• RARITAN, N.J., February 8, 2021 - The Janssen Pharmaceutical Companies of Johnson & Johnson announced today results from the final analysis of the Phase 3 TITAN study, which demonstrated the continued statistically significant benefit of the addition of ERLEADA ® (apalutamide) to androgen deprivation therapy (ADT) in overall survival (OS) in patients with metastatic castration-sensitive prostate cancer (mCSPC), regardless of extent of disease, when compared to placebo plus ADT. (jnj.com)
  • This milestone is a testament to Xtandi's legacy and robust clinical profile, with overall survival demonstrated for patients with metastatic castration-resistant prostate cancer, nonmetastatic castration-resistant prostate cancer, and metastatic castration-sensitive prostate cancer. (pharmabiz.com)
  • ERLEADA ® (apalutamide) is an androgen receptor inhibitor indicated for the treatment of patients with non-metastatic castration-resistant prostate cancer (nmCRPC) and for the treatment of patients with metastatic castration-sensitive prostate cancer (mCSPC). (crohnscolitisprofessional.org)
  • These SARDs exhibit the ability to effectively degrade the androgen receptor, hence offering potential therapeutic benefits in the management of castration-resistant cancer (CRPC). (rhodeislandchronicle.com)
  • Castration-resistant prostate cancer (CRPC) remains an aggressive incurable disease in men mainly due to treatment resistance. (brad.ac.uk)
  • Yoshihiko Hatanaka , 'Astellas') announced today that the Phase 3 PROSPER trial evaluating XTANDI ® (enzalutamide) plus androgen deprivation therapy (ADT) versus ADT alone in patients with non-metastatic (M0) Castration-Resistant Prostate Cancer (CRPC) met its primary endpoint of improved metastasis-free survival (MFS). (astellas.us)
  • The Phase 3 randomized, double-blind, placebo-controlled, multi-national trial enrolled approximately 1,400 patients with non-metastatic castration-resistant prostate cancer (CRPC) at sites in the United States , Canada , Europe , South America and the Asia Pacific region. (astellas.us)
  • I also have a collaborative project investigating marker proteins of castration-resistant prostate cancer in patient tumor samples. (edu.lb)
  • Because castration-resistant prostate cancer is not just one disease, and tumors from individual patients clearly responded differently, Dr. Alumkal closed his discussion with this comment: "The key question as we return to the clinic is what is the tumor biology in the patient sitting before us? (ascopost.com)
  • RO also simultaneously lowered levels of androgen receptor (AR), a pro-proliferative proteins, in hormone-dependent prostate tumor cells and activated estrogen receptor (Er selvf?lgelig), a potent antiproliferative proteins,12C16 in both castration-resistant and hormone-dependent prostate tumor cells in vitro. (abt-888.net)
  • Finally, RO imprisoned the development of individual castration-resistant prostate tumor cell xenografts in vivo. (abt-888.net)
  • EGFR and cMET are both validated targets that are co-expressed in multiple tumor types, including head and neck squamous cell carcinoma, non-small cell lung cancer, colorectal cancer, and pancreatic ductal adenocarcinoma. (lumiraventures.com)
  • The hypothesis is that checkpoint immunotherapy, which works by blocking the off-signals on T cells, will boost anti-tumor responses elicited by vaccines. (pcf.org)
  • The most important and established prognosticators for prostate carcinoma include the Gleason grade, the extent of tumor volume, and the presence of capsular penetration or margin positivity at the time of prostatectomy. (medscape.com)
  • The future design of clinical trials in prostate cancer will learn a lot from current studies that are studying metastasis-free survival and are exploring the nature of therapies in the nonmetastatic castration-resistant patient population. (onclive.com)
  • With this approval, Xtandi becomes the first and only androgen receptor signalling inhibitor approved by the FDA for the treatment of patients with nonmetastatic castration-sensitive prostate cancer (nmCSPC) with biochemical recurrence at high risk for metastasis (high-risk BCR). (pharmabiz.com)
  • The approval is based on results from the phase 3 EMBARK trial, which evaluated Xtandi plus leuprolide, placebo plus leuprolide, and Xtandi (single agent) in patients with nonmetastatic hormone- (or castration-) sensitive prostate cancer (nmHSPC or nmCSPC) with high-risk BCR. (pharmabiz.com)
