Phenomenon reperfusion injury. Medical search. Frequent questions

It can be applied directly or remotely when cycles of ischemia and reperfusion are applied to a distant site or organ. (wjgnet.com)
Administration of interventional drugs at the initiation of reperfusion is limited since they must be introduced within 10 minutes of reperfusion starting, yet therapeutic targeting of intracellular processes invoked during both ischemia and reperfusion remain a promising strategy for the prevention and/or limitation of both the occurrence and the extent of I/R injury. (tocris.com)
Immature calcium handling in immature myocardium raises intracellular calcium concentrations after ischemia and reperfusion. (medscape.com)

In animal models, those with intramyocardial hemorrhage had a more rapid expansion of myocardial necrosis than those without hemorrhage, and within 72 hours of reperfusion, a fourfold greater loss in salvageable myocardium was evident in hemorrhagic MIs. (medscape.com)
After 24 hours of reperfusion, TMF-treated rats had significantly lower RE values, ΔT1 values, serum ALT levels, and necrotic area percentage than did untreated rats. (researchsquare.com)
Methods: C57B6/J wild type (WT) mice and GAL-3 knockout (KO) mice were used for murine model of IR injury in the heart where a period of 30 minutes ischemia was followed by 24 hours of reperfusion. (uaeu.ac.ae)

It has been known for many years that hemorrhage is often seen in the myocardium in large MIs, but it has not been established before now whether it contributes to the injury or not, Dharmakumar explained. (medscape.com)
This phenomenon occurs during a myocardial infarction , when an occlusive thrombus within a coronary artery prevents blood supply to the myocardium, but can also occur during cardiac surgery as a result of pharmacological intervention to temporarily stop the heart. (tocris.com)
The reperfusion of an ischemic myocardium following a period of ischemia is also a focus of research. (tocris.com)
Cardiac Dysfunction and Disease Diseases affecting the myocardium, such as ischemic and other cardiomyopathies, metabolic abnormalities, rhythm and electrical disturbances, heart failure, and inflammatory disorders, often develop as a continuum that begins with injury and progresses over time to overt dysfunction and failure. (nih.gov)
Although restoration of blood flow to the jeopardized myocardium is a perquisite for myocardial salvage, reperfusion itself may lead to accelerated and additional myocardial injury, termed reperfusion injury, beyond that generated by ischemia alone. (nih.gov)
Because of the increased ability of the immature myocardium to rely on anaerobic glycolysis, it can withstand ischemic injury better than adult myocardium can. (medscape.com)
Ischemia-reperfusion injury (IRI) is a syndrome affecting the myocardium upon blood flow restoration following a sufficiently long interruption, such as encountered in a coronary thrombosis or heart surgery [1,2]. (justia.com)
The role of microvascular damage in the genesis of the "no-reflow" phenomenon was investigated in the left ventricular myocardium of dogs subjected to temporary occlusions of a major coronary artery for 40 and 90 min. (jci.org)
Background/Aims: Myocardial reperfusion has the potential to salvage the ischemic myocardium after a period of coronary occlusion. (uaeu.ac.ae)
Conclusion: Our study shows that GAL-3 can affect the redox pathways, controlling cell survival and death, and plays a protective role on the myocardium following IR injury. (uaeu.ac.ae)

