Phagocyte. Medical search. Frequent questions

The professional phagocytes include many types of white blood cells (such as neutrophils, monocytes, macrophages, mast cells, and dendritic cells). (wikipedia.org)
After phagocytosis, macrophages and dendritic cells can also participate in antigen presentation, a process in which a phagocyte moves parts of the ingested material back to its surface. (wikipedia.org)
Monocytes give rise to macrophages, which are another type of phagocyte . (synonym.com)
Most tissues harbor resident mononuclear phagocytes, that is, dendritic cells and macrophages. (hindawi.com)
Mononuclear phagocytes are a group of phenotypic distinct members, often referred to as either macrophages or dendritic cells (DC), that derive from myeloid precursors and that contribute to the functions of peripheral tissues [ 1 ]. (hindawi.com)
This study has demonstrated that a subset of mononuclear phagocytes, mature macrophages, are responsible for tumour necrosis factor secretion and this could have implications for targeted management in sarcoidosis in the future. (ersjournals.com)
Macrophages and fibrosis: how resident and infiltrating mononuclear phagocytes account for organ injury, regeneration or atrophy. (bvsalud.org)
Mononuclear phagocytes (MP), i.e., monocytes , macrophages , and dendritic cells (DCs), are essential for immune homeostasis via their capacities to clear pathogens, pathogen components, and non-infectious particles. (bvsalud.org)
Coating nanotube s with "eat-me"-phospholipid signal, phosphatidylserine proved to be an effective strategy for targeting particles to professional phagocytes, specifically macrophages both in vitro and in vivo. (cdc.gov)

A tissue-centric view assumes that changing tissue microenvironments shape the phenotypes of their resident and infiltrating mononuclear phagocytes to fulfill the tissue's need to maintain or regain homeostasis. (hindawi.com)

some amoebae behave like macrophage phagocytes, which suggests that phagocytes appeared early in the evolution of life. (wikipedia.org)
The immune monocyte/phagocyte system (MPS) includes numerous cell subsets of the myeloid lineage including monocyte, macrophage, and dendritic cell (DC) populations that are heterogeneous both phenotypically and functionally. (vanderbilt.edu)
Due to their considerable plasticity and heterogeneity, the tissue-based DC and macrophage populations have been defined as mononuclear phagocytes [ 1 , 6 , 7 ]. (hindawi.com)

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The term mononuclear phagocyte system has replaced the former reticuloendothelial system, which also included less active phagocytic cells such as fibroblasts and endothelial cells. (bvsalud.org)

In these circumstances, oxygen is reduced by the phagocyte NADPH oxidase, and reactive oxygen species (ROS), which are important for the microbicidal activity of the cells, are generated. (nih.gov)
The generation of reactive oxygen species (ROS) by phagocytes is one of the irreplaceable microbicidal tools of innate immunit. (nel.edu)

Other cellular components of the innate immune system include mononuclear phagocytes, dendritic cells, and NK cells. (medscape.com)

Non-professional phagocytes do not have efficient phagocytic receptors, such as those for opsonins. (wikipedia.org)
Taken together, these data point to a previously unappreciated and evolutionarily conserved role for calcium flux at two distinguishable steps: formation of the phagocytic cup and internalization of the apoptotic cell, and the anti-inflammatory signaling induced in phagocytes by contact with apoptotic cells. (aai.org)

