• Distribution of lymphocytes of the alpha(E)beta(7) phenotype and E-cadherin in normal human urothelium and bladder carcinomas. (ox.ac.uk)
  • Squamous cell carcinoma of the urinary bladder is a malignant neoplasm derived from bladder urothelium with pure squamous phenotype. (medscape.com)
  • If the human bladder works similarly, then loss of normal urothelium mechanosensory signals due to disease or injury may lead to some forms of urinary frequency, urinary urgency, and urinary incontinence in people, and treatments based on this knowledge may follow. (nih.gov)
  • Loss of β1‑integrin from urothelium results in overactive bladder and incontinence in mice: a mechanosensory rather than structural phenotype. (nih.gov)
  • Almost all bladder cancers originate in the urothelium, which is a 3- to 7-cell mucosal layer within the muscular bladder. (medscape.com)
  • Loss of CAR expression correlates with the invasive phenotype in our analysis of bladder cancer. (elsevierpure.com)
  • However, the mechanism of CLDN4 upregulation and promotion of malignant phenotype is not clear. (mdpi.com)
  • ZNF326 promotes a malignant phenotype of breast cancer by interacting with DBC1. (cancerindex.org)
  • Therefore, we concluded that ZNF326 is highly expressed in breast cancer, is associated with poor prognosis, and plays a vital role in promoting the malignant phenotype of breast cancer cells by interacting with DBC1. (cancerindex.org)
  • The primary aim of this work was to survey normal urothelium and transitional cell carcinoma (TCC) for the presence of T lymphocytes expressing the intraepithelial, CD103(+) phenotype. (ox.ac.uk)
  • Immunochemistry demonstrated a stage and grade-dependent decrease in CAR expression (90.0%, 83.3%, and 31.3% of normal urothelium and superficial and invasive transitional cell carcinoma [TCC] and 83.3% and 39.5% of low and high-grade TCC, respectively). (elsevierpure.com)
  • Uroplakin expression by transitional cell carcinoma cell lines was related to their differentiated phenotype in vitro. (york.ac.uk)
  • Transient siRNA knockdown of P63 revealed that P63 favoured a basal-like phenotype by inhibiting differentiation and promoting expression of basal marker genes. (uea.ac.uk)
  • In cancer, deletion or mutation of the Ku80 (or Ku70) genes results in a highly radiosensitive phenotype. (ms-validatedantibodies.com)
  • Hypoxia-inducible genes have been linked to the aggressive phenotype of cancer. (ox.ac.uk)
  • A knowledge graph of biological entities such as genes, gene functions, diseases, phenotypes and chemicals. (edu.sa)
  • Future studies could explore whether people with urinary frequency, urinary urgency, and urinary incontinence also have abnormal integrin signaling in their urothelium. (nih.gov)
  • Furthermore, we found a stage and grade-dependent increase in α v integrin expression (13.3%, 46.0%, and 56.3% of normal urothelium, superficial TCC, and invasive TCC and 25% and 52.6% of low and high-grade TCC, respectively). (elsevierpure.com)
  • Regions of chromatin identified by FAIRE-seq as having altered accessibility during differentiation were found to be enriched with sequence-specific binding motifs for transcription factors predicted to be involved in driving basal and differentiated urothelial cell phenotypes, including FOXA1, P63, GRHL2, CTCF and GATA3. (uea.ac.uk)
  • Cultured normal human urothelial cells showed a proliferative basal/intermediate cell phenotype and constitutive expression of UPIb only. (york.ac.uk)
  • The immunohistochemical phenotype of focal neuroendocrine differentiation in prostate cancer has been intensively studied. (wikipedia.org)
  • One hypothesis is that tumor cells ac- quire at some state of the tumor development a mutator phenotype, which is characterized by an increased mutation rate due to a malfunction of gene pro- ducts responsible for the maintenance of genetic stability (see Section 14. (banglaforexacademy.com)
  • These types of prostate cancer comprise true neuroendocrine cancers, such as small cell carcinoma, carcinoid and carcinoid-like tumors, as well as prostatic adenocarcinoma exhibiting focal neuroendocrine phenotype. (wikipedia.org)
  • Occasional T lymphocytes (CD3(+)) were seen in normal urothelium and lamina propria. (ox.ac.uk)
  • T lymphocytes of the CD103(+) phenotype are present in normal urothelium where they may play a role in immunosurveillance. (ox.ac.uk)
  • Normal urothelium expressed mRNA for all four uroplakins, although UPIII could be detected only by ribonuclease protection assay. (york.ac.uk)
  • whereas human epidermal growth factor receptor 2 (HER2)-positive breast cancers can be targeted by specific drugs, the triple-negative breast cancer phenotype is defined by chromosomal instability and low expression levels of estrogen receptor (ER) alpha, progesterone receptor (PR), and HER2, rendering treatment rather difficult. (dovepress.com)
  • Thus a comparable degree of skepticism should exist on the notion of the exclusive involvement of intercellular channels in many studies correlating Cx and Panx expression with certain responses or phenotypes. (biobender.com)
