• receptors
  • Nearly every cell and tissue in the human body expresses at least one of these receptors, allowing EFA-based signaling to influence nearly every aspect of human physiology. (mdpi.com)
  • potent
  • 18 19 The mammalian secretory group II PLA 2 (14 kDa) is mobilized at sites of inflammation and exerts potent antibacterial activity against Gram-positive bacteria. (arvojournals.org)
  • inflammatory
  • PLA 2 is secreted from a number of cells, 16 including polymorphonuclear leukocytes (PMNs), and is found at high concentrations in inflammatory fluids 17 and human tears. (arvojournals.org)
  • These phospholipases are involved in cell signaling processes, such as inflammatory response. (wikipedia.org)
  • Calcium
  • Our study reports inhibition of myocardial intracellular calcium-independent phospholipase A 2 (iPLA 2 ) activity by clinically relevant concentrations of the drug. (aacrjournals.org)
  • Regulation
  • 11 These observations support physiological and pathophysiological roles for 20-HETE in regulation of natriuresis and BP in humans. (ahajournals.org)
  • mediators
  • That action may prevent the unintended consequences that come from eating imbalanced diets which support excessive chronic actions of n -6 mediators that harm human health. (mdpi.com)

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  • barrier
  • Increased sPLA2 activity is observed in the cerebrospinal fluid of humans with Alzheimer's disease and multiple sclerosis, and may serve as a marker of increases in permeability of the blood-cerebrospinal fluid barrier. (wikipedia.org)
  • expression
  • The relative contents of almost all PC species in liver decreased from 1 h, appeared to be lowest at 6 h, and then return to normality at 24 h, which might be partly explained by the suppression of phospholipases mRNA expressions and the induction of choline kinase (Chka) expression. (biomedcentral.com)