• The metabolic and immune responses to obesity affect many organs and particularly the adipose tissue where macrophages are key effector cells modulating inflammation through the signals received from adipocytes. (bmj.com)
  • We aimed to study if M2 macrophage-like cell transplantation could reduce the inflammation in salivary glands in Sjogren's syndrome mouse models. (nii.ac.jp)
  • The meeting will also highlight recent work on macrophage inflammation in the context of SARS-CoV-2 infection and work from recently-funded NIMH, NIDA, and NINDS investigators. (nih.gov)
  • A panel will discuss research gaps and priorities related to human macrophage reservoirs and inflammation/comorbidities and treatment strategies for HIV remission and cure. (nih.gov)
  • A fundamental problem in understanding how macrophages regulate inflammation is their phenotypical and functional heterogeneity. (nature.com)
  • Many types of cells are involved in the progression of RA joint inflammation, among which the overactivation of M1 macrophages and osteoclasts has been thought to be an essential cause of joint inflammation and bone destruction. (elifesciences.org)
  • But, at the same time, theincrease of the pro-inflammatory response that follows the bacterial processingpromotes the clearance of apoptotic cells by these macrophages contributing tothe resolution of local inflammation. (conicet.gov.ar)
  • Dermal sensitization (50% and 25% w/v) with TMA and an inhalation challenge of 15 mg/m3 TMA-induced apneas, laryngeal inflammation, increased numbers of eosinophils, neutrophils and macrophages in bronchoalveolar lavage (BAL), and increased immunoglobulin E levels in serum and lung tissue. (cdc.gov)
  • In particular, the enzyme appears to be involved in the growth and development of certain immune system cells, including macrophages, which are a type of white blood cell that plays a critical role in inflammation. (medlineplus.gov)
  • Some macrophages are pro-inflammatory, meaning they promote inflammation, while others are anti-inflammatory, meaning they reduce inflammation. (medlineplus.gov)
  • They speculate that the enzyme deficiency may disrupt the balance between pro-inflammatory and anti-inflammatory macrophages in various tissues, leading to a buildup of pro-inflammatory macrophages and abnormal inflammation. (medlineplus.gov)
  • Results: Macrophage polarization was the main immune infiltration pattern in GC, and the state of macrophage polarization was closely related to the pathological grading of GC and the clinical stage of patients. (portlandpress.com)
  • Low AKR1B10 expression induced M2 macrophage polarization and promoted the malignant phenotype of GC. (portlandpress.com)
  • Conclusion: M2 macrophage polarization is the main immune infiltration pattern in GC. (portlandpress.com)
  • Low AKR1B10 expression induces M2 macrophage polarization and promotes the malignant transformation of GC. (portlandpress.com)
  • We previously revealed that corosolic acid, a triterpenoid compound, inhibits the M2 polarization of human monocyte-derived macrophages (HMDM). (spandidos-publications.com)
  • OA significantly inhibited the expression of CD163, one of the phenotype markers of M2 macrophages, as well as suppressed the secretion of IL-10, one of the anti-inflammatory cytokines preferentially produced by M2 macrophages, thus suggesting that OA suppresses the M2 polarization of macrophages. (spandidos-publications.com)
  • These results indicate that OA suppresses the M2 polarization of macrophages and tumor cell proliferation by inhibiting STAT3 activation. (spandidos-publications.com)
  • The DNMT3A-mutated AML cells attenuated M1 macrophage polarization and resisted its killing effect in vitro and in vivo . (frontiersin.org)
  • The decreased expression and inhibition of nuclear transfer of GLI1 downregulated macrophage M1 polarization and osteoclast activation, the effect of which was achieved by modulation of DNA methyltransferases (DNMTs) via transcriptional regulation and protein interactions. (elifesciences.org)
  • HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. (lu.se)
  • To investigate whether Trib3 regulates the polarisation state of macrophages, bone marrow derived macrophages (BMDMs) were isolated and polarised in vitro to further characterise their pro- or anti- inflammatory properties. (bmj.com)
