Persistent cells chromosomes. Medical search. Frequent questions

A persistent high frequency of these errors (chromosomal instability (CIN)) is predicted to profoundly impact tumor evolution and therapy response. (nature.com)
Using three-dimensional live-cell imaging of patient-derived tumor organoids (tumor PDOs), we show that CIN is widespread in colorectal carcinomas regardless of background genetic alterations, including microsatellite instability. (nature.com)
We identify distinct patterns of copy-number evolution indicating multigenerational chromosomal instability that is initiated by cell division errors but propagated only after p53 loss. (bvsalud.org)
Our analysis elucidates how multigenerational chromosomal instability generates copy-number variation in BE cells, precipitates complex alterations including DNA amplifications, and promotes their independent clonal expansion and transformation. (bvsalud.org)
These findings suggest copy-number heterogeneity in advanced cancers originates from chromosomal instability in precancerous cells and such instability may be identified from the presence of sloping copy-number variation in bulk sequencing data. (bvsalud.org)
Advances in molecular biology techniques allow us to obtain a better understanding of precise molecular mechanisms and to identify the chromosome instability region and key driver genes in the carcinogenesis and progression of SOC. (bvsalud.org)
In vitro and in vivo genomic engineering, leveraging loss-of-function studies, along with a model of partial trisomy of chromosome 21q, demonstrated a dosage-dependent effect of the interferon receptor genes cluster as an adaptive mechanism to deleterious chromosomal instability in metastatic progression. (bvsalud.org)
In more recent years, findings of persistent postirradiation genomic instability, bystander effects, and other types of cellular response have posed additional questions regarding the mechanisms underlying the cytogenetic and mutagenic effects of radiation and their potential to contribute to radiation tumorigenesis. (nationalacademies.org)
8. De Storme, N. and Mason, A., Plant speciation through chromosome instability and ploidy change: cellular mechanisms, molecular factors and evolutionary relevance, Curr. (cytgen.com)

We developed sensitive human leukocyte antigen-specific (HLA-specific) PCR assays and targeted nonshared maternal HLA genes to test for persistent maternal microchimerism in subjects with scleroderma and in healthy normal subjects. (jci.org)
Although haploid human ES cells resembled their diploid counterparts, they also displayed distinct properties including differential regulation of X chromosome inactivation and genes involved in oxidative phosphorylation, alongside reduction in absolute gene expression levels and cell size. (nih.gov)
Recurrently mutated ovarian cancer driver genes, including LRP1B, KMT2A, ARID1A, KMT2C and ATRX were also found in two cell lines. (bvsalud.org)
The CNVs of MED1, GRB7 and MIEN1 located at 17q12 were found to be correlated with the overall survival of SOC patients (MED1: p = 0.028, GRB7: p = 0.0048, MIEN1: p = 0.0051), and the expression of the three driver genes in the ovarian cell line IOSE80 and EOC cell lines SKOV3 and A2780 was confirmed by western blot and cell immunohistochemistry. (bvsalud.org)
Transfection is a powerful technique that enables the study of the function of genes and gene products in cells. (labettor.com)
Among the genes required for cells with CIN, KIF18A stood out as especially promising. (volastratx.com)
Where immune cell activity would dissipate quickly in other scenarios, in the brain, according to the team's theory, immune signaling persists in a way that reduces the activity of genes needed for the building of olfactory receptors. (kingwoodconnection.com)
These genes, acquired at conception or mutated during life, make the affected person prone to most cancers by altering or impairing several processes: & Production of nuclear transcription factors that control cell growth. (ehd.org)
Indeed, a number of genes identified as potential manipulators of the host cell phenotype are absent from the T . equi genome. (biomedcentral.com)
T . equi has lost the putative genes for host cell transformation, or the genes were acquired by T . parva and T . annulata after divergence from T . equi . (biomedcentral.com)
la hipermetilación del DNA está implicada en la regulación transcripcional de genes supresores de tumoresen diferentes tipos de neoplasias hematológicas incluyendo la leucemia mieloide crónica (LMC). (udea.edu.co)
Se realizó una revisiónsistemática siguiendo las indicaciones propuestas en la guía PRISMA (Preferred Reporting Items for Systematic reviewsand Meta-Analyses) con el objetivo de identificar los principales genes hipermetilados en pacientes con LMC en las tresfases clínicas de la enfermedad de acuerdo con lo publicado en la literatura científica entre 2003-2013. (udea.edu.co)
en los análisis de hipermetilación en pacientes con LMC se evaluaron 39 genes clasificados como supresoresde tumores, reguladores del ciclo circadiano, codificantes para factores de transcripción/receptores, involucrados enreparación del DNA, vías de señalización y metabolismo de nucleótidos, entre otros. (udea.edu.co)
Además, se obtuvo un valor de p = 0,000 en las comparaciones múltiples de la proporción de hipermetilación según la fase clínica de la enfermedad,estableciendo una posible relación entre la progresión de la enfermedad y el porcentaje de metilación de genes enpacientes con LMC. (udea.edu.co)
Chromosome abnormalities Chromosomes are structures within cells that contain a person's genes. (msdmanuals.com)
These genes produce proteins that regulate growth and alter cell division and other basic cell properties. (msdmanuals.com)
Oncogenes are mutated or amplified forms of genes that in their normal state regulate cell growth. (msdmanuals.com)
Tumor suppressor genes normally suppress the development of cancers by coding for proteins that repair damaged DNA or suppress the growth of cancerous cells. (msdmanuals.com)
The alpha and beta-subunits have separate genes on separate chromosomes (chromosomes 6 and 19, respectively). (medscape.com)