  • We are proud that Xtandi can now be offered to a subset of men with nonmetastatic castration-sensitive prostate cancer with biochemical recurrence and at high risk for metastases. (pharmabiz.com)
  • With today's approval, we look forward to bringing this therapy to even more patients who have nonmetastatic castration-sensitive prostate cancer at high risk for their cancer metastasizing. (pharmabiz.com)
  • The Astellas- and Pfizer-led phase 3, randomized, double-blind, placebo-controlled, multi-national trial enrolled 1,068 patients with nonmetastatic hormone- (or castration-) sensitive prostate cancer (nmHSPC or nmCSPC) with high-risk BCR at sites in the US, Canada, Europe, South America, and the Asia-Pacific region. (pharmabiz.com)
  • RARITAN, N.J., February 28, 2023 - The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the submission of a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) seeking approval of niraparib in combination with abiraterone acetate, in the form of a dual-action tablet (DAT), plus prednisone, for the treatment of patients with BRCA-positive metastatic castration-resistant prostate cancer (mCRPC). (medworm.com)
  • 5. Bellicum Pharmaceuticals Inc. (BLCM), which is developing novel, controllable cellular immunotherapies for cancers, has a couple of data readouts lined up for 2023. (businessinsider.com)
  • A phase 1/2 dose escalation clinical trial of BPX-601 GoCAR-T in patients with previously treated metastatic castration-resistant prostate cancer is ongoing, with a data update expected in the first quarter of 2023. (businessinsider.com)
  • Kintor Pharmaceutical, a leading clinical-stage drug corporation dedicated to creating small molecule treatments for various androgen receptor-linked ailments, has successfully performed clinical trials on their drug candidate, Kintor Pyrilutamide (KX-826). (hair-loss.com)
  • What Other Diseases Does Kintor Pharmaceutical Focus on in Addition to Androgen Receptor-Related Diseases? (hair-loss.com)
  • The lack of overall survival benefit or second radiographic progression-free survival benefit in other studies, including the ALLIANCE A031201 study that failed to show a benefit with combining androgen receptor-signaling inhibitors vs a single-agent androgen receptor-signaling inhibitor, raises questions about the utility of combining drugs that target the androgen receptor in men with castration-resistant prostate cancer," Dr. Alumkal told listeners. (ascopost.com)
  • It is critical to understand that to move the needle on outcomes for patients with castration-resistant prostate cancer, especially those resistant to androgen receptor-signaling inhibitors. (ascopost.com)
  • The UK's Medicines and Healthcare Products Regulatory Agency (MHRA) has granted marketing authorisation for Pluvicto ® (lutetium [ 177 Lu] vipivotide tetraxetan), for the treatment of adult patients with prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC) who have been treated with androgen receptor (AR) pathway inhibition and taxane-based chemotherapy or who are not medically suitable for taxanes. (europeanpharmaceuticalreview.com)
  • These pharmaceutical substances have the potential to be beneficial in the management of reduced testosterone levels in elderly males, a condition often referred to as ADAM (androgen decline in aging males) or andropause. (rhodeislandchronicle.com)
  • The selective androgen receptor modulators (SARMs) were subjected to a series of human clinical studies, including Phase I, Phase II, and Phase III, to evaluate their efficacy in managing cachexia among individuals with cancer. (rhodeislandchronicle.com)
  • These two anti-cancer therapies work by inhibiting androgen receptor signalling. (bioengineer.org)
  • The purpose of this work was to evaluate the effect of androgen receptor (AR) inhibition on prostate-specific membrane antigen (PSMA) uptake imaged using 68 Ga-PSMA-11 PET in a mouse xenograft model and in a patient with castration-sensitive prostate cancer. (snmjournals.org)
  • Additionally, we imaged one patient with castration-sensitive prostate cancer before and 4 wk after treatment with androgen deprivation therapy (ADT). (snmjournals.org)
  • Pluvicto demonstrated a statistically significant and clinically meaningful improvement in radiographic progression-free survival (rPFS) in patients with PSMA-positive metastatic castration-resistant prostate cancer (mCRPC) after treatment with androgen-receptor pathway inhibitor (ARPI) therapy, compared to a change in ARPI 1 . (swisslifesciences.com)
