• Choline kinase (also known as CK, ChoK and choline phosphokinase) is an enzyme which catalyzes the first reaction in the choline pathway for phosphatidylcholine (PC) biosynthesis. (wikipedia.org)
  • ATP + choline ⇌ {\displaystyle \rightleftharpoons } ADP + O-phosphocholine Thus, the two substrates of this enzyme are ATP and choline, whereas its two products are adenosine diphosphate (ADP) and O-phosphocholine. (wikipedia.org)
  • A related enzyme, ethanolamine kinase, tends to co-purify with choline kinase leading to a suggestion that the two activities are mediated by two distinct active sites on a single protein. (wikipedia.org)
  • The systematic name of this enzyme class is ATP:choline phosphotransferase. (wikipedia.org)
  • As the literature describing biochemical changes in OCD yields conflicting results, we focused on accurate metabolite quantification of total N-acetyl aspartate (tNAA), total creatine (tCr), total choline-containing compounds (tCh), and myo-inositol (mI) in the anterior cingulate cortex (ACC) to capture the small metabolic changes between OCD patients and controls and between OCD patients with and without medication. (bvsalud.org)
  • Muscle enzymes (e.g., creatine kinase) are elevated in inclusion body myositis as they are in IIM but usually less so in inclusion body myositis (as much as 10 times normal) than in PM/DM (as much as 50 times normal). (rheumaknowledgy.com)
  • By itself, choline elicited nicotine-like actions commensurate with its promotion of cholinergic neurotransmission. (nature.com)
  • Muscle enzymes (e.g., creatine kinase) are elevated in inclusion body myositis as they are in IIM but usually less so in inclusion body myositis (as much as 10 times normal) than in PM/DM (as much as 50 times normal). (rheumaknowledgy.com)
  • Choline kinase (also known as CK, ChoK and choline phosphokinase) is an enzyme which catalyzes the first reaction in the choline pathway for phosphatidylcholine (PC) biosynthesis. (wikipedia.org)
  • JCR 795b is a competitive, small molecule inhibitor of choline kinase (ChoK) with in vitro IC50 of 3.5 uM. (probechem.com)
  • Hemicholinium-3 (HC-3) is a competitive, small molecule inhibitor of choline kinase (ChoK) with ex vivo IC50 of 500 uM, also bolcks the sodium and chloride-dependent transport system and affects choline acetyltransferase. (probechem.com)
  • MN58b is a potent, selective choline kinase α (ChoKα) inhibitor with IC50 of 1.4 uM, >30-fold selectivity over ChoKβ and does not affect MAPKs, PI3Ks, and other enzymes involved in the regulation of phospholipid metabolism. (probechem.com)
  • JAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly, prevents choline phosphorylation and induces cell death in breast cancer cell lines. (probechem.com)
  • V-11-0711 (V-11 0711) is a novel potent and selective choline kinase alpha (ChoKα) inhibitor with IC50 of 20 nM, with 11 fold less activity against ChoKβ. (probechem.com)
  • EB-3D is a novel potent and selective choline kinase ChoKα inhibitor with IC50 of 1.0 uM (purified ChoKα1), strongly impairs cell proliferation in a variety of different cancer cell lines. (probechem.com)
  • A potent, specific, competitive inhibitor of choline kinase-α (Chok-α) by targeting the choline binding site. (probechem.com)
  • The systematic name of this enzyme class is ATP:choline phosphotransferase. (wikipedia.org)
  • It is synthesized from choline through choline acetyltransferase, which exerts its greatest activity in the caudate nucleus. (medscape.com)
  • A related enzyme, ethanolamine kinase, tends to co-purify with choline kinase leading to a suggestion that the two activities are mediated by two distinct active sites on a single protein. (wikipedia.org)
  • Choline kinase catalyzes the formation of phosphocholine, the committed step in phosphatidylcholine biosynthesis. (wikipedia.org)
  • It has been proposed that in the CKα-2 mechanism, ATP binds first, followed by choline, and then the transfer of the phosphoryl group takes place. (wikipedia.org)
  • It is degraded by cholinesterase with the formation of choline, which may be used once again for synthesis by the presynaptic neuron. (medscape.com)