In the 1970s, somatic cell genetic techniques were developed to allow the quantification and characterization of specific gene mutations arising in irradiated cultures of somatic cells. (nationalacademies.org)
Based on the nature of experiments, we may need a stable DNA transfection in cells for persistent gain-of-function or loss-of-function of the target gene. (labettor.com)
in the absence of functional tkv gene product, visceral mesoderm parasegment 7 cells fail to express Ultra-bithorax , but instead accumulate Antennapedia protein. (biologists.com)
The defective gene is carried on the X chromosome. (medlineplus.gov)
If a boy has an X chromosome with the defective gene, he may inherit this condition. (medlineplus.gov)
If a girl has 1 X chromosome with the defective gene, the other X chromosome may have a working gene to make up for it. (medlineplus.gov)
The sex-determining region Y-box 2 ( SOX2 ) gene, located on chromosome 3q26.3-q27, belongs to the SOX family [ 6 ]. (biomedcentral.com)
To identify vulnerabilities unique to the survival of chromosomally unstable tumor cells, we conducted computational mining using gene dependency data from over 1,000 tumor cell lines. (volastratx.com)
In the current study, experiments confirmed that SARS-CoV-2 infection, and the immune reaction to it, decreases the ability of DNA chains in chromosomes that influence the formation of olfactory receptor building to be open and active, and to loop around to activate gene expression. (kingwoodconnection.com)
Gene fusions by chromothripsis of chromosome 5q in the VCaP prostate cancer cell line. (strangeindia.com)
One human chromosome 21 gene is Pericentrin (PCNT), encoding a component of the centrosome. (sciety.org)
The authors use several models with 3 or 4 copies of human chromosome 21 (or mouse equivalents) to reveal how increasing PCNT gene dosage alters ciliogenesis and ciliary signaling. (sciety.org)
The PCNT gene is found on human chromosome 21, and the same group previously showed that its increased expression is associated with reduced trafficking to the centrosome and reduced cilia frequency, which suggests a possible connection between cilia and ciliary trafficking, SHH signaling, and Down syndrome phenotypes. (sciety.org)
Cancer is more likely when DNA damage impairs tumor suppressor gene function, allowing affected cells to multiply continuously. (msdmanuals.com)

Many patients with extragonadal germ cell tumors have histories of infertility, and testicular biopsy in these patients shows various abnormalities, including decreased spermatogenesis, peritubular fibrosis, and interstitial edema. (health.am)
Although JTs have been reported in neoplasms and constitutional chromosome abnormalities, they are rare chromosome rearrangements in neoplastic diseases. (biomedcentral.com)
High-risk types (e.g., types 16 and 18) can cause low-grade cervical cell abnormalities, high-grade cervical cell abnormalities that are precursors to cancer, and cancers ( 5 - 7 ). (cdc.gov)

RNA sequencing analysis was performed on a total of 15 samples, including haploid and diploid human parthenogenetic embryonic stem cells at different differentiation states and cell cycle phases. (nih.gov)

Conclusions: There does not appear to be a strong effect in these dry cleaning workers of PCE exposure on persistent chromosome damage as measured by translocations. (cdc.gov)

