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Leukocytes, MononuclearLymphomaLymphoma, B-CellLymphoma, T-CellLymphoma, Large B-Cell, DiffuseLymphoma, Non-HodgkinLymphoma, Mantle-CellLymphocytesT-LymphocytesMonocytesLymphoma, FollicularCells, CulturedCarcinoma, Large CellLymphocyte ActivationLymphoma, Large-Cell, AnaplasticFlow CytometryBurkitt LymphomaB-LymphocytesAntigens, CD30PhytohemagglutininsLymphoma, T-Cell, CutaneousInterferon-gammaLymphoma, T-Cell, PeripheralCytokinesImmunophenotypingLymphoma, B-Cell, Marginal ZoneAntibodies, MonoclonalPolymerase Chain ReactionAntigens, CDRNA, MessengerHIV-1Interleukin-2Hodgkin DiseaseMolecular Sequence DataCD4-Positive T-LymphocytesCell LineKiller Cells, NaturalBase SequenceLymph NodesBlood CellsLymphoma, AIDS-RelatedInterleukin-10Translocation, GeneticImmunohistochemistryHerpesvirus 4, HumanReverse Transcriptase Polymerase Chain ReactionCytotoxicity, ImmunologicTime FactorsTumor Necrosis Factor-alphaCell SeparationLymphoid TissueCell DivisionEnzyme-Linked Immunosorbent AssayAntigens, CD3VincristinePokeweed MitogensHIV InfectionsInterleukin-4Leukocyte CountTumor Cells, CulturedDNA, ViralBone MarrowImmunity, CellularConcanavalin ALymphoma, Large-Cell, ImmunoblasticVirus ReplicationCD8-Positive T-LymphocytesAntigens, CD20SpleenCarcinoma, NeuroendocrineAntigens, NeoplasmGene ExpressionApoptosisAntigens, SurfaceLeukocytesPrednisoneCyclophosphamideClone CellsImmunoglobulin GCase-Control StudiesProvirusesReceptor Protein-Tyrosine KinasesChromosomes, Human, Pair 14T-Lymphocyte SubsetsAntigens, CD5Gene Expression ProfilingPhenotypeLymphoproliferative DisordersAntibodies, Monoclonal, Murine-DerivedTransplantation, AutologousMycosis FungoidesCell Line, TumorAntigens, Differentiation, T-LymphocyteSkin NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsLymphoma, Primary Cutaneous Anaplastic Large CellMacrophagesRecombinant ProteinsT-Lymphocytes, CytotoxicLymphocyte Subsets
KinaseLymph nodesALCLCutaneousAntigenReactiveAntigens2021TumorGeneHodgkin'sCarcinomaUncommonReceptorFound in bone marrowTissuesLymphocytesInvolvementMembraneLeukemiaMalignancyNeoplasmBoneProliferationAbnormal cellsMycosis fungoidesPrecursorSpecimensStem cellsHistopathologicalAffectsMutationPatientsCD28BasalCytologicalLesionsCancerSpectrumPathophysiologyDiseasePresentAntitumorTherapy
Kinase6
  • Anaplastic lymphoma kinase (ALK) protein may be detected in most cases (60-70%) of systemic ALCL by immunohistochemistry. (medscape.com)
  • This lymphoma is caused by chromosomal translocations involving the anaplastic lymphoma kinase gene (ALK). (biomedcentral.com)
  • Anaplastic large cell lymphoma with anaplastic lymphoma kinase gene translocations (ALK+ ALCL) is a mature T-cell lymphoma that primarily affects lymph nodes, but also gives rise to tumors in extranodal organs and occasional characteristic skin lesions. (biomedcentral.com)
  • Front-line treatment of ceritinib improves efficacy over crizotinib for Asian patients with anaplastic lymphoma kinase fusion NSCLC: The role of systemic progression control. (uams.edu)
  • Anaplastic Lymphoma Kinase. (lab-ally.com)
  • ALK is one of the receptor tyrosine kinase (RTK) family of enzymes, which have significant roles in the proliferation and differentiation of cells. (lab-ally.com)
Lymph nodes3
  • They can skin and can extend to the bone marrow, simulate benign skin disorders, making them blood lymphocytes, lymph nodes, and a diagnostic challenge for dermatologists1,2. (bvsalud.org)
  • 4.2 Adoptive T Cell Therapy Take action is a malignancy immunotherapy method in which T cells are collected from your tumor, lymph nodes, or peripheral blood of a patient and returned Vanin-1-IN-1 to the patients body after proliferation and selection of tumor-specific T cells. (azd1152.com)
  • Dendritic cells display a large amount of MHC-peptide complexes at their surface and can increase the expression of costimulatory receptors and migrate to the lymph nodes, spleen, and other lymphoid tissues, where they activate specific T cells. (medscape.com)
ALCL8
  • ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
  • In 1988, ALCL was added as a distinct entity to the revised Kiel classification, and in 1994, it was included in the Revised European-American Lymphoma (REAL) classification. (medscape.com)
  • PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
  • Histologically, ALCL is characterized by sheets of large pleomorphic cells with abundant cytoplasm, horseshoe- or wreath-shaped nuclei, and multiple prominent nucleoli. (medscape.com)
  • Anaplastic large cell lymphoma positive for ALK (ALK+ ALCL) is a rare type of non-Hodgkin lymphoma. (biomedcentral.com)
  • Murine tumors displayed the phenotypic diversity observed in ALK+ ALCL patients, including CD4+ and CD8+ lymphomas. (biomedcentral.com)
  • Specifically, we found that the WNT signaling cell surface receptor ROR2 represented a robust and genuine marker of all ALK+ ALCL patient tumor samples. (biomedcentral.com)
  • The majority of ALK+ ALCL tumor cells have been shown to express at least one T-cell specific marker. (biomedcentral.com)
Cutaneous9
  • This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)
  • Prognostic significance of a polymerase chain reaction-detectable dominant T-cell clone in cutaneous lesions of patients with mycosis fungoides. (jamanetwork.com)
  • Genotypic analysis of cutaneous T-cell lymphoma: a comparative study of southern blot analysis with polymerase chain reaction amplification of the T-cell receptor-gamma gene. (jamanetwork.com)
  • Bottaro MBerti EBiondi AMigone NCrosti L Heteroduplex analysis of T-cell receptor gamma gene rearrangements for diagnosis and monitoring of cutaneous T-cell lymphomas. (jamanetwork.com)
  • Scheller UMuche JMSterry WLukowsky A Detection of clonal T cells in cutaneous T-cell lymphoma by polymerase chain reaction: comparison of mutation detection enhancement-polyacrylamide gel electrophoresis, temperature gradient gel electrophoresis and fragment analysis of sequencing gels. (jamanetwork.com)
  • Tok JSzaboles MJSilvers DNZhong JMatsushima AY Detection of a clonal T-cell receptor gamma chain gene rearrangements by polymerase chain reaction and denaturing gradient gel electrophoresis (PCR/DGGE) in archival specimens from patients with early cutaneous T-cell lymphoma: correlation of histologic findings with PCR/DGGE. (jamanetwork.com)
  • Veelken HWood GSSklar J Molecular staging of cutaneous T-cell lymphoma: evidence for systemic involvement in early disease. (jamanetwork.com)
  • Cutaneous T-cell lymphoma is a general term from mycosis fungoides or occur spontane- to identify non-Hodgkin's T-cell lymphomas ously, although some authors now consider that primarily affect the skin. (bvsalud.org)
  • subtypes of cutaneous T-cell lymphoma, SS is a malignant neoplasm originating the most common of which are mycosis from T lymphocytes, which involves the fungoides and Sézary syndrome (SS). (bvsalud.org)
Antigen6
  • Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
  • Take action can be performed with unmanipulated cells or designed cells that express chimeric antigen receptors (CAR-T cells). (azd1152.com)
  • Committed stem cells can mature to become antigen-processing cells, with some possessing phagocytic capabilities. (medscape.com)
  • [ 11 ] Immature dendritic cells respond to GM-CSF (not to macrophage colony-stimulating factor [M-CSF]) and become committed to generating dendritic cells, which are "professional" antigen-presenting cells (APCs). (medscape.com)
  • [ 12 ] These cells can capture antigen and migrate to lymphoid organs, where they present the antigens to naive T cells. (medscape.com)
  • Effective induction of antigen-specific T-cell responses requires interaction between the dendritic cells and T lymphocytes to prime the latter cells for expansion and subsequent immune responses. (medscape.com)
Reactive2
  • Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
  • Each category of histiocytosis can be traced to reactive or neoplastic proliferation in one of these cell lineages. (medscape.com)
Antigens3
  • Sixty percent of cases express 1 or more T-cell antigens (CD3 + , CD43, or CD45RO). (medscape.com)
  • A second concern is usually cytokine release syndrome due to the CAR-T cells activation following binding to antigens in both tumor cells and normal cells (226). (azd1152.com)
  • The importance of dendritic cells in presenting antigens to T and B lymphocytes is increasingly recognized. (medscape.com)
20211
  • Session 4 of the 2021 European Association of Haematopathology/Society for Hematopathology Workshop focused on nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). (bvsalud.org)