  • The company specializes in the manufacture of pharmaceutical-grade hormone replacement therapies and is focused on the development of testosterone and progesterone creams for the treatment of various endocrine deficiencies and medical conditions. (wikipedia.org)
  • We are committed to supporting the critical work Arvinas is doing to discover and develop breakthrough therapies that help patients who suffer from these conditions," said Joseph F. Donahue, Chief Business Officer at GNS Healthcare. (aitiabio.com)
  • Its pharma products include therapies for diabetes, cancer, immune system diseases and a wide range of mental health conditions. (balanceandcharge.com)
  • Following the release of those results, Eli Lilly closed its acquisitions of Dice Therapeutics, Sigilon Therapeutics and Versanis Bio, adding a wide range of therapies to its portfolio, including Dice's experimental oral treatment for psoriasis and Versanis' bimagrumab candidate, which is being assessed for obesity. (balanceandcharge.com)
  • Sigilon and Eli Lilly have worked together since 2018 on cell therapies for type 1 diabetes that would help remove the need for constant disease management. (balanceandcharge.com)
  • Janssen received FDA approval for two of its therapies in August: Talvey for relapsed or refractory heavily pre-treated multiple myeloma, and Akeega for BRCA-positive, metastatic, castration-resistant prostate cancer. (balanceandcharge.com)
  • Merck & Company has a massive product line and pipeline, including therapies for diabetes, cancer, vaccines, hospital care and animal health. (balanceandcharge.com)
  • ERLEADA ® has shown a statistically significant improvement in OS with a consistent safety profile in both approved indications of mCSPC (TITAN) and non-metastatic castration-resistant prostate cancer or nmCRPC (SPARTAN). (jnj.com)
  • It's not enough to just murder people with chemotherapy or with toxic medications that actually promote liver disease and promote metabolic disorders and promote cancer, and promote osteoporosis and Alzheimer's and dementia and everything else - they also want their drugs to be given to children as chemical castrations," the Health Ranger says. (medicalviolence.com)
  • This drug is generally recommended to the patient to receive at least one prior chemotherapy, including docetaxel. (theindianpharma.com)
  • Roughly half of patients with advanced ovarian cancer have homologous recombination deficiency (HRD)-positive tumors, including those with a BRCA mutation, and one in four women have a BRCA mutation. (merck.com)
  • castration-resistant prostate cancer 1187075-34-8 manufacture cell lines. (abt-888.net)
  • Combining RO with an ER agonist increased its ability to reduce castration-resistant prostate cancer cell viability. (abt-888.net)
  • In addition, RO effectively suppressed the growth of aggressive castration-resistant human prostate cancer cell xenografts in vivo without 1187075-34-8 manufacture any signs of toxicity to experimental animals. (abt-888.net)
  • in addition, RO induced apoptosis of both hormone-dependent and castration-resistant prostate cancer cells in vitro. (abt-888.net)
  • The VISION trial showed that PSMA-targeted molecular radiotherapy (MRT) can prolong survival and improve quality of life of patients with advanced metastatic castration-resistant prostate cancer ( 1 ). (snmjournals.org)
  • Lesions with low PSMA expression and high glycolytic activity (PSMA-negative/ 18 F-FDG-positive) can occur in up to 30% of metastatic castration-resistant prostate cancer patients referred for PSMA-targeted MRT ( 14 , 15 ). (snmjournals.org)
  • PSMA PET/CT of patient with metastatic castration-resistant prostate cancer before treatment with 177 Lu-PSMA therapy. (snmjournals.org)
  • Lynparza ® (olaparib) will be extended on the PBS to include the treatment of metastatic castration‑resistant prostate cancer in patients with specific pathogenic gene variants. (health.gov.au)
  • Abiraterone acetate is a CYP17 inhibitor used to treat metastatic castration-resistant prostate cancer when combined with prednisone. (theindianpharma.com)
  • If approved the combination will be the first DAT available in the European Union for first-line treatment of adults with gene-mutated metastatic castration resistant prostate cancer (mCRPC) with BRCA1/2 (the genes that can offer protection from certain cancers) mutations. (outsourcing-pharma.com)