These telomere associations need to be resolved prior to cell division to avoid loss of telomere function. (ubc.ca)
To determine the effect of TRF1 protein levels on telomere associations, we used live-cell fluorescence microscopy to visualize telomeres and chromosome dynamics in cells expressing defined levels of TRF1. (ubc.ca)
We also observed telomere aggregates, mitotic bypass, and TRF1 bridges persisting into the following cell cycle. (ubc.ca)
The essential helicase RTEL1 was observed at the extremities of persistent TRF1 bridges, possibly indicating a function for RTEL1 in the resolution of TRF1-induced telomere associations. (ubc.ca)
According to research, persistent stress may hasten telomere shortening, which is linked to aging and a number of health problems. (goodhealthwellnessblog.com)
Using the mechanistic insight gained, we have developed a new strategy for targeting telomerase and have identified and designed small molecules that promote telomere dysfunction in telomerase reactivated cancer cells. (thetaylorlab.com)
We are investigating how telomerase is upregulated in most cancers and, conversely, how a smaller proportion of cells use a different strategy called ALT (alternative lengthening of telomeres) to maintain telomere length and, thus, immortality. (thetaylorlab.com)
We found that plasma telomeric cfDNA levels decreased with age in healthy individuals ( n = 42, R 2 = 0.094, P = 0.048), suggesting that cfDNA is likely derived from somatic cells in which telomere length shortens with increasing age. (oncotarget.com)
Telomeres are protective DNA structures that are located at the end of chromosomes, and proper telomere maintenance is indispensable for chromosomal integrity and overall genomic stability. (oncotarget.com)
Telomere maintenance is normally controlled by telomerase activity as well as telomerase-associated factors throughout the cell cycle in tissue- and cell type-specific manners [ 1 - 3 ]. (oncotarget.com)
It is well known that telomere length in white blood cells is inversely correlated with age, implying that telomere length may serve as a biological clock to determine the lifespan of a cell and an organism [ 4 ]. (oncotarget.com)

For stable transfection, integration of a DNA vector into the chromosome is crucial which requires selective screening and clonal isolation. (labettor.com)

Diploid varieties have to set of chromosomes (2n = 14) in each cell, their cells are smaller in size with lower water (moisture) content, plant structures (leaves and seed size) are smaller, and the plant tend to produce more tillers. (msucares.com)
Diploidy is a fundamental genetic feature in mammals, in which haploid cells normally arise only as post-meiotic germ cells that serve to insure a diploid genome upon fertilization. (nih.gov)
Human sex cells are diploid cells. (shalom-education.com)
How many chromosomes do human diploid cells have? (shalom-education.com)

Chromosome segregation errors cause aneuploidy and genomic heterogeneity, which are hallmarks of cancer in humans. (nature.com)
Fig. 1: Live imaging of chromosome segregation errors in PDOs. (nature.com)
Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. (strangeindia.com)
p53 Prohibits propagation of chromosome segregation errors that produce structural aneuploidies. (strangeindia.com)

While abnormal mitosis, including whole-genome duplication, underlies chromosomal copy-number changes, segmental alterations display signatures of successive breakage-fusion-bridge cycles and chromothripsis of unstable dicentric chromosomes. (bvsalud.org)
It is defined by persistent errors in chromosome segregation during cell division (mitosis). (volastratx.com)
KIF18A is a protein that helps usher cells through mitosis by helping to align chromosomes. (volastratx.com)
Our KIF18A inhibitor traps chromosomally unstable tumor cells in mitosis - preventing them from proliferating, and ultimately leading to cell death - with minimal effects on normal, healthy cells. (volastratx.com)
This selectivity is important since therapies that interfere with mitosis broadly - like many chemotherapies do today - can have toxic effects on normal dividing cells, making them difficult to tolerate by patients due to their adverse effects. (volastratx.com)
DNA breaks and chromosome pulverization from errors in mitosis. (strangeindia.com)
During mitosis , chromosomes establish connections to mitotic spindle microtubules (MTs) via specialized protein complexes, called kinetochores, and subsequently translocate to the midzone of the bipolar spindle. (axonmedchem.com)

X inactivation, by chance, resulted in two contrasting cell masses with different active X chromosomes. (bmj.com)
Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining. (strangeindia.com)

Scientists have identified a characteristic shared by most patients with this type of lymphoma: a genetic abnormality affecting certain chromosomes. (moffitt.org)
This abnormality and other genetic changes may trigger the overproduction of a protein that causes tumor cell division and growth. (moffitt.org)
Researchers continue to study whether family history, environmental factors or both play a role in the genetic changes that may lead to mantle cell lymphoma. (moffitt.org)
Such cells release proteins called cytokines that changed the genetic activity of olfactory nerve cells, even though the virus cannot infect them, say the study authors. (kingwoodconnection.com)
The most of extra chromosomes seem to be the genetic ballast for the cell, which it gets rid of using a wide range of cellular tools, in particular: chromosomal rearrangements, chromatin diminution, asymmetry of division, cytomixis, and programmed cell death. (cytgen.com)
While single-cell sequencing provides valuable insights into cellular differences within diverse tissue samples, current tools are only able to detect a small amount of SNVs, limiting information on genetic ancestry. (mdanderson.org)
During the second month of fetal life, the indifferent gonad is guided to develop into a testis by genetic information present on the short arm of the Y chromosome. (medscape.com)
The existence of patients with 46,XX testicular DSD, who have testicular tissue in the absence of an obvious Y chromosome or SRY genetic material, clearly requires other genetic explanations. (medscape.com)
The nanotube bundles are similar to the potential of nanotubes to induce genetic damage size of microtubules that form the mitotic spindle in normal lung cells, cultured primary and immor- and may be incorporated into the mitotic spindle talized human airway epithelial cells were apparatus. (cdc.gov)

