affected his or her dephosphorylation. (micrornaarray.com)

A representative example of a 'druggable' 'hot spots' included specific topological features of the β -catenin interaction. (chemdiv.com)
Phosphorylation of RB1 disturbs its interaction with E2F1. (proteopedia.org)

CK2-dependent phosphorylation of CDC34 and UBC3B functions by regulating BTRC substrate recognition (1). (rockland.com)

The core of β-catenin consists of several very characteristic repeats, each approximately 40 amino acids long. (wikipedia.org)
The primary structure of beta-catenin consists of an NH2-terminal domain (NDT), a central region represented by 12 Arm-repeats (R1-12), and a COOH-terminal end (CTD). (chemdiv.com)

The presence of cardiomyocyte MPO was associated with higher chlorination and peroxidation activity, increased levels of 3-chlorotyrosine-modified cardiac myosin binding protein-C (MYBPC3), attenuated phosphorylation of MYBPC3 at Ser-282, perturbed calcium signalling, and impaired cardiomyocyte relaxation. (bvsalud.org)

All the diversity of catenins forms a complex functional network. (chemdiv.com)

Thus, β-catenin became one of the first examples of moonlighting: a protein performing more than one radically different cellular function. (wikipedia.org)
β-Catenin is a fascinating protein with many important cellular and developmental functions. (chemdiv.com)

2004. The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells. . (oregonstate.edu)
Importantly, we confirmed the tumorigenic profiles of PKC-zeta, beta-catenin, and Yap in human colon adenocarcinoma samples. (sbpdiscovery.org)

5 mmHg) führte zu einem Anstieg interendothelialer Lückenbildung, Aktivierung des kontraktilen Apparates (MLC und MYPT1 Phosphorylierung), F-Aktin Stressfaser-Bildung und Verlußt von VE-Cadherin und beta-Catenin an Zellverbindungen. (uni-giessen.de)

Alterations in the localization and expression levels of β-catenin have been associated with various forms of heart disease, including dilated cardiomyopathy. (wikipedia.org)

The correlation of human results with our in-vivo mouse studies strongly suggests that Yap and beta-catenin are potential targets of PKC-zeta function and potential targets for new anti-cancer therapies. (sbpdiscovery.org)

Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. (proteopedia.org)

USP37 is activated by phosphorylation and thus triggers G1-S transition. (proteopedia.org)

As sketched above, the ARM domain of β-catenin acts as a platform to which specific linear motifs may bind. (wikipedia.org)
Beta-crystallins are similar in structure to GAMMA-CRYSTALLINS in that they both contain Greek key motifs. (lookformedical.com)

The antimicrobial peptide, beta-defensin-1, has antiviral activity against both enveloped and non-enveloped viruses. (cdc.gov)

Interestingly, treatment with the MPO inhibitor, AZD5904, reduced 3-chlorotyrosine-modified MYBPC3 levels, restored MYBPC3 phosphorylation, and alleviated the calcium signalling and relaxation defects. (bvsalud.org)

HelixC is not necessary for β-catenin to function in cell-cell adhesion. (wikipedia.org)
Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. (lookformedical.com)

Expression is particularly high in the pancreas where it is thought to play a role in the differentiation of pancreatic beta cells. (embl.de)

In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)

EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. (proteopedia.org)
NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. (proteopedia.org)

Anatomy22

Organisms11

Diseases6

Chemicals and Drugs148

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes45

Disciplines and Occupations1

Information Science3

Degradation13

Inhibits5

Pathway15

Regulates2

CTNNB14

Stabilization4

Serine2

Transcriptional activity1

Apoptosis2

Adenomatous poly1

Canonical3

Proteins2

Inhibition5

Modulators1

Tumor2

Destruction complex1

Signaling10

Regulation2

Hepatocellular carcinoma1

Downregulation3

Subunit2

Mammalian2

Adherens1

Actin2

Tyrosine1

Regulator1

Vertebrate1

Frat12

Enzyme2

Molecule2

GSK32

Subsequent2

Homologous2

Tissues2

Interaction2

Substrate1

Consists2

Cardiac1

Complex1

Cellular2

Colon2

Cadherin1

Localization1

Strongly1

Activation1

Transition1

Motifs2

Activity1

Levels1

Cell2

Expression1

Suggests1

Promotes2