  • Consultant oncologist, Elena Castro, who works at Sanitaria Hospital, Madrid, said: "Metastatic castration-resistant prostate cancer remains a lethal disease, with high unmet needs in terms of treatment options, particularly for patients with BRCA1/2 gene mutations. (outsourcing-pharma.com)
  • Munich, Germany: A strategy of alternately flooding and starving the body of testosterone is producing good results in patients who have metastatic prostate cancer that is resistant to treatment by chemical or surgical castration, according to new findings. (bioengineer.org)
  • In an ongoing study called RESTORE, 47 men with castration resistant prostate cancer that had started to spread to other parts of the body (metastasise), who showed no symptoms but whose disease had become resistant to treatment with either abiraterone (17 patients) or enzalutamide (30 patients) receive a high dose of testosterone (400 mg), injected into the muscle every 28 days. (bioengineer.org)
  • The VISION trial, an international randomized phase III clinical trial for selected patients with metastatic castration-resistant prostate cancer (mCRPC), is one of these. (blueribbonsoiree.org)
  • Other arguments against pretreatment assessments of target expression with PET include the burden of an additional procedure, long waiting times due to limited availability, and high costs of PSMA PET imaging. (snmjournals.org)
  • On the basis of these data and our own experience, not characterizing target expression before PSMA-targeted treatment appears as nonsensical as omitting breast cancer receptor phenotyping from the standard work-up of breast cancer patients. (snmjournals.org)
  • After administration into the bloodstream, Pluvicto binds to target cells, including prostate cancer cells that express PSMA, a transmembrane protein 3 . (swisslifesciences.com)
  • Examples of these "treatments" include hormone or puberty blocking drugs and surgical procedures like those that remove the uterus, penis or breasts. (theflstandard.com)
  • Online, stories abound of "detransitioners" - men and women attempting to stop or reverse the effects of surgical or pharmaceutical transitioning. (theflstandard.com)
  • citation needed] After an extensive career in the pharmaceutical retail sector, Michael came to the conclusion that bio-identical hormones (Hormones matching chemicals that the body produces) must be better than using synthetic alternatives to treat disorders. (wikipedia.org)
  • Once convinced that bio-identical hormones were superior over their synthetic alternatives, he started the company Lawley Pharmaceuticals in 1995 to manufacture pharmaceutical grade bio-identical hormone creams for use by pharmacies, doctors, and hospitals. (wikipedia.org)
  • Now suffering from a host of medical complications as a result of years of hormone treatment, including phantom pain in his groin and bouts of severe depression, he is five years into his detransition journey and is reintegrating with his anatomically male body. (christianpost.com)
  • They can then focus on their work and deliverables, which is about providing transformative solutions and improving outcomes for all patients. (iptonline.com)
  • As the treatment of genitourinary cancers becomes more complex, we continue to work with urologists and their teams to improve outcomes for patients across the continuum of disease," said Craig Tendler , M.D., Vice President, Late Development and Global Medical Affairs, Janssen Research & Development, LLC. (crohnscolitisprofessional.org)
  • Recent studies highlight the great potential impact of HDAC inhibitors (HDACis) in suppressing TNBC, even though clinical trials including a single HDACis demonstrated unsatisfactory outcomes against TNBC. (bvsalud.org)
  • The phase III ACIS trial met its primary endpoint at 6 months showing that apalutamide plus abiraterone acetate/prednisone (AAP) extended radiographic progression-free survival vs abiraterone acetate/prednisone alone in patients with chemotherapy-naive metastatic castration-resistant prostate. (ascopost.com)
  • Roche Pharmaceuticals internal reference: RO0488071) (RO) is a potent inhibitor of OSC.10,11 For this 1187075-34-8 manufacture reason, we conducted a series of studies to examine the anticancer properties of RO. (abt-888.net)