Tumor6
  • and or tumor cells infected with oncolytic viruses release PAMPs, which increases immune responses (217, 218). (azd1152.com)
  • The results of phase I and II trials showed that the use of Newcastle virus-infected tumor cells reduced recurrence and increased OS in CRC patients (44, 219). (azd1152.com)
  • In the context of mCRC, CAR-T cells as monotherapy or in combination with cytokines such as IL-12 had encouraging effects such as tumor reduction and long-term disease Vanin-1-IN-1 stability in some Vanin-1-IN-1 patients (222C225). (azd1152.com)
  • The use of tumor-specific unmanipulated cells has also yielded positive results in CRC. (azd1152.com)
  • BACKGROUND: Hodgkin lymphoma (HL) is a highly curable malignant tumor. (bvsalud.org)
  • The added value of further immunophenotypic characterization of both tumor cells and microenvironment to support the differential diagnosis was presented. (bvsalud.org)
Gene6
  • Landa NGZelickson BDPeters MSMuller SAPittelkow MR Lymphoma versus pseudolymphoma of the skin: gene rearrangement study of 21 cases with clinicopathologic correlation. (jamanetwork.com)
  • Detection of clonal T-cell receptor gamma gene rearrangements in early mycosis fungoides/Sézary syndrome by polymerase chain reaction and denaturing gradient gel electrophoresis (PCR/DGGE). (jamanetwork.com)
  • Chhanabhai MAdomat SAGascoyne RDHorsman DE Clinical utility of heteroduplex analysis of TCR gamma gene rearrangements in the diagnosis of T-cell lymphoproliferative disorders. (jamanetwork.com)
  • Utility of microdissection and polymerase chain reaction for the detection of immunoglobulin gene rearrangement and translocation in primary intraocular lymphoma. (jamanetwork.com)
  • The oncogenic potential of the NPM-ALK fusion gene was first demonstrated in vitro using murine cell lines and primary cells. (biomedcentral.com)
  • Based on a large collection of cases, the defining morphological, immunophenotypical, and gene expression features of T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) and THRLBCL-like NLPHL (pattern E) were reviewed to explore this challenging differential diagnosis and critically evaluate whether aggressive behavior and transformation of NLPHL can be predicted in practice. (bvsalud.org)
Hodgkin's2
  • Pan LXDiss TCPeng HZNorton AJIsaacson PG Nodular lymphocyte predominance Hodgkin's disease: a monoclonal or polyclonal B-cell disorder? (jamanetwork.com)
  • but given no improvement was observed, a second cervicotomy was performed, with the histopathological diagnosis of the latter of Hodgkin's lymphoma. (bvsalud.org)
Carcinoma2
  • Basal Cell Carcinoma. (lab-ally.com)
  • The second group includes large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC). (springeropen.com)
Uncommon2
  • In addition, cytoplasmic vacuoles are not uncommon in large cell lymphomas involving body cavities. (cytojournal.com)
  • Anaplastic Anemia is an uncommon disease resulting in deficiencies of blood cell production by bone marrow. (lab-ally.com)
Receptor3
  • Clonal rearrangements of T-cell receptor genes in mycosis fungoides and dermatopathic lymphadenopathy. (jamanetwork.com)
  • Langerak AWScczepanski Tvan der Burg MWolvers-Tettero ILvan Dongen JJ Heteroduplex PCR analysis of rearranged T-cell receptor genes for clonality assessment in suspect T-cell proliferations. (jamanetwork.com)
  • The first signal may involve interaction between an MHC I-bound and/or MHC II-bound peptide on an APC with the T-cell receptor (TCRs) on the effector lymphocytes. (medscape.com)
Found in bone marrow2
Tissues1
Lymphocytes2
Involvement1
Membrane1
  • A cell-mediated immune defense mechanism in which the immune system actively breaks down the membrane of a target cell. (lab-ally.com)
Leukemia4
  • Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
  • However, we know less about the biological effects of IL-21 and its signaling mechanisms in leukemia cells and monocytes. (intechopen.com)
  • In this chapter, we will focus on IL-21's biological effects and signaling pathways as well as discuss the potential implications and applications of IL-21 in leukemia cells. (intechopen.com)
  • B-Cell Acute Lymphoblastic Leukemia. (lab-ally.com)
Malignancy2
