Phenotype t lymphocytes. Medical search. Frequent questions

Here we show that co-engagement of CD3 and the complement regulator CD46 in the presence of IL-2 induces a Tr1-specific cytokine phenotype in human CD4 + T cells. (nature.com)
Tumor infiltrating lymphocytes and PBLs were phenotyped by their surface markers, cytokine pattern, proliferation rate, and cytotoxic ability. (nih.gov)
Oral exposure to inorganic mercury alters T-lymphocyte phenotypes and cytokine gene expression in BALB/C Mice. (cdc.gov)
The autoimmune nature of diabetes and inflammatory cytokine IL-10 (as markers the major contribution of lymphocyte T- of inflammatory changes) and the soluble cells are well established. (who.int)

The percentages of T lymphocytes and both helper and cytotoxic T lymphocytes were significantly lower in the group of infected newborns, and the proportions of unlabeled cells were significantly increased in this group. (paedcro.com)
Natural-killer (NK) cells are specialized lymphocytes that have cytotoxic properties in addition to their ability to produce cytokines that assist in the orchestration of adaptive immunity. (medscape.com)
RVFV-specific CD8 T cells were expanded and of a cytotoxic and proliferating phenotype in the liver following infection. (cdc.gov)

In order to investigate the characteristics of lymphocyte phenotype in neonates with early signs of perinatal infection, their lymphocyte populations were analyzed and compared to healthy newborns. (paedcro.com)
The phenotypes of both lymphocyte populations were very heterogeneous. (nih.gov)
Here we collected the blood samples from 18 healthy donors (HD) and 38 COVID-19 patients to analyze changes in the adaptive immune cell populations and phenotypes. (medrxiv.org)

Compared with controls, the detectable proportion of HIV-1 particles derived from CD14 macrophages and CD26 lymphocytes was increased in persons with acute malaria coinfection and correlated with markedly increased plasma concentrations of both proinflammatory cytokines and soluble markers of macrophage and lymphocyte activation. (lww.com)
Tumor-associated macrophages (TAMs) are dynamic cells displaying a spectrum of states and phenotypes ranging from antitumor/immunostimulating (often termed M1-like) to protumor/immunosuppressive (also known as M2-like). (lu.se)
The exaggerated immune response to repeated inhalation of these particles leads to infiltration and proliferation of activated pulmonary macrophages and lymphocytes, resulting in lymphocytic alveolitis and bronchiolitis with noncaseating granulomas. (cdc.gov)
Toquet et al investigated the phenotype of the lesional inflammatory cell infiltrate in patients with eosinophilic fasciitis and demonstrated a predominance of macrophages, CD8 + lymphocytes, and few eosinophils. (medscape.com)

In some individuals, expansions of antigen-specific CD8+ T lymphocytes bearing specific TCR Vbeta chains were restricted to cells of particular CD45 isoforms. (ox.ac.uk)
After a complex process of education and maturation, a circulating lymphocyte can bind to an antigen. (medscape.com)
The NK-1 monoclonal antibody specifically reacts with a 110 kDa carbohydrate antigen associated with myelin-associated glycoprotein expressed on 7-35% of normal peripheral blood lymphocytes including a subset of natural killer cells, a subset of CD8-positive peripheral blood T cells, and on some neural tissues. (bdbiosciences.com)
Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. (thermofisher.com)
Human primary tumor cells could also be reprogrammed to increase their capability to present antigen and to activate patient-specific tumor-infiltrating lymphocytes. (lu.se)

Owing to the prognostic value of B-CLL ZAP-70 expression, this phenotype may reflect intrinsic biological differences between the two subsets of disease. (elsevierpure.com)
We get adequate blood samples in three intervals (before surgery and two and six months after operation) from our patients to measure immunoglobulins IgA, IgM, IgG and IgG subclasses by nephelometric assay and to count lymphocyte subsets (markers CD2, Cd3, CD4, CD8, CD19, CD23 and CD56) by flow cytometry and ELISA methods. (theijcp.org)
Research studies showed that T and B cell lymphocyte subsets are increased in tonsillitis [ 7 , 8 ]. (theijcp.org)
CD4+ T-cells and other lymphocyte subsets in persons infected with human immunodeficiency virus (HIV). (cdc.gov)
The guidelines describe single-platform technology (SPT), a process in which absolute counts of lymphocyte subsets are measured from a single tube by a single instrument. (cdc.gov)
With CD45 gating, the relative numbers of beads and lymphocyte subsets are enumerated, and their absolute numbers and percentage values are calculated. (cdc.gov)