  • Niraparib is an orally administered, highly selective poly (ADP ribose) polymerase (PARP) inhibitor, currently being studied on an ongoing basis by Janssen and additional ongoing studies include the phase 3 Amplitude study. (outsourcing-pharma.com)
  • An additional analysis combining FOURIER and FOURIER-OLE data for 152 OLE participants originally randomized to receive Repatha showed that long-term treatment with this medication had no significant impact on measures of executive function, working and episodic memory, and psychomotor speed over time as compared to baseline. (investingnews.com)
  • The incidence of adverse events, including those of grade 3 or higher, during treatment was higher in the lutetium ( 177 Lu) vipivotide tetraxetan plus SOC group than in the SOC only group11. (europeanpharmaceuticalreview.com)
  • At Janssen, we are dedicated to continued innovation in prostate cancer and now look forward to working with health authorities to bring this niraparib-based treatment option to patients as soon as possible. (outsourcing-pharma.com)
  • We are still in the early stages of figuring out how this works and how to incorporate it into the treatment paradigm for prostate cancer. (bioengineer.org)
  • Dr. Sartor work combines basic, translational, and clinical prostate cancer research and emphasizes state-of-the-art treatment for prostate cancer patients. (blueribbonsoiree.org)
  • Of men who have undergone definitive prostate cancer treatment, including radical prostatectomy, radiotherapy, or both, an estimated 20-40% will experience biochemical recurrence (BCR) within 10 years. (pharmabiz.com)
  • The quarter included breakthroughs for the company's Alzheimer's disease treatment donanemab and its obesity treatment tirzepatide, and Eli Lilly submitted applications for both to the US Food and Drug Administration (FDA). (balanceandcharge.com)
  • The company also submitted a new drug application to the agency - it is looking to expand the indication of its HIV-1 treatment Edurant to include children weighing over 10 kilograms. (balanceandcharge.com)
  • Its diabetes treatment offerings include the app-supported NovoPen 6 and NovoPen Echo Plus, which give diabetes patients a less invasive way to monitor and record dosing information than traditional methods. (balanceandcharge.com)
  • Today's FDA approval is the culmination of over a decade of research and development as we've worked to bring Xtandi forward for as many patients with prostate cancer as possible who may benefit," said Ahsan Arozullah, M.D., MPH, senior vice president and head of oncology development, Astellas. (pharmabiz.com)
  • Xtandi is currently under review with other regulatory authorities around the world, including the European Medicines Agency, to support an expanded indication in nmHSPC (or nmCSPC) with high-risk BCR based on the results of EMBARK. (pharmabiz.com)
  • There is still no clear indication from authorities as to why transgender shooter Audrey Hale's manifesto must remain hidden from public view, but the Health Ranger thinks it has to do with Big Pharma and its mind-altering pharmaceutical drugs - and particularly the kind that transgenders take to "transition" into another gender. (medicalviolence.com)
  • And the transgender industry is working hand-in-hand with Big Pharma to push this, the so-called 'gender affirmation surgeries' which are nothing but child mutilations. (medicalviolence.com)
  • My PhD work focused on the cellular mechanism of a natural product as a potential therapeutic against prostate cancer. (edu.lb)
  • This press release contains forward-looking statements that involve substantial risks and uncertainties, including statements regarding the potential advantages and therapeutic benefits of our product candidates, the future development and potential marketing approval and commercialization of our product candidates, including the initiation of and timing of data from our clinical trials. (biospace.com)
  • The individual has a specific inclination towards the development of pharmaceuticals for underrepresented geographical areas lacking in therapeutic options, as well as the innovation of medicines that minimize undesirable side effects. (rhodeislandchronicle.com)
  • Its pharmaceutical subsidiary is Janssen Pharmaceuticals, which focuses on six therapeutic areas: cardiovascular disease and metabolism, infectious diseases and vaccines, neuroscience, oncology, immunology and pulmonary hypertension. (balanceandcharge.com)
