• 2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. (scielo.br)
  • For NSCLC, much of the work in the last decade has been focussed on mutations of the epidermal growth factor receptor (EGFR) and on the abnormal fusion of the anaplastic lymphoma kinase (ALK) being inhibited successfully with EGFR tyrosine kinase inhibitors (TKI) and crizotinib respectively. (amegroups.org)
  • Non-small cell lung cancer (NSCLC) treatment in advanced stage like IIIB, IIIC, and IV is based on several driver mutations analysis including mutations/alterations of the epidermal growth factor receptor, anaplastic lymphoma kinase, ROS1, and PDL-1 expression. (asjo.in)
  • In addition to binding to the insulin receptor, IRS1 also binds to and transmits signals from the receptors of prolactin, growth hormone (GH), leptin, vascular endothelial growth factor (VEGF), tropomyosin receptor kinase B (TrkB), anaplastic lymphoma kinase (ALK), insulin like growth factor (IGF1), and integrins ( Vuori and Ruoslathi , 1994 Vuori K and Ruoslahti E (1994) Association of insulin receptor substrate-1 with integrins. (scielo.br)
  • Protein kinase C regulates human pluripotent stem cell self-renewal. (rndsystems.com)
  • Then, the C/EBP 3â UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. (omicsonline.org)
  • Metz H, Busch SE, Hanke ML, Kargl J, Kim KH and Houghton M (2014) Insulin receptor substrate-1 regulates immune cell content in lung adenocarcinoma. (scielo.br)
  • For instance, IKK2 is found to be mainly responsible for phosphorylating serine 536 in monocytes and macrophages, or in CD40 receptor binding in hepatic stellate cells. (wikipedia.org)
  • This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. (cancerindex.org)
  • Such immune dysfunction may be due to a disorder in thymic output function (in particular in young patients), which results in a lower level of naive T-cells in the peripheral blood available for an immune response to the proliferation and abnormal expression of the T cell receptor (TCR) repertoire. (biomedcentral.com)
  • Rational design of chimeric antigen receptor T (CAR-T) cells based on the recognition of antigenic epitopes capable of evoking the most potent CAR activation is an important objective in optimizing immune therapy. (nature.com)
  • Small-molecule inhibitors, antagonistic monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), bispecific antibodies or biologics (bsAbs) and chimeric antigen receptor-modified T cells (CAR-Ts) targeting Notch signaling components have been developed as investigational anti-cancer drugs ( 10 - 12 ). (spandidos-publications.com)
  • In contrary, tumor cells have evolved immune escape mechanisms whereby overexpression of PD-L1 induces anergy and/or apoptosis of PD-1 positive T cells by interfering with T cell receptor signal transduction. (studylib.net)
  • The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. (cancer-genetics.org)
  • Also, our mutants induced proliferation, glucose uptake, inhibited the migration of 293T cells and affected the responsiveness of the cells to cisplatin and radiation. (scielo.br)
  • An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
  • Knockdown of nuclear PATZ1 by siRNA in an immortalized normal follicular epithelial cell line (Nthy-ori 3-1) altered cellular morphology and significantly increased cell proliferation, migration, and invasion. (oncotarget.com)
  • When PATZ1 was silenced in differentiated thyroid cancer (DTC) cell lines (TPC-1 and FTC-133), proliferation, cellular motility, and expression of uPA and MMPs were significantly increased. (oncotarget.com)
  • Forced expression of exogenous PATZ1 decreased proliferation, cellular motility, and the expression of uPA and MMPs in ATC cell lines (ACT-1 and FRO). (oncotarget.com)
  • Knockdown of KDM1B inhibits cell proliferation and induces apoptosis of pancreatic cancer cells. (cancerindex.org)
  • Combined treatment with selumetinib and a dose of palbociclib sufficient to reinforce G1 arrest in selumetinib-sensitive cells, but not to impair proliferation of resistant cells, delays the emergence of resistant colonies, meaning that escape from G1 arrest is critical in the formation of resistant clones. (babraham.ac.uk)
  • Increasing evidences have shown that Notch-1 is involved in the regulation of tumor cell growth, proliferation, apoptosis, metastasis and chemo- or radioresistance. (biomedcentral.com)