  • Originating either from monocytes that come from bone marrow, or tissue-resident macrophages that arise during embryonic development, they can repress antitumor immunity by secreting cytokines such as IL-10, which blocks dendritic cell activation, and TGF-β, which blunts T-cell responses (1). (the-scientist.com)
  • The same applies to the bone marrow that requires macrophages for the clearance of the nuclei that get expelled from erythroblasts during their maturation towards erythrocytes [ 8 ]. (hindawi.com)
  • SCAP had previously been shown to reduce tumour necrosis factor alpha (TNFα) gene (Tnf) expression in vitro, whilst ECM hydrogels had been shown to induce the M2-like phenotype in naïve monocytes. (nottingham.ac.uk)
  • As an immunomodulator, OHR/AVR118 exerts broad effects on immunocytes, especially on monocytes and macrophages. (scirp.org)
  • umors use chemokine signals to draw monocytes and tissue-resident macrophages into the tumor microenvironment, where the cells become tumor-associated macrophages (TAMs). (the-scientist.com)
  • They did this by isolating monocytes from the blood of healthy donors and then inducing them to differentiate into different macrophage types. (genomeweb.com)
  • We also found that the same ferritin biomineralization mechanism occurs after the uptake of Ce-ions into polarized macrophages and into unpolarized human monocytes and murine RAW 264.7 cells. (cdc.gov)
  • This slightly different perspective may somewhat shape our understanding of macrophage heterogeneity and tissue pathology but certainly also raise new questions for future research. (hindawi.com)
  • Fortunately, technological innovations are finally allowing us to address these issues, and in 2019 single-cell approaches and new fate mapping tools greatly advanced our understanding of macrophage heterogeneity. (nature.com)
  • To explore the influence of human amniotic mesenchymal stem cells (hAMSCs) on the in vivo and in vitro regulation of macrophage phenotypes and inflammatory factors associated with wound healing of full-thickness skin wounds in mice . (bvsalud.org)
  • Furthermore, drugs elevating Ca 2+ levels correct the NPC1 phenotype in vitro , reduce neurological disturbances, and prolong survival in a mouse model of NPC1 disease. (jneurosci.org)
  • Then we used an antibody screen to determine which markers were most informative for distinguishing between the [different] macrophages that we were able to generate in vitro ," he said. (genomeweb.com)
  • The authors did note, however, that it was possible the macrophage panel might be "biased towards these in vitro polarized cells. (genomeweb.com)
  • In vitro, ivacaftor does not alter LPS-induced CD80 and tumor necrosis factor alpha mRNA increases in BV2 microglial cells, while augmenting mRNA levels of these markers in mouse macrophages and differentiated human THP-1-derived macrophages. (lu.se)
  • Fujiwara Y, Komohara Y, Kudo R, Tsurushima K, Ohnishi K, Ikeda T and Takeya M: Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3. (spandidos-publications.com)
  • To further show that the effect of OHR/AVR118 depends on cellular environment, we monitored U937 differentiation towards mature macrophages in the presence of drug. (scirp.org)
  • Phenotype switching: plasticity and/or differentiation of stromal cells and their progenitors within the tumour microenvironment regulate tumour fate. (europa.eu)
  • Macrophage differentiation into functional phenotypes influences the fate of nanomaterials taken up by these immune cells. (cdc.gov)
  • Predominance of a proinflammatory phenotype in monocyte-derived macrophages from subjects with low plasma HDL-cholesterol. (cims-ops.cz)
  • Comparative transcriptome analyses of monocyte-derived macrophages (MDM) from a large population of low HDL-C subjects and age- and sex-matched controls revealed a cluster of inflammatory genes highly expressed in low HDL-C subjects. (cims-ops.cz)
  • Conclusion The results obtained in this pilot study suggest a role for Trib3 in macrophages due to expression differences measured in Trib3 deficient BMDMs, linked to a pro-inflammatory macrophage phenotype. (bmj.com)
  • We have developed a therapy that consists of using anti-inflammatory cells called m2 macrophage-like cells. (nii.ac.jp)
  • Our results showed that m2 macrophage-like cell transplantation in these mice reduced inflammatory gene expression. (nii.ac.jp)