Phagocytes of humans and other animals are called "professional" or "non-professional" depending on how effective they are at phagocytosis. (wikipedia.org)
He went on to extend his observations to the white blood cells of mammals and discovered that the bacterium Bacillus anthracis could be engulfed and killed by phagocytes, a process that he called phagocytosis. (wikipedia.org)
Mechnikov was awarded (jointly with Paul Ehrlich) the 1908 Nobel Prize in Physiology or Medicine for his work on phagocytes and phagocytosis. (wikipedia.org)
Phagocytosis occurs after the foreign body, a bacterial cell, for example, has bound to molecules called "receptors" that are on the surface of the phagocyte. (wikipedia.org)
Professional phagocytes increase their consumption of molecular oxygen during the phagocytosis of microbes or when encountering a variety of nonparticulate stimuli. (nih.gov)
A growing body of evidence points to the possibility that phagocytes are capable of NADPH oxidase assembly in nonphagosomal intracellular membranes, resulting in ROS generation within intracellular organelles also in the absence of phagocytosis. (nih.gov)
Phagocytes are a type of white blood cell that use phagocytosis to engulf bacteria, foreign particles, and dying cells to protect the body . (planschwitzer-naturstein.de)
Heme strongly inhibited phagocytosis and the migration of human and mouse phagocytes by disrupting actin cytoskeletal dynamics via activation of the GTP-binding Rho family protein Cdc42 by the guanine nucleotide exchange factor DOCK8. (ox.ac.uk)
Carbon nanotube s are not effectively recognized by professional phagocytes and delayed clearance of particles within the lung parenchyma can thus be majorly attributed to impaired phagocytosis or deficiency in components involving their effective degradation. (cdc.gov)

During an infection, chemical signals attract phagocytes to places where the pathogen has invaded the body. (wikipedia.org)
Excessive inflammation by phagocytes during Aspergillus fumigatus infection is thought to promote lung function decline in CF patients. (elsevierpure.com)
Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions. (ox.ac.uk)
In vitro studies show that Leishmania infection decreases the adhesion of inflammatory phagocytes to connective tissue by a mechanism dependent on the modulation of integrin function. (biomedcentral.com)
In this work, we used a model of chronic peritonitis induced by thioglycollate to study the effect of L. amazonensis infection on the ability of inflammatory phagocyte populations to migrate from an inflammatory site to the draining lymph node. (biomedcentral.com)

Phagocytes are cells that protect the body by ingesting harmful foreign particles, bacteria, and dead or dying cells. (wikipedia.org)
Phagocytes are crucial in fighting infections, as well as in maintaining healthy tissues by removing dead and dying cells that have reached the end of their lifespan. (wikipedia.org)
Some phagocytes then travel to the body's lymph nodes and display the material to white blood cells called lymphocytes. (wikipedia.org)
Mechnikov traveled to Vienna and shared his ideas with Carl Friedrich Claus who suggested the name "phagocyte" (from the Greek words phagein, meaning "to eat or devour", and kutos, meaning "hollow vessel") for the cells that Mechnikov had observed. (wikipedia.org)
The structure and function of the NADPH oxidase have been resolved in part by studying cells from patients with chronic granulomatous disease (CGD), a condition characterized by the inability of phagocytes to assemble a functional NADPH oxidase and thus to produce ROS. (nih.gov)
To examine the possible involvement of cytokines in reperfusion injury, we have studied production of IL-1 by human vascular cells, including smooth muscle and mononuclear phagocytes. (jci.org)
Exposure of cells to hypoxia (pO2 approximately 14 torr) followed by reoxygenation led to significant release of IL-1 only from the mononuclear phagocytes. (jci.org)
The phagocytes of the immune system engulf other particles or cells, either to clean an area of debris, old cells, or to kill pathogenic organisms such as bacteria. (planschwitzer-naturstein.de)
You have your inflammatory response , which really just gets things to where the action is at and then you also have your phagocytes , which are these cells that are engulfing things . (planschwitzer-naturstein.de)
Furthermore, we discuss how published data supports the view that changing tissue environments induce the well-known different phenotypes of mononuclear phagocytes, a process that not only enforces each of the different environments but also explains the contribution of these cells to the different tissue pathologies. (hindawi.com)
At the inoculation site, amastigotes are maintained in the interior of the mononuclear phagocytes, and the immunoreactions elicited by these cells are associated with different types of nodular lesions or ulcers. (biomedcentral.com)
In CGD, immune system cells called phagocytes are unable to kill some types of bacteria and fungi. (medlineplus.gov)
Largely the product of mononuclear phagocyte activation, it is unclear whether TNF-α production at disease sites is a feature of all mononuclear phagocytes that accumulate there or whether it is secreted by a subset of these cells. (ersjournals.com)
Molecular analysis of amoeboid chemotaxis: parallel observations in amoeboid phagocytes and metastatic tumor cells. (elsevierpure.com)
Dive into the research topics of 'Molecular analysis of amoeboid chemotaxis: parallel observations in amoeboid phagocytes and metastatic tumor cells. (elsevierpure.com)
Chronic granulomatous disease (CGD) is an inherited disease in which the body's cells that eat invaders (also called phagocytes) do not make hydrogen peroxide and other chemicals. (primaryimmune.org)
We also show that calcium is crucial for the anti-inflammatory TGF-β response seen in phagocytes during engulfment of apoptotic cells. (aai.org)