More heavily exposed participants and a larger sample size will be needed to determine whether PCE exposure induces significant levels of persistent chromosome damage. (cdc.gov)
Persistent DDR induces a permanent proliferation arrest known as replicative senescence, which is thought to function as a tumor suppressor [ 6 - 8 ]. (oncotarget.com)
4. Induces epigenetic alterations usual y arises as the cell attempts to repair the DNA damage. (who.int)

Male or female patient with reduced numbers of CD3+ T cells (less than 1500/mm 3 ) and a deletion of chromosome 22q11.2. (lu.se)
The majority of patients with DiGeorge syndrome are recognized to have immunodeficiency in the first few months of life when they are being evaluated for cardiac malformations that are highly associated DiGeorge syndrome and/or deletions of chromosome 22q11.2. (lu.se)
T Cell Transcriptome in Chromosome 22q11.2 Deletion Syndrome. (cdc.gov)

Fig. 4: Single-cell genome sequencing reveals karyotype heterogeneity in tumor PDOs. (nature.com)
The accession number for the single-cell and bulk whole-genome sequencing is PRJEB27084 (ENA repository). (nature.com)
Intriguingly, we found that a haploid genome is compatible not only with the undifferentiated pluripotent state, but also with differentiated somatic fates representing all three embryonic germ layers, despite a persistent dosage imbalance between the autosomes and X chromosome. (nih.gov)
Linear eukaryotic chromosomes contain specialized protective structures at the chromosome ends, called telomeres, which are essential for maintaining genome stability. (ubc.ca)
Mechanisms generating cancer genome complexity from a single cell division error. (strangeindia.com)
An earlier analysis of aberrations in the painted portion of the genome was performed in all cells, irrespective of the possible aberrations in the unpainted part of the genome. (ukhsa.gov.uk)

There are over 60 varieties of annual ryegrass commercially available that are grouped in two different types based on their number of chromosomes (ploidy level). (msucares.com)

Purpose: To investigate whether translocations in 'stable' lymphocytes, i.e. those not containing unstable aberrations in any chromosome including counterstained ones, would have a longer persistence with time compared with those measured in all cells. (ukhsa.gov.uk)
Chromosome painting was performed using probes for chromosomes 1, 2 and 4 with a pan-centromeric probe, and chromosomal aberrations involving the painted chromosomes were scored using a developed version of the Protocol for Aberration Identification and Nomenclature Terminology (PAINT) nomenclature. (ukhsa.gov.uk)
Evaluation was performed on images, counting all chromosomes and checking the counterstained chromosomes for unstable aberrations, i.e. dicentrics, acentrics or ring chromosomes. (ukhsa.gov.uk)
In scoring the images, it was investigated whether translocation yields in 'stable' cells, i.e. cells not containing unstable aberrations in any chromosome including counterstained ones, would be constant with time. (ukhsa.gov.uk)
The analysis was based on the assumption that during the production of new lymphocytes, this type of cell would have a better potential to survive during cell division than those containing so-called unstable aberrations. (ukhsa.gov.uk)

Recent studies indicate that fetal cells persist in maternal blood for decades after pregnancy. (jci.org)
Maternal cells are known to engraft and persist in infants with immunodeficiency, but whether maternal cells persist long-term in immunocompetent offspring has not specifically been investigated. (jci.org)
HLA-specific PCR also frequently revealed persistent maternal microchimerism in healthy control subjects. (jci.org)
With few exceptions, mothers of subjects with persistent maternal microchimerism were HLA incompatible with subjects for class I and class II alleles. (jci.org)
These results clearly indicate that HLA-disparate maternal cells can persist in immunocompetent offspring well into adult life. (jci.org)
Analysis of an X linked DNA polymorphism in 16 independent somatic cell hybrids made between cells derived from each girl and a mouse line suggest that in one twin only the maternal X chromosome is active, whereas in the other the active X was paternally derived. (bmj.com)
A screening centre, usually the maternal by MS/MS (API 3200TM, HVD/Perkin sickle-cell disease (SCD) screening and child health (MCH) centre of Elmer). (who.int)

Using high throughput sequencing and computational approaches, I reconstruct the lineage of B cells that produce HIV-specific bnAbs, working backward, up to a pre-HIV infection timepoint. (wrfseattle.org)
Published online February 2 in the journal Cell , the new study found that infection with the pandemic virus, SARS-CoV-2, indirectly dials down the action of olfactory receptors (OR), proteins on the surfaces of nerve cells in the nose that detect the molecules associated with odors. (kingwoodconnection.com)
Experiments showed that the presence of the virus near nerve cells (neurons) in olfactory tissue brought an inrushing of immune cells, microglia and T cells, that sense and counter infection. (kingwoodconnection.com)
Transmission of arthropod-borne apicomplexan parasites that cause disease and result in death or persistent infection represents a major challenge to global human and animal health. (biomedcentral.com)
Persistent infection with oncogenic HPV types can cause cervical cancer in women as well as other anogenital and oropharyngeal cancers in women and men. (cdc.gov)
Although most infections cause no symptoms and are self-limited, persistent HPV infection can cause cervical cancer in women as well as other anogenital cancers, oropharyngeal cancer, and genital warts in men and women. (cdc.gov)