Ischaemia-reperfusion-induced pulmonary dysfunction is a significant clinical problem in cardiac surgery and, particularly, lung transplantation 1 . (ersjournals.com)
Furthermore, although anaerobic metabolism, mitochondria, oxidative stress, intracellular calcium overload, liver Kupffer cells (KC), neutrophils, cytokines, and chemokines have been found to be involved in the hepatic IR injury process, effective prevention or treatment in clinical practice is still lacking. (researchsquare.com)
Promising preclinical findings highlight the potential clinical use of EVs for I-R injury. (houstonmethodist.org)
Background and purpose: Ischemic/reperfusions are regarded as the clinical consensus for stroke treatment, which results in secondary injury of brain tissues. (aging-us.com)
However, currently, quick recovery of the blood supply has been regarded as the clinical consensus for the treatment of stroke, in which way, ischemic/reperfusion is inevitable. (aging-us.com)
Therefore, the injury to brain tissues resulting from ischemic/reperfusion has been taken as a tough task post clinical stroke treatment. (aging-us.com)
2 Among the most pressing problems are quantifying the disparity between reperfusion success and clinical outcomes, the lack of access to thrombectomy in many locations both within the USA and globally, and the complexity of translating promising neuroprotective agents into human studies. (bmj.com)
3. The hypoxanthine-xanthine oxidase axis is not involved in the initial phase of clinical transplantation-related ischemia-reperfusion injury. (nih.gov)
Acute kidney injury (AKI) is an important clinical syndrome with increased short- and long-term morbidity and mortality, which is often caused by ischemia-reperfusion (IR), nephrotoxic drugs, sepsis and urinary tract obstruction [ 1 ]. (biomedcentral.com)
The complement system has been implicated in a variety of clinical conditions, from autoimmune diseases to ischemia-reperfusion injury in transplantation. (akjournals.com)
Coronary slow flow phenomenon clinical findings and predictors. (ac.ir)
Hemolysis, vaso-occlusion, and ischemia-reperfusion injury are the clinical hallmarks of sickle cell disease (SCD). (medscape.com)

Reperfusion injury can be characterized/monitored by oxidative stress parameters, inflammatory markers and by post-operat ive complication rate. (iospress.com)
However, harmful stimuli (such as ischemia-reperfusion, oxidative stress, and toxic chemicals) can change the direction and efficiency of intercellular mitochondrial transfer. (frontiersin.org)
Oxidative stress is implicated in pathogenesis of cardiac reperfusion injury, characterized by cellular Ca 2+ overload and hypercontracture. (asahq.org)
This study investigated electrophysiological mechanisms underlying cardioprotective effects of sevoflurane against oxidative stress-induced cellular injury. (asahq.org)
Al-Salam, S & Hashmi, S 2018, ' Myocardial Ischemia Reperfusion Injury: Apoptotic, Inflammatory and Oxidative Stress Role of Galectin-3 ', Cellular Physiology and Biochemistry , vol. 50, no. 3, pp. 1055-1067. (uaeu.ac.ae)

Various chemical and cellular mediators have been implicated in the pathogenesis of intestinal ischemia/reperfusion, such as reactive oxygen, cytokines, endotoxins, and neutrophils [1]. (lupinepublishers.com)
In the pathogenesis of this phenomenon are important not only quantitative but also qualitative parameters of immunity, as well as the characteristics of the causative agents of opportunistic lesions. (ter-arkhiv.ru)