  • Organ toxicity was characterized by depression of cell proliferation (hematopoiesis and spermatogenesis) and changes suggestive of reduced metabolism and/or physiological imbalances (e.g. (jaksignaling.com)
  • Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. (cusabio.com)
  • This review presents the current knowledge on the role of Nestin in essential stem cell functions, including self-renewal/proliferation, differentiation and migration, in the context of the cytoskeleton. (cusabio.com)
  • However, tumor cells can evade host's immune surveillance using a number of protective mechanisms, including downregulation of MHC-I molecules, secretion of anti-inflammatory cytokines, in other words, TGF-β and IL-10, secretion of immunosuppressive factors, VEGF, upregulation of PD-L1 and downregulation of co-stimulatory molecules thereby preventing activation of T cells, resulting in cancer invasion. (studylib.net)
  • Our results suggest that these novel mutations play a role in the phenotype of lung cancer. (scielo.br)
  • Loss‑of‑function NOTCH1 mutations are early events during esophageal tumorigenesis, whereas gain‑of‑function NOTCH1 mutations are late events during T‑cell leukemogenesis and B‑cell lymphomagenesis. (spandidos-publications.com)
  • Melanoma in particular exhibits a high incidence of activating BRAF and NRAS mutations and such cells are addicted to the activity of these mutant oncoproteins. (babraham.ac.uk)
  • The observation that one inch of cancerous liver tissue can have more than 100 000 000 mutations and an identical mutation can result in different phenotypes, depending on the environment surrounding that mutation, makes it very unlikely that mutations by themselves are causative of most cancers. (4open-sciences.org)
  • Humanized anti-CD123 antibody facilitates NK cell antibody-dependent cell-mediated cytotoxicity (ADCC) of Hodgkin lymphoma targets via ARF6/PLD-1. (rndsystems.com)
  • Discordant lymphomas of classic Hodgkin lymphoma and peripheral T-cell lymphoma following dupilumab treatment for atopic dermatitis. (u-tokyo-hemat.com)
  • The differential diagnosis will include anaplastic ependymoma, atypical teratoid rhabdoid tumor (AT/RT), or other forms of highly proliferative malignant neuroectodermal tumors. (medscape.com)
  • Our study demonstrates that PATZ1 knockdown enhances malignant phenotype both in thyroid follicular epithelial cells and thyroid cancer cells, suggesting that PATZ1 functions as a tumor suppressor in thyroid follicular epithelial cells and is involved in the dedifferentiation of thyroid cancer. (oncotarget.com)
  • The importance of independent 3â UTR RNA (referred as I3â UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. (omicsonline.org)
  • Immunohistochemical staining for cytokeratin 5/6 was applied on cell block sections of 23 cases of benign and 25 cases of malignant breast lesions using avidin biotin peroxidase technique. (ijpmonline.org)
  • Medulloblastoma is defined by the World Health Organization (WHO) as "an embryonal neuroepithelial tumor arising in the cerebellum or dorsal brainstem, presenting mainly in childhood and consisting of densely packed small round undifferentiated cells with mild to moderate nuclear pleomorphism and high mitotic count. (medscape.com)
  • Histologic subtypes of medulloblastoma include: (1) desmoplastic/nodular type, (2) medulloblastoma with extensive nodularity, and (3) large-cell/anaplastic medulloblastoma. (medscape.com)
  • 1] Several subtypes of medulloblastoma have been recognized including: (1) desmoplastic/nodular type, (2) medulloblastoma with extensive nodularity, (3) large-cell variant, and (4) anaplastic medulloblastoma. (medscape.com)
  • For example, neurons receive trophic inputs from blood through astrocytic glial cells, which make contact with capillaries through their specialized foot processes. (rmmj.org.il)
  • This may be secondary to a germinal center origin or attributable to increased apoptosis via induction of bax and/or enhanced T-cell interaction, resulting in improved autologous tumor response. (aacrjournals.org)
  • Murine PD-1 mRNA expression has been shown to be correlated with activation-induced apoptosis in a mouse T-cell hybridoma cell line and murine thymocytes [ 13 ]. (biomedcentral.com)
  • Bennett J, Baumgarten SC, Stocco C. GATA4 and GATA6 Silencing in Ovarian Granulosa Cells Affects Levels of mRNAs Involved in Steroidogenesis, Extracellular Structure Organization, IGF-I Activity, and Apoptosis. (chicagobiomedicalconsortium.org)