Intracellular generation of superoxide by the phagocyte NADPH oxidase: how, where, and what for? (nih.gov)
Whereas inhibition of p38/MAPK did not result in improved neutrophil defense, pharmacological blockade of the phagocyte oxidase (PHOX) or its genetic ablation mimicked the impaired antimicrobial activity detected under high salt conditions. (frontiersin.org)

Ehrlichia chaffeensis is a small, gram negative, obligately intracellular bacterium that preferentially infects mononuclear phagocytes. (frontiersin.org)
Here we discuss the accumulating knowledge of intracellular ROS production in phagocytes and speculate on the precise role of these oxidants in regulating the inflammatory process. (nih.gov)

The phagocyte then stretches itself around the bacterium and engulfs it. (wikipedia.org)
Once inside this phagocyte, the bacterium is trapped in a compartment called a phagosome. (wikipedia.org)

The phagocytes move by a method called chemotaxis. (wikipedia.org)
On a molecular level, much of what is known about amoeboid chemotaxis has been learned through work with Dictyostelium discoideum, a lower eukaryotic amoeboid phagocyte. (elsevierpure.com)

In summary, CFTR modulators have potential for additional immunomodulatory benefits to prevent or treat Aspergillus-induced inflammation in CF. The comparable effects of CFTR modulators observed in phagocytes from control subjects questions their exact mechanism of action. (elsevierpure.com)
Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus . (ilrs.de)
Mech F, Thywissen A, Guthke R, Brakhage AA, Figge MT (2011) Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus . (ilrs.de)

At the Leishmania inoculation site, various phagocytes have the potential to phagocytize and transport live amastigotes or killed parasites, which may also act as antigens, to the draining lymph node. (biomedcentral.com)

Granulocytes are mobile phagocytes that travel to areas of inflammation to engulf and destroy invading microorganisms. (medscape.com)
We further discuss how injuries alter tissue environments and how this primes mononuclear phagocytes to enforce this particular environment, for example, to support host defense and pathogen clearance, to support the resolution of inflammation, to support epithelial and mesenchymal healing, and to support the resolution of fibrosis to the smallest possible scar. (hindawi.com)
Taken together, the results from the doctoral work suggest that targeting of nanotube s to professional phagocytes can be achieved by coating with certain biomolecules and this targeting can reduce the biopersistence and inflammation associated due to the presence of otherwise relatively biodurable nanotube s in biological ambience. (cdc.gov)

This Osmosis High-Yield Note provides an overview of Phagocyte deficiencies essentials. (osmosis.org)

An immune-centric view assumes that a particular priming of phagocytes then causes a particular type of pathology in target tissues, conceptually similar to antigen-specific T-cell priming. (hindawi.com)
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Gallin, J. I. (1987) Disorders of phagocyte function. (bvsalud.org)

Although the importance of these discoveries slowly gained acceptance during the early twentieth century, the intricate relationships between phagocytes and all the other components of the immune system were not known until the 1980s. (wikipedia.org)
Describe the types of phagocytes and their roles in initiating an immune response . (planschwitzer-naturstein.de)

The main difference between professional and non-professional phagocytes is that the professional phagocytes have molecules called receptors on their surfaces that can detect harmful objects, such as bacteria, that are not normally found in the body. (wikipedia.org)
These chemicals may come from bacteria or from other phagocytes already present. (wikipedia.org)
When phagocytes come into contact with bacteria, the receptors on the phagocyte's surface will bind to them. (wikipedia.org)
This binding will lead to the engulfing of the bacteria by the phagocyte. (wikipedia.org)