To determine the immunologic characteristics of tumor infiltrating lymphocytes (TILs) in comparison with the corresponding peripheral blood lymphocytes (PBLs) of patients with ovarian cancer in order to detect specific antitumor-reactive-immunocompetent cells. (nih.gov)
CD4 Phenotypes Are Associated with Reduced Expansion of Tumor-Infiltrating Lymphocytes in Melanoma Patients Treated with Adoptive Cell Therapy. (amedeo.com)
Moreover, pro-tumor TAMs contribute to tumor growth by inhibiting tumor-infiltrating lymphocytes (TILs) that target tumor cells. (lu.se)

Figure 1: CD3/CD46 stimulation induces IL-10 production in human peripheral blood CD4 + T lymphocytes. (nature.com)
Peripheral blood lymphocytes had a higher proliferative activity and cytotoxicity against natural killer-sensitive tumor cells than the corresponding TILs. (nih.gov)
Peripheral blood lymphocytes showed more potentially valuable behavioral characteristics than TILs. (nih.gov)
and (iii) the dramatic reductions to lymphocyte numbers and function 1-2 h after exercise reflects a transient and time-dependent redistribution of immune cells to peripheral tissues, resulting in a heightened state of immune surveillance and immune regulation, as opposed to immune suppression. (frontiersin.org)
Flow cytometric analysis of CD57 expression on human peripheral blood lymphocytes. (bdbiosciences.com)
Co-administration of a clinically relevant dexamethasone dosage with ablative radiotherapy reduces peripheral lymphocytes but does not alter in vivo intratumoral lymphocyte phenotype or inhibit efficacy of radiotherapy in a murine colorectal tumor model. (rochester.edu)

We have therefore investigated the CD8+ T-lymphocyte response against CMV directly ex vivo using Class I tetramers combined with stains for a range of phenotypic markers followed by four-colour flow cytometric analysis. (ox.ac.uk)
Flow cytometric analysis of lymphocyte phenotypes in AIDS using monoclonal antibodies and simultaneous dual immunofluorescence. (bdbiosciences.com)

Although decreased serum levels of immunoglobulin G (IgG) and immunoglobulin A (IgA) are characteristic, approximately 50% of patients with the deficiency also have diminished serum immunoglobulin M (IgM) levels and T-lymphocyte dysfunction. (medscape.com)

Infiltration by CD103(+) lymphocytes was not related to the intensity of E-cadherin expression. (ox.ac.uk)
At the start of the disease there is a small focal infiltration of lymphocytes beneath the capsule of the thyroid. (vin.com)
A focal infiltration by lymphocytes occurs. (vin.com)

Chief Medical Officer proliferation of CD4-positive T lymphocytes. (cdc.gov)
Signaling through BAFF-R and BCMA stimulates B lymphocytes to undergo proliferation and to counter apoptosis . (wikidoc.org)

The higher proportion of unlabeled lymphocytes in infected newborns reflects the reduced expression of cell surface molecules and means a more immature and less efficient immune system. (paedcro.com)
Besides phagocytosis, they play a critical role in nonspecific defense (innate immunity) and also help initiate specific defense mechanisms (adaptive immunity) by recruiting other immune cells such as lymphocytes. (wikipedia.org)
The adaptive immune system consists of 2 types of lymphocytes: T cells (70-75% of the adaptive immune force) and B cells (10-20% of the adaptive immune force). (medscape.com)
Van Parijs, A. & Abbas, A. K. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. (nature.com)
Conclusions The gene expression profile of T-cell/histiocyte-rich large B-cell lymphoma, in comparison with that of nodular lymphocyte-predominant Hodgkin's lymphoma, shows features suggestive of a distinct tolerogenic host immune response that may play a key role in the aggressive behavior of this lymphoma, and that may serve as a potential target for future therapy. (haematologica.org)

The cord blood lymphocytes from 14 infected and 52 uninfected newborns were labeled by monoclonal antibodies and counted using two-color flow cytometry. (paedcro.com)