  • The binding of T cells expressing PD-1 and tumor cells expressing PD-L1 initiates an array of inhibitory signals resulting in reduced function and/or apoptosis of T cells [8,11] providing a mechanism for tumor cell evasion of host's immune surveillance [12-14]. (studylib.net)
  • RELA is expressed alongside p50 in various cell types, including epithelial/endothelial cells and neuronal tissues. (wikipedia.org)
  • Here we analyzed cell-free, methylated DNA released from dying cells into the circulation to evaluate radiation-induced cellular damage in different tissues. (bvsalud.org)
  • To map the circulating DNA fragments to human and mouse tissues, we established sequencing-based, cell-type-specific reference DNA methylation atlases. (bvsalud.org)
  • Strikingly, patients treated for right-sided breast cancers also showed increased hepatocyte and liver endothelial DNA in the circulation, indicating the impact on liver tissues. (bvsalud.org)
  • Thus, changes in cell-free methylated DNA can uncover cell-type-specific effects of radiation and provide a readout of the biologically effective radiation dose received by healthy tissues. (bvsalud.org)
  • Developing top down proteomics to maximize proteome and sequence coverage from cells and tissues. (chicagobiomedicalconsortium.org)
  • Although immunotherapy using tumor infiltrating cells (TIL) or vaccine treatment have been expected as a promising modality to treat cancer, recent reports have indicated several mechanisms in tumor tissues to protect cancer cells from immune attacks [ 10 ]. (biomedcentral.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Because of this, the pH gradient current amongst the extracellular microenvironment plus the cell cytosol is expanded in some solid tumors relative towards the pH gradient in usual tissues. (pkainhibitors.com)
  • Here, we generate dromedary camel nanobodies targeting B7-H3 and demonstrate that CAR-T cells, based on the nanobodies recognizing the IgC but not IgV domain, had potent antitumour activity against large tumors in female mice. (nature.com)
  • However, the successful application of these emerging cell-based therapies in solid tumors remains limited. (nature.com)
  • My research interests comprise cutaneous tumors with emphasis in lymphomas and melanoma. (mdanderson.org)
  • In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)
  • In the past decade, many clinical trials have been investigating anti-CTLA-4 as well as anti-programmed cell death protein 1 (PD-1) therapies in various solid tumors, including HCC. (stanford.edu)
  • Main Outcome(s) and Measure(s): The primary study outcome was to determine the prognostic value of p53 Abs from a large population of patients with solid tumors, as determined before data collection. (stanford.edu)
  • Phase III clinical trials of Rova‑T for patients with small‑cell lung cancer and a phase III clinical trial of nirogacestat for patients with desmoid tumors are ongoing. (spandidos-publications.com)
  • Recently, the treatment of newly diagnosed anaplastic glioma (AG) has changed, particularly in patients with 1p19q codeleted tumors. (surgicalneurologyint.com)
  • While brain tumor cells express tissue factor (TF) and other effectors of the coagulation system (coagulome), their propensity to induce local and peripheral thrombosis is highly diverse, most dramatic in the case of glioblastoma multiforme (GBM), and less obvious in pediatric tumors. (rmmj.org.il)
  • 1 The most frequent primary tumor types of anterior mediastinal masses are thymic tumors and lymphoma, with approximate proportions of 35% and 25% among mediastinal lesions, respectively. (allenpress.com)
  • Histologically, these tumors are usually World Health Organization (WHO) grade 3 (anaplastic) astrocytomas or glioblastoma (WHO grade 4). (medilib.ir)
  • nontargeting shRNA-transduced cells had been used as controls.As depicted in Figure 4A, MET knockdown xenografts showed slower development in addition to a substantially decreased volume at examine termination as compared with control tumors. (pkainhibitors.com)
  • Knockdown of ANCO1 in early-stage TNBC cells led to aneuploidy, cellular senescence, and enhanced invasion in a 3D matrix. (bvsalud.org)
  • In addition, the expression of urokinase-type plasminogen activator (uPA), matrix metalloproteinase (MMP) 2, MMP9, and MMP11 was increased by PATZ1 knockdown in Nthy-ori 3-1 cells. (oncotarget.com)