  • Lymphoma was the second most common malignancy accounted for 22% of pediatric cases, of which 34 (68%) were non-Hodgkin?s lymphoma (NHL). (ijmpo.org)
  • A type of clonal malignancy characterized by excess accumulation of lymphoblasts that phenotypically resemble the early stages of normal B-cell differentiation. (lab-ally.com)
Neoplasm1
  • A dermatology work-up was initiated, and the síndrome de Sézary initial diagnosis of malignant T-cell neoplasm was confirmed. (bvsalud.org)
Bone3
Proliferation2
  • Its roles include regulation of proliferation, promotion of immune system and activation of apoptosis in B cells. (intechopen.com)
  • In these cells, IL-21 does not promote proliferation but enhances apoptosis and chemotaxis. (intechopen.com)
Abnormal cells2
  • Interleukin-21 (IL-21) is produced by activated T cells and it plays many diverse roles by regulating the functions of normal and abnormal cells. (intechopen.com)
  • It is thought that leiomyoma is the result of either transformation of normal uterine muscle cells into abnormal cells through somatic mutations , or through the growth of abnormal uterine muscle cells into tumors. (wikidoc.org)
Mycosis fungoides1
Precursor1
  • Rare cases of precursor B-LL involving orbital mass and plasmablastic lymphoma involving paranasal sinuses were studied. (ijmpo.org)
Specimens1
  • In general, hematolymphoid cells manifest as dyshesive cells in cytological specimens. (cytojournal.com)
Stem cells1
Histopathological1
  • On microscopic histopathological analysis, elongated and spindle-shaped cells with a cigar-shaped nucleus are characteristic findings of leiomyoma. (wikidoc.org)
Affects1
  • This is a cancer that usually affects the skeletal cells in the trunk, arms, and legs. (lab-ally.com)
Mutation2
  • The mutation-specific CD8+ T cells were selected and returned to the patient, resulting in the removal of 85% of metastatic lesions (227). (azd1152.com)
  • Feasibility and effectiveness of afatinib for poor performance status patients with EGFR-mutation-positive non-small-cell lung cancer: a retrospective cohort study. (uams.edu)
Patients1
  • Consolidation treatment of durvalumab after chemoradiation in real-world patients with stage III unresectable non-small cell lung cancer. (uams.edu)
CD282
  • These CAR-T cells contain immune activating domains of CD28 and CD137. (azd1152.com)
  • Costimulatory interaction (i.e., second signal) is between CD80(B7.1)/CD86(B7.2) on the dendritic cell, and CD28 on the T cells. (medscape.com)
Basal2
  • In breast tissue, the luminal epithelial cells express CK 8/18, CK 7 and CK 19, while basal/myoepithelial cells express CK 5/6, CK 14 and CK 17. (ijpmonline.org)
  • BCC is a type of skin cancer that creates lesions and uncontrolled growth in the basal cells of the epidermis. (lab-ally.com)
Cytological1
  • This diagnoses results from the appearance of cytological abnormalities in glandular cells that do not demonstrate all the characteristics of adenocarcinomas. (lab-ally.com)
Lesions1
  • Immunohistochemical staining for cytokeratin 5/6 was applied on cell block sections of 23 cases of benign and 25 cases of malignant breast lesions using avidin biotin peroxidase technique. (ijpmonline.org)
Cancer2
Spectrum1
  • First, the spectrum of immunophenotypic variations in NLPHL and the defining criteria for classic Hodgkin Lymphoma (CHL) were discussed. (bvsalud.org)
Pathophysiology1
  • Most recently, this designation was changed to Langerhans cell histiocytosis based on the suggestion by Nezelof that the Langerhans cell represented the primary cell involved in the pathophysiology of the disease. (medscape.com)
Disease1
  • [ 2 ] For example, the entity now referred to as Langerhans cell histiocytosis (LCH) was initially divided into eosinophilic granuloma, Hand-Schüller-Christian disease, and Abt-Letterer-Siwe disease, depending on the sites and severity. (medscape.com)
Present1
  • The present study was therefore carried out to standardize the preservation of continuous cell lines at deep freezer (-85ºC) for 6 months. (ijpmonline.org)
Antitumor1
  • CAR-T cells are impartial of MHCs, and due to transporting costimulatory domains, they could induce strong antitumor responses (2). (azd1152.com)
Therapy1
  • Identification of TSAs is one of the current difficulties in CAR-T cell therapy (18). (azd1152.com)