The central role of lung ischaemia-reperfusion injury in pulmonary dysfunction after cardiac surgery, particularly thoracic organ transplantation, has been well recognised. (ersjournals.com)
Recent studies suggest that lung apoptosis following ischaemia-reperfusion could be equally important in the development of post-operative lung dysfunction. (ersjournals.com)
The current literature on the mechanism and pathways involved in pulmonary dysfunction and, in particular, its relationship with apoptosis after lung ischaemia-reperfusion is briefly reviewed here. (ersjournals.com)
Post-operative pulmonary dysfunction following the use of cardiopulmonary bypass is a frequently observed phenomenon that is associated with lung ischaemia-reperfusion injury 2 , 3 . (ersjournals.com)
However, understanding of the complex pathophysiology of ischaemia-reperfusion-induced lung injury remains incomplete. (ersjournals.com)
Unlike any other organ in the human body, the lung possesses two blood supply networks with extensive anastomotic connections and a total of three potential sources of lung tissue oxygenation, thus making lung ischaemia-reperfusion injury more intriguing to study 2 . (ersjournals.com)
Since the mid-1980s, the role of neutrophils, free radicals and other inflammatory mediators in ischaemia-reperfusion injury has been extensively investigated 4 . (ersjournals.com)
Nevertheless, these mediators appear to contribute only in part to lung ischaemia-reperfusion injury. (ersjournals.com)
The final pathways, after lung ischaemia and reperfusion, leading to cellular damage, necrosis or apoptosis of the pulmonary epithelium remain to be fully elucidated. (ersjournals.com)
Recently, the mechanisms involved in pulmonary apoptosis following lung ischaemia-reperfusion have begun to be understood 5 . (ersjournals.com)
The current review highlights the latest research findings in apoptosis after acute lung ischaemia-reperfusion injury. (ersjournals.com)
Pulmonary ischaemia-reperfusion can cause cellular breakdown and death of lung epithelial tissue, which may contribute to the magnitude and duration of pulmonary dysfunction seen after cardiopulmonary bypass and lung transplantation 2 , 4 . (ersjournals.com)
Since the late 1990s, scientists have recognised that the different processes following ischaemia-reperfusion, although closely related, cause lung injury by activation of different inflammatory pathways 2 , 4 , 6 . (ersjournals.com)
Tissue necrosis after lung ischaemia-reperfusion injury has been recognised to be associated with significantly worsened lung function, related to the high degree of inflammation. (ersjournals.com)
However, the complex relationship between ischaemia-reperfusion and lung apoptosis is only beginning to emerge. (ersjournals.com)
In experimental studies of rodent single-lung transplantation, a short duration of ischaemia (20 min) and reperfusion was associated with neither increased cellular necrosis nor apoptosis of the transplanted lung compared with the pre-retrieval lungs 12 . (ersjournals.com)
These involve the activation of Jak/STAT3 and PI3K/Akt, which subsequently decreases mitochondrial permeability transition pore (mPTP) opening and increases mitochondrial K ATP (Mito K ATP ) channel opening, which attenuates myocardial ischaemia reperfusion injury. (researchgate.net)
Myocardial ischaemia reperfusion injury is the leading cause of death in patients with cardiovascular disease. (researchgate.net)
Interventions such as ischaemic pre and postconditioning protect against myocardial ischaemia reperfusion injury. (researchgate.net)
as a feasible method for reduction of myocardial ischaemia-reperfusion (IR) injury. (researchgate.net)
As myocardial infarction is a major cause of mortality and morbidity in these patients, treatments that increase cell survival in response to ischaemia and reperfusion are needed. (researchgate.net)
We then outline the diverse, multicellular effects of ischaemic stroke and the complex temporal sequences of the pathophysiological cascade during and following ischaemia, reperfusion, and recovery. (bmj.com)
described a phenomenon now recognised as ischaemic preconditioning, whereby infarct size as a result of acute coronary occlusion may be attenuated by a preceding period of ischaemia. (ecrjournal.com)

A 75-year-old Japanese man who was undergoing periodic follow-ups for CKD stage G3aA3 with membranous nephropathy was diagnosed with acute kidney injury (AKI) (estimated glomerular filtration rate [eGFR]: 15 mL/min/1.73 m2) without prerenal AKI. (bvsalud.org)
In our study, we investigated its role in ischemia-reperfusion injuries (IR) as this phenomenon is extremely relevant to the early intervention after acute MI. (uaeu.ac.ae)
Intestinal ischemia-reperfusion (I-R) injury is a severe condition resulting from acute mesenteric ischemia, small bowel transplantation, abdominal aortic aneurysm, hemorrhage, trauma, septic shock, or severe burns. (lupinepublishers.com)
Mitochondrial dysfunction is an important pathogenic event in acute kidney injury (AKI). (biomedcentral.com)
In this study, we investigated the effects of chloral hydrate (CH) on the acute inflammatory response in BALB/c mice using lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced acute lethal liver injury and zymosan A-induced peritonitis models. (nih.gov)

