• The prototypical PDE4 inhibitor is rolipram. (wikipedia.org)
  • Piclamilast, a more potent inhibitor than rolipram. (wikipedia.org)
  • Concentrations of a type IV-specific phosphodiesterase inhibitor, rolipram, which had no significant effect on basal cAMP concentration, increased the cAMP response of hippocampal slices to stimulation with forskolin and induced persistent long-term potentiation in CA1 after a single tetanic train. (biopsychiatry.com)
  • The aim of this study was to evaluate the effects of rolipram, a selective phosphodiesterase-4 inhibitor (PDE-4I), and pentoxifylline, a general PDE inhibitor, using a rat model of DN. (bvsalud.org)
  • Siguazodan plus rolipram was also more effective at inducing cAMP-dependent transcription than either inhibitor alone. (aspetjournals.org)
  • Targeting METTL3 by single-guide RNA, nanoparticle small interfering RNA (siRNA), or pharmacological inhibitor (STM2457) in combination with anti-programmed cell death protein 1 (PD-1) synergized to reinvigorate cytotoxic CD8+ T cells and mediate tumor regression. (bvsalud.org)
  • In respect to cAMP-dependent transcription, inhibitors of PDE3 (siguazodan, cilostazol) and PDE4 (rolipram, GSK256066, roflumilast N -oxide) each sensitized to the LABA, formoterol. (aspetjournals.org)
  • This editorial highlights the relevance of interfering in cancer cell progression through the pharmacological manipulation on the cell metabolism of cyclic nucleotides such as cAMP, and on the intracellular Ca2+ signaling, which may avail the reduction of toxic effects promoted by chemotherapy, radiotherapy and immunotherapy, thus decreasing the incidence of interruption in antitumoral treatment. (researchgate.net)
  • In both young and aged mice, rolipram treatment before training increased long- but not short-term retention in freezing to context, a hippocampus-dependent memory task. (biopsychiatry.com)
  • Bergantin LB, Caricati-Neto A. Challenges for the pharmacological treatment of neurological and psychiatric disorders: Implications of the Ca(2+)/cAMP intracellular signalling interaction. (eurekaselect.com)
  • Rats were treated with rolipram (1 mg/kg), pentoxifylline (100 mg/kg), and combination of rolipram (0.5 mg/kg) and pentoxifylline (50 mg/kg), orally for 5 weeks. (bvsalud.org)
  • Importantly, the combination of siguazodan plus rolipram prolonged the duration of gene expression induced by formoterol, dexamethasone, or dexamethasone plus formoterol. (aspetjournals.org)
  • Studies using pharmacological inhibitors and genetic manipulations have shown that this difference in response depends on the activity of cAMP-dependent protein kinase A. Genetic studies have also indicated that protein kinase A and one of its target transcription factors, cAMP response element binding protein, are important in memory in vivo. (biopsychiatry.com)
  • Caricati-Neto A, García AG, Bergantin LB. Pharmacological implications of the Ca(2+)/cAMP signaling interaction: from risk for antihypertensive therapy to potential beneficial for neurological and psychiatric disorders. (eurekaselect.com)
  • The prototypical PDE4 inhibitor is rolipram. (wikipedia.org)
  • Using the tissue bath technique, they demonstrated that the PDE4 inhibitor rolipram and PDE5 inhibitor zaprinast were effective in reversing the tension induced by potassium chloride of circular ureteral segments. (medscape.com)
  • confirmed the relaxing properties of inhibitors of PDE4 (rolipram) and PDE5 (E-4021, MSPP) on isolated human ureteral smooth musculature. (medscape.com)
  • examined the potential of the PDE4 inhibitor rolipram to induce ureteral relaxation. (medscape.com)
  • Hippocampal LTP is abolished in the presence of selective NMDA antagonist, AP5, and enhanced by the selective PDE4 inhibitor, rolipram. (psychogenics.com)
  • B, LTP following theta-burst stimulation (TBS, 10 trains delivered at 5 Hz, each train consists of 4 stimuli delivered at 100 Hz) is enhanced by the selective PDE4 inhibitor, rolipram (1μM, heavy bar). (psychogenics.com)
  • 1. Effects of zaprinast and rolipram on platelet aggregation and arrhythmias following myocardial ischaemia and reperfusion in anaesthetized rabbits. (nih.gov)
  • The introduction of PDE5 inhibitors as safe and well-tolerated orally active drugs for the treatment of erectile dysfunction has not only become a clinical and pharmaceutical success, but has also brought further attention to PDE isoenzymes as putative pharmacological targets in a variety of disorders of the human genitourinary tract. (medscape.com)
  • As the important regulators of signal transduction mediated by second messenger molecules such as cAMP and cGMP, PDEs are often targets for pharmacological inhibition due to their unique tissue distribution, structural properties, and functional properties. (hdbiosciences.com)