Ex vivo analysis of phenotype and TCR usage in relation to CD45 isoform expression on cytomegalovirus-specific CD8+ T lymphocytes. (ox.ac.uk)
Our findings show that SLO is vital to in vivo phenotype and illness final result. (holliseden.com)

We show that T cells express high levels of the inhibitory exhaustion markers programmed cell death 1 (PDCD1, also termed PD-1) and lymphocyte-activation gene 3 (LAG3), whereas CLL cells express high levels of CD274 (also termed PD-ligand 1). (nih.gov)
Tonsil is part of Waldeyer's ring and was known as reactive lymphoid organ that present high concentration of B and T cell lymphocytes in response to pathogens [ 4 , 5 ]. (theijcp.org)
The primary aim of this work was to survey normal urothelium and transitional cell carcinoma (TCC) for the presence of T lymphocytes expressing the intraepithelial, CD103(+) phenotype. (ox.ac.uk)
We have previously categorised stable adult asthma into four inflammatory phenotypes based on induced sputum inflammatory cell counts [ 2 ]. (ersjournals.com)
In comparison to HD, the lymphocyte percentage was slightly decreased, the percentages of CD4 and CD8 T cells in lymphocytes are similar, whereas B cell percentage increased in COVID-19 patients. (medrxiv.org)
The Cambridge Biotech HIV-1 Western Blot Kit is manufactured by Calypte Corporation from HIV-I propagated in an H9/HTLV-IIIb T-lymphocyte cell line. (cdc.gov)
Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
[4] [9] CLL results in the buildup of B cell lymphocytes in the bone marrow, lymph nodes, and blood . (wikipedia.org)
Most people are diagnosed as having CLL based on the result of a routine blood test that shows a high white blood cell count, specifically a large increase in the number of circulating lymphocytes . (wikipedia.org)
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by the accumulation of CD5CD23 B-cell lymphocytes. (haematologica.org)
Our studies in these patients revealed that DOCK8 is crucial for lymphocytes to maintain cell shape integrity when they move within skin that is distinct from other tissues in being characterized by having many highly confined spaces. (nih.gov)
These receptors are expressed mainly on mature B lymphocytes and their expression varies in dependence of B cell maturation (TACI is also found on a subset of T-cells and BCMA on plasma cells ). (wikidoc.org)
The aggressive T-cell/histiocyte-rich large B-cell lymphoma and the indolent nodular lymphocyte-predominant Hodgkin's lymphoma are both characterized by a paucity of tumor cells embedded in an overwhelming background. (haematologica.org)
Design and Methods We collected 33 cases of T-cell/histiocyte-rich large B-cell lymphoma and 56 cases of nodular lymphocyte-predominant Hodgkin's lymphoma and performed microarray gene expression profiling on ten cases of each lymphoma, to obtain a better understanding of the lymphoma host response. (haematologica.org)
By quantitative reverse transcriptase polymerase chain reaction we verified that these 20 selected cases were representative of the entire population of T-cell/histiocyte-rich large B-cell and nodular lymphocyte-predominant Hodgkin's lymphomas. (haematologica.org)
Results We observed that the microenvironment in nodular lymphocyte-predominant Hodgkin's lymphoma is molecularly very similar to a lymph node characterized by follicular hyperplasia, while the microenvironment in T-cell/histiocyte-rich large B-cell lymphoma is clearly different. (haematologica.org)
1 Initial studies demonstrated that a particular subgroup of T-cell-rich B-cell lymphomas mirror nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL) and are characterized by a T-cell and histiocyte-rich stroma. (haematologica.org)
Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
Enforced expression of the transcription factors PU.1, IRF8, and BATF3 (PIB) was sufficient to induce the cDC1 phenotype in 36 cell lines derived from human and mouse hematological and solid tumors. (lu.se)