  • How the production of inflammatory mediators generated by macrophages with different gene expression profile (M1 and M2) might activate inflammatory pathways, such as cyclooxygenase-2 (COX-2) and 5-, 12-, and 15-lipoxygenase (LOX), in human granulosa cells (hGCs) remains unclear. (biomedcentral.com)
  • Our data showed that M2 macrophages with anti-inflammatory characteristics were able to significantly increase the expression of COX-2 in hGCs. (biomedcentral.com)
  • We also demonstrated that M1 macrophages with pro-inflammatory characteristics were able to significantly increase the expression of 12-LOX in hGCs. (biomedcentral.com)
  • Whereas, after activation, OHR/AVR118 induced an anti-inflammatory phenotype, as indicated by reduced phagocytosis and increased IL-10 secretion. (scirp.org)
  • Influence of human amniotic mesenchymal stem cells on macrophage phenotypes and inflammatory factors in full-thickness skin wounds of mice]. (bvsalud.org)
  • The mRNA expressions of IL-10 , macrophage inflammatory protein 1 α (MIP-1α), and MIP-2 in the wounds were detected by real- time fluorescent quantitative reverse transcription polymerase chain reaction . (bvsalud.org)
  • RNA-seq results showed that transcription factors and macrophage inflammatory proteins were significantly downregulated in the DNMT3A mutant clones. (frontiersin.org)
  • M1 macrophages have strong pro-inflammatory and antigen-presenting capabilities. (frontiersin.org)
  • single-cell sequencing combined with new macrophage-specific genetic tools has provided unexpected insights into the tissue-specific and inflammatory diversity of macrophages. (nature.com)
  • In addition, a new mechanism of inflammatory control of macrophage diversity based on lactate-mediated histone modifications was discovered. (nature.com)
  • An unexpected 'timing' mechanism mediated by lactate seems to control macrophage inflammatory transitions. (nature.com)
  • By pharmacological inhibition of GLI1, the proportion of proinflammatory macrophages and the number of osteoclasts were significantly reduced, and the joint inflammatory response and bone destruction in CIA mice were alleviated. (elifesciences.org)
  • This study presents an important finding on the role of GLI1 in macrophages and osteoclasts in the pathogenesis of inflammatory arthritis, and suggests a therapeutic potential of GLI1 targeting in rheumatoid arthritis. (elifesciences.org)
  • Macrophageshave been described to polarize into either pro-inflammatory/microbicidal oranti-inflammatory/efferocytic phenotypes. (conicet.gov.ar)
  • While the epithelium provides a physical barrieragainst this gram-negative pathogen, innate immunity and, specifically,phagocytosis by neutrophils and macrophages are key determinants in the abilityof the host to control P. aeruginosa infection.Thus, the host inflammatory response is intimately connected to the phagocyticclearance of the bacteria. (conicet.gov.ar)
  • Our results show that, when confronted to thispathogen, macrophages respond through a pro-inflammatory response andmicrobicidal action to destroy the infectious agent. (conicet.gov.ar)
  • Likewise, an ivacaftor-mediated augmentation of MI-associated pro-inflammatory macrophage phenotype characterized by higher CD80-positivity is observed in the MI lung. (lu.se)
  • Monocytic dendritic and macrophage cells each play unique and essential roles in maintaining and restoring polarized immune responses [6]. (scirp.org)
  • Most tissues harbor resident mononuclear phagocytes, that is, dendritic cells and macrophages. (hindawi.com)
  • Thus, organ- and disease phase-specific microenvironments determine macrophage and dendritic cell heterogeneity in a temporal and spatial manner, which assures their support to maintain and regain homeostasis in whatever condition. (hindawi.com)
  • Mononuclear phagocytes are a group of phenotypic distinct members, often referred to as either macrophages or dendritic cells (DC), that derive from myeloid precursors and that contribute to the functions of peripheral tissues [ 1 ]. (hindawi.com)
  • In this paper we apply the tissue-centric perspective to discuss the role of resident and infiltrating macrophages and dendritic cells in different organs. (hindawi.com)