  • More than 95% of thyroid cancers are derived from thyroid follicular epithelial cells and are classified into differentiated thyroid cancer (DTC), including papillary and follicular thyroid cancer (PTC and FTC), poorly differentiated thyroid cancer (PDTC), and anaplastic thyroid cancer (ATC). (oncotarget.com)
  • Obinutuzumab and reduced bendamustine is effective for elderly patients with follicular lymphoma. (u-tokyo-hemat.com)
  • Other target organs were the pancreas (acinar cell vacuolation), thyroid gland (follicular cell hypertrophy), and salivary gland (secretory depletion of convoluted ducts). (jaksignaling.com)
  • Moreover, increasing data have shown that peripheral T-cell tolerance is an essential property of the specific immune response to tumor cells. (biomedcentral.com)
  • Between February 1986 and March 1990, 56 patients with relapsed Hodgkin's disease treated with high-dose cyclophosphamide, carmustine, and etoposide (CBV) received an autologous peripheral stem cell transplantation (PSCT) rather than an autologous bone marrow transplantation (ABMT) because each patient had a marrow abnormality, either hypocellularity or tumor involvement. (shengsci.com)
  • At least 6.5 x 10(8) [corrected] mononuclear cells/kg patient weight were collected from the peripheral blood of each patient, cyropreserved, and returned intravenously following CBV administration. (shengsci.com)
  • Recent studies have shown that soluble factors elaborated by human T lymphocytes enhance erythroid burst formation by human peripheral blood null cells. (shengsci.com)
  • [email protected] ‡ Authors contributed equally Aim: Expression of PD-1 on T/B cells regulates peripheral tolerance and autoimmunity. (studylib.net)
  • 2004) Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer. (scielo.br)
  • The analysis of serum samples from patients with breast cancer undergoing radiation treatment revealed distinct dose-dependent and tissue-specific epithelial and endothelial responses to radiation across multiple organs. (bvsalud.org)
  • Preemptive immunotherapy in childhood acute myeloid leukemia for patients showing evidence of mixed chimerism after allogeneic stem cell transplantation. (shengsci.com)
  • Engraftment, clinical, and molecular follow-up of patients with multiple myeloma who were reinfused with highly purified CD34+ cells to support single or tandem high-dose chemotherapy. (shengsci.com)
  • Eighty-two patients with advanced multiple myeloma (MM) were enrolled in 2 sequential clinical studies of 1 or 2 courses of myeloablative therapy with stem cell support. (shengsci.com)
  • Furthermore, upregulation of PD-L1 by cancer cells results in cancer invasion and correlates with poor prognostic outcomes in breast, gastric, meningioma, non-small-cell lung carcinoma (NSCLC) and soft-tissue sarcoma patients [9,26-29]. (studylib.net)
  • Gene landscape and correlation between B-cell infiltration and programmed death ligand 1 expression in lung adenocarcinoma patients from The Cancer Genome Atlas data set. (cancer-genetics.org)
  • T-cell activation and dysfunction relies on direct and modulated receptors. (biomedcentral.com)
  • NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are cell surface receptors that transduce juxtacrine signals of delta-like canonical Notch ligand (DLL)1, DLL3, DLL4, jagged canonical Notch ligand (JAG)1 and JAG2 from adjacent cells ( 1 - 3 ). (spandidos-publications.com)
  • In melanoma, i have focused in acral lentiginous melanoma for which we described KIT mutation and protein expression status in a large series of cases and described TERT amplification in progression to metastasis. (mdanderson.org)
  • Lung cancer is divided into two major groups: non small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). (scielo.br)
  • In a mouse model, thoracic radiation-induced tissue damage was reflected by dose-dependent increases in lung endothelial and cardiomyocyte methylated DNA in serum. (bvsalud.org)
  • Notch signaling is aberrantly activated in breast cancer, non‑small‑cell lung cancer and hematological malignancies, such as T‑cell acute lymphoblastic leukemia and diffuse large B‑cell lymphoma. (spandidos-publications.com)
  • However, Notch signaling is inactivated in small‑cell lung cancer and squamous cell carcinomas. (spandidos-publications.com)