In-depth research reveals telomeres, which are protective caps at the ends of our chromosomes. (goodhealthwellnessblog.com)
The lifespan of the cell is imposed by telomeres, the caps of linear chromosomes. (thetaylorlab.com)
For example, we have identified a number of pyrimidine nucleotide analogs that are preferentially inserted by telomerase into the telomeres of cancer cells. (thetaylorlab.com)

ABSTRACT The national neonatal screening programme in the United Arab Emirates currently includes 16 disorders: congenital hypothyroidism, sickle-cell diseases, congenital adrenal hyperplasia, biotinidase deficiency and 12 amino acid, organic acid and fatty acid disorders. (who.int)

Kravets E.A., Plohovskaya S.G., Horyunova I.I., Yemets A.I., Blume Ya.B. Sources of chromosomal polymorphism of microsporocytes in species of Lilium L. Allium L: cytomixis, extra chromosomes, chromatin diminuation, Tsitol Genet. (cytgen.com)
Sources of Chromosomal Polymorphism of Microsporocytes in Species of Lilium L. and Allium L.: Cytomixis, Extra Chromosomes, and Chromatin Diminution, Cytol Genet . (cytgen.com)

Single-cell karyotype sequencing confirmed heterogeneity of copy number alterations in tumor PDOs and showed that monoclonal lines evolved novel karyotypes over time in vitro. (nature.com)
Here we analyzed a large collection of human parthenogenetic ES cell lines originating from haploid oocytes, leading to the successful isolation and maintenance of human ES cell lines with a normal haploid karyotype. (nih.gov)
Nevertheless, some extra chromosomes can participate in the rearrangement of the microsporocyte and microspore karyotype. (cytgen.com)
Repeat bone marrow aspirate and biopsy after 8 cycles of azacitidine, with persistent pancytopenia, showed no changes in morphology, and karyotype was again normal. (biomedcentral.com)
Karyotype was abnormal, with unbalanced 1q JTs to the short arms of acrocentric chromosomes 14 and 21, leading to gain of 1q. (biomedcentral.com)

More importantly, several patients have had an identical chromosomal abnormality (an isochromosome of the short arm of chromosome 12) in the neoplastic cells from the mediastinal germ cell tumor and the hematologic neoplasm, providing strong evidence for a common origin. (health.am)

The term "lymphoma" refers to cancer of the body's lymphatic system, a network of tissues and organs that produce white blood cells to fight off infections and other diseases. (moffitt.org)
In converse, some diseases appear to primarily involve the T cells and do not appear to affect antibody production. (medscape.com)
Those diseases are discussed in T-Cell Disorders. (medscape.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

Jumping translocations (JTs) are rare chromosome rearrangements characterized by re-localization of one donor chromosome to multiple recipient chromosomes. (biomedcentral.com)
Jumping translocations (JTs) are chromosomal rearrangements comprising one donor chromosome and multiple recipient chromosomes [ 1 ]. (biomedcentral.com)
JTs are characterized by translocations of one donor chromosome to various recipient chromosomes, resulting in several gains of this chromosomal segment and possible loss of segments of the recipient chromosomes [ 1 , 2 ]. (biomedcentral.com)
Fusion of the break-off donor chromosome segment to telomeric or interstitial regions of recipient chromosomes can form different chromosomal patterns of jumping translocations. (biomedcentral.com)
In the present study of stable cells, the results showed that the yield of translocations is constant with time. (ukhsa.gov.uk)
Conclusions: The results show that translocations observed in stable cells are persistent with time. (ukhsa.gov.uk)
discrepancies and to improve the FISH technique as a retrospective dosimeter, the suggestion of analysing translocations in stable cells was put forward during discussions within a Concerted Action funded by the European Union. (ukhsa.gov.uk)

Hematologic Neoplasia A unique association between mediastinal nonseminomatous germ cell tumors and a variety of hematologic neoplasms is now well described. (health.am)
All hematologic neoplasms developed in the 287 patients with mediastinal nonseminomatous germ cell tumors, for a 2% incidence in this group. (health.am)
Recent evidence indicates that the hematologic neoplasms in this setting are not treatment related, but rather arise from clones of malignant lymphoblasts or myeloblasts contained within the mediastinal germ cell tumor. (health.am)
However, the specific association of leukemias and other hematologic neoplasms with mediastinal nonseminomatous germ cell tumors, rather than with all germ cell tumors, remains unexplained. (health.am)