  • Pancreatic tumor-associated macrophages are considered M2 macrophages and are thought to support tumor progression through the engagement of multiple mechanisms that promote immune tolerance. (aacrjournals.org)
  • Another well-documented role of M2 macrophages is the remodeling of the tumor stroma via collagen production and degradation, with the latter being mediated by mannose receptor (Mrc1)-mediated endocytosis of collagen. (aacrjournals.org)
  • Given our previous work showing that protein scavenging by tumor cells can be utilized as a nutrient delivery mechanism, we set out to investigate the functional significance of collagen scavenging by macrophages. (aacrjournals.org)
  • Our findings suggest a new modality for the functional modulation of tumor-associated macrophages through the coupling of extracellular matrix remodeling to protein scavenging. (aacrjournals.org)
  • At the same time, Tie2 + macrophages come together with cancer cells and blood vessel endothelial cells to form complexes, called tumor. (the-scientist.com)
  • In xenografts, the tumor volumes in the experimental group were significantly larger than those in the control group, and the proportion of M2 macrophages was significantly higher. (frontiersin.org)
  • Using Fluidigm's Helios mass cytometry instrument, the researchers measured several dozen protein markers in 3.5 million immune cells, identifying 17 different tumor-associated macrophage (TAM) phenotypes and 22 T cell phenotypes. (genomeweb.com)
  • And then it turned out that those markers were also highly informative for analyzing the macrophage subsets in the tumor samples. (genomeweb.com)
  • Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages. (lu.se)
  • 2. We revealed the regulatory mechanisms of neutrophil function by macrophages, and the molecular mechanisms of netosis. (nii.ac.jp)
  • Introduction regulate choices of expressed genes as part of the macrophage/ neutrophil lineage. (lu.se)
  • A more tissue-centric view of these processes, claiming that the tissues define phenotype and function of resident and infiltrating immune cells to meet tissues needs during homeostasis and disease, seems provocative [ 4 , 5 ]. (hindawi.com)
  • All solid organs and most other tissues harbor a network of DC or macrophages (Table 1 ). (hindawi.com)
  • To address this new area of biology, BBS student Erika Gruber, D.V.M. '06 , grew macrophages on finely tuned engineered surfaces that approximate human tissues from both normal and diseases states. (cornell.edu)
  • In CRC patient tissues and xenografts from mouse model, presence of increased amount of M2 macrophages was observed. (lu.se)
  • Recent evidence, however, supports a dual role for macrophages in the regulation of tumour proliferation and immune control 10 , 16 , and indicates that the local tissue microenvironment plays a critical role in determining cell phenotypes. (ersjournals.com)
  • Moreover, iNOS+ARG1+ double-positive macrophages are present in the microenvironment of pancreatic tumors. (aacrjournals.org)
  • It relieved the inhibitory effect of DNMT3A mutation, promoted the phenotypic recovery of the co-cultured macrophages, eliminated resistance, and regulated the immune microenvironment. (frontiersin.org)
  • Macrophages are the most abundant white blood cells in the immune microenvironment and have a high degree of heterogeneity. (frontiersin.org)
  • The role of macrophage phenotypes in tumour progression has been extensively reviewed 6 - 10 . (ersjournals.com)
  • Published this week in Cell , the study used mass cytometry to characterize T cells and macrophages in samples from 73 ccRCC patients and five healthy matched kidney samples, identifying immune phenotypes associated with progression free-survival as well as potential biomarkers that could be useful for purposes including immunotherapy development. (genomeweb.com)
  • For instance, patients with larger presence of the M-11 and/or M-13 phenotype as well as a smaller presence of the M-5 phenotype had shorter progression-free survival. (genomeweb.com)
  • Welcome to the Macrophage Infection of HIV Implications for Pathogenesis and Cure meeting, jointly organized by the National Institute of Mental Health and the Ragon Institute of MGH, MIT, and Harvard. (nih.gov)
  • So we at the NIMH Division of AIDS Research are very happy to be co-sponsoring this conference with the Ragon Institute, recognizing the importance of macrophages in HIV pathogenesis and cure efforts. (nih.gov)