  • By contrast, somatic alterations in the genes encoding Notch signaling components drive various types of human cancer, such as breast cancer, small-cell lung cancer (SCLC) and T-cell acute lymphoblastic leukemia (T-ALL) ( 6 - 9 ). (spandidos-publications.com)
  • The second group includes large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC). (springeropen.com)
  • In recent years, there has been a major paradigm shift in the management of non-small cell lung cancer (NSCLC). (amegroups.org)
  • Over the last decade, molecular translational research advances have heralded major breakthroughs in the understanding, diagnosis and management of lung cancer, particularly for the more common (~80%) non-small cell lung cancer (NSCLC). (amegroups.org)
  • Conversely, treatment for small cell lung cancer remains chemotherapy-based and whilst there are promising results with novel cytotoxics, its platinum-etoposide backbone holds strong ( 2 ). (amegroups.org)
  • Non-small cell lung cancer (NSCLC) accounts for 70%-80% in lung cancer, and among them, lung adenocarcinoma (LAD) accounting for almost half of lung cancers, was one of the most common histologic subtype. (biomedcentral.com)
  • PD-L1 upregulation can impede infiltrating T-cell functions in lung adenocarcinoma (LUAD), a lung cancer subtype. (cancer-genetics.org)
  • Renal cell carcinoma (RCC) incidence has increased over the past two decades. (hindawi.com)
  • Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)
  • Broadly speaking, the main subtypes are pulmonary adenocarcinoma, squamous cell carcinoma (SCC) and large cell carcinoma. (amegroups.org)
  • The traditional and now over-simplified histological distinctions within NSCLC include adenocarcinoma, SCC and large cell carcinoma ( Figure 1 ). (amegroups.org)
  • CK 5/6 expression breast carcinoma implies a 'basal like' molecular phenotype and is associated with poor prognosis. (ijpmonline.org)
  • Here, we explore the evolution of reprogramming and directed differentiation approaches within the context of hepatocyte to β-cell transdifferentiation focussing on how the introduction of new techniques has improved our ability to generate β-cells. (silverchair.com)
  • The first-in-human testing of scFv-based B7-H3 CAR-T cells has shown antitumor response against anaplastic meningioma and childhood diffuse intrinsic pontine glioma without severe side effects 16 , 17 . (nature.com)
  • In thyroid cancer cell lines, PATZ1 functioned as a tumor suppressor regardless of p53 status. (oncotarget.com)
  • In breast tissue, the luminal epithelial cells express CK 8/18, CK 7 and CK 19, while basal/myoepithelial cells express CK 5/6, CK 14 and CK 17. (ijpmonline.org)
  • In normal breast tissue, nestin is expressed in the basal/myoepithelial cells. (cusabio.com)
  • In summary, Nestin was strongly associated with germline BRCA1 related breast cancer, a basal-like phenotype, reduced survival, and stemness characteristics. (cusabio.com)
  • We investigated the homing-related chemokine expression levels of MSCs treated with a prostate cancer cell line (PC-3) -conditioned medium. (cancerindex.org)
  • Enhancement of human erythroid progenitor cell growth by media conditioned by a human t-lymphocyte line. (shengsci.com)
  • Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. (cusabio.com)
  • Molecular characterization and Biomarkers are becoming increasingly important in the management of HGG especially with respect to anaplastic glioma (AG) that have refined prognosis and increasingly are predictive with respect to treatment. (surgicalneurologyint.com)
  • Conversely, the coagulant microenvironment may also influence the molecular evolution of brain tumor cells through selective and instructive cues. (rmmj.org.il)
  • Moreover, T cell function becomes suppressed with disease progression. (biomedcentral.com)
  • Therefore, we investigated the role of infiltrating B cells in LUAD progression and its correlation with PD-L1 expression. (cancer-genetics.org)
  • Mesenchymal stem cells up-regulate the invasive potential of prostate cancer cells via the eotaxin-3/CCR3 axis. (cancerindex.org)
  • The presence of a subpopulation of ANCO1-depleted cells enabled invasion of the overall cell population in vitro and they converted more rapidly to invasive lesions in a xenograft mouse model. (bvsalud.org)
  • This study aimed to clarify the role of mesenchymal stem cells (MSCs) as a component of the cancer microenvironment. (cancerindex.org)