  • Apocrine metaplasia is a reversible transformation of cells to an apocrine phenotype . (wikipedia.org)
  • 32 mast cells/mm 2 in the detrusor muscle and particularly the location beneath the urothelium were statistically significant and typical for BPS/IC with Hunner's lesion. (amegroups.org)
  • Upk3b is dispensable for development and integrity of urothelium and mesothelium. (mpg.de)
  • Oncogenic ß-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids. (mpg.de)
  • The inner surface of the urinary tract is lined with epithelial tissue, or urothelium, which functions as a barrier to bacteria, environmental carcinogens, toxins, and the numerous and variable waste products in urine. (nih.gov)
  • In the urothelium the majority of these T lymphocytes (71%) were also CD8(+) and of these 68% expressed the CD103 marker. (ox.ac.uk)
  • Fasting insulin levels and cardiometabolic risk factors across glycemic abnormality phenotypes were also compared. (cdc.gov)
  • Heterarchy of transcription factors driving basal and luminal cell phenotypes. (earlham.ac.uk)
  • Recently, the tissue-specific stem cells of the normal urothelium have been proposed to reside in the basal layer, and investigators have isolated phenotypically similar populations of cells from urothelial cancer cell lines and primary tumors. (eurekaselect.com)
  • RNA-Seq of MK2i-NP-treated primary human VSMCs revealed programmatic switching toward a contractile VSMC gene expression profile, increasing expression of antiinflammatory and contractile-associated genes while lowering expression of proinflammatory, promigratory, and synthetic phenotype-associated genes. (jci.org)
  • Human orthologues of genes whose knockdown modified the phenotype in the Gal4-UAS fly model were further examined in ATRT samples and SMARCB1-deficient rhabdoid tumor cells. (cancerindex.org)
  • The lethal phenotype was shifted to later stages of development upon additional siRNA knockdown of 89 of 1083 genes screened in vivo. (cancerindex.org)
  • They have developed novel approaches to target gene recombination specifically to bladder urothelium, and have used these approaches to generate unique GEMMs of muscle invasive bladder cancer. (nih.gov)
  • As the Figure 2 shows, bladder cancer generally originates from the urothelium of the bladder and is referred to as urothelial carcinoma, which is the most common type of bladder cancer. (cusabio.com)
  • In UCC, microRNA alterations occur in a tumor phenotype-specific manner and can predict disease progression. (ox.ac.uk)
  • Analysis of Nkx3.1 mutant mice provided the foundation for their extensive series of GEMMs based on genomic alterations that occur in human prostate cancer, which represent the spectrum of prostate cancer phenotypes, ranging from pre-invasive to lethal castration-resistant and metastatic disease. (nih.gov)
  • Knockdown of Snr1, the fly orthologue of SMARCB1, resulted in a lethal phenotype and epigenetic alterations in the fly model. (cancerindex.org)
  • These types of prostate cancer comprise true neuroendocrine cancers, such as small cell carcinoma, carcinoid and carcinoid-like tumors, as well as prostatic adenocarcinoma exhibiting focal neuroendocrine phenotype. (wikipedia.org)
  • MUC1 appears to be a marker of aggressive phenotype and may facilitate the vascular spread of carcinoma cells. (bmj.com)
  • In normal urothelium from patients with UCC, 11% of microRNAs had altered expression when compared with disease-free controls. (ox.ac.uk)
  • Molecular markers of the VSMC contractile phenotype were sustained over time in culture in rat primary VSMCs treated with potent, long-lasting MK2 inhibitory peptide nanopolyplexes (MK2i-NPs), a result supported in human saphenous vein specimens cultured ex vivo. (jci.org)
  • Finally, these results were confirmed using an in vivo rabbit vein graft model where brief, intraoperative treatment with MK2i-NPs decreased IH and synthetic phenotype markers while preserving contractile proteins. (jci.org)
  • Thus, in pancreatic neoplasia, MUC1 and MUC2 have potential diagnostic and prognostic value as markers of aggressive and indolent phenotypes, respectively, and have potential as therapeutic targets. (bmj.com)
  • In this regard, homografts and allografts have been implemented in bladder augmentation with varying results, but recent studies have shown promising data in terms of proliferation of urothelium and muscle cells by using biological silk grafts. (springermedizin.at)
  • Secondly, a study by Protze SI showed that RA can enhance the phenotype of biological pacemakers. (biomedcentral.com)
  • Proliferating astrocytes can exhibit a reactive phenotype, with increased cytoplasmic volume, thicker cell processes, and larger, more vesicular nuclei. (nih.gov)
  • The innermost layer of the bladder (called mucosa or urothelium), which comes in contact with the urine stored inside the bladder. (cusabio.com)