  • Meyts I, Aksentijevich I. Deficiency of Adenosine Deaminase 2 (DADA2): Updates on the Phenotype, Genetics, Pathogenesis, and Treatment. (medlineplus.gov)
  • However, adipocyte and macrophage numbers were increased in the Trib3KO mice. (bmj.com)
  • Ten C57BL/6 mice (all male , aged 6 to 8 weeks, the same gender and age below) were selected for extracting mouse peritoneal macrophages by intraperitoneal lavage , and M1-type macrophages were induced by Dulbecco's modified eagle medium (DMEM) medium containing interferon -γ. (bvsalud.org)
  • No significant differences in gene expression of classical polarisation markers were found in ATMs, however differential gene expression of proteins involved in macrophage function and phenotype was found in Trib3KO BMDMs compared to wild type results among the different polarisation states. (bmj.com)
  • In the case of T cells, the researchers used a panel consisting largely of canonical T cell markers providing an overview of the T cell phenotype landscape and proteins known to be relevant to immunotherapy. (genomeweb.com)
  • Adipose tissue macrophages (CD11b+ATMs) were isolated from adipose tissue using magnetics beads and the expression of polarisation markers was evaluated by qPCR. (bmj.com)
  • CD68 + macrophages expressing markers of a cytotoxic M1 phenotype or a noncytotoxic M2 phenotype were identified in the islets and stroma of surgically resected tumours from 20 patients with extended survival (median 92.7 months) and 20 with poor survival (median 7.7 months), using immunohistochemistry. (ersjournals.com)
  • In the extended survival group, M1 islet density was significantly increased compared with M2 density, 70% of islet macrophages were positive for M1 markers versus 38% for M2, and the islet:stromal ratio of M1 macrophages was markedly increased compared with M2. (ersjournals.com)
  • The expressions of macrophage surface markers [CD68 and inducible nitric oxide synthase (iNOS) double positive cells and CD68 and arginase 1 double positive] in the wounds were detected by immunofluorescent staining . (bvsalud.org)
  • For instance, the study found that while the marker PD-1 was broadly expressed across the observed T cell phenotypes, the markers TIM-3, CTLA-4, and 4-1BB were expressed only in certain cases. (genomeweb.com)
  • A classification that sufficiently covers their phenotypic heterogeneity and plasticity during homeostasis and disease does not yet exist because cell culture-based phenotypes often do not match those found in vivo . (hindawi.com)
  • Due to their considerable plasticity and heterogeneity, the tissue-based DC and macrophage populations have been defined as mononuclear phagocytes [ 1 , 6 , 7 ]. (hindawi.com)
  • However, the twin problems of dissecting macrophage phenotypical heterogeneity and specific function at a given time and place remain. (nature.com)
  • The M1 phenotype (classically activated) macrophages are thought to be induced by interferon-γ, with or without lipopolysaccharide and tumour necrosis factor (TNF)-α, and exert a cytotoxic effect against cancer cells. (ersjournals.com)
  • Furthermore, OA inhibited the proliferation of U373 human glioblastoma cells, and the activation of signal transducer and activator of transcription-3 (STAT3) in both human macrophages and glioblastoma cells. (spandidos-publications.com)
  • This suggests that m2 macrophage-like cells are an effective therapy for alterations in salivary glands caused by immune disorders such as Sjogren's syndrome. (nii.ac.jp)
  • In this study, we evaluated how M1 and M2 macrophages found in the ovaries affect the functions of hGCs isolated from women undergoing assisted reproductive technology (ART) and human ovarian granulosa COV434 cells. (biomedcentral.com)
  • For this purpose, a model of interaction between hGCs and COV434 cells and conditioned media (CMs) obtained from culture of M0, M1 and M2 macrophages was established. (biomedcentral.com)
  • Regarding COV434 cells, we found that CM from M2 macrophage resulted in an increase in COX-2, 5-LOX and 15-LOX mRNA and protein levels. (biomedcentral.com)
  • No expression of 12-LOX by COV434 cells was observed when exposed to CMs from M1 and M2 macrophages. (biomedcentral.com)
  • Macrophages are also experts at phagocytosing and degrading foreign cells, including cancer cells (2). (the-scientist.com)