  • Experimental Design: Bcl -6, CD10, and CD40 were chosen as markers for a germinal center phenotype, CD23 as a marker of pre/early germinal center origin, and CD138 as a marker for postgerminal center origin. (aacrjournals.org)
  • Transduction of CLL cells by CD40 ligand enhances an antigen-specific immune recognition by autologous T cells. (shengsci.com)
  • A promising approach is provided by the transduction of CLL cells with CD40 ligand (CD40L) by viral vectors to enhance their immunogenicity. (shengsci.com)
  • Increasingly, complimentary cell culture techniques, which recapitulate the developmental microenvironment, are employed to coax cells to adopt new identities by indirectly regulating transcription factor activity via intracellular signalling pathways. (silverchair.com)
  • Notch signaling cascades crosstalk with fibroblast growth factor and WNT signaling cascades in the tumor microenvironment to maintain cancer stem cells and remodel the tumor microenvironment. (spandidos-publications.com)
  • CCDC88C-FLT3 gene fusion in CD34-positive haematopoietic stem and multilineage cells in myeloid/lymphoid neoplasm with eosinophilia. (u-tokyo-hemat.com)
  • The role of PD-1 and PD-L1 in T-cell immune suppression and the potential for immunotherapy via blocking PD-1 and PD-L1 in hematological malignancies are also reviewed. (biomedcentral.com)
  • An oncoantigen was defined as a molecule with high immunogenicity in our immune system and with oncogenic function that plays a critical role in the growth of tumor cells. (biomedcentral.com)
  • Conclusion: For immunotherapy/vaccines to be successful, the expression of PD-L1/PD-1 on immune cells should be considered, and the combination of checkpoint inhibitors and vaccines may pave the way for successful outcomes to disease. (studylib.net)
  • However, for cancer prevention, the elimination or inactivation of mutated cells is debated on whether this is a prime function of the immune system. (studylib.net)
  • Their theory concurred with studies by Doherty and Zinkernagel, where they demonstrated that the immune system plays an essential role in immune surveillance by recognizing small peptide epitopes in conjunction with the MHC-I presented on the surface of virus infected cells [5]. (studylib.net)
  • Consequently, it was shown by others that tumor cells also expressed MHC-I and presented short tumor-associated peptides to immune cells [6]. (studylib.net)
  • Review: Evaluation of pancreatic cancer stem cells-related markers CD133, CD44, Oct4, and Nestin proteins in PANC-1 and SW1990 cells by western blotting. (cusabio.com)
  • METHODS: We asked whether host stromal senescence after CDK4/6 inhibition affects metastatic seeding and growth of CDKi-resistant mammary cancer cells by using the p16-INK-ATTAC mouse model of inducible senolysis. (bvsalud.org)
  • The most potent nanobody-based CAR-T cells show inhibition of large tumor xenografts in mice with rigorous T-cell signaling and significant T-cell infiltration into the tumor. (nature.com)
  • ERKi treatment of cells drives the poly-ubiquitylation and proteasome-dependent turnover of ERK2 and pharmacological or genetic inhibition of Cullin-RING E3 ligases prevents this. (babraham.ac.uk)
  • This approach was based on the assumption that the deregulation of a protein was causally linked to a disease state, and the pharmacological intervention through inhibition of the deregulated target was able to restore normal cell function. (biomedcentral.com)
  • Mol Cell Proteomics 8:519-534. (scielo.br)
  • Single-cell transcriptome RNA sequencing coupled with functional T-cell proteomics analysis uncovers the top-upregulated genes that might be critical for the persistence of polyfunctional CAR-T cells in mice. (nature.com)
  • Transdifferentiation is a type of cellular reprogramming involving the conversion of one differentiated cell type to another. (silverchair.com)
  • Cellular identity is determined by the transcriptional profile which comprises the subset of mRNAs, and therefore proteins, being expressed by a cell at a given point in time. (silverchair.com)
  • Here, we discuss how transcription factors, and their unique position as the gatekeepers of cellular identity, are exploited in cell reprogramming protocols by exploring work focusing on one reprogramming paradigm - the transdifferentiation of hepatocytes to pancreatic beta cells (β-cell). (silverchair.com)
