• immune system
  • Acquired immune system cells called T-cells are known to be present at the site of lesions. (wikipedia.org)
  • Other immune system cells called macrophages (and possibly mast cells) also contribute to the damage. (wikipedia.org)
  • Recent studies show that gliadin can cross-link to gangliosides in a transglutaminase independent manner, indicating that gliadin specific T-cell could present these antigens to the immune system. (wikipedia.org)
  • Inflammation starts mainly due to immune system failure. (wikipedia.org)
  • Reduction of consciousness Hypothalamic lesions may also affect the immune system, which is known in alcohol abusers, causing dysplasias and infections. (wikipedia.org)
  • Injuries
  • Many affected individuals only become aware of the disease when they notice painless injuries and burns or when they seek medical advice for slowly healing wounds or foot ulcers. (wikipedia.org)
  • treatment
  • Official sites for physicians to obtain BabyBIG, an FDA approved orphant drug for treatment of infant botulism type A and B. Also provides parent support forum and medical/clinical information on the disease. (dmoztools.net)
  • autoimmune
  • Some demyelinating diseases are caused by genetics, some by infectious agents, some by autoimmune reactions, and some by unknown factors. (wikipedia.org)
  • Evolutionary considerations for the role of prolonged cortical myelination as a risk factor for demyelinating disease are particularly pertinent given that genetics and autoimmune deficiency hypotheses fail to explain many cases of demyelinating disease. (wikipedia.org)
  • Thyroid autoimmune diseases can also be volatile: hyperthyroidism can interchange with hypothyroidism and euthyroidism. (wikipedia.org)
  • occur
  • Loss of touch sensation in the feet, ankles and legs, as well as in the hands, wrists and arms occur with various types of the disease. (wikipedia.org)
  • Early and late onset forms occur with 'on and off' painful spasmodic muscular contractions that can be disabling when the disease activates. (wikipedia.org)
  • mechanisms
  • Advances in molecular genetics have enabled identification of most genes associated with HSAN I. However, the molecular mechanisms that underlie the disease are not fully understood and are under investigation. (wikipedia.org)
  • The field draws on both neuroscience and developmental biology to provide insight into the cellular and molecular mechanisms by which complex nervous systems develop. (wikipedia.org)
  • Synaptopathies are attracting research interest because they provide an insight into fundamental mechanisms of synaptic transmission and because an improved understanding of disease mechanisms may lead to new treatments. (wikipedia.org)
  • onset
  • The onset of the disease varies between the 2nd and 5th decade of life, albeit congenital or childhood onset has occasionally been reported. (wikipedia.org)
  • The extended period of cortical myelination in humans may allow greater opportunity for disruption in myelination, resulting in the onset of demyelinating disease. (wikipedia.org)
  • diagnosis
  • Despite its rarity, the patient's ethnic background and the typical radiographic findings should prompt the clinicians to include NBD in the differential diagnosis of optic neuritis and demyelinating disease in the young. (wikipedia.org)
  • progresses
  • The loss of sensation can also extend to the proximal parts of the lower limbs and the upper limbs as the disease progresses. (wikipedia.org)
  • Weakness in the hands and forearms occurs in many people as the disease progresses. (wikipedia.org)
  • Neuroscience
  • Neuroscience (or neurobiology) is the scientific study of the nervous system. (wikipedia.org)
  • The scope of neuroscience has broadened over time to include different approaches used to study the molecular, cellular, developmental, structural, functional, evolutionary, computational, psychosocial and medical aspects of the nervous system. (wikipedia.org)
  • As a result of the increasing number of scientists who study the nervous system, several prominent neuroscience organizations have been formed to provide a forum to all neuroscientists and educators. (wikipedia.org)
  • The following outline is provided as an overview of and topical guide to neuroscience: Neuroscience is the scientific study of the nervous system. (wikipedia.org)
  • Neurolinguistics Neuroimaging functional Magnetic Resonance Imaging Positron emission tomography Systems neuroscience is a subdiscipline of neuroscience which studies the function of neural circuits and systems. (wikipedia.org)
  • Neural oscillation Molecular neuroscience is a branch of neuroscience that examines the biology of the nervous system with molecular biology, molecular genetics, protein chemistry and related methodologies. (wikipedia.org)
  • Nutritional neuroscience Neurochemistry Computational neuroscience includes both the study of the information processing functions of the nervous system, and the use of digital computers to study the nervous system. (wikipedia.org)
  • clinical
  • In hospitals that possess clinical neurophysiology facilities, the major diagnostic modalities employed include: Electromyography and nerve conduction studies: These diagnostic tests of the peripheral nervous system, especially useful in evaluating diseases of the muscles, nerves, and nerve roots. (wikipedia.org)
  • Therefore
  • Therefore, the role of the human-specific prolonged period of cortical myelination is an important evolutionary consideration in the pathogenesis of demyelinating disease. (wikipedia.org)
  • neural
  • Brain mapping Electrophysiology Extracellular recording Intracellular recording Brain stimulation Electroencephalography Intermittent rhythmic delta activity Category:Neurophysiology Neuroanatomy is the study of the anatomy of nervous tissue and neural structures of the nervous system. (wikipedia.org)
  • In other words, it can distinguish NBD from non-NBD neural disease. (wikipedia.org)
  • nerve
  • however, information for them is conveyed centrally in two distinct systems that both use the same nerve bundle and spinothalamic tract. (wikipedia.org)
  • dementia
  • What is known for sure is that by the turn of the 20th century the old concept of insanity had become fragmented into 'diseases' (psychoses) such as paranoia, dementia praecox, manic-depressive insanity and epilepsy (Emil Kraepelin's classification). (wikipedia.org)
  • distal
  • The hallmark of the disease is the marked loss of pain and temperature sensation in the distal parts of the lower limbs. (wikipedia.org)
  • tissue
  • Behçet's disease is recognized as a disease that cause inflammatory perivasculitis, inflammation of the tissue around a blood or lymph vessel, in practically any tissue in the body. (wikipedia.org)
  • Study
  • The purpose of this study is to collect data on the incidence, complications, economic burden and impact on the quality of life in adults aged ≥ 50 years with HZ disease in Italy. (clinicaltrials.gov)
  • The earliest study of the nervous system dates to ancient Egypt. (wikipedia.org)