Results showed that while troponin levels were not different before reperfusion, patients with intramyocardial hemorrhage had significantly higher cardiac troponin levels after reperfusion and these levels peaked earlier than in patients without hemorrhage. (medscape.com)
Numerous metabolic changes result from cardiac ischemia and, if it is prolonged, ischemia may result in irreversible injury. (tocris.com)
In order to maintain cardiac output in the face of injury or stress, the heart may compensate by increasing muscle mass through a hypertrophic process. (nih.gov)
By inducing hormesis, protective cellular internal antioxidant enzymes (glutathione, catalase, superoxide dismutase) are activated prior to a stroke (or heart attack), so when blood circulation is restored there will not be any resultant cardiac or heart muscle damage (called reperfusion injury). (optometrytimes.com)

Hence, studies of the effects of alcohol on cellular stress pathways are critical to understand the mechanisms of alcohol-induced injuries or protection to develop new strategies for prevention, diagnosis and treatment. (nih.gov)
The study evaluated nano structured extract Morinda citrifolia L. (Noni) conveyed in enteral form, in an experimental model of intestinal ischemia/reperfusion (I/R), as well as in the prevention of bacterial translocation. (lupinepublishers.com)
While the goal of recanalisation therapy is very apparent and has good indicators for translation, cerebroprotection must ideally fulfil a multitude of purposes, including the improvement of cerebral microcirculation, the reduction of infarct progression, the tight regulation of metabolic processes, and the prevention of reperfusion injury, inflammation and haemorrhagic transformation. (bmj.com)
The Company intends to become a leader in advancing DMT as a prescription pharmaceutical, and as previously reported, is the first organization to receive orphan drug designation by the U.S. FDA for DMT in the prevention of ischemia-reperfusion injury in patients undergoing solid organ transplantation, which includes the liver, kidney, heart, and lungs. (psychedelicalpha.com)
In the management of such patients, the basis for treatment was the prevention of ischemic, reperfusion injuries of organs and hemorrhagic complications. (ter-arkhiv.ru)

3) develop potential stress related biomarkers for prognosis, diagnosis of tissue injury/protection, furthermore identify new targets for their therapeutic interventions. (nih.gov)
Reperfusion injury, e.g. potential therapeutic value of non-anticoagulant glycosaminoglycans. (nih.gov)

Liver ischemia-reperfusion injury is a major cause of postoperative liver dysfunction, morbidity and mortality following liver resection and transplantation. (wjgnet.com)
Hepatic ischemia-reperfusion (IR) injury commonly occurs during liver transplantation or resection and is considered a leading cause of liver damage and dysfunction. (researchsquare.com)
Liver ischemia/reperfusion (I/R) injury is a clinically important phenomenon encountered during transplantation that contributes to initial graft function and subsequent allograft rejection. (atcmeetingabstracts.com)
Buemi A, Duisit J, Musuamba F, Darius T, De Meyer M, Aydin S, Kanaan N, Devresse A, Goffin E, Mourad M. Donor Age and Ischemia Time Are Independent Factors Affecting Graft Survival after En Bloc Kidney Transplantation from Donors Less than Three Years of Age. (lidsen.com)
En bloc kidney transplantation from donors aged less than one year was associated with high early graft loss and poor long-term survival rates. (lidsen.com)

abstract = "As the incidence of ischemia-reperfusion (I-R) injury has substantially increased, there is a pressing need to develop effective strategies to treat this global health issue. (houstonmethodist.org)
Huang H, Tohme S, Al-Khafaji A, Tsung A. Damage Associated Molecular Patterns (DAMPs)-Activated Neutrophil Extracellular Trap Formation Exacerbates Liver Ischemia/Reperfusion Injury [abstract]. (atcmeetingabstracts.com)

17. [The role of xanthine dehydrogenase (xanthine oxidase) in ischemia-reperfusion injury in rat kidney]. (nih.gov)
As an important regulation mode of mitochondrial homeostasis, the decline of mitochondrial biogenesis inevitably leads to the reduction of mitochondrial quantity and inhibition of mitochondrial respiration, which may further induce mitochondrial damage and lead to renal intrinsic cell death, kidney injury and possible organ failure [ 7 ]. (biomedcentral.com)
A total of 52 en bloc kidney graft transplantations were performed. (lidsen.com)