  • In all of the FDA regulatory requirements for using these drugs in the M0 space, time to metastasis seems to be the endpoint that the FDA is most comfortable with in working with the pharmaceutical company and saying "Look, if you meet this endpoint with this product, we're going to consider that for FDA approval. (onclive.com)
  • We are excited about the innovative work with AstraZeneca as we advance this and other programs under our broad collaboration agreement. (lumiraventures.com)
  • FPI-2068 will be the first program to enter clinical development under the Company's previously announced collaboration agreement with AstraZeneca, which includes joint discovery, development and the option to co-commercialize novel TATs leveraging Fusion's proprietary Fast-Clear™ linker technology platform with antibodies from AstraZeneca's oncology portfolio, as well as exploration of potential combination strategies involving existing assets in their respective portfolios. (lumiraventures.com)
  • GNS' partners include seven out of the top ten pharmaceutical companies, leading research centers, medical societies, and patient advocacy groups globally, and our advisory board consists of a renowned group of scientific and medical experts. (aitiabio.com)
  • Buckley moved to Perth in 1983 to work as pharmacist in both hospital and retail pharmacy environments. (wikipedia.org)
  • To date, published results on ERLEADA ® include data from more than 2,000 patients across Phase 3 clinical studies. (jnj.com)
  • Invited discussant of the ACIS study, Joshi J. Alumkal, MD , leader of the Genitourinary Medical Oncology Section at the University of Michigan Rogel Cancer Center, noted that the toxicities were slightly higher with apalutamide plus abiraterone acetate/prednisone, including fatigue, hypertension, skin rash, cardiac disorders, and grade 3 and 4 events. (ascopost.com)
  • This suggests subsequent therapy worked less well in patients enrolled on the apalutamide plus abiraterone acetate/prednisone combination arm vs those enrolled on the abiraterone/prednisone only arm. (ascopost.com)
  • Based on these data, ADT alone should no longer be considered sufficient for patients with advanced, castration-sensitive disease. (jnj.com)
  • Abiraterone Acetate works by blocking the production of Testosterone and results in slowing down the spread and growth of cancerous tissue. (theindianpharma.com)
  • The active pharmaceutical ingredient in the medicine Abirapro is Abiraterone acetate with inactive ingredients are lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, povidone, sodium lauryl sulfate, magnesium stearate, and colloidal silicon dioxide. (theindianpharma.com)
  • As for its pipeline, Eli Lilly's clinical trial research areas include cardiovascular health, weight management and neurodegenerative diseases such as Alzheimer's disease. (balanceandcharge.com)
  • These findings suggest that even if some individuals in a population have high levels of testosterone, they can impact the behavior of those around, and drive the transmission of diseases transmitted by close contact such as the respiratory pathogen Bordetella," explained Grear, whose work is funded by the National Science Foundation. (vetscite.org)
  • Fusion Pharmaceuticals Inc. (Nasdaq: FUSN), a clinical-stage oncology company focused on developing next-generation radiopharmaceuticals as precision medicines, today announced the clearance of investigational new drug (IND) applications for [ 225 Ac]-FPI-2068 (FPI-2068) and corresponding imaging analogue [ 111 In]-FPI-2107 (FPI-2107) to the U.S. Food and Drug Administration (FDA). (lumiraventures.com)
  • Fusion Pharmaceuticals is a clinical-stage oncology company focused on developing next-generation radiopharmaceuticals as precision medicines. (lumiraventures.com)
  • John is an exceptional leader with deep experience and a strong track record in the pharmaceutical industry, and I am pleased to welcome him to Arvinas' Board of Directors," said Dr. Houston. (biospace.com)
  • I am extremely impressed with the tremendous work Arvinas is doing in the targeted protein degradation space," added Mr. Young. (biospace.com)
  • The board will consider a rule that would prohibit physicians from administering puberty blockers and performing chemical castration and invasive surgeries that remove breasts and genitals on anyone under 18. (theflstandard.com)