In progressive forms of cutaneous leishmaniasis, parasites and parasite molecules are continuously observed in the interior of the mononuclear phagocytes in the skin lesion and in the marginal sinus of the draining lymph nodes, suggesting that these phagocytes continuously transport parasite and parasite molecules [ 4 ]. (biomedcentral.com)

Phagocyte Bactericidal Dysfunction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)

Some phagocytes kill the ingested pathogen with oxidants and nitric oxide. (wikipedia.org)

Aug 15, 2008 · Phagocytes are also important sources of pro- and anti- inflammatory cytokines, thus participating in host defenses through a variety of mechanisms . (planschwitzer-naturstein.de)

Interleukin-10 (IL-10) activates a diverse array of functional responses in mononuclear phagocytes. (nih.gov)
Mononuclear phagocytes: tissue distribution and functional heterogeneity. (ox.ac.uk)

Mechnikov proposed that phagocytes were a primary defense against invading organisms. (wikipedia.org)
Mononuclear phagocytes contributions to tissue pathologies relate to their central roles in orchestrating all stages of host defense and wound healing, which often become maladaptive processes, especially in sterile and/or diffuse tissue injuries. (hindawi.com)

Here we discuss the latter concept, for example, why different organs host different types of mononuclear phagocytes during homeostasis. (hindawi.com)

H1-antihistamines and oxidative burst of professional phagocytes. (nel.edu)
The functionalization of single-walled carbon nanotube s with biomolecules to target professional phagocytes and promote biodegradation. (cdc.gov)
We in our research coated nanotube s with biomolecules to promote recognition, uptake and biodegradation by professional phagocytes. (cdc.gov)

Experimental factors like reaction volume, time, and phagocyte-prey concentrations often have a large impact on the outcome, as is the choice of detection strategy with different fluorescent or colorimetric labels of prey and phagocyte. (lu.se)

Here we provide a protocol to define a reference map for the myeloid compartment, including sample preparation, to produce reference cell subsets from the monocyte/phagocyte system. (vanderbilt.edu)
Using studies in cell lines and in the context of a whole organism, we demonstrate that apoptotic cell recognition induces both an acute and sustained calcium flux within phagocytes and that such calcium flux is essential for engulfment. (aai.org)
It can be assessed on both the population and single-cell level of the phagocytes, separating adhesion and internalization. (lu.se)

Phagocytes are important throughout the animal kingdom and are highly developed within vertebrates. (wikipedia.org)
This process is important in building immunity, and many pathogens have evolved methods to evade attacks by phagocytes. (wikipedia.org)
Furthermore, we provide evidence that both the release of calcium from the endoplasmic reticulum and the entry of extracellular calcium via CRAC channels into the phagocytes are important during engulfment. (aai.org)

The authors review the procoagulant role of mononuclear phagocytes in the activation of blood clotting. (planschwitzer-naturstein.de)

One litre of human blood contains about six billion phagocytes. (wikipedia.org)
Synthesis and release of interleukin 1 by reoxygenated human mononuclear phagocytes. (jci.org)

Azithromycin and acebilustat had no effect on ROS production by CF or control subject phagocytes. (elsevierpure.com)
It is hypothesised that mononuclear phagocyte TNF-α production early in the pathophysiology of granuloma formation is a pivotal factor in the initiation of disease. (ersjournals.com)

Anatomy14

Organisms1

Diseases3

Chemicals and Drugs25

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes8

Macrophages9

Resident and infiltrating mononucle1

Macrophage3

Mononuclear Phagoc6

Reactive2

Dendritic1

Phagocytic2

Phagocytosis9

Infection5

Cells17

Oxidase2

Intracellular2

Bacterium2

Chemotaxis2

Aspergillus3

Phagocytize1

Inflammation3

Deficiencies1

PATHOLOGY2

Disorders1

Immune2

Bacteria4

Parasite1

MeSH1

Oxidants1

Inflammatory1

Functional2

Defense2

Types1

Professional3

Reaction1

Cell3

Important3

Activation1

Human2

Production2