  • Although CD4 T cells are the main targets of HIV infection, macrophages also become infected and resist the cytopathic effects of infection, contributing potentially to HIV reservoir persistence. (nih.gov)
  • Furthermore, we discuss how published data supports the view that changing tissue environments induce the well-known different phenotypes of mononuclear phagocytes, a process that not only enforces each of the different environments but also explains the contribution of these cells to the different tissue pathologies. (hindawi.com)
  • Therefore, we co-cultured AML cells with macrophages. (frontiersin.org)
  • In this study, GLI1 expression in the synovial tissue of RA patients was positively correlated with RA-related scores and was highly expressed in collagen-induced arthritis (CIA) mouse articular macrophage-like cells. (elifesciences.org)
  • We are culturing human fat cells (adipocytes) and tumour cells together, to find out how adipocytes alter tumour cell phenotype and response to therapy. (otago.ac.nz)
  • In particular, it plays a vital role in the physiological and pathological activities of the three important cells, Endothelial cells, macrophages and vascular smooth muscle cells. (wjgnet.com)
  • For this purpose, we exposed primary bonemarrow-derived macrophages (BMDM) to apoptotic cells, bacteria andbacteria-laden apoptotic cells and examined their internalization(independently or in conjuction) by confocal microscopy and subsequent imageanalysis in order to investigate the phagocytic and efferocytic efficiencies.To study bacterial clearance, we measured intracellular survival over time.Also changes in cytokine expression levels were measured by real-time RT-PCR. (conicet.gov.ar)
  • Gaucher disease is a rare genetic disorder characterized by the deposition of glucocerebroside in cells of the macrophage-monocyte system. (medscape.com)
  • The glycolipid storage gives rise to the characteristic Gaucher cells, macrophages engorged with lipid with a crumpled-tissue-paper appearance and displaced nuclei. (medscape.com)
  • In contrast, both macrophage phenotypes show identical nanoceria biotransformation to cerium phosphate nanoneedles and simultaneous nanoceria with ferritin co-precipitation within the cells. (cdc.gov)
  • Tumour cells are able to recruit macrophages and change their behaviour. (lu.se)
  • CD47 is involved in crosstalk between colon cancer cells and macrophages by interacting with its ligand signal-regulatory protein α on macrophages. (lu.se)
  • Unsensitized animals challenged with TMA exhibited also an increased number of macrophages in BAL, but gene expression in the above-mentioned gene pathways was unchanged or down-regulated. (cdc.gov)
  • This study clarified the mechanism of GLI1 in macrophage phenotypic changes and activation of osteoclasts, suggesting potential applications of GLI1 inhibitors in the clinical treatment of RA. (elifesciences.org)
  • For example, organs like the lung and the liver are exposed to pathogen components from the air or from the gut barrier, respectively, which explains the predominance of a macrophage phenotype that has a higher capacity for phagocytic clearance of pathogen components. (hindawi.com)
  • MMP-12 (macrophage elastase) is implicated in the pathology of many diseases such as emphysema, aortic lesions and cancer. (anaspec.com)
  • The dedicated editorial team welcomes studies that advances people's knowledge on phenomics, the study of phenome that is a set of measurable properties of physical, chemical and biological phenotypes of individuals and populations other than the genome. (springer.com)
  • How can we determine (and potentially target) a pathogenic or protective macrophage function if there are multiple types of macrophage in any given tissue site and if these populations temporally change their phenotypes in response to local extrinsic cues? (nature.com)
  • The survival advantage conferred by islet macrophage infiltration may be related to their cytotoxic antitumour activity. (ersjournals.com)
  • There is a marked survival advantage for patients with nonsmall cell lung cancer (NSCLC) expressing high numbers of macrophages in their tumour islets. (ersjournals.com)
  • Macrophages infiltrating the tumour islets in nonsmall cell lung cancer were predominantly of the M1 phenotype in patients with extended survival. (ersjournals.com)