Ischemic/reperfusion was found to be harmful to the recovery of the tissues when people noticed that a new type of tissue injury could arise from the sudden oxygen supply post-long-term hypoxia, which is also verified in the aggravation of brain dysfunction after ischemic/reperfusion on brain tissues [ 6 , 7 ]. (aging-us.com)

Ischaemic postconditioning confers cardioprotection through the survivor activating factor enhancement (SAFE) and reperfusion injury salvage kinase (RISK) pathways. (researchgate.net)

Death of severely ischemic myocardial cells in this model occurs before the onset of capillary damage and the no-reflow phenomenon. (jci.org)
It has been shown that following restoration of flow in a previously obstructed vessel, an increase in blood flow above basal levels frequently occurs - a phenomenon known as reactive hyperaemia. (ecrjournal.com)

We are totally rethinking what a myocardial infarction is - what causes the injury and the time course of the injury - our results suggest that it's not just ischemic damage and a lot of the harm is caused by hemorrhage after reperfusion. (medscape.com)
Pathological settings such as myocardial infarction, stroke, hemorrhagic shock, and solid organ transplant are particularly prone to cause I-R injury. (houstonmethodist.org)
Increasing myocardial cell death and aggravating myocardial infarction are the most serious consequences of ischemia-reperfusion injury. (biomedcentral.com)

After prolonged periods (up to 18 h) of cold ischaemic lung preservation without reperfusion, a high percentage of cell necrosis (but not apoptosis) can be observed 12 , 13 . (ersjournals.com)
This may be explained by several factors that encompass practical considerations such as study design, implementation, and evaluation, focusing on a singular putative target in the ischaemic cascade or failing to consider potentially influencing factors such as the patient's reperfusion status. (bmj.com)
2 This adaptive phenomenon is believed to repay the oxygen debt of the ischaemic episode. (ecrjournal.com)

Aryl hydrocarbon receptors (AhRs) have been reported to be important mediators of ischemic injury in the brain. (researchsquare.com)
These results suggest that 40 min of ischemia were tolerated by the capillary bed of the dog heart without serious capillary damage or perfusion defects, but that 90 min of ischemic injury was associated with the "no-reflow" phenomenon, i.e., failure to achieve uniform reperfusion. (jci.org)

The authors explain that it is now recognized that reperfusion injury can contribute to increasing infarct size, which they refer to as "infarct surge. (medscape.com)
Previous studies have also shown that reperfusion injury can contribute to as much as 50% of the final infarct size, but the factors contributing to the observed variability are not known, and previous attempts to limit infarct surge from reperfusion injury have failed. (medscape.com)
The concept of infarct size limitation ultimately provided the rationale for early thrombolytic and reperfusion therapies and the use of beta-blockers. (nih.gov)

Contraction bands and mitochondrial Ca 2+ accumulation were prominent features of irreversible injury with reflow at 40 min but were not noted after 90 min of ischemia in areas with poor perfusion. (jci.org)
This blockage of blood vessels by leukocytes is responsible for the no reflow phenomenon in which the ischemic tissue is never fully reperfused. (drugcarts.com)
19. Xanthine oxidase: its role in the no-reflow phenomenon. (nih.gov)

Alcohol induces cellular stress pathways in the cytoplasm and in the endoplasmic reticulum that may significantly be involved in alcohol-induced tissue injury or mediate tissue protection depending on the quantity, frequency, duration, and temporal pattern of drinking. (nih.gov)
Ischemia (hypoxia) and/or reperfusion (reoxygenation) induces various forms of cellular and structural damage. (houstonmethodist.org)

The underlying mechanisms of renal injury or sickle cell nephropathy (SCN) relate mainly to hypoxia and ischemia. (medscape.com)