Whole-exome sequencing was performed on the normal ovarian cell line IOSE80 and the EOC cell lines SKOV3 and A2780. (bvsalud.org)

All human cells possess their own pre-determined lifespan. (thetaylorlab.com)
Female XX sex chromosomes increase survival and extend lifespan in aging will therefore not only expand our knowledge of this microbial ecosystem, disentangling causal relationships is intractable in humans, motivating the emerging yet already compelling evidence supporting a role for the cell surface amyloid curli proteins made by E. These data hold even when adjusting for socioeconomic status, ethnicity, and education. (chemdbsoft.com)

Proper segregation of replicated chromosomes is essential for cell division in all organisms. (ubc.ca)

In situ hybridization with double labeling for X and Y chromosome-specific sequences revealed female cells in peripheral blood samples from 2 male scleroderma patients. (jci.org)
Unlike most cancers, chronic myelogenous leukemia (CML) is classified into phases rather than stages, based partly on the percentage of immature white blood cells (blasts) in peripheral blood and bone marrow. (medscape.com)
Methods: Eighteen dry cleaning workers and 18 laundry workers (unexposed controls) provided a peripheral blood sample for cytogenetic analysis by whole chromosome painting. (cdc.gov)

We make use of tkv loss-of-function mutations to examine the consequences of the failure of embryonic cells to respond to dpp and/or other TGFβ homologs. (biologists.com)
Without this ability, cells would accumulate damage over time that would eventually overwhelm their innate repair systems, resulting in persistent and potentially disease-causing mutations. (thetaylorlab.com)
Artemis deficiency (with mutations in the Artemis protein resulting in defective VDJ recombination) decreases both T cells and B cells and can be considered part of a subset of SCIDs. (medscape.com)
Tipifarnib in Head and Neck Squamous Cell Carcinoma With HRAS Mutations. (cdc.gov)

Ly, P. & Cleveland, D. W. Rebuilding chromosomes after catastrophe: emerging mechanisms of chromothripsis. (strangeindia.com)

Disruption of 9p21 locus is an evolutionary driver to systemic disease through the rapid acquisition of complex karyotypes in cancer cells. (bvsalud.org)
Chromosome mis-segregation generates cell-cycle-arrested cells with complex karyotypes that are eliminated by the immune system. (strangeindia.com)

Elevated levels of TRF1 induced anaphase bridges containing thin "thread-like" stretches of TRF1 foci connecting segregating chromosomes. (ubc.ca)
Foci of malignant lymphoblasts have been recognized histologically in several mediastinal germ cell tumors. (health.am)

By carefully selecting a viral delivery system and related reagents we can ensure safe and highly-efficient delivery of expression constructs for high-level constitutive or inducible expression in any mammalian cell type. (labettor.com)
A few patients present with persistent viral or fungal infections, or with hypocalcemic tetany. (lu.se)

The present analysis has taken into account the 'stable/unstable' nature of the complete cell. (ukhsa.gov.uk)

Tetraploid varieties are developed by treating germinating seed with specific compounds that cause a mutation in the chromosome number. (msucares.com)

A few studies have reported that SOX2 is overexpressed in cervical squamous cell carcinoma (SCC), and plays an important role in the progression from squamous dysplasia to SCC. (biomedcentral.com)
FAS and FASL variations in outcomes of tobacco- and alcohol-related head and neck squamous cell carcinoma patients. (cdc.gov)

Acute Myeloid Leukemia (AML) Acute myeloid leukemia is a life-threatening disease in which the cells that normally develop into the types of white blood cells called neutrophils, basophils, eosinophils, and monocytes become. (msdmanuals.com)

Although the molecular process is not yet elucidated, proof was found that Kif18A is a motile microtubule depolymerase essential for chromosome congression [3] , and controls the persistent movement of chromosomes by both increasing the rate at which they make directional switches and slowing the velocity of their movement. (axonmedchem.com)
The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression. (axonmedchem.com)
Utilizing ciliogenesis time course experiments, we reveal how Pericentrin, microtubule networks, and components of ciliary vesicles are reorganized for ciliogenesis in euploid cells. (sciety.org)
Early in ciliogenesis, chromosome 21 polyploidy results in elevated Pericentrin and microtubule networks away from the centrosome that ensnare MyosinVA and EHD1, blocking mother centriole uncapping that is essential for ciliogenesis. (sciety.org)

10. Alters cell proliferation, cell death, or nutrient supply nomes with high accuracy. (who.int)

RAG1 and RAG2 cause a defect in the variable diversity joining (VDJ) rearrangement needed for mature T and B cells to develop. (medscape.com)

Although certain features of the biopsy were atypical, the clinical diagnosis was supported by persistent markedly raised blood creatine kinase levels and findings typical of DMD on electromyography and magnetic resonance spectroscopy. (bmj.com)
For a biopsy, a small tissue sample is removed and analyzed under a microscope to determine whether cancer cells are present. (moffitt.org)