  • Thus, increasing numbers of macrophages within the tumour islets conferred a marked survival advantage, while increased numbers of macrophages in the tumour stroma were associated with worse prognosis. (ersjournals.com)
  • M2 (alternatively activated) macrophages are thought to be modulated by IL-4 and -13 and associated with tumour formation. (ersjournals.com)
  • Additionally, M2 macrophages have been traditionally thought of as being the predominant macrophage phenotype in solid tumours (tumour-associated macrophages). (ersjournals.com)
  • Vascular endothelial growth factor (VEGF), a key component in the process of angiogenesis, is known to be produced by tumour-associated macrophages 17 , 18 , which have been traditionally reported as M2 macrophages. (ersjournals.com)
  • The association between prognosis and islet macrophage count has been confirmed recently by others in an independent cohort of patients 5 but the stromal macrophage counts in that study were not associated with survival. (ersjournals.com)
  • A tissue-centric view assumes that changing tissue microenvironments shape the phenotypes of their resident and infiltrating mononuclear phagocytes to fulfill the tissue's need to maintain or regain homeostasis. (hindawi.com)
  • M1-type macrophages predominantly sequester nanoceria near the plasma membrane, whereas nanoceria are more uniformly distributed throughout M2 macrophage cytoplasm. (cdc.gov)
  • Ferritin greatly increased with a macrophage phenotype-dependent distribution. (cdc.gov)
  • Ferritin biomineralization is a direct response to nanoparticle uptake inside both macrophage phenotypes. (cdc.gov)
  • A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment. (nature.com)
  • 1. We revealed roles of intestinal CD169-positive macrophages in colitis, and identified the transcriptional factor regulating the function of these macrophages. (nii.ac.jp)
  • High-resolution electron microscopy was used to investigate the uptake, distribution, and biotransformation of nanoceria in human and murine M1 and M2 macrophages in unprecedented detail. (cdc.gov)
  • M2 macrophages derived from human monocyte cell line THP-1 secreted high levels of IL-8 and leukotriene D4 (LTD4), which induced colon cancer cell migration, and Th2 cytokines (IL-4, IL-10) to maintain a tumoral immunosuppressive environment. (lu.se)
  • MRP 8/14 is enhanced by interferon-γ and lipopolysaccharide 13 , 14 , a characteristic of M1 macrophages, and also has bacteriostatic properties 15 . (ersjournals.com)
  • Single-cell sequencing revealed unexpected macrophage diversity in all organs examined so far. (nature.com)
  • Lung single-cell signaling interaction map reveals basophil role in macrophage imprinting. (nature.com)
  • It's a target of immunotherapies, but we have shown that in many exhausted [T cell] phenotypes that we discovered, at least in ccRCC, it is actually not expressed. (genomeweb.com)
  • We also show that the composition of T cell phenotypes is heterogenous across different patients, which means that in some patients a certain therapy might work, and in other patients it may not be very successful," he added. (genomeweb.com)
  • However, in whole blood, opsonophagocytic and intracellular killing assays, the LH/HC phenotype demonstrated higher resistance to host phagocytic killing. (cdc.gov)
  • Myeloid related protein (MRP) 8/14 expression by macrophages is associated with the release of TNF-α 12 . (ersjournals.com)
  • GBS β-h/c expression is linked to expression of an orange pigment with antioxidant properties ( 6 , 15 ), and these 2 factors act in concert to impair macrophage-based immune clearance ( 16 ). (cdc.gov)
  • and second, macrophages are sufficiently plastic that they can adopt tissue-specific phenotypes independent of their origin. (nature.com)
  • Overall, these findings suggest that OHR/AVR118 has a dual action on monocyte/macrophage function depending on cellular activation state, resulting in either further activation or suppression. (scirp.org)
  • However, macrophages function implicatesmuch more complexity. (conicet.gov.ar)
  • In this work we further showed that, afterphagocyting and processing P. aeruginosa,macrophages highly increase their efferocytic capacity without affecting theirphagocytic function. (conicet.gov.ar)