• receptors
  • Nearly every cell and tissue in the human body expresses at least one of these receptors, allowing EFA-based signaling to influence nearly every aspect of human physiology. (mdpi.com)
  • extracellular
  • The extracellular forms of phospholipases A2 have been isolated from different venoms (snake, bee, and wasp), from virtually every studied mammalian tissue (including pancreas and kidney) as well as from bacteria. (wikipedia.org)
  • potent
  • 18 19 The mammalian secretory group II PLA 2 (14 kDa) is mobilized at sites of inflammation and exerts potent antibacterial activity against Gram-positive bacteria. (arvojournals.org)
  • inflammatory
  • PLA 2 is secreted from a number of cells, 16 including polymorphonuclear leukocytes (PMNs), and is found at high concentrations in inflammatory fluids 17 and human tears. (arvojournals.org)
  • These phospholipases are involved in cell signaling processes, such as inflammatory response. (wikipedia.org)
  • venom
  • Both sulfhydryl reagents stimulated AA release from the HEK293T cells expressing human sPLA(2)X, and stimulated the sPLA(2) activities of bee venom sPLA(2) and the soluble fraction of sPLA(2)X-expressing cells. (biomedsearch.com)
  • Venom phospholipases help to immobilize prey by promoting cell lysis. (wikipedia.org)
  • Calcium
  • Our study reports inhibition of myocardial intracellular calcium-independent phospholipase A 2 (iPLA 2 ) activity by clinically relevant concentrations of the drug. (aacrjournals.org)
  • Regulation
  • 11 These observations support physiological and pathophysiological roles for 20-HETE in regulation of natriuresis and BP in humans. (ahajournals.org)
  • mediators
  • That action may prevent the unintended consequences that come from eating imbalanced diets which support excessive chronic actions of n -6 mediators that harm human health. (mdpi.com)
  • occurs
  • Even though the processing of human neutrophil alpha-defensins occurs during neutrophil maturation prior to cellular release from the bone marrow, matrilysin may participate in the activation of beta-defensins or other antimicrobial peptides in the human airways. (asmscience.org)

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  • barrier
  • Increased sPLA2 activity is observed in the cerebrospinal fluid of humans with Alzheimer's disease and multiple sclerosis, and may serve as a marker of increases in permeability of the blood-cerebrospinal fluid barrier. (wikipedia.org)
  • activation
  • The binding of IgE to human mast cells and basophils, a process termed sensitization , prepares these cells for subsequent antigen-specific activation. (mhmedical.com)
  • Syk activates not only phospholipase Cγ, which associates with the Linker of Activated T Cells at the plasma membrane, but also phosphatidylinositol 3-kinase to provide phosphatidylinositol-3,4,5-trisphosphate, which allows membrane targeting of the Tec family kinase Btk and its activation by Lyn. (mhmedical.com)