Therefore, any T-cell disorder theoretically has the potential to cause defective B-cell function. (medscape.com)
Development of mature functioning B and T cells involves a complex series of steps, each of which may be defective, resulting in B-cell and T-cell deficiency. (medscape.com)
Male patients with thrombocytopenia and eczema may have Wiskott-Aldrich syndrome with defective T-cell function and resultant recurrent infections. (medscape.com)
These data suggest that either a congenital or an acquired germ cell defect contributes not only to defective spermatogenesis but also to the development of extragonadal germ cell tumors. (health.am)

Characterization of Infants with Idiopathic Transient and Persistent T Cell Lymphopenia Identified by Newborn Screening-a Single-Center Experience in New York State. (cdc.gov)

In addition, patients who are successfully treated for extragonadal germ cell tumors have a markedly increased risk of developing a subsequent testicular germ cell tumor. (health.am)

A major class of signalling proteins implicated in cell to cell communication is represented by members of the TGFβ superfamily. (biologists.com)
Sadly, this presents a nonnative (nonself) proteins into the tumor cells that could form the foundation for an artifactual anti-tumor immune system response as well as full rejection from the allografted tumor cells, as noticed previously (15). (rockstarsagainstliveearth.com)

Traditionally, B cells have been believed to be the lymphocytes responsible for antibody production via maturation into plasma cells (ie, humoral immunity), and T cells have been believed to be the lymphocytes responsible for killing other cells or organisms (ie, cellular immunity). (medscape.com)

Haploid human ES cells exhibited typical pluripotent stem cell characteristics such as self-renewal capacity and a pluripotency-specific molecular signature. (nih.gov)
We expect that haploid human ES cells will provide novel means for studying human functional genomics, development and evolution. (nih.gov)
Small cell neuroendocrine carcinoma of the uterine cervix (SCNEC) is a rare cancer involving the human papilloma virus (HPV), and has few available treatments. (biomedcentral.com)
The work, in addition to another study from the tenOever group, also suggests how the pandemic virus, which infects less than 1 % of cells in the human body, can cause such severe damage in so many organs. (kingwoodconnection.com)
In both hamster and human olfactory neuronal tissue, the research team detected persistent and widespread downregulation of olfactory receptor building. (kingwoodconnection.com)
Kato, H. & Sandberg, A. A. Chromosome pulverization in human cells with micronuclei. (strangeindia.com)
Because the expression of human and mouse Survivin splice variants in cancer cells continues to be proven on the mRNA level, we performed RT PCR to examine the presence of SurvivinGp splice kinds in adult guinea pig tissues. (mirnamimic.com)
A plasmid create was made to communicate full-length human being ORF for hMSLN and megakaryocyte potentiating element (MPF) in the follicular subset of thyroid cells with a rat thyroid particular peroxidase (TPO) promoter to operate a vehicle transgene manifestation. (rockstarsagainstliveearth.com)

The association of Klinefelter syndrome and mediastinal nonseminomatous germ cell tumors is now well recognized. (health.am)
Four of 22 consecutive patients (18%) treated at Indiana University for primary mediastinal germ cell tumors had karyotypic confirmation of Klinefelter syndrome, and an additional patient had clinical features. (health.am)
The average age of patients with Klinefelter syndrome who develop extragonadal germ cell tumors is approximately 18 years, 10 years younger than the median age of those developing this tumor in the absence of Klinefelter syndrome. (health.am)
Increasing evidence indicates that many individuals who develop germ cell tumors have underlying germ cell defects. (health.am)
In a series of 635 patients with extragonadal germ cell tumors, 17 patients developed hematologic malignancies at a median of 6 months after the extragonadal germ cell tumor was diagnosed. (health.am)
In addition to hematologic neoplasia, several cases of idiopathic thrombocytopenia in association with mediastinal nonseminomatous germ cell tumors have been reported. (health.am)
research examining the experience of hMSLN-targeted therapeutics against tumors expressing hMSLN can be carried out using individual cell lines inoculated into tolerant immunocompromised mice, the evaluation of hMSLN-targeted therapies in conjunction with immune system modulatory agents isn't feasible in these immunocompromised systems. (rockstarsagainstliveearth.com)

Gamete manipulation has yielded haploid embryonic stem (ES) cells from several mammalian species, but as of yet not from humans. (nih.gov)

4. Bretagnolle, F. and Thompson, J.D., Gametes with the somatic (sic) chromosome number: mechanisms of their formation and role in the evolution of autopolypoid plants, N. Phytol. (cytgen.com)
The cells have lost normal control mechanisms and thus are able to multiply continuously, invade nearby. (msdmanuals.com)

Differentiation of distinct cell types at specific locations within a developing organism depends largely on the ability of cells to communicate. (biologists.com)

Trends Cell Biol. (crossref.org)
Cell Biol. (strangeindia.com)