While the autoreactive cells displayed significantly reduced Tregs numbers, the alloreactive transplacentally acquired maternal lymphocytes had high functional Tregs. (hindawi.com)
In some cases, T cells may present, as a result of residual autologous cells or transplacentally acquired maternal lymphocytes [ 1 ]. (hindawi.com)
The origin of the reactive cells in such patients are either thymic release of T-cells that expand at the periphery or transplacentally transfers of maternal T lymphocytes. (hindawi.com)
A distinctive feature of SCID patients, which sometimes can clinically resemble Omenn, [ 6 ] is the presence of alloreactive cells originated from transplacentally maternal T lymphocytes. (hindawi.com)
However, it remains unclear whether CLL-B cells aberrantly acquire ZAP-70 expression during the transformation process or whether ZAP-70 may be expressed under certain conditions in normal human B-lymphocytes. (elsevierpure.com)
According to lymphocyte phenotypes, CD4+, CD23+ and CD56+ cells and CD4/CD8 ratio were constant through the three intervals. (theijcp.org)
These CD3/CD46-stimulated IL-10-producing CD4 + cells proliferate strongly, suppress activation of bystander T cells and acquire a memory phenotype. (nature.com)
HIV infection is characterized by a decrease and, eventually, a depletion of CD4+ T-lymphocytes (helper T cells). (cdc.gov)
Using immunophenotyping, HIV-positive blood samples and age-matched controls were tested for the proportion of lymphocytes that are T cells, B cells, natural killer (NK) cells, CD4+ T cells (helper T cells), and CD8+ T cells (suppressor/inducer T cells). (cdc.gov)
Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)
Diagnosis is by detecting lymphopenia, absence or a very low number of T cells, and impaired lymphocyte proliferative responses to mitogens. (msdmanuals.com)
Common variable immunodeficiency (CVID) is a disorder that involves the following: (1) low levels of most or all of the immunoglobulin (Ig) classes, (2) a lack of B lymphocytes or plasma cells that are capable of producing antibodies, and (3) frequent bacterial infections. (medscape.com)
RVFV-specific CD4 T cells were identified in the liver and spleen following infection and phenotyped as largely Th1 or Tfh subtypes. (cdc.gov)
CD4 and CD8 T lymphocytes play an import role in the inflammatory response, as these cells may manage the profile of cytokines produced against an infectious agent 4 . (bvsalud.org)
CD4 T cells may assume different phenotypes under different stimulations, changing to Th1 and Th2 cells. (bvsalud.org)
Lymphocytes, B and T cells, can respond selectively to thousands of non-self materials. (lu.se)
Deficiencies are highly variable with regard to symptoms, phenotype, genotype, severity, etc, because many cells and molecules are required for both natural and adaptive immunity . (lu.se)

Platelets were isolated for phenotype analysis, and DNA was isolated from lymphocytes for genotype determination. (aacrjournals.org)

Immunity against CMV comprises a large population of CD8+ T lymphocytes with heterogeneous potential, a spectrum in which CD45 isoform expression may play a central role. (ox.ac.uk)

How individual variation in genome sequence translates into differences in phenotype and disease susceptibility is a major challenge in biomedical research. (findaphd.com)

We found that a spectrum of phenotypes exists stably, from CD45R0(high)/RA(low) through CD45RA(high)/R0(low), and that expression of other surface markers such as CD28 and CD62L, and also TCR usage, may vary in parallel with CD45 isoform expression. (ox.ac.uk)

In the surrounding stroma 52% of lymphocytes were CD8(+) and 82% of this subset expressed CD103. (ox.ac.uk)

The results were similar when only the preterm newborns of less than 32 gestational weeks were analyzed, with the exception of T helper lymphocytes which did not differ between the groups. (paedcro.com)

The fluorescence histograms were derived from gated events with the forward and side light-scattering characteristics of viable lymphocytes. (bdbiosciences.com)

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. (thermofisher.com)

T lymphocyte phenotype of contact-allergic patients: experience with nickel and p-phenylenediamine. (durham.ac.uk)
By applying similar experimental approaches to other patients having novel combined immunodeficiencies, we hope to gain insights into the molecular regulation of the human lymphocytes for antiviral immunity in both normal and diseased states. (nih.gov)
Les IFN et les IL-10 étaient signi cativement élevés chez ceux qui présentaient une néphropathie diabétique (ND) et une maladie rénale en phase terminale (MRPT) par rapport aux témoins et aux patients diabétiques sans ND. (who.int)

We suggest that a high-tolerance capacity of the alloreactive transplacentally acquired maternal lymphocytes represents a toleration advantage, yet still associated with severe immunodeficiency. (hindawi.com)

