4. Pretreatment (30 min) with the non-selective muscarinic antagonists scopolamine (0.1, 0.3 or 1 mg kg(-1), i.p.) and atropine (0.3, 1 or 3 mg kg(-1), s.c.) but not methylatropine (1, 3 or 10 mg kg(-1), s.c) significantly inhibited stretching induced by Ro 04-6790 (30 mg kg(-1), i.p.). 5. (lookformedical.com)
Atropa belladonna is a highly poisonous plant which contains variety of active alkaloids such as atropine, scopolamine and many others. (ijpsonline.com)
This alkaloid is called scopolamine or hyoscine. (medprep.info)
The altered state of consciousness produced by common or 'classical' deliriant substances such as scopolamine , atropine and diphenhydramine is primarily mediated through the drug compounds' competitive antagonism of the peripheral and central muscarinic acetylcholine receptors . (wikipedia.org)
Atropa3
It is prepared from plant Atropa belladonna, commonly known as 'deadly nightshade' known to be most poisonous plant in world[ 3 ]. (ijpsonline.com)
in the factory isolation of the alkaloid from plants, it is traditionally obtained its inactive racemate - atropine in the form of a salt - Atropini sulfas. (medprep.info)
Medicinal products contain the drug atropine as a racemate (1: 1 mixture of the enantiomers), whereby the use of the enantiomer which is more effective or has fewer side effects would be preferable for fundamental reasons. (zxc.wiki)
Terpenes1
The compounds found in plants are diverse, with most in four biochemical classes: alkaloids, glycosides, polyphenols, and terpenes. (wikipedia.org)
The plant contains alkaloids with fused pyrrolidine and piperidine rings (derivatives of tropine, scopine and ecgonine). (medprep.info)
Other tropane derivatives, found in the same plants in small quantities, as well as liquid and volatile pyridine derivatives, often associated with tropane alkaloids, are of no practical importance. (medprep.info)
Substances1
Of natural pharmacologically active substances, alkaloids are the main group from which modern medicine draws the largest number of highly effective drugs. (medprep.info)
Nightshade1
From 1833 on, the Darmstadt company Merck produced atropine from the roots of the deadly nightshade. (zxc.wiki)
Toxic1
However, due to its toxic nature and adverse teratogenic effect, it is important to investigate the possible toxicity and safety level of belladonna mother tincture. (ijpsonline.com)
Tincture6
In this study, zebrafish embryos were used to evaluate fetal embryo toxicity of the belladonna mother tincture. (ijpsonline.com)
Briefly, eggs were exposed to different concentration (1, 5 and 10 %) of belladonna mother tincture and ethyl alcohol for 1 h. (ijpsonline.com)
Results showed that exposure to belladonna mother tincture at higher concentration (5, 10 %) cause embryonic malformation including pericardial edema, increase in body length, eye width and heart rate, while decrease hatching rate with no effect on mortality. (ijpsonline.com)
The behavioural parameters revealed that belladonna mother tincture increases the locomotor activity of larvae at its 1 % concentration rather than 5 and 10 % in comparison to control. (ijpsonline.com)
Further developmental toxicity studies on animals need to be carried out to validate use of belladonna mother tincture clinically in low concentration or high dilution.s. (ijpsonline.com)
From the leaves and herbs of belladonna (Folium et Herba Belladonnae), prepare tincture, thick and dry extracts, which are part of numerous medicines. (medprep.info)
Tropine1
The diversity of these alkaloids depends on which amino alcohol was formed in the process of biosynthesis from tropane (tropine, scopine or ecgonine) and with what organic acids these amino alcohols subsequently formed esters. (medprep.info)
Drugs2
Now a days, for scientific validation and global acceptance of homoeopathic drugs, in vitro as well as in vivo pharmacological evaluation of these drugs has been greatly increased[ 1 ]. (ijpsonline.com)
Belladonna is one of the most popular homoeopathic drugs used in baby teething, sudden severe pain and pain with inflammation or infection[ 2 ]. (ijpsonline.com)
Plants4
Alkaloids are called natural nitrogen-containing compounds of the main character, formed in plants. (medprep.info)
According to world literature, by the end of the past decade, the number of alkaloids isolated from the higher plants of the Earth's flora exceeded 5000. (medprep.info)
According to modern concepts, alkaloid-bearing plants make up 10% of the entire world flora. (medprep.info)
Intentional abuse with hallucinogenic plants (eg, Datura stramonium [jimson weed]) and mushrooms can cause anticholinergic syndrome due to the presence of anticholinergic tropane alkaloids . (medscape.com)
Compounds1
Groups of proteinogenic amines (for example, tyramine) and betaines (stakhidrin, trigonelline, etc.) adjoin the alkaloids, which are considered as transitional compounds from the simplest nitrogen-containing compounds (methylamine, trimethylamines, etc.) to the alkaloids proper. (medprep.info)
Varies1
In the same species, the amount of alkaloids is different in different organs of the plant and, moreover, varies depending on the phase of vegetation and environmental conditions. (medprep.info)
Plant1
Isoquinoline alkaloids - Isoquinoline alkaloids 1-Benzyl isoquinoline type: Papaverine: An opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. (powershow.com)
Action2
The action of atropine and thioscyamine is antispasmodic, dilating the pupil, relaxing smooth muscles, analgesic, limiting the secretion of sweat glands, relieving the symptoms of motion sickness, and stimulating the central nervous system. (medprep.info)