In situ hybridization with double labeling for X and Y chromosome-specific sequences of PBMCs from male patients with scleroderma (above) and scleroderma/myositis overlap (below). (jci.org)

One of many types of cancer that can develop in the lymphatic system, mantle cell lymphoma is a rare form of non-Hodgkin lymphoma, affecting only about one in 200,000 Americans annually. (moffitt.org)
To understand a diagnosis of mantle cell lymphoma, it is helpful to briefly consider where in the body it develops. (moffitt.org)
Mantle cell lymphoma develops in the B lymphocytes. (moffitt.org)
In fact, it is a subtype of B-cell non-Hodgkin lymphoma . (moffitt.org)
As with other forms of cancer, lymphoma is a malignancy caused by abnormal cell growth. (moffitt.org)
In the case of mantle cell lymphoma, the cancer starts in the outer edge of a lymph node follicle, an area known as the mantle zone. (moffitt.org)
What are the common symptoms of mantle cell lymphoma? (moffitt.org)
Many people with mantle cell lymphoma have no symptoms during the early stages of the disease. (moffitt.org)
When symptoms begin, they are often similar to those caused by a wide variety of other health conditions, which makes mantle cell lymphoma somewhat challenging to diagnose. (moffitt.org)
Perhaps the most telling sign of mantle cell lymphoma is the persistent, painless swelling of lymph nodes in the neck and throat areas. (moffitt.org)
What causes mantle cell lymphoma? (moffitt.org)
How is mantle cell lymphoma diagnosed? (moffitt.org)
If a diagnosis of mantle cell lymphoma is confirmed, the doctor will determine what stage the cancer is in. (moffitt.org)
Because patients with this type of lymphoma often display no symptoms or have symptoms that are similar to those of other health conditions, mantle cell lymphoma is often diagnosed in its late stages. (moffitt.org)
How is mantle cell lymphoma treated? (moffitt.org)
For patients who are diagnosed with a less aggressive form of mantle cell lymphoma, physicians may recommend a short period of "watchful waiting"-or monitoring the cancer progression before starting active treatment. (moffitt.org)
The primary purpose of this study is to test whether CD22-CAR T cells can be successfully made from immune cells collected from adults with relapsed/refractory B-cell malignancies (leukemia and lymphoma). (stanford.edu)
Subjects with aggressive B-cell NHL: must have evaluable or measurable disease according to the revised IWG Response Criteria for Malignant Lymphoma[38]. (stanford.edu)

To obtain more information on this issue, the stability status of all cells in any future fluorescence in situ hybridization follow-up of a radiation accident should be noted. (ukhsa.gov.uk)

However, dysregulation of the DDR pathway allows cells to proliferate beyond senescence limits. (oncotarget.com)

The low density and small size of these bridges, and aneuploid chromosome number biologically persistent particles makes respiratory were observed. (cdc.gov)

therefore, the association with mediastinal germ cell tumor seems specific. (health.am)

Here we report a severe life-threatening complication of treatment with streptozotocin in a patient with pancreatic island-cell carcinoma. (cancerindex.org)
When T-cell deficiency is especially severe or involves the T-helper cell function, the deficiency causes an antibody deficiency. (medscape.com)
We discovered that immunotoxin treatment causes severe and persistent histologic adjustments to serosal membranes in Msl mice while individual mesothelin-expressing thyroid follicular cells in TPO mice are resistant to immunotoxin despite exceptional medication delivery. (rockstarsagainstliveearth.com)

Mastocytosis is a diverse group of disorders characterised by the expansion and accumulation of mast cells in one or more organ systems. (dermnetnz.org)

Anatomy66

Organisms11

Diseases28

Chemicals and Drugs30

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Psychiatry and Psychology1

Phenomena and Processes169

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science4

Health Care1

Instability9

Genes19

Gene14

Abnormalities3

Embryonic stem1

Measured by translocations1

Telomere11

Clonal1

Diploid4

Segregation errors4

Mitosis7

Inactivation2

Genetic9

Induces3

22q11.23

Genome6

Ploidy1

Aberrations5

Maternal7

Infection6

Telomeres3

Abstract1

Chromatin2

Karyotype5

Neoplastic1

Diseases4

Translocations7

Neoplasms4

Sequencing was performed1

Lifespan2

Proper1

Peripheral blood3

Mutations4

Chromothripsis1

Complex karyotypes2

Foci2

Viral2

Unstable1

Mutation1

Squamous cell carc2

Basophils1

Microtubule4

Proliferation1

Rearrangement1

Biopsy2

Defective4

Characterization1

Markedly1

Proteins2

Organisms1

Human8

Tumors7

Mammalian1

Mechanisms2

Differentiation1

Biol2

Sequences1

Lymphoma18

Fluorescence1

Dysregulation1

Bridges1

Germ1

Severe3

Accumulation1