Observe the protective and repairing effect of Noni's nanoemulsified extract in the presence of induced bacterial translocation, by an experimental model of intestinal ischemia/reperfusion. (lupinepublishers.com)

Ischemia/Reperfusion (I/R) injury is defined as the cellular damage that results from a period of ischemia that is followed by the reestablishment of the blood supply to the infarcted tissue. (tocris.com)
Reperfusion restores blood supply to ischemic tissue, but this is paradoxically associated with further tissue damage. (tocris.com)
This process of initial ischemia-related damage followed by further damage induced by reperfusion is known as ischemia/reperfusion (I/R) injury. (tocris.com)
BACKGROUND: Patients having coronary artery disease treated by coronary bypass or PCI procedure are exposed to tissue damage because of the phenomenon called reperfusion injury. (iospress.com)
This means that ischemia-induced AhR activation and tissue damage after reperfusion could be greater in the liver than in the brain. (researchsquare.com)
Progression to renal damage by ischemia-reperfusion injury (IRI) is the result of the dysregulation of various tissue damage repair mechanisms. (researchgate.net)
Development of NETs subsequently exacerbates organ damage and initiates inflammatory responses during liver I/R injury. (atcmeetingabstracts.com)

Apoptosis is a form of programmed cell death involved in a wide range of adaptive processes, from embryogenesis to stress injury responses. (biomedcentral.com)

1 - 5 The mechanisms of hepatic IR injury have been extensively investigated, but nevertheless remain largely unclear. (researchsquare.com)
Additionally, the mechanisms by which EVs protect against I-R injury are discussed. (houstonmethodist.org)
we sought to determine the mechanisms by which NETs are stimulated and how they contribute to the innate immune and inflammatory response during liver I/R injury. (atcmeetingabstracts.com)
however, the precise injury mechanisms remain unclear making it worthy to perform more studies on Pb-induced renal toxicity and to discover potential treatment. (molcells.org)
The coronary slow flow phenomenon: Characteristics, mechanisms and implications. (ac.ir)

As the heart responds to such an injury, various critical events are initiated. (nih.gov)
GSTP1-AA allele pair has negative effect on ischemia-reperfusion tolerance of the heart. (iospress.com)
The invention pertains to a polypeptide for the protection against heart ischemia-reperfusion injury. (justia.com)
The phenomenon may be modelled in an experimental setting, in this case on an isolated rat heart. (justia.com)
One object of the present invention is to provide a therapy of heart ischemia-reperfusion injury by applying GLP-1 analogues which can be administered as single component and avoiding administration of the drug with a second compound. (justia.com)
The present invention is based on the surprising finding that the peptides of the invention have protective cardiovascular effects without simultaneous administration of other compounds, specifically they have protective effects on the heart against ischemia-reperfusion injury. (justia.com)
Postconditioning using N-Ac-GLP-1(7-34)amide N-terminally blocked and C-terminally truncated results in a limitation of ischemia-reperfusion injury in an isolated rat heart. (justia.com)
This review provides an overview of EV-based therapeutics for I-R injury in kidneys, liver, heart, lungs, and brain. (houstonmethodist.org)
Volatile anesthetics protect the heart against reperfusion injury primarily by attenuating Ca 2+ overload. (asahq.org)
Results: Our results show that there was a significant increase in GAL-3 levels in the heart which shows GAL-3 is playing a role in the ischemia reperfusion injury. (uaeu.ac.ae)
Retrograde aortic perfusion of the heart in the Langendorff mode is used by numerous laboratories to evaluate the effect of various factors on ventricular contractile function and ischemia reperfusion injury [ 1 - 3 ]. (omicsonline.org)
The isolated perfused heart model is widely used in academia and industry and was instrumental in the discovery of the phenomena of ischemic preconditioning and in the identification of a multitude of ionotropic and chronotropic factors [ 1 , 4 ]. (omicsonline.org)
Moreover, it was observed that, PGRN protects the heart against ischemia-reperfusion injury. (biomedcentral.com)