  • We found that cell-type-specific DNA blocks were mostly hypomethylated and located within signature genes of cellular identity. (bvsalud.org)
  • Cancer Cell. (chicagobiomedicalconsortium.org)
  • Polydopamine-enabled surface functionalization of gold nanorods for cancer cell-targeted imaging and photothermal therapy. (chicagobiomedicalconsortium.org)
  • Through 1990â s to 2000â s, world scientists found several 3â UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. (omicsonline.org)
  • In fact, cancer cells, in particular renal and breast cells express high levels of PD-L1 leading to poor patient survival [15,16]. (studylib.net)
  • The Cancer Genome Atlas (TCGA) LUAD data set was used to explore associations among B-cell infiltration, PD-L1 expression, clinical outcome, and gene landscape. (cancer-genetics.org)
  • Melatonin disturbs SUMOylation-mediated crosstalk between c-Myc and nestin via MT1 activation and promotes the sensitivity of paclitaxel in brain cancer stem cells. (cusabio.com)
  • Nestin, originally identified as a marker of neural stem cells, was demonstrated to be expressed in breast cancer (BC). (cusabio.com)
  • Especially, weakly simple medication are predicted to accumulate to a lesser degree inside cancer cells at steady state when extracellular pH is decreased. (pkainhibitors.com)
  • Also, it can be conceivable the favorable intracellular distribution Secretase inhibitors of weakly essential drugs within cancer cells with defective lysosomal acidification could offset the aforementioned unfavorable accumulation differences that could exist. (pkainhibitors.com)
  • Despite success in some cancer survival rates, these numbers differ by race, ethnicity, socioeconomics, health policy, geography, and age so the overall survival numbers ignore the large variations within any given group. (4open-sciences.org)
  • Helps maintain human pluripotent stem cells in undifferentiated state. (rndsystems.com)
  • Previous studies have shown that children with acute myeloid leukemia (AML) who developed mixed chimerism (MC) were at high risk for relapse after allogeneic stem-cell transplantation (allo-SCT). (shengsci.com)
  • Independent origins of fetal liver haematopoietic stem and progenitor cells. (u-tokyo-hemat.com)
  • A culture platform to study quiescent hematopoietic stem cells following genome editing. (u-tokyo-hemat.com)
  • Heterozygous Dnmt3a R878C induces expansion of quiescent hematopoietic stem cell pool. (u-tokyo-hemat.com)
  • Also, it is been detected in BC stem cells and newly-formed tumor vessels promoting invasion and metastasis. (cusabio.com)
  • They can arise everywhere, since neuroendocrine cells are virtually distributed in each organ. (springeropen.com)
  • Western blot and Semi-quantitative Reverse transcription-polymerase chain reaction (RT-PCR) assays, as well as immunohisitochemistry, were performed to detect the expression of Notch-1 in LAD cells and tissue samples. (biomedcentral.com)
  • Despite this, clinical responses are typically transient as tumour cells develop resistance. (babraham.ac.uk)
  • Based on their functional outcome, co-signaling molecules can be divided as co-stimulators and co-inhibitors, which positively and negatively control the priming, growth, differentiation and functional maturation of a T-cell response. (biomedcentral.com)
  • and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
  • It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
  • Moreover, it has been shown that the PD-1 ligand (PD-L1) is highly expressed in leukemia cells. (biomedcentral.com)
  • In addition, PD-1/PD-L1 interactions contribute to functional T-cell impairment, which fails to elicit minimal residual disease and may be related to leukemia relapse. (biomedcentral.com)
  • Methods: Fixed number of Vero and Hep2 cells were preserved at -85ºC deep freezer in separate vials and were revived at one month interval to check the growth pattern. (ijpmonline.org)
  • Cell Rep Methods. (u-tokyo-hemat.com)
  • Tubular atrophy, single cell necrosis of the germ cells and in epididymides reduced spermatozoa were recorded microscopically. (jaksignaling.com)
  • T-cell anergy is defined as the state in which T-cells fail to respond to previously encountered antigenic stimulation by functional APCs. (biomedcentral.com)
  • PD-1 is expressed on activated T cells, B cells, and myeloid cells. (biomedcentral.com)