  • I realized the future of motherhood had been stolen from me by medical professionals my family entrusted me to," Cole said at a September press conference for Rep. Marjorie Taylor Greene's H.R. 8731 bill that would criminalize genital mutilation and chemical castration of children. (theflstandard.com)
  • Next steps following this proof of principle trial, are to test the agent in less heavily pre-treated patients, including those diagnosed with metastatic prostate cancer and no prior hormonal treatments. (blueribbonsoiree.org)
  • For medical issues or concerns, including decisions about medications and other treatments, consumers should always consult their physician or, in serious cases, seek immediate assistance from emergency personnel. (clinicaloptions.com)
  • Emerging treatments with limited long-term data include targeted therapy and whole-gland ablation. (medscape.com)
  • The Morrison Government is also listing additional important and lifesaving drugs on the PBS from today, including for Australians with asthma, prostate cancer, Castleman disease, Human Immunodeficiency Virus (HIV) and Crohn's disease. (health.gov.au)
  • Evidence suggests that elevated Lp(a) contributes to cardiovascular events, including heart attack, stroke and peripheral arterial disease. (investingnews.com)
  • Prostate specific antigen (PSA) levels [2] fell in the majority of the men, tumours shrank in some men, in several the disease did not progress and this included some whose disease continued to be stable for more than a year. (bioengineer.org)
  • Evidence of how existing theories work in practice is scarce, and the practices in low-income countries are unknown. (brad.ac.uk)
  • Additionally, Mr. Young currently serves as a board member for Johnson Controls International (JCI), Haleon PLC (HLN), and Imbria Pharmaceuticals Inc., and will serve on the Board of Directors of Haleon, the Consumer Healthcare joint venture between GlaxoSmithKline and Pfizer, when it is separated in 2022. (biospace.com)
  • Kintor Pharmaceutical is planning for Phase III trials in both nations, aiming to continue leading the global charge in developing topical PROTAC drugs. (hair-loss.com)
  • A significant issue that arises when working with research data is the inability to validate and reproduce findings to demonstrate that the experimental result is in fact true. (appliedclinicaltrialsonline.com)
  • Further investigation revealed a reduction in mRNA interferon gamma (IFNγ) level of Edn2-iKO lungs and suppression of its downstream signaling, including phosphorylated level of STAT1 and IL-1ß secretion, leading to reduced NFĸB activation. (bvsalud.org)
  • The United States Preventive Services Task Force (USPSTF) recomended against prostate cancer screening in 2011-2012, but in 2018 reversed the recommendation to include screening after an informed discussion. (medscape.com)
  • My current research interests include the role of RhoGAPs and TGF-beta in breast cancer progression. (edu.lb)
  • He has personally helped to obtain multiple drug approvals in advanced prostate cancer including Quadramet, Jevtana, Xofigo, and Pluvicto by helping to lead, or co-lead, pivotal trials leading to FDA approval. (blueribbonsoiree.org)
  • He has published approximately 500 peer-reviewed medical journals (to review some of his publications, please click here ) and serves on a variety of advisory committees for both major and startup pharmaceutical firms that focus on advanced prostate cancer. (blueribbonsoiree.org)
  • The company works in partnership with MERCK & CO Inc, Dawnrays Pharmaceutical Holdings Ltd, Sino Biopharmaceutical Ltd and China Biopharma. (pharmaceutical-technology.com)
  • Additional research presented at AHA will include Mass General Brigham Lp(a) registry data on whether the association between Lp(a) and major adverse cardiovascular events (MACE) differs based on baseline ASCVD status. (investingnews.com)
  • The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) is working with industry to promote social housing during cardiovascular telemetry recordings within non-rodent safety pharmacology and toxicology studies. (awionline.org)
  • On a practical level, laboratory experiments can involve long hours, and researchers may have to come back into the lab at unsociable hours, so it's important to have working and collaborative spaces that are very accessible but highly secure. (iptonline.com)