Following adhesive interactions among neutrophils and endothelial cells, neutrophil accumulation in the intestinal mucosa contributes to intestinal ischemia/ reperfusion injury via production of reactive oxygen metabolites and proteases. (lupinepublishers.com)

The renal injury of AKI mice was reflected by the levels of creatinine and urea nitrogen and the pathological changes of renal tissue. (biomedcentral.com)

In the present study, we investigated the protective effects of AhR antagonism after ischemia in a rat hepatic IR injury model. (researchsquare.com)
Modern ophthalmological pharmacological studies have also found that Ligusticum chuanxiong could treat retinal vein occlusion [ 8 ], and Astragalus membranaceus could reduce retinal ischemia-reperfusion injury, and it also had a significant protective effect on the retinal ganglion injury model [ 9 , 10 ]. (hindawi.com)

I-R injury can affect all organs and is associated with high morbidity and mortality rates. (houstonmethodist.org)

Elevated matrix Ca 2+ concentrations and reactive oxygen species (ROS) are the primary activators of the MPTP during I/R. Inhibition of ion exchangers that influence cytosolic Ca 2+ levels, such as the Na + /H + exchanger (NHE) and Na + /Ca 2+ exchanger (NCX), have been shown to reduce I/R injury. (tocris.com)

Leukocyte accumulation is a complex phenomenon that also involves endothelium-based adhesion molecules as well as leukocyte chemotaxis factors such as interleukin-8 (IL-8) [2,3]. (lupinepublishers.com)

The cell death that underlies I/R injury is characterized by features typical of apoptosis, autophagy and necrosis. (tocris.com)

Ischemic postconditioning applies brief episodes of ischemia at the onset of reperfusion following a prolonged ischemia. (wjgnet.com)

The phenomenon of intercellular mitochondrial transfer has been discovered in the cardiovascular system. (frontiersin.org)

However, cell death is a very complex phenomenon and descriptions were, in many cases, based on methods available in a particular laboratory rather than standardized methods. (biomedcentral.com)

Fatalities caused by parasitic infections often occur as a result of tissue injury that results from a form of host-cell death known as apoptosis. (biomedcentral.com)

This Funding Opportunity Announcement (FOA) issued by the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, encourage s Research Project Grant (R2 1) applications that propose studying the role of cellular stress responses, the cytoplasmic classical stress response or heat shock response (HSR) and the endoplasmic reticulum (ER) stress, in alcohol-induced tissue injury and tissue protection. (nih.gov)

Fineschi M, Gori T. Coronary slow-flow phenomenon or syndrome Y: A microvascular angina awaiting recognition. (ac.ir)

BACKGROUND: Coronary slow flow (CSF), an angiographic phenomenon that is characterized by a delayed coronary blood flow in the absence of obstructive coronary artery stenosis, is known as a disorder of the coronary microcirculation. (ac.ir)

No change in LGE was detected while microvascular obstruction and intra-myocardial haemorrhage peaked at different time points within the first week of reperfusion. (biomedcentral.com)

Anatomy23

Organisms11

Diseases63

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment39

Phenomena and Processes33

Disciplines and Occupations1

Information Science3

Health Care8

Ischemia and reperfusion3

Hours of reperfusion3

Myocardium10

Clinical12

Oxidative stress5

Pathogenesis2

Ischaemia23

Acute5

Cardiac4

Prevention5

Therapeutic2

Transplantation5

Abstract2

Kidney3

Dysfunction1

Salvage1

Occurs2

Myocardial infarction3

Ischaemic3

Ischemic injury2

Infarct3

Reflow3

Induces2

Hypoxia1

Translocation1

Damage7

Processes1

Mechanisms5

Heart13

Neutrophils1

Renal injury1

Protective2

Morbidity and morta1

Reactive1

Involves1

Necrosis1

Onset1

Cardiovascular1

Complex phenomenon1

Apoptosis1

Cellular1

Syndrome1

Background1

Microvascular1