• Idarubicin hydrochloride is a DNA-intercalating analog of daunorubicin which has an inhibitory effect on nucleic acid synthesis and interacts with the enzyme topoisomerase II. (nih.gov)
  • Initially, treatment begins with the administration of the non-chemotherapy drug all-trans-retinoic acid (ATRA), which is most often combined with an anthracycline chemotherapy (chemo) drug (either daunorubicin or idarubicin), which may also be used in combination with the chemo drug cytarabine (ara-c). (xediton.com)
  • Virtually all chemotherapeutic drug regimens include some combination of an anthracycline (most often daunorubicin [daunomycin]) with cytosine arabinoside (cytarabine). (medscape.com)
  • This randomized phase III trial is studying how well combination chemotherapy works in treating young patients with newly diagnosed acute lymphoblastic leukemia that is likely to come back or spread. (clinicaltrialsgps.com)
  • This phase II trial studies how well combination chemotherapy works in treating patients with newly diagnosed stage II-IV diffuse anaplastic Wilms tumors (DAWT) or favorable histology Wilms tumors (FHWT) that have come back (relapsed). (clinicaltrials.gov)
  • This partially randomized phase II/III trial studies how well, in combination with surgery, cisplatin and combination chemotherapy works in treating children and young adults with hepatoblastoma or hepatocellular carcinoma . (ucsf.edu)
  • This randomized phase III trial studies how well combination chemotherapy works in treating young patients with newly diagnosed B acute lymphoblastic leukemia that is likely to come back or spread, and in patients with Philadelphia chromosome (Ph)-like tyrosine kinase inhibitor (TKI) sensitive mutations. (uchicagomedicine.org)
  • The International Berlin-Frankfurt-Münster (BFM) Study Group reported that children with relapsed AML who received liposomal daunorubicin (DNX) in conjunction with the FLAG regimen (fludarabine, cytarabine, and granulocyte colony-stimulating factor [G-CSF]) had improved early treatment response. (medscape.com)
  • Female patients who are pregnant or breastfeeding or female and male patients of reproductive potential who are not willing to employ effective birth control method. (who.int)
  • In the Phase 3 trial, 35% of VYXEOS-treated patients received a hematopoietic stem cell transplant after treatment compared to 25% of patients treated with 7+3. (vyxeospro.com)
  • The aim of this phase of treatment is to clear the blood of leukemia cells (called blasts) and reduce the blast number in the bone marrow to normal levels. (xediton.com)
  • Both of the men and women: avoid conceive a child (get pregnant) while on treatment with Veenat 400mg(Imatinib 400mg) . (myapplepharma.com)
  • Patients in the standard arm (surgery alone) will undergo large en- bloc curative intent surgery will be performed within 4 weeks following randomization. (who.int)
  • The experiment on 71 non-inbred white pregnant rats, 316 fetuses and placentas, 323 first progeny in experimental chronic impairment of uteroplacental circulation in females with pregnancy in the ploid period has found that decimetric waves (DW) in a weak heat dose (40 mW/cm2) prevents hypotrophy and disorders of fetal and placental development. (maxwellmagneticmeds.co.za)
  • A cell cycle goes through three phases: resting, active growing, and mitosis (division). (drugs.com)
  • Alkylating agents work best in the resting phase of the cell cycle, although they may also work in the active phase. (drugs.com)
  • APL treatment has three phases: induction, consolidation, and maintenance. (medscape.com)
  • Inclusion Criteria: Age ≤30.99 years old Disease Status (Part A - Safety Phase) - ALL in 1st, 2nd or 3rd relapse OR primary induction failure. (mycancergenome.org)
  • 5.1.2.2 (Part B - Efficacy Phase) - ALL in 2nd or 3rd relapse OR primary induction failure. (mycancergenome.org)
  • 9. First report of successful management of acute promyelocytic leukemia in a pregnant female with All-Trans-Retinoic Acid and Arsenic Trioxide-based induction regimen. (nih.gov)
  • The first part of the study includes the first two phases of therapy: Induction and Consolidation. (ucsf.edu)
  • Patients who received more than one anthracycline prior to study entry should have each individual agent cumulative dose converted to doxorubicin equivalent and added together (eg, a patient who received cumulative dose of Daunorubicin at 200 mg/m2 and Mitoxantrone 48 mg/m2 has a total doxorubicin dose equivalent of 358.6 mg/m2 (200 mg/m2 x 0.833 + 48 mg/m2 x 4). (mycancergenome.org)
  • The cumulative dose of daunorubicin in adults should be limited to 400 mg/square metre when radiation therapy to the mediastinum has previously been administered. (medscape.co.uk)
  • To describe the 5-year event-free survival (EFS) for patients with mixed phenotype acute leukemia (MPAL) receiving mBFM HR B-ALL therapy that includes a second IM phase with Capizzi intravenous (IV) methotrexate without leucovorin rescue plus pegaspargase or calaspargase pegol (C-MTX). (ucsf.edu)
  • 12. Oral arsenic plus retinoic acid versus intravenous arsenic plus retinoic acid for non-high-risk acute promyelocytic leukaemia: a non-inferiority, randomised phase 3 trial. (nih.gov)
  • During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. (mayo.edu)
  • The traditional paradigm of pharmacological clinical research involves carrying out phase 1, 2, and 3 studies. (bvsalud.org)
  • Tissue Necrosis: Daunorubicin has been associated with local tissue necrosis at the site of drug extravasation. (nih.gov)
  • The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle. (lookformedical.com)
  • Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. (mayo.edu)