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  • Genotypes
  • Data is being made available through NIH databases (database of Genotypes and Phenotypes (dbGaP) and National Database for Autism Research (NDAR)) with DNA released in Dist 11.0. (biomedcentral.com)
  • One of the objectives of the OMIA is to match genotypes to phenotypes. (wikipedia.org)
  • It is capable of representing many of the general classes of data frequently encountered in modern biology such as sequence, sequence comparisons, phenotypes, genotypes, ontologies, publications, and phylogeny. (gmod.org)
  • By performing ordinal regression, MultiPhen tests the linear combination of phenotypes most associated with the genotypes at each SNP, and thus potentially captures effects hidden to single phenotype GWAS. (nih.gov)
  • In particular, we demonstrate that other multivariate methods that assume the genotypes are normally distributed, such as canonical correlation analysis (CCA) and MANOVA, can have highly inflated type-1 error rates when testing case-control or non-normal continuous phenotypes, while MultiPhen produces no such inflation. (nih.gov)
  • genetic
  • In a unique public-private partnership, 13 sites with extensive experience in both the assessment and diagnosis of ASD embarked on an ambitious, 2-year program to collect samples for genetic and phenotypic research and begin analyses on these samples. (biomedcentral.com)
  • This article is from PLoS ONE, volume 9.AbstractIn the context of genetics and breeding research on multiple phenotypic traits, reconstructing the directional or causal structure between phenotypic traits is a prerequisite for quantifying the effects of genetic interventions on the traits. (duhnnae.com)
  • heritable
  • 2006) describe the OMIA as a "comparative biology resource" "(The) OMIA is a comprehensive resource of phenotypic information on heritable animal traits and genes in a strongly comparative context, relating traits to genes where possible. (wikipedia.org)
  • The most associated linear combinations of the lipids estimated by MultiPhen at the leading SNPs accurately reflect the Friedewald Formula, suggesting that MultiPhen could be used to refine the definition of existing phenotypes or uncover novel heritable phenotypes. (nih.gov)
  • autism
  • At almost every site, additional phenotypic measures were collected, including the Broad Autism Phenotype Questionnaire (BAPQ) and Repetitive Behavior Scale-Revised (RBS-R), as well as the non-word repetition scale, Communication Checklist (Children's or Adult), and Aberrant Behavior Checklist (ABC). (biomedcentral.com)
  • syndrome
  • In 2006, Agochukwu and her colleagues concluded that "A distinct Muenke syndrome phenotype includes: uni or bilateral coronal synostosis, midface hypoplasia, broad toes, and brachydactyly. (wikipedia.org)
  • describes
  • The Flexible Phenotype attempts a true synthesis of animal physiology, behavior, and ecology by developing an empirical argument that describes the intimate connections between animal phenotype and environment. (oup.com)
  • Results
  • Power results based on simulations described in the text for MultiPhen (red lines) and the standard single-phenotype approach (black lines). (nih.gov)
  • The latter assumes that cultural and behavioral change results from phenotypic adaptations to varying social and ecological environments. (wikipedia.org)
  • basis
  • The integrated story of the flexible phenotype is weaved throughout the book on the basis of the authors' long-term research program on migrant shorebirds and their invertebrate prey. (oup.com)
  • No symbol before an entry number generally indicates a description of a phenotype for which the Mendelian basis, although suspected, has not been clearly established or that the separateness of this phenotype from that in another entry is unclear. (wikipedia.org)
  • development
  • For example, cancer cells undergo epithelial to mesenchymal transition (EMT) that plays important roles in their survival, proliferation, and development of resistance to therapeutic treatments, or switch to a phenotype that mimics stem cell-like features - the so-called Cancer Stem Cells (CSCs) or Tumour-initiating Cells. (wikipedia.org)
  • multiple
  • MultiPhen: joint model of multiple phenotypes can increase discovery in GWAS. (nih.gov)
  • Here we compare the performance of modelling multiple phenotypes jointly with that of the standard univariate approach. (nih.gov)
  • We introduce a new method and software, MultiPhen, that models multiple phenotypes simultaneously in a fast and interpretable way. (nih.gov)
  • There is a boost in power for variants that affect multiple phenotypes and for those that affect only one phenotype. (nih.gov)
  • main
  • Mutation occurred in fabI, which encodes the main triclosan target in all SCVs and the phenotype was reversed by fatty acid supplementation, demonstrating an association between fatty acid metabolism and triclosan-induced SCV. (shu.ac.uk)
  • cell
  • Although state switching is essential for normal functioning, the repertoire of phenotypes in a normal cell is albeit limited. (wikipedia.org)
  • However
  • For example, if a mutation is maternal effect recessive, then a female homozygous for the mutation may appear phenotypically normal, however her offspring will show the mutant phenotype, even if they are heterozygous for the mutation. (wikipedia.org)
  • database
  • Phene" is used as to refer to relevant phenotypic traits in the OMIA (Online Mendelian Inheritance in Animals) database. (wikipedia.org)
  • DECIPHER, a database of chromosomal imbalance and associated phenotype in humans, using Ensembl resources. (wikipedia.org)
  • normal
  • A hallmark of the factors implicated in phenotypic switching whether in cancer or in normal cells is that they are Intrinsically disordered proteins (IDPs). (wikipedia.org)
  • Search
  • Since the term "phenotype" has been used to describe traits and syndromes and population characteristics it is not helpful in the collective search for specific traits that could be a consequence of a single gene or gene-environmental interaction. (wikipedia.org)