  • Collaborative working spaces are about empowering the entire team, and site and support staff also play a key role in creating the right environment. (iptonline.com)
  • The aim is to provide a snapshot of some of the most exciting work published in the various research areas of the journal. (mdpi.com)
  • His areas of expertise have included but are not limited to research on anticancer drugs, the development of conformationally restricted analogs of ephedrine, insights into the steric interactions shown by imidazolines, catecholamines, and tetrahydroisoquinolines while interacting with adrenoceptors. (rhodeislandchronicle.com)
  • Importantly, siRNA suppression of ALDH1A3 and ALDH7A1 led to reduced SC properties of primary prostate cultures including reduced cell viability, migration and colony formation, and increased differentiation of transit amplifying (TA) cells to committed basal (CB) cells. (brad.ac.uk)
  • In many ways, Hale is an archetype of what happens to a young person's mind after being exposed to pharmaceutical drugs. (medicalviolence.com)
  • Similarly, he has worked with Dr. Ryan Yates in the creation of anti-inflammatory drugs, which have also been licensed to RxBio. (rhodeislandchronicle.com)
  • The biggest pharmaceutical companies in the world are responsible for developing and manufacturing the vast majority of prescription drugs, giving them a key role in the life science industry. (balanceandcharge.com)
  • Lawley Pharmaceuticals is a privately owned Australian pharmaceutical company established by pharmacist Michael Buckley in 1995. (wikipedia.org)
  • Lawley Pharmaceuticals was founded in 1996 as an offshoot from a retail company and is based in Perth, Western Australia. (wikipedia.org)
  • Company products include AndroForte, AndroFeme and ProFeme, which are all TGA approved. (wikipedia.org)
  • For those who aren't explicitly progressive in their political or religious beliefs, the Walt Disney Company is becoming a more difficult place to work. (capitolhilltimes.com)
  • This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData's Pharmaceutical Intelligence Center . (pharmaceutical-technology.com)
  • Further details about these data and the ways Janssen is working to shape the future of urologic care will be made available throughout AUA 2021 via the Janssen AUA Virtual Newsroom. (crohnscolitisprofessional.org)
  • It also offers kangfang integrated development platform (ACE Platform) which covers all drug R & D, including target verification, antibody discovery and also development functions. (pharmaceutical-technology.com)
  • Efforts to streamline regulatory submissions for new product approvals have encouraged the development, largely through the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH), 6 to standardize and harmonize the structure of these submissions as eCommon Technical Documents (eCTD). (appliedclinicaltrialsonline.com)
  • The Janssen Pharmaceutical Companies of Johnson & Johnson recently announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended marketing authorisation for Akeega, a combination dual action tablet (DAT) given with prednisolone. (outsourcing-pharma.com)
  • Previously, he served as a board member for the European Federation of Pharmaceutical Industries Associations, The Biotechnology Innovation Organization, and the National Committee on United States-China Relations. (biospace.com)
  • Abirapro is a pharmaceutical drug that legally requires a medical prescription to be dispensed. (theindianpharma.com)
  • Vocabria® and Cabenuva® work to keep the amount of virus in the body at a low level and help maintain the level of a type of white blood cell called "CD4+" in the blood, which is important in helping the body to fight infection. (health.gov.au)
  • He became a member of Pfizer's Executive Leadership Team in 2012 and held a number of senior roles across the organization including Group President, Pfizer Innovative Health, Group President, Pfizer Essential Health, President & General Manager, Primary Care Business Unit, and Regional President, Primary Care, Europe, Canada. (biospace.com)
  • As a results-driven leader, Dr. Miller has led an impressive repertoire of prior roles including but not limited to, serving as an NIH Fellow at the University of Washington, faculty member of Ohio State University, to Professor and Chairman of the Division of Medicinal Chemistry and Pharmacology. (rhodeislandchronicle.com)