To discriminate between these two possibilities, we assessed ZAP-70 expression in normal human B-lymphocytes. (elsevierpure.com)
Distribution of lymphocytes of the alpha(E)beta(7) phenotype and E-cadherin in normal human urothelium and bladder carcinomas. (ox.ac.uk)
Belimumab (Benlysta) is a monoclonal antibody developed by Human Genome Sciences and GlaxoSmithKline , with significant discovery input by Cambridge Antibody Technology , which specifically recognizes and inhibits the biological activity of B-Lymphocyte stimulator (BLyS) and is in clinical trials for treatment of Systemic lupus erythematosus and other autoimmune diseases. (wikidoc.org)
Single-platform technology (SPT) is designed to enable de- system and managing the health care of persons infected with terminations of both absolute and percentage lymphocyte sub- human immunodeficiency virus (HIV) ( 1-4 ). (cdc.gov)

Inflammatory phenotypes are recognised in stable adult asthma, but are less well established in childhood and acute asthma. (ersjournals.com)
This study examined the prevalence of inflammatory phenotypes and the presence of current C. pneumoniae infection in adults and children with stable and acute asthma. (ersjournals.com)
The pattern of inflammatory phenotypes differs between adults and children, with eosinophilic inflammation being more prevalent in both acute and stable childhood asthma, and neutrophilic inflammation being the dominant pattern of acute asthma in adults. (ersjournals.com)
The occurrence and relative frequency of these phenotypes in acute asthma and childhood asthma are not known. (ersjournals.com)

Over the years, Rolny and colleagues have demonstrated that reprogramming the pro-tumor phenotype of TAMs into an anti-tumor Page 2(3) phenotype represents a promising anti-cancer strategy. (lu.se)

To exclude the effect of shorter gestation on the lymphocyte phenotype, of the infected newborns, who were all prematures, the analysis was carried out separately for prematures of less than 32 gestational weeks and for prematures of 32 - 37 weeks. (paedcro.com)

In carcinomas significantly greater numbers of CD103(+) T lymphocytes were present in the surrounding stroma rather than infiltrating the carcinomas (P = 0.0006). (ox.ac.uk)

Our findings demonstrate how the local environment directly affects disease risk phenotypes and that genetic variation, including less common variants, can modulate individual's response to environmental challenges. (nature.com)

While exposure to allergen in a sensitised individual can elicit an eosinophilic response, the triggers of the noneosinophilic phenotypes have been less well studied. (ersjournals.com)

The secondary aim was to determine the pattern of distribution of CD103(+) lymphocytes in relation to E-cadherin expression in bladder cancer. (ox.ac.uk)

Paucigranulocytic asthma was the most common phenotype in both adults and children with stable asthma. (ersjournals.com)
Thus, C. pneumoniae may play a potential role in modulating the different inflammatory phenotypes of asthma, and NA in particular. (ersjournals.com)

However, our understanding of how these distinct TAM phenotypes manifest remains limited. (lu.se)

By carefully investigating these "experiments of nature" we can draw inferences about molecular functions based on patient phenotype. (nih.gov)

Our data demonstrate that ZAP-70 is expressed in a subpopulation of tonsillar and splenic normal B-lymphocytes that express an activated phenotype. (elsevierpure.com)

Anatomy47

Organisms15

Diseases10

Chemicals and Drugs97

Analytical, Diagnostic and Therapeutic Techniques and Equipment39

Phenomena and Processes53

Disciplines and Occupations1

Information Science3

Health Care1

Cytokine4

Cytotoxic3

Populations3

Macrophages4

Antigen5

Subsets6

Tumor-Infiltrating3

Peripheral6

Cytometric analysis2

Serum Immunoglobulin1

Infiltration3

Proliferation2

Immune5

Monoclonal antibodies1

Vivo2

Cell19

Cells18

Genotype1

Heterogeneous1

Susceptibility1

Markers1

Subset1

Helper1

Characteristics1

Differentiate1

Patients3

Severe1

Human4

Acute4

Represents1

Analysis1

Significantly1

Affects1

Eosinophilic1

Relation1

Asthma2

Distinct1

